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5-Fluoro-2-(Trifluoromethyl)Benzeneboronic Acid

5-Fluoro-2-(Trifluoromethyl)Benzeneboronic Acid

Hongda Chemical

    Specifications

    HS Code

    884301

    Chemical Formula C7H5BF4O2
    Molecular Weight 210.92
    Appearance White to off - white solid
    Cas Number 1256355-49-9
    Purity Typically high purity, e.g., 95%+
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
    Boiling Point Decomposes before boiling
    Melting Point 135 - 139 °C
    Storage Conditions Store in a cool, dry place, protected from moisture
    Stability Stable under normal conditions, but sensitive to strong acids and bases

    As an accredited 5-Fluoro-2-(Trifluoromethyl)Benzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 5 - fluoro - 2 - (trifluoromethyl)benzeneboronic acid in a sealed plastic bottle.
    Storage Store 5 - fluoro - 2 - (trifluoromethyl)benzeneboronic acid in a cool, dry place away from heat and ignition sources. Keep it in a tightly sealed container to prevent moisture absorption, which could affect its stability. Store separately from incompatible substances, like strong oxidizing agents, to avoid potential reactions.
    Shipping 5 - fluoro - 2 - (trifluoromethyl)benzeneboronic acid is shipped in well - sealed containers, following strict chemical transportation regulations. Packaging ensures protection from moisture and physical damage during transit to the destination.
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    5-Fluoro-2-(Trifluoromethyl)Benzeneboronic Acid 5-Fluoro-2-(Trifluoromethyl)Benzeneboronic Acid
    General Information
    Historical Development
    5 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid is an important compound in organic synthesis. Tracing its historical development, the field of organic synthesis has gradually paid attention to fluoroboronic acid-containing compounds in the past. At that time, scholars studied new organoboron reagents and hoped to expand the synthesis path. The initial appearance of this compound originated from digital chemists exploring the introduction of fluorine-containing groups into the phenylboronic acid structure. After repeated experiments, the reaction conditions were optimized, and effective synthesis methods were gradually obtained from the initial low yield exploration. In the early days, it was only prepared on a small scale in the laboratory for academic research. With the advancement of science and technology, the understanding of its properties and applications was deepened, and the industry also paid attention, which promoted the improvement of the synthesis process and moved towards large-scale production. It emerged in the fields of medicine, materials science and other fields, opening a new chapter of development.
    Product Overview
    Today there is a substance called 5 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid. It is a derivative of phenylboronic acid, and the fluorine atom and trifluoromethyl are cleverly connected to the benzene ring. This substance is quite useful in the field of chemical synthesis.
    Its shape or white crystalline powder is relatively stable in nature. It is often used as a key intermediate in organic synthesis reactions. With its unique structure, it can react delicately with many compounds to build a variety of organic molecular structures.
    Chemists can use specific reaction conditions to participate in the formation of carbon-boron bonds, and then derive a series of organic materials with special properties. Whether it is the development of new drugs in medicinal chemistry or the creation of new functional materials in materials science, they can all find their active presence, which is an indispensable and important substance for chemical research and production.
    Physical & Chemical Properties
    5 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid is an organic compound. Its physical properties, at room temperature or as a solid, look at its crystalline state, or have a regular shape. Color or nearly colorless, showing a pure state. Its melting point and boiling point are the key to characterizing its physical properties. As for chemical properties, the boron atom in this compound has unique chemical activity and can react with many nucleophiles, which is widely used in the field of organic synthesis. Its fluorine-containing group gives the molecule special electronic and spatial effects, which affect the activity and selectivity of its reaction. In chemical reactions, it can participate in a variety of organic reactions, such as coupling reactions, and is an important raw material for building complex organic molecular structures. It exhibits unique physical and chemical properties and is of great value in chemical research and industrial production.
    Technical Specifications & Labeling
    5 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid is an important chemical substance. Its process specifications and identification (product parameters) are crucial. The preparation of this product requires a specific chemical process to precisely control the conditions of each link. From the selection of raw materials, high purity should be selected to ensure the quality of the product. The reaction temperature and time also need to be strictly controlled, such as reacting for several hours in a specific temperature range to obtain the ideal product.
    In terms of identification, the chemical name, molecular formula, molecular weight and other parameters should be clearly marked. And the purity standard should be clearly stated. If the purity should reach a certain exact value, the impurity content must be lower than a specific proportion. In this way, the process specifications and identification (product parameters) of this product are clarified, which lays a solid foundation for subsequent research and application.
    Preparation Method
    This product is made of 5 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid. First, fluoro-generation m-trimethylbenzene is taken as the raw material. It is slowly added dropwise with n-butyl lithium in a low temperature environment, such as minus 70 to 80 degrees Celsius, so that it undergoes lithium-halogen exchange to obtain an active lithiated intermediate.
    Second dose trimethyl borate, warm to room temperature, and promote its full reaction. This step is the key transformation to form the boron ester structure of the target product. After the reaction, hydrolyze with dilute acid, such as a dilute solution of hydrochloric acid or sulfuric acid, and adjust to a suitable pH value to hydrolyze the boron ester into boric acid.
    After extraction, distillation, recrystallization and other purification methods, pure 5-Fluoro-2 - (Trifluoromethyl) Benzeneboronic Acid can be obtained. Extraction selects suitable organic solvents, such as dichloromethane, ethyl acetate, etc.; distillation and temperature control are precise, and separation is based on the difference in boiling point of each substance; recrystallization selects the appropriate solvent system to separate high-purity products. Throughout the process, temperature control, time control and material ratio need to be careful to ensure the quality and quantity of the product.
    Chemical Reactions & Modifications
    Since modern times, the art of chemistry has advanced day by day. In the study of 5 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid, scholars have devoted their attention to it. The beauty of its chemical reaction is like the pivot of ingenuity, which is related to many synthesis paths.
    At the beginning, the reaction of this compound is often hindered, and the obtained effect is not ideal. However, many researchers continue to explore, gain insight into the structure of its molecules and the properties of electrons, and find ways to improve it. After repeated experiments, change the reaction conditions, such as temperature control, pressure regulation, or more easily catalyzed substances.
    Finally, good results are obtained, the reaction rate is greatly increased, and the purity of the product is also good. And its performance improvement is extraordinary in the fields of medicine and materials. This is the pursuit of chemical refinement, and it is also an example for future generations to study other things, showing that they insist on exploring, improving and innovating.
    Synonyms & Product Names
    5-Fluoro-2- (trifluoromethyl) phenylboronic acid, which has attracted much attention in chemical research. There are many other names, such as the genus of aromatic boron, or named according to its structural characteristics. The names of the trade names are also different, and they are all well known in the industry.
    This compound has unique chemical properties and is widely used in the field of organic synthesis. It can be used as a key intermediate to participate in various reactions to construct complex organic molecular structures. Its reactivity and selectivity are relied on by chemical craftsmen, and can help synthesize various materials and drugs with special functions. In the current trend of chemical research and development, 5-fluoro-2-trifluoromethyl phenylboronic acid, with its characteristics, may be the key to opening a new synthesis path, leading chemical exploration to a new realm.
    Safety & Operational Standards
    5 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid is an important chemical. During its preparation and use, safety and handling practices are of paramount importance.
    When preparing this substance, it needs to be handled in a well-ventilated environment. Due to the irritation and toxicity of some raw materials, operators must wear appropriate protective equipment, such as protective gloves, goggles and gas masks, to avoid direct contact and inhalation of harmful substances.
    In the operation of the reaction, strict control of the reaction conditions is the key. Temperature, reaction time and the proportion of reactants can all affect the quality and yield of the product. The established reaction process should be accurately followed, and the parameters should not be changed without authorization.
    For the storage of the product, it should be placed in a dry, cool and ventilated place, away from fire sources and oxidants. Due to its certain chemical activity, improper storage can easily lead to danger.
    When using this substance for subsequent reactions, it should also follow the standard operating procedures according to the specific reaction requirements. After the experiment, the treatment of the remaining product and waste must comply with environmental protection requirements to prevent pollution to the environment.
    In short, the entire process of 5 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid, from preparation to use to waste disposal, must strictly abide by safety and operating practices to ensure the safety of personnel, the smooth progress of the experiment and the environment.
    Application Area
    5 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid is also a wonder of chemistry. Its application field is extensive. In research and development, it can be used as an important tool to help improve the development of new technologies and improve the quality and performance of general diseases. In the field of materials, it can be used to synthesize special materials, to improve the characteristics of materials, such as increasing their quality and performance. It can also be used in the delicate synthesis of synthetic materials, as an efficient tool, leading to the trend of reverse, and improving the yield of materials. This compound is used in the field of diversification research and research, such as a spoon, and can be used in new applications, promoting the progress of chemical technology, for the benefit of the world.
    Research & Development
    In recent years, I have been studying chemical substances, focusing on the compound 5 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid. When I first started, its structure and properties made me feel amazing, and it contained many unknowns to be explored.
    I began to study the synthesis path of this substance, and tried many different methods, or improved the previous method, or found a new way. During the process, I encountered many problems, such as the precise control of reaction conditions and the effective removal of impurities. However, I was not discouraged and tried repeatedly, and finally obtained a more ideal synthesis method, and the yield also improved.
    The application of it in the field of organic synthesis was further studied, and it was found that it can participate in a variety of key reactions, providing the possibility for the creation of novel compounds. After continuous practice, it expands its application scope and contributes a little to chemical research. Looking forward to the future, I am willing to use this as a foundation and continue to improve, hoping to make more breakthroughs, and promote the research and development of this compound to a new level.
    Toxicity Research
    Today there is a thing called "5 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid", and our generation takes toxicity research as its business. The toxicity of this compound is related to the safety of all living beings and cannot be ignored.
    Examine its nature carefully, or it may be harmful to living beings. Although it has an ordinary appearance, it should not be taken lightly because of its appearance. If you want to explore its toxicity, you must follow the scientific method and take rigor as the key.
    Take all animals and feed them with an appropriate amount of this thing, and observe the changes in their behavior, posture and physiology. Or see them languishing, their diet is waste, or even their organs are damaged. Also observe its impact on environmental organisms, aquatic genera and native insects should not be ignored.
    After many experiments, it has been proved that its signs of toxicity can be used by the world to avoid its harm and use it wisely, so as to live up to our research and ensure the safety of all things.
    Future Prospects
    I have tried to study 5 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid, thinking about its future development, and I have some thoughts.
    Looking at this compound today, it has unique properties, or it has pioneering power in the field of medicine. Its structure is exquisite, its activity can be explored, or it can be used for the creation of new drugs, opening up a new path. It can be used for targeted drugs, precise targets of diseases, and relieving the pain of patients.
    Or in the world of materials, it can bloom unique light. It can give new properties to materials, such as increasing their stability and changing their optoelectronic properties, making materials suitable for various needs, used in electronic and optical devices.
    Although the current research is not complete, I believe that with time, I will be able to dig deeper into its potential. In the future, when we study hard, we hope to use this thing to contribute to the advancement of science and the benefit of people's livelihood, to develop infinite possibilities, and to live up to the expectations of my generation of researchers.
    Where to Buy 5-Fluoro-2-(Trifluoromethyl)Benzeneboronic Acid in China?
    As a trusted 5-Fluoro-2-(Trifluoromethyl)Benzeneboronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 5-Fluoro-2-(Trifluoromethyl)Benzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of 5-fluoro-2- (trifluoromethyl) phenylboronic acid?
    5-Hydroxy-2- (trihydroxymethyl) aminoethanesulfonic acid, also known as TES, is a commonly used biological buffer. Its chemical properties are unique and have many characteristics.
    First, it is in the form of zwitterions, which can efficiently maintain the pH stability of the solution within a specific pH range. This characteristic is like a loyal guardian. In the biochemical experimental environment, no matter how external factors try to change the pH of the solution, it can resist and ensure the pH value is stable. Because of its good buffering ability, it is widely used in many biochemical research fields such as enzymatic reactions, protein purification and cell culture.
    Second, the substance has good solubility, whether it is in polar solvents such as water or some organic solvents, it can be well dissolved. This is like a practitioner who is good at integrating into different environments, so that in various experimental systems, it can quickly disperse evenly, exert its own buffering effect, and provide a stable environment for experiments.
    Third, its chemical properties are relatively stable, and it is not easy to react with common chemicals under general experimental conditions. Like a calm and stable person, in a complex and changeable chemical environment, it adheres to its own characteristics and is not easily disturbed by the outside world, thus ensuring the stability of the experimental system and avoiding affecting the accuracy of experimental results due to its own reaction.
    Fourth, for most biomolecules, 5-hydroxy-2- (trihydroxymethyl) aminoethanesulfonic acid has no significant interference. In biochemical experiments, many biomolecules, such as proteins, nucleic acids, etc., need to be studied under specific conditions. This substance acts as a friendly helper and will not negatively affect the structure and activity of these important biomolecules, ensuring that the experimental results are true and reliable.
    5-Hydroxy-2- (trihydroxymethyl) aminoethanesulfonic acid occupies an important position in the field of biochemistry and molecular biology experiments due to its unique chemical properties, providing researchers with reliable tools to help them explore the mysteries of life science in depth.
    What are the common synthesis methods of 5-fluoro-2- (trifluoromethyl) phenylboronic acid?
    5-Hydroxy-2- (triethylmethyl) indoleacetic acid. There have been many ways to synthesize this substance through the ages.
    First, indole is used as the starting material. First, indole is reacted with formaldehyde and dimethylamine under specific conditions to generate N - (dimethylaminomethyl) indole. Afterwards, this product is reacted with ethyl chloroacetate in an alkaline environment, and the corresponding ester is obtained through nucleophilic substitution reaction. Then through hydrolysis step, under suitable acid-base conditions, the ester group is hydrolyzed to a carboxyl group to obtain the target product 5-hydroxy- 2 - (triethylmethyl) indoleacetic acid. In this process, the control of the reaction conditions is very critical. Temperature, pH and the proportion of reactants will all affect the process and yield of the reaction.
    Second, o-nitrotoluene can also be used as the starting material. First, through a series of reactions, such as nitrification, reduction and other steps, it is converted into the corresponding amine compound. Then the amine is reacted with the appropriate aldehyde and diethyl malonate, and the indole ring structure is constructed by condensation and other reactions. Subsequent hydroxylation reactions introduce hydroxyl groups, and at the same time modify the side chains to finally achieve the synthesis of 5-hydroxy- 2 - (triethyl) indole acetic acid. This path involves a multi-step reaction, each step requires fine operation to ensure the smooth progress of the reaction and the purity of the product.
    Third, biosynthesis can be used. Using the metabolic pathways of certain microorganisms or plant cells, with the help of their own enzyme system, under suitable culture conditions, suitable precursors can be converted into 5-hydroxy- 2 - (triethylmethyl) indole acetic acid. This method has the advantages of green and environmental protection, but it requires high requirements for culture conditions and biological systems. It is necessary to precisely control the temperature, humidity, nutrients and other factors of the culture environment to promote the efficient progress of biosynthesis.
    In which fields is 5-fluoro-2- (trifluoromethyl) phenylboronic acid used?
    5-Hydroxy-2- (triethylmethyl) pyridylic acid is used in various fields. In the field of medicine, this substance is often a key raw material for pharmaceuticals. Because of its unique chemical structure and biological activity, it can help create a variety of specific drugs. For example, some antibacterial drugs, with their properties to destroy the structure of bacteria, inhibit their reproduction, and treat human infections. And in the development of neurological drugs, it may regulate the secretion and transmission of neurotransmitters, which can relieve neurological diseases such as depression and anxiety.
    In the field of agriculture, 5-hydroxy-2- (triethylmethyl) pyridylic acid is also indispensable. It can prepare plant growth regulators and regulate the growth process of crops. Or promote seed germination, make seedling root system thrive, increase plant resistance to drought, waterlogging, cold and other stress; or control the flowering and fruiting period of crops, make the fruit size uniform, excellent quality, and then increase the quantity and quality of agricultural yield. And in pest control, this substance may have the effect of repelling and inhibiting pests, reducing the application of chemical pesticides, and maintaining the ecological environment.
    In the chemical industry, 5-hydroxy- 2 - (triethyl) pyridinic acid is an important intermediate for the synthesis of special materials. For example, in the synthesis of polymer materials, by participating in the reaction, the material can be endowed with special properties, such as improving the toughness and heat resistance of plastics, making plastic products more durable and widely used. It also has potential in high-end manufacturing fields such as aviation and automobiles. And in the preparation of coatings and adhesives, it can optimize product performance, make coatings adhere better, weather resistance is strong, and adhesives bond more firmly.
    What are the storage conditions for 5-fluoro-2- (trifluoromethyl) phenylboronic acid?
    5 - 2 - (trimethylmethyl) glutaric acid, often in its active form 5 - 2 - (trimethylmethyl) glutaric acid acetylase A (HMG - CoA), is a biochemical reaction. The storage of this compound is studied.
    Because of its special properties, it is necessary to avoid tides, and the environment of tides is easy to cause the reaction of hydrolysis and equalization, which destroys its chemical properties and reduces or even loses its biological activity. Therefore, it should be stored in dry places, such as in a dry place, and the dry place can be placed in the dry place to maintain the dry environment.
    Furthermore, the degree is also a factor. This compound is sensitive to chemical degradation and is prone to decomposition or degradation due to high temperature. Therefore, it usually needs to be refrigerated, and the temperature should generally be controlled at 2-8 ° C. At this temperature, it can effectively delay its reaction rate and maintain its qualitative and biological activity.
    In addition, light also causes its own shadow. Light may cause photochemical reactions, causing it to change. Therefore, to avoid light, use brown bottles or opaque containers to store in dark, so that 5-2- (trimethylmethyl) glutaric acid can be properly preserved, so that it can maintain good activity and chemical quality in research or other related applications.
    What is the market price of 5-fluoro-2- (trifluoromethyl) phenylboronic acid?
    Wen Jun inquired about the market price of pentahydroxytryptamine bis (trimethylamino) indoleacetic acid. This medicine is widely used in medicine, but its price varies due to many reasons, and it cannot be hidden in a word.
    First, the price varies depending on the place of production. If the product is good, the materials are abundant, the labor force is easy, and the price is flat; if the place is remote and the mining and transportation are difficult, the price will be high.
    Second, the quality is also the key to the price. Those who are of high quality have the same degree of test, pure but not miscellaneous, and the effect is outstanding, and its value is high; those who are of poor quality, miscellaneous but not pure, and the effect is not enough, and the price will drop.
    Third, the supply and demand of the city has a lot to do with it. If there are many people in need, but there are few suppliers, the price will rise; if the supply exceeds the demand, the price will trend downwards.
    Fourth, the operation of the business also involves the price. The big merchants are huge, the goods are well-known, the purchase and sale volume is wide, the cost can be controlled, or the price can be slightly reduced; the small merchants and hawkers are difficult to operate, the amount is small and the profit is small, and the price may be slightly higher.
    According to the current market conditions, the price ranges from tens of gold to hundreds of gold, but this is not the exact number, and the times change, and the price also changes. If you want to know the exact price, you should consult the pharmaceutical companies and merchants, and carefully observe the market conditions before you can obtain it.