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5-Fluoro-2-Methoxybenzeneboronic Acid

5-Fluoro-2-Methoxybenzeneboronic Acid

Hongda Chemical

Specifications

HS Code

807971

Chemical Formula C7H8BO4F
Molar Mass 185.947 g/mol
Appearance White to off - white solid
Melting Point 140 - 145 °C
Solubility In Water Slightly soluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, ethanol
Pka Around 8 - 9 (approximate value for boronic acid group)
Stability Stable under normal conditions, but sensitive to strong oxidizing agents
Boiling Point Decomposes before boiling

As an accredited 5-Fluoro-2-Methoxybenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 5 - fluoro - 2 - methoxybenzeneboronic Acid: 100g in a sealed, chemical - resistant bottle.
Storage 5 - fluoro - 2 - methoxybenzeneboronic acid should be stored in a cool, dry place away from heat and direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption, as boronic acids can react with water. Store separately from incompatible substances, like strong oxidizing agents. Ideal storage is in a well - ventilated chemical storage area to minimize risks.
Shipping 5 - fluoro - 2 - methoxybenzeneboronic acid is shipped in well - sealed containers, often in accordance with chemical transport regulations. It's carefully packaged to prevent spills, with appropriate labeling for safety during transit.
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5-Fluoro-2-Methoxybenzeneboronic Acid 5-Fluoro-2-Methoxybenzeneboronic Acid
General Information
Historical Development
5-Fluoro-2-methoxyphenylboronic acid is also an organic compound. Its origin can be traced back to the era of chemical research in the past. At that time, Zhu Xian delved into the mystery of chemistry and explored the properties of substances. After years of experimentation, thinking, and research, this compound was discovered.
Initially, in a simple laboratory, Zhu Gong used limited equipment and materials to try out various reactions. After repeated attempts, the method of preparation was gradually obtained. With the passage of time, chemical technology has advanced, and the method of preparation has become more exquisite and efficient.
Since its initial appearance, many scholars have devoted themselves to the study of this substance. Explore the wonders of its structure and study the rules of its reaction. In the field of organic synthesis, it has gradually become important, assisting in the research and development of new drugs, material creation and many other aspects. Over the years, the research on 5-fluoro-2-methoxyphenylboronic acid has not stopped, adding a touch of brilliance to the development of chemistry, and also laying the foundation for future research, waiting for more wonderful discoveries.
Product Overview
5-Fluoro-2-methoxyphenylboronic acid, this chemical is also. Its color is pure and clean, and it is often in the form of a white powder. Its properties are stable, and it can be stored for a long time at room temperature without melting.
The preparation method is based on the process of fine grinding, through various reactions. First take a specific raw material, dissolve it with a suitable solvent, control the temperature and respond, and then separate and purify it to obtain this product.
In the field of organic synthesis, its function is very great. It is often a key reagent, helping to form a variety of compounds. Or used to build complex molecular structures, or participate in catalytic reactions, making various synthesis paths smoother. Therefore, 5-fluoro-2-methoxyphenylboronic acid is indispensable for chemical research and industrial production.
Physical & Chemical Properties
5 - Fluoro - 2 - Methoxybenzeneboronic Acid, it is also a chemical substance. Its physical properties, color is often white, or powder. In the melting process, it begins to melt at a certain degree, which is its important physical characteristic.
Its chemical properties, boron atoms are active, and can be used to react to many compounds. Its acidity is not low, but under specific conditions, it can exhibit the characteristics of acid, and it can be reversed. And because of its fluorine, methoxy and other groups, its chemical properties are very high, and it can be used for many synthetic reactions. It can be used for chemical research and engineering.
Technical Specifications & Labeling
5-Fluoro-2-methoxyphenylboronic acid is an important substance for chemical research. Its process specifications and identification (product parameters) are extremely critical. The appearance of this substance is often white to off-white crystalline powder. In terms of process specifications, the synthesis requires a multi-step reaction. The starting materials are put in precise proportions, and gradually converted into the target product under specific temperature, pressure and catalyst action. The reaction process needs to be strictly monitored to ensure the progress and purity of the reaction. In the identification (product parameters), it is clear that the purity should be above 98%, the moisture content is less than 0.5%, and the melting point is in a specific range. Through precise process specifications and clear identification, the quality and application effect of the product in the field of scientific research and production can be guaranteed.
Preparation Method
5 - Fluoro - 2 - Methoxybenzeneboronic Acid is an important organic compound, and its preparation method is very important. As for raw materials, 2 - methoxy - 5 - fluorobrobenzene can be used as a starting material, which is a common and easy-to-obtain raw material. In the synthesis process, 2 - methoxy - 5 - fluorobrobenzene is reacted with magnesium chips in an anhydrous and oxygen-free environment to make Grignard reagent. Subsequently, Grignard reagent reacts with borate ester to obtain the target product crude product. The reaction step requires strict control of temperature and reaction time. The temperature should be maintained at a low temperature, such as -78 ° C, to ensure the smooth progress of the reaction. In terms of post-treatment mechanism, after the reaction, hydrolysis, extraction, column chromatography and other purification methods can remove impurities and improve the purity of the product, so that high purity 5-Fluoro-2-Methoxybenzeneboronic Acid can be prepared.
Chemical Reactions & Modifications
5-Fluoro-2-methoxyphenylboronic acid, the chemical reaction and modification of this compound are related to the gist of our research. During the reaction, the molecular structures interact with each other, just like the ancient art of war, each atom is rearranged and combined according to a specific rule. In order to achieve a smooth reaction, it is necessary to study the reaction conditions, such as temperature and solvent. When modifying, the intention is to optimize its performance, or increase its stability, or change its activity. This is like carving beautiful jade and applying art carefully. On the road of chemistry, exploring the reaction and modification of this compound can open up new paths, such as the ancients exploring the secrets, unremitting and far-reaching, adding bricks and tiles to the progress of chemistry, in order to achieve a delicate environment.
Synonyms & Product Names
5-Fluoro-2-methoxyphenylboronic acid, the alias and trade name of this compound are related to its characteristics. It is an organoboron compound, which is very important in the field of organic synthesis.
The alias is because of the chemical structure, and chemists also call it him. The trade name varies depending on the manufacturer and the market.
View this compound, 5-fluoro and 2-methoxy are phenyl ring additive properties, and the boric acid group gives it reactivity. When synthesized, this structure can lead to a variety of chemical reactions, which are useful in medicine and materials science.
Although the alias is different from the trade name, it refers to this specific compound. Chemists and industry practitioners understand its essence and choose to name it according to their needs and circumstances.
Safety & Operational Standards
5 - Fluoro - 2 - Methoxybenzeneboronic Acid Safety and Practice
5 - Fluoro - 2 - Methoxybenzeneboronic Acid is a compound commonly used in chemical research. When conducting research operations, safety is the top priority, and it is necessary to strictly abide by the practice.
This compound has specific chemical properties or has potential hazards to the human body and the environment. When exposed, appropriate protective equipment is required. If you are experimenting, you must wear protective gloves. The material should be selected to effectively block this chemical to prevent it from contacting the skin, causing skin irritation or absorption poisoning. Face protection is also indispensable. Wearing a protective mask can prevent it from splashing into the eyes and damaging eye tissue.
The operating environment should be well ventilated, and it is best to operate in a fume hood. The fume hood can expel volatile chemicals in time, reduce the concentration in the air, and avoid respiratory damage caused by inhalation by the experimenter.
For storage, it should be placed in a dry, cool and ventilated place. Keep away from fire and heat sources, because it may be flammable or unstable by heat. The storage container must be well sealed to prevent it from reacting with air, moisture, etc., causing deterioration to affect the experimental effect, and avoiding leakage and causing safety accidents.
When taking the compound, use clean and precise appliances. Accurately measure according to the amount required for the experiment to avoid waste and excessive use and subsequent treatment problems. After measuring, quickly seal the container to maintain its stability.
After the experiment is completed, the remaining compounds and related waste should be properly disposed of in accordance with regulations. It should not be discarded at will, but should be collected in a centralized manner and disposed of according to the chemical waste treatment process to prevent pollution to the environment.
In short, during the whole process of research and operation of 5-Fluoro-2-Methoxybenzeneboronic Acid, safety and standardized operations should be kept in mind to ensure the smooth operation of the experiment, and to ensure the safety of personnel and the environment is not damaged.
Application Area
5 - Fluoro - 2 - Methoxybenzeneboronic Acid is a unique chemical substance with a wide range of application fields. In the field of pharmaceutical research and development, it can be used as a key intermediate to help synthesize compounds with specific pharmacological activities, which is expected to bring new opportunities for the treatment of many diseases. In the field of materials science, it may participate in the construction of new functional materials, giving materials such as unique optical and electrical properties. In organic synthesis chemistry, with its own structural properties, it can be used as a highly efficient boron source to catalyze many organic reactions, improve reaction efficiency and selectivity. This compound has shown important value in many application fields due to its unique properties, providing new avenues and possibilities for related research and industrial development.
Research & Development
Wutao is dedicated to the research and development of 5 - Fluoro - 2 - Methoxybenzeneboronic Acid. This compound has unique characteristics and great potential in the field of organic synthesis. Initially, the method of its preparation was explored, and various attempts were made to improve traditional paths or innovative processes. In the process, the influence of reaction conditions, such as temperature, solvent, catalyst, was carefully observed, and precise regulation was strived.
Then, study its reactivity and selectivity. Tested in different substrates and reaction systems to gain insight into the laws of its participation in reactions. It is hoped that it can expand its application scope and provide new strategies for organic synthesis.
After unremitting research, its strengths and limitations are gradually understood. In the future, we will continue to refine the preparation process to improve yield and purity. We will also deepen application exploration, hoping to find new opportunities in the fields of drug research and development, materials science, etc., to promote its rapid development and contribute to the chemical field.
Toxicity Research
I have been focusing on the physical properties of chemistry for a long time. Recently, I studied the chemical 5 - Fluoro - 2 - Methoxybenzeneboronic Acid. The study of its toxicity is crucial.
At the beginning, examine the molecular structure in detail, and explore the basis of its possible toxicity. Review its state in different media and observe its interaction with other substances. After various experiments, I know its effect on biological cells. If it encounters with living cells, it may cause changes in cell morphology and metabolism.
It is also tested on the way into the body. Inhalation from the mouth, nose, and skin touch cannot be ignored. After entering the body, or spreading around the body, damaging the function of the viscera. Although the current research is not complete, it can be concluded that it is toxic. It must be handled with caution, and strict regulations must be followed in access and storage to prevent its poisoning and ensure the safety of people and the environment.
Future Prospects
I have tried to study 5 - Fluoro - 2 - Methoxybenzeneboronic Acid, and I think its future is quite promising. It is in the field of organic synthesis, and may be the cornerstone of building exquisite structures. Due to the properties of the boron base, it can lead to various reactions, expand the synthesis path, and if the stars guide it, illuminate the unknown path of organic synthesis.
And it may emerge in materials science. It may be able to optimize material properties, such as improving optical and electrical properties, and create a new situation for future advanced materials. With time, through continuous research and refinement, we will be able to bloom in many fields such as chemical engineering and medicine, and become the fruits of our generation's scientific research, which will be used by future generations.
Where to Buy 5-Fluoro-2-Methoxybenzeneboronic Acid in China?
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Frequently Asked Questions

As a leading 5-Fluoro-2-Methoxybenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 5-Fluoro-2-Methoxybenzeneboronic Acid?
5-Fluoro-2-methoxyphenylboronic acid, which is a useful compound in organic synthesis. Its properties are multi-terminal, let me explain in detail.
When it comes to physical properties, this substance is usually in the form of a white to light yellow solid powder. It is quite stable under normal temperature and pressure, but under extreme conditions, such as hot topics and strong oxidation environments, it may change. The characteristics of its melting point and boiling point are of great significance for its separation and purification during synthesis operations. Generally speaking, the accurate grasp of its melting point can be purified by methods such as recrystallization, while the boiling point data is related to the implementation of separation methods such as distillation.
In terms of chemical properties, its boron atom has electron-deficient properties, making this compound an electrophilic reagent that can react with many electron-rich substrates. The most typical example is the Suzuki-Miyaura coupling reaction with halogenated aromatics or olefins catalyzed by palladium. This reaction is a powerful tool for building carbon-carbon bonds, and is widely used in the fields of drug synthesis and materials science. In the reaction, the boric acid group of 5-fluoro-2-methoxyphenylboronic acid and the halogen atom of the halogen are bridged by palladium catalyst to form a new carbon-carbon bond, thereby expanding the molecular skeleton.
Furthermore, its acidity is relatively weak, and the boric acid group can be complexed with some metal ions, which is also useful in the field of catalysis and supramolecular chemistry. For example, it can form stable complexes with some transition metal ions, thereby changing the activity and selectivity of the reaction, opening up new paths for organic synthesis.
5-fluoro-2-methoxyphenylboronic acid has active and unique chemical properties. It plays an indispensable role in the stage of organic synthesis and provides a powerful means for the construction of many complex organic molecules.
What are the main uses of 5-Fluoro-2-Methoxybenzeneboronic Acid?
5-Fluoro-2-methoxyphenylboronic acid, an important reagent in organic synthesis, is widely used in many fields.
First, in the field of medicinal chemistry, it is often a key intermediate. When creating new drug molecules, with its unique structure, it can be cleverly linked with other organic molecules through specific chemical reactions. For example, the synthesis of compounds with specific pharmacological activities can be used to couple Suzuki with halogenated aromatics to build a complex drug molecular skeleton, helping to develop various specific drugs such as antibacterial and anti-cancer.
Second, in the field of materials science, it also plays an important role. In the preparation of functional organic materials, it can be used to participate in the reaction and endow the material with unique photoelectric properties. For example, in the synthesis of organic Light Emitting Diode (OLED) materials, through rational design of reactions, the structure is introduced into the material to optimize the luminous efficiency and stability of the material, so that the display screen presents more brilliant colors.
Third, in the field of organic synthetic chemistry, as a commonly used boron reagent, it is widely used in carbon-carbon bond construction reactions. In addition to Suzuki coupling reaction, it can also participate in other metal catalytic coupling reactions, providing an effective way to synthesize organic compounds with diverse structures, assisting organic chemists to construct complex and novel molecular structures, and expanding the boundaries of organic synthetic chemistry.
What are the synthetic methods of 5-Fluoro-2-Methoxybenzeneboronic Acid?
There are several common methods for the synthesis of 5-fluoro-2-methoxyphenylboronic acid.
First, halogenated aromatics are used as starting materials. Take 5-fluoro-2-methoxybromobenzene, put it and magnesium chips into an appropriate amount of anhydrous ether or tetrahydrofuran solvent in an anhydrous and oxygen-free environment, stir to heat up, initiate a Grignard reaction, and generate 5-fluoro-2-methoxyphenylmagnesium bromide. After that, the Grignard reagent is slowly dropped into trimethyl borate, and the reaction is maintained at a certain temperature for several hours. After the reaction is completed, 5-fluoro-2-methoxyphenylboronic acid can be obtained by hydrolysis, adjusting the pH value with dilute acid, and then extracting, drying, distillation and other operations. The raw materials of this method are easy to obtain, but the Grignard reaction conditions are harsh, and it needs to be strictly anhydrous and anaerobic, and the operation is complicated.
Second, the coupling reaction catalyzed by palladium is used. Using 5-fluoro-2-methoxybromobenzene and double pinacol borate as raw materials, in a suitable organic solvent, a palladium catalyst such as tetrakis (triphenylphosphine) palladium and an appropriate amount of alkali such as potassium carbonate are added. Under nitrogen protection, the reaction is heated and stirred. After the reaction is completed, the products are separated and purified by means of column chromat The reaction conditions of this route are mild and the selectivity is good. However, the palladium catalyst is expensive, and the separation process may require professional equipment and technology.
Third, it starts from 5-fluoro-2-methoxybenzoic acid. First, it is converted into the corresponding acid chloride, and then interacts with reducing agents such as sodium borohydride to generate 5-fluoro-2-methoxybenzyl alcohol. After that, 5-fluoro-2-methoxybenzaldehyde is oxidized to obtain 5-fluoro-2-methoxybenzaldehyde, and then condensation with borate esters to finally obtain the target product. This route has a little more steps, but the reagents used are common, and the reaction conditions of each step are relatively easy to control. The choice of synthesis method should be based on actual needs, taking into account factors such as raw material cost, reaction conditions, product purity and yield.
5-Fluoro-2-Methoxybenzeneboronic Acid during storage and transportation
5-Fluoro-2-methoxyphenylboronic acid is a commonly used reagent in organic synthesis. When storing and transporting, many key matters must be paid attention to.
When storing, the first environmental conditions. It should be placed in a cool, dry and well-ventilated place. This reagent is quite sensitive to humidity, and humid environments can easily cause its hydrolysis and deterioration. Therefore, the humidity in the warehouse should be strictly controlled, and it is generally appropriate to maintain the relative humidity at 40% - 60%. If the humidity is too high, a desiccant, such as anhydrous calcium chloride, silica gel, etc. can be placed in the storage area to absorb water vapor and keep it dry.
The temperature should not be ignored, and the storage temperature should usually be between -20 ° C and 0 ° C. If the temperature is too high, it will accelerate its chemical reaction rate and promote its decomposition; while if the temperature is too low, although it can slow down the reaction, it may cause crystallization and other conditions, which will affect its subsequent use. For those who need long-term storage, it is even more necessary to ensure that the temperature is constant, which can be achieved with the help of professional low-temperature refrigerators or cold storage.
Furthermore, avoid contact with oxidants, acids, alkalis and other substances. 5-Fluoro-2-methoxyphenylboronic acid is chemically active and encounters with the above substances, which is prone to chemical reactions and causes it to fail. When storing, it should be stored separately from these substances, following the principle of "classified storage".
When transporting, be sure to pack tightly. Special sealed containers are often used to ensure that there is no risk of leakage during transportation The outer packaging should be sturdy to resist vibration and collision. And a clear label of hazardous chemicals must be posted, so that transporters and regulators can see at a glance and treat it with caution.
Temperature control must also be paid attention to during transportation, especially long-distance transportation. Measures such as refrigerated trucks or adding ice packs can be used to maintain a suitable temperature. At the same time, transporters should be professionally trained and familiar with the characteristics of this reagent and emergency treatment methods. In the event of an accident such as a leak, they can respond quickly and correctly to prevent the harm from expanding.
5-Fluoro-2-Methoxybenzeneboronic the market price of Acid
I think what you are asking is the market price of 5-fluoro-2-methoxyphenylboronic acid. However, this price is not constant, and it is affected by many factors.
First, the supply and demand situation has a great impact on its price. If there is a strong demand for this product in the market and the supply is limited, the price will tend to rise; conversely, if the supply exceeds the demand, the price may drop.
Second, the price of raw materials is also the key. The synthesis of this product requires specific raw materials, and fluctuations in the price of raw materials will cause changes in its production costs, which in turn will affect the market price. If raw materials are scarce or prices rise, the price of 5-fluoro-2-methoxyphenylboronic acid will also rise.
Third, the production process is related to the technical level. Advanced technology can reduce costs and increase output. If producers have high-efficiency technology, they may be able to enter the market at a better price; while those with laggard technology have high costs and high prices.
Fourth, the market competition situation is involved. When there are many manufacturers and fierce competition, they may compete for share or reduce prices; however, if the market is almost monopolized, the price will be controlled by a few or remain high.
Fifth, policies and regulations and the international trade situation also have an impact. Stringent environmental protection policies may increase production costs; trade frictions, tariff adjustments, etc., can make prices fluctuate.
Due to the complex intertwining of the above factors, in order to determine the market price of 5-fluoro-2-methoxyphenylboronic acid, it is necessary to constantly observe market trends and consult suppliers, traders and industry insiders in order to obtain a more accurate price.