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5-Fluoro-2-Methoxybenzeneacetonitrile

5-Fluoro-2-Methoxybenzeneacetonitrile

Hongda Chemical

    Specifications

    HS Code

    161451

    Chemical Formula C9H8FNO
    Molecular Weight 165.164 g/mol
    Appearance Solid (usually)
    Solubility In Water Low solubility, considered insoluble as it is an organic compound with a non - polar benzene ring and hydrophobic groups
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate, etc. due to its organic nature
    Density Estimated around 1.1 - 1.2 g/cm³ based on similar aromatic nitrile compounds
    Flash Point Estimated around 120 - 130 °C, typical for aromatic organic compounds with nitrile functional group

    As an accredited 5-Fluoro-2-Methoxybenzeneacetonitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 5 - fluoro - 2 - methoxybenzeneacetonitrile, 100g, packaged in a sealed, corrosion - resistant bottle.
    Storage 5 - fluoro - 2 - methoxybenzeneacetonitrile should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Since it's a chemical, store it separately from incompatible substances like oxidizing agents and acids to avoid potential reactions.
    Shipping 5 - fluoro - 2 - methoxybenzeneacetonitrile is shipped in sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations, ensuring proper handling to prevent spills and maintain product integrity during transit.
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    5-Fluoro-2-Methoxybenzeneacetonitrile 5-Fluoro-2-Methoxybenzeneacetonitrile
    General Information
    Historical Development
    5-Fluoro-2-methoxyphenylacetonitrile is also an organic compound. Its origin originated in the past when chemists were studying the way of organic synthesis. At the beginning, exploring the preparation of these compounds was like finding a path in the fog, and it was difficult to prepare.
    At that time, Zhu Xian Da worked hard and tried countless times to apply different reactions with various chemical raw materials, hoping to get something. Although he suffered many setbacks, he did not change his mind. Finally, there were wise people who found the key in complicated reactions and used exquisite methods to initially produce this substance.
    In the following years, science and technology advanced, and the method of preparing 5-fluoro-2-methoxyphenylacetonitrile was also continuously improved. Chemists use more precise means to improve its yield and purity. This compound has thus emerged in the fields of medicine, materials and other fields, opening a new chapter, used by future generations, and has a wider impact. It is an important chapter in the development of chemistry.
    Product Overview
    5-Fluoro-2-methoxyphenylacetonitrile is a key intermediate in organic synthesis. It is a colorless to light yellow liquid with specific chemical activities and physical properties. This compound is often used as a starting material for the synthesis of various drugs in the field of medicinal chemistry. Through specific chemical reaction steps, different functional groups can be introduced to construct complex drug molecular structures. In the field of materials science, or because of its unique electronic properties and spatial structure, it can be applied to the preparation of specific functional materials. After repeated experiments and studies, we have analyzed its reaction conditions and paths in detail, and strived to optimize the synthesis method, improve the purity and yield of the product, and hope to apply this compound more efficiently in many fields and promote the development and progress of related disciplines.
    Physical & Chemical Properties
    5 - Fluoro - 2 - Methoxybenzeneacetonitrile is a special compound. Its physical properties are specific, and the outer shape is often specific, or it is solid and has a specific color, which is determined by its molecular properties. Its melting and boiling also have certain values, and these values reflect the weakness of its molecular force.

    And its chemical properties, due to the presence of nitrile groups and benzene groups, have a phase reactivity. Nitrile groups can generate hydrolysis, and the fluorine and methoxy groups on benzene can affect the reactivity and positional properties of their substitution. Moreover, the solubility of this compound is poor in different solubility, which is also caused by the solubility and solubility of its molecules. In addition, 5 - Fluoro - 2 - Methoxybenzeneacetonitrile physicalization, laying the foundation for its application in multiple domains.
    Technical Specifications & Labeling
    Nowadays, there is a chemical substance called 5-Fluoro-2-Methoxybenzeneacetonitrile, and its process specifications and identification (product parameters) are the key. The process specifications for the preparation of this substance need to be precisely controlled according to the method, and the material allocation, reaction temperature, and time control are all fixed. The material is precisely matched and the proportion is appropriate to make the reaction go forward. The temperature of the reaction should be stable between moderation. If it is too high, the quality will be variable, and if it is too low, it should be slow and difficult to achieve. The control of time cannot be ignored. If it is long, it can be consumed, and if it is short, it should not be complete.
    As for the identification (product parameters), it includes shape, quality, and purity. The shape is also in the form of crystal, or in the state of liquid, which is clearly distinguishable. The quality, the stability of the nature, and the weakness of the transformation should be detailed. Purity is a crucial item, high quality is high, and low is limited. Make sure that the process specifications are in line and the identification (product parameters) is clear, so that the best product can be obtained to meet the needs of all parties.
    Preparation Method
    This 5 - Fluoro - 2 - Methoxybenzeneacetonitrile is the key to raw materials, production processes, reaction steps, and catalytic mechanisms. Fluoromethoxylbenzene is taken as the starting material, and acetonitrile is added. Under the catalysis of alkali, the two meet and initiate a nucleophilic substitution reaction. The base can be potassium carbonate or the like. When stirring at a suitable temperature, such as 60 to 80 degrees Celsius, the molecules interact and the chemical bonds are rearranged. After the reaction, the impurities are removed by extraction and distillation, and the pure product is retained. In this process, the catalytic mechanism is alkali-activated acetonitrile to increase its nucleophilicity and make the reaction smooth. In this process, 5-Fluoro-2-Methoxybenzeneacetonitrile of high purity can be obtained, which lays a solid foundation for subsequent chemical use.
    Chemical Reactions & Modifications
    I tried to study the chemical thing, in 5 - Fluoro - 2 - Methoxybenzeneacetonitrile this thing, and thought deeply about its chemical reaction and modification.
    The way of its reaction, you can use various methods. With the technique of organic synthesis, select the appropriate reagent, control temperature, pressure and time, so that the molecules can be rearranged and bonded to form a new structure. For example, with a catalyst, it can be combined with other substances, or other products can be obtained to increase its chemical activity.
    As for modification, it is designed to expand its use. It can be added to its structure to change its physical and chemical properties. If the hydrophilic base is added, it may be better dispersed in the aqueous phase; the rigid chain may be increased, or its mechanical performance may be strengthened. In this way, 5-Fluoro-2-Methoxybenzeneacetonitrile can be used in more fields, adding new color to the chemical industry and helping it progress.
    Synonyms & Product Names
    5 - Fluoro - 2 - Methoxybenzeneacetonitrile, the synonym of this thing and the trade name, there is quite a bit of research. The name of the chemical substance often changes due to time, place and use. Its synonyms are either based on structural characteristics or derived from synthetic paths. As for the trade name, it is mostly for marketing considerations, seeking its easy to remember and unique.
    View 5 - Fluoro - 2 - Methoxybenzeneacetonitrile, its synonyms, or according to its structure containing fluorine, methoxy and phenylacetonitrile, get different names. And the trade name, the merchant in order to make it unique in the market, or with auspicious meaning, or for special purposes, so the naming is ingenious.
    Although the origin of chemical substances lies in their inherent properties, synonyms and trade names are also important for academic and industry communication. In academic exchanges, precise synonyms help research to be correct; in commercial circulation, unique product names attract customer attention. Therefore, exploring synonyms and trade names of 5-Fluoro-2-Methoxybenzeneacetonitrile is of great value in chemical research and marketing activities.
    Safety & Operational Standards
    5 - Fluoro - 2 - Methoxybenzeneacetonitrile Safety and Operating Practices
    5 - Fluoro - 2 - Methoxybenzeneacetonitrile is an important chemical product, which is related to experimental safety and operating practices. It is essential and should not be ignored.
    In terms of storage, be sure to choose a cool, dry and well-ventilated place. This chemical has certain chemical activity. If exposed to humid or high temperature environment, it may cause deterioration, or even cause dangerous chemical reactions. Keep away from fire and heat sources. In case of open flame or hot topic, there is a risk of combustion and explosion. It should be stored separately from oxidants, acids, alkalis, etc., and should not be mixed to prevent interaction and cause accidents.
    When operating, the experimenter must strictly follow the norms. Appropriate protective clothing, including experimental clothing, protective gloves, etc., must be worn to avoid skin contact. Because it may be allergenic and corrosive to the skin. Good ventilation equipment is required in the operation room to prevent inhalation of volatile chemical gases and damage to the respiratory system. If you accidentally touch the skin, you should immediately rinse with a large amount of flowing water, and then seek medical attention according to the injury. If inhaled, quickly move to a fresh air place to keep the respiratory tract unobstructed. If breathing difficulties require oxygen, perform artificial respiration and seek medical attention if necessary.
    Furthermore, during use, the use needs to be precise, and the dosage should be strictly controlled according to the experimental needs. Experimental equipment should also be clean and dry to avoid impurities affecting its chemical properties. Discarded 5 - Fluoro - 2 - Methoxybenzeneacetonitrile and related reaction products should not be discarded at will. They should be properly disposed of according to the prescribed waste treatment process to prevent environmental pollution.
    Only by strictly observing safety and operating standards can we ensure the safety of the experiment, achieve the expected experimental effect, and protect the safety of the experimenter and the surrounding environment.
    Application Area
    Today there is a product, named 5 - Fluoro - 2 - Methoxybenzeneacetonitrile. The application field of this product is quite wide. In the field of medicinal chemistry, it can be a key intermediate, helping to create new drugs, and is expected to exert curative effect on a variety of diseases. In the field of materials science, it may also be able to participate in the synthesis of special materials, endowing materials with specific properties.
    The ancient study of Fang family is all about the characteristics and applications of heavy objects. Today, this substance has a unique chemical structure, which can lead to various reactions and expand the path of application. Or in fine chemicals, it can become a raw material for high-end products; or in scientific research and exploration, opening the door to unknown fields. Its application potential still awaits our generation's in-depth study, such as the ancients exploring the depths and seeking knowledge, in order to understand its more wonders and benefit the world.
    Research & Development
    We are committed to the research and development of 5 - Fluoro - 2 - Methoxybenzeneacetonitrile. Initially, we explored its synthesis method. After repeated experiments, we tried various raw materials and routes to find a feasible method.
    During the synthesis process, carefully observe the influence of reaction conditions, such as temperature, pressure, and catalyst dosage. If the temperature is too high, the product is impure; the pressure is not appropriate, and the reaction rate is retarded. After many adjustments, the synthesis process was optimized to improve the purity and yield of the product.
    Then its properties were studied. This substance has unique solubility in specific solvents and chemical stability. Based on this, the idea and its application can be used for the preparation of new materials, which is expected to show its effectiveness in the field of materials. I will continue to study and hope to make more breakthroughs, so that it can shine in practical applications and contribute to the development of related fields.
    Toxicity Research
    Today there is a chemical substance called 5 - Fluoro - 2 - Methoxybenzeneacetonitrile. As a chemical researcher, I explore its toxicity. Although this substance is not widely known, the study of toxicity is crucial.
    Detailed investigation of its molecular structure, fluorine, methoxy group and phenylacetonitrile, may lead to unique properties. Fluoride, although small, can change the extreme of molecules, change its chemical properties, and have an impact on the behavior of organisms. The presence of methoxy groups, or the charge distribution of molecules, affects its reactivity.
    In cell experiments, this compound inhibits cell proliferation at specific concentrations. Biochemical analysis may disturb the metabolic pathways of cells, and the activities of enzymes are also disrupted by it. However, more research is needed to understand the toxicity. The development of animal experiments and the long-term view can only know the effect of the whole organism. The research on toxicity cannot stop here, but must be investigated in depth to understand its harm, paving the way for safe use, health protection and human well-being.
    Future Prospects
    5 - Fluoro - 2 - Methoxybenzeneacetonitrile is a chemical that I have dedicated myself to studying. Although this substance has a certain foundation in the industry today, I am full of expectations for its future.
    Looking back at the past, many chemical substances have been deeply explored and finally blossomed for the well-being of the world. 5 - Fluoro - 2 - Methoxybenzeneacetonitrile also has this potential. I expect that in the field of pharmaceutical research and development, it may become a key intermediate, helping to create new drugs and treating diseases for patients.
    Furthermore, in the field of materials science, its unique chemical structure may lead to new materials with excellent performance, which are widely used in electronics, optics and many other fields. Although the road ahead may be full of thorns, I uphold the heart of research and am determined to explore. With unremitting efforts, I hope to reveal more potential of 5-Fluoro-2-Methoxybenzeneacetonitrile, so that it will shine in the future and contribute to human progress.
    Where to Buy 5-Fluoro-2-Methoxybenzeneacetonitrile in China?
    As a trusted 5-Fluoro-2-Methoxybenzeneacetonitrile manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 5-Fluoro-2-Methoxybenzeneacetonitrile supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 5-Fluoro-2-Methoxybenzeneacetonitrile?
    5-Fluoro-2-methoxyphenylacetonitrile is an organic compound. It has a wide range of uses and has important applications in many fields.
    First, in the field of pharmaceutical synthesis, it acts as a key intermediate. The construction of many drug molecules with specific pharmacological activities requires this as the starting material. Through a series of chemical reactions, its structure can be ingeniously modified and modified to prepare drugs with the effect of treating specific diseases. For example, in the development of some innovative drugs for neurological diseases or cardiovascular diseases, 5-fluoro-2-methoxyphenylacetonitrile plays an indispensable role and contributes to the development of human health.
    Second, in the field of pesticides, 5-fluoro-2-methoxyphenylacetonitrile also shows unique value. It can be used as an important component in the synthesis of new pesticides. By combining with other chemicals, high-efficiency, low-toxicity and environmentally friendly pesticide products can be created. This kind of pesticide has a significant effect on the prevention and control of crop diseases and pests, which helps to improve the yield and quality of crops and ensure the stable development of agriculture.
    Furthermore, in the field of materials science, it has also emerged. The synthesis of some functional materials will be applied to 5-fluoro-2-methoxyphenylacetonitrile. These materials may have special optical, electrical or mechanical properties, and have potential application prospects in electronic devices, optical instruments, etc., which promotes the continuous development of materials science.
    In short, 5-fluoro-2-methoxyphenylacetonitrile has a profound impact on modern technology and production and life due to its wide application in medicine, pesticides and materials science.
    What are the physical properties of 5-Fluoro-2-Methoxybenzeneacetonitrile?
    5-Fluoro-2-methoxyphenylacetonitrile is an important raw material in organic synthesis. Its physical properties are unique and it has key uses in many fields.
    Looking at its properties, under room temperature, 5-fluoro-2-methoxyphenylacetonitrile is usually a colorless to light yellow liquid with a clear appearance, highlighting its unique physical form. This substance has a certain volatility and can evaporate slowly in the air, but its volatilization rate is not rapid and is still in a controllable range.
    In terms of density, the density of 5-fluoro-2-methoxyphenylacetonitrile is relatively stable, about [X] g/cm ³. This density characteristic is not only related to its distribution in various solutions, but also has a profound impact on the mixing and separation of the substance. The precise value of density lays a solid foundation for precise measurement and control of it in practical applications.
    Solubility is also one of its important physical properties. 5-fluoro-2-methoxyphenylacetonitrile is soluble in a variety of organic solvents, such as ethanol, ether, acetone, etc. Good solubility allows it to fully contact and mix with many reactants in organic synthesis reactions, thus promoting the efficient progress of the reaction. However, its solubility in water is not good, and this characteristic needs to be specially considered in the reaction or separation process involving the aqueous phase. The melting point and boiling point of 5-fluoro-2-methoxyphenylacetonitrile also show specific values. Its melting point is about [X] ° C, and its boiling point is about [X] ° C. The determination of the melting point and boiling point not only helps to purify the substance, but also provides a key basis for the control of temperature conditions during storage and transportation.
    In addition, 5-fluoro-2-methoxyphenylacetonitrile also has a certain refractive index. As a characteristic physical constant of a substance, refractive index is of important reference value for identifying the purity of the substance and distinguishing its authenticity. Its refractive index is about [X], and the accurate determination of this value can provide strong support for quality control and quality identification.
    In summary, the physical properties of 5-fluoro-2-methoxyphenylacetonitrile, including properties, density, solubility, melting point, boiling point, and refractive index, are interrelated and affect its application in organic synthesis and other related fields. The in-depth understanding and accurate grasp of these physical properties are the keys to their efficient utilization and proper handling.
    What is the chemical synthesis method of 5-Fluoro-2-Methoxybenzeneacetonitrile?
    The synthesis method of 5-fluoro-2-methoxyphenylacetonitrile is the most important in the field of organic synthesis. Its methods are multi-terminal, and each has its own advantages and disadvantages. The choice should be based on actual needs and conditions.
    One method can start with 5-fluoro-2-methoxybenzoic acid. First, it is heated with thionyl chloride, and benzoic acid can be converted into acid chloride. The first step is to control temperature and remove impurities to maintain the purity of acid chloride. Acyl chloride has been obtained, and it reacts with cuprous cyanide in a suitable solvent, such as N, N-dimethylformamide (DMF). After nucleophilic substitution, 5-fluoro-2-methoxyphenylacetonitrile can be obtained. Although the steps in this way are slightly simplified, but cuprous cyanide is highly toxic, the operation must be careful, and the recovery and treatment of DMF cannot be ignored.
    Another method uses 5-fluoro-2-methoxybromobenzene as the starting material. First, the Grignard reagent is prepared in anhydrous ether with magnesium chips. This process avoids water, the atmosphere needs to be dry, and the temperature control is very important to prevent the decomposition of Grignard reagents. After the Grignard reagent reacts with acetonitrile, it is hydrolyzed to obtain the target product. This method is easy to obtain raw materials, but the Grignard reagent has high activity, and the preparation and reaction need to be strictly anhydrous and anaerobic, which requires high operation requirements.
    There is another one, starting with 5-fluoro-2-methoxybenzaldehyde. First, under the catalysis of malononitrile in a base, such as piperidine, the Knoevenagel condensation reaction is carried out in an ethanol solvent to obtain an intermediate product, and then reduced, such as with sodium borohydride, to obtain 5-fluoro-2-methoxyphenylacetonitrile. The reagents used in this approach are relatively mild, but the steps are slightly complicated, and the control of condensation and reduction conditions is related to the yield and purity of the product.
    Synthesis methods have their own advantages and disadvantages. Experimenters should weigh factors such as raw material cost, ease of operation, safety risks and yield purity, and choose carefully to obtain 5-fluoro-2-methoxyphenylacetonitrile with high efficiency.
    What are the precautions in storage and transportation of 5-Fluoro-2-Methoxybenzeneacetonitrile?
    5-Fluoro-2-methoxyphenylacetonitrile is an important raw material for organic synthesis. During storage and transportation, many matters need to be paid attention to.
    When storing, the first environment should be selected. It should be placed in a cool, dry and well-ventilated place. Cover because of its nature or affected by temperature and humidity, high temperature and humidity are prone to deterioration. If it is in a high temperature environment, the molecular activity of the substance is enhanced, or chemical reactions are triggered to change the composition; in a humid environment, or it is eroded by moisture, and reactions such as hydrolysis occur.
    Furthermore, it needs to be stored separately from oxidants, acids, bases, etc. This is due to the active chemical properties of 5-fluoro-2-methoxyphenylacetonitrile, contact with the above substances, or cause violent chemical reactions, resulting in serious consequences such as combustion and explosion.
    Packaging should not be ignored. Appropriate packaging materials must be selected to ensure good sealing to prevent leakage. Leakage not only wastes raw materials, pollutes the environment, and increases safety risks in case of open flames.
    When transporting, the transport vehicle should ensure that the vehicle is in good condition and has corresponding safety facilities. Drivers need to be professionally trained and familiar with the characteristics of the substances contained and emergency treatment methods. During transportation, it should be protected from exposure to the sun, rain, and high temperature.
    During loading and unloading, it must be handled lightly to avoid violent impact and vibration. Because it is a fine chemical, severe vibration or impact may cause package damage and cause leakage.
    In short, the storage and transportation of 5-fluoro-2-methoxyphenylacetonitrile is related to personnel safety, the environment and the production process. All links must be operated in strict accordance with regulations to ensure that nothing goes wrong.
    What is the market price range for 5-Fluoro-2-Methoxybenzeneacetonitrile?
    The market price range of 5-fluoro-2-methoxyphenylacetonitrile fluctuates due to various factors, so it is difficult to determine exactly.
    First, it is about its quality. If the quality is high, there are few impurities, and it meets the needs of high-end medicine, fine chemicals and other harsh fields, the price will be high; on the contrary, if the quality is slightly inferior, the price will be reduced accordingly.
    Second, the market supply and demand situation has a great impact. When many pharmaceutical companies and chemical companies have strong demand for it, but the supply is limited, it is like a rare thing is expensive, and the price will rise; if the market supply is abundant, but the demand is flat, the price may fall.
    Third, the preparation cost is a key factor. From the procurement of raw materials, the price may vary depending on the origin, season, and market conditions, to the energy consumption, manpower, and equipment depreciation in the production process, all of which affect the cost. If the cost is high, the selling price is also high in order to ensure profits.
    Fourth, regional differences also have an impact. Different regions, due to different economic levels, logistics costs, and industrial agglomeration degrees, prices will also vary. In places where the chemical industry is concentrated, prices may be relatively low due to competition and economies of scale; in remote and inconvenient places, prices may increase due to increased transportation costs.
    Looking at past market data, the price per kilogram may range from hundreds to thousands of yuan. However, this is only a rough range. To know the exact price, it is necessary to gain real-time insight into the market dynamics of chemical raw materials, consult relevant suppliers, distributors, or refer to professional chemical product quotation platforms in order to obtain accurate figures.