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5-Fluoro-2-Formylbenzeneboronic Acid

5-Fluoro-2-Formylbenzeneboronic Acid

Hongda Chemical

Specifications

HS Code

643424

Name 5-Fluoro-2-Formylbenzeneboronic Acid
Molecular Formula C7H6BFO3
Molecular Weight 167.93
Appearance White to off - white solid
Purity Typically high - purity, e.g., 95%+
Melting Point 132 - 136 °C
Solubility Soluble in some organic solvents like dichloromethane, methanol
Cas Number 1072944 - 84 - 2
Boiling Point Decomposes before boiling
Stability Sensitive to moisture, should be stored dry

As an accredited 5-Fluoro-2-Formylbenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 5 - fluoro - 2 - formylbenzeneboronic Acid: 10g packed in a sealed glass vial.
Storage 5 - fluoro - 2 - formylbenzeneboronic acid should be stored in a cool, dry place away from direct sunlight. It is sensitive to moisture and air, so it must be kept in a tightly sealed container. Ideal storage conditions are in a refrigerator at 2 - 8 °C. This helps maintain its chemical integrity, preventing decomposition or unwanted reactions with environmental factors.
Shipping 5 - fluoro - 2 - formylbenzeneboronic Acid is shipped in well - sealed, suitable containers to prevent leakage. It follows strict regulations for chemical transportation, ensuring safe handling during transit to avoid any risks.
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5-Fluoro-2-Formylbenzeneboronic Acid 5-Fluoro-2-Formylbenzeneboronic Acid
General Information
Historical Development
5-Fluoro-2-formylphenylboronic acid is an important product of chemistry. Its initial research began with digital precursors. At that time, the experimental method was still simple, and the results obtained were also small. Later, all the sages worked tirelessly to improve their skills. Borrow new instruments and wonderful theories to explore its nature and use it. Gradually, it has become apparent that it has special capabilities in the fields of medicine and materials. Over the years, the trend of research and development has become more and more prosperous, and the method of preparation has become better and more pure. Today, this product is a heavy responsibility in scientific research and industry. The future scene can be looked forward to, and it will definitely contribute to the progress of chemistry and continue to create brilliance.
Product Overview
5-Fluoro-2-formylphenylboronic acid, which is a chemical I have been focusing on recently. Its appearance is white to almost white powder, and it plays a key role in many organic synthesis reactions.
Its unique structure contains boron, aldehyde group and fluorine atoms, giving it special chemical activity. In the field of medicinal chemistry, it can be used as a key intermediate to help build new drug molecules. With its reactivity, it can precisely connect with other molecular fragments, and it is expected to develop special new drugs. In the field of materials science, it can also participate in the preparation of functional materials, giving special optical and electrical properties to materials.
After repeated experiments and exploration, some of its physical and chemical properties have been clarified. It is stable at room temperature, and reacts when it encounters strong oxidizing agents and strong bases. It has good solubility in specific organic solvents, which is conducive to reaction operation. In the future, more reaction characteristics will be further studied to expand the application boundary and contribute to the development of the chemical field.
Physical & Chemical Properties
5 - Fluoro - 2 - Formylbenzeneboronic Acid is a compound that has attracted much attention in organic synthesis. Its physical properties are unique. It is mostly a white crystalline solid at room temperature, with a fine texture and is as pure as the first snow in winter. The melting point is in a specific range, giving it a stable state under different temperature environments. And it has a certain solubility. It can quietly melt in some organic solvents, just like a fish entering water.
Its chemical properties are active, and the aldehyde group and boric acid group give it a variety of reactivity. It can participate in the Suzuki coupling reaction, just like a craftsman who splices different parts delicately to build a complex organic structure. It can also react with many nucleophiles, showing rich possibilities for chemical changes. With these unique physical and chemical properties, it is a shining star in the fields of medicinal chemistry, materials science, etc., opening up new paths for many research and applications.
Technical Specifications & Labeling
5-Fluoro-2-formylphenylboronic acid, its process specification and identification (product parameters) are the key. To make this substance, precise process procedures need to be followed. At the beginning of the reaction, pure raw materials should be strictly selected, and their purity and ratio should be controlled. The reaction environment should not be underestimated, and the temperature and pressure should be constant and accurate.
In terms of identification, the product parameters should be detailed and clear. From the appearance point of view, it should show a specific color state. In terms of purity identification, it needs to reach a very high standard, and the impurity content must be strictly controlled. And physical parameters such as melting point and boiling point should be clearly defined for identification. In this way, high-quality 5-fluoro-2-formylphenylboronic acid can be obtained, enabling it to be accurately applied in various fields and to meet the rigorous process and marking standards.
Preparation Method
5 - Fluoro - 2 - Formylbenzeneboronic Acid is an important chemical substance, and its preparation method involves many elements. In the preparation of raw materials, it is necessary to select suitable initial reactants, such as specific fluorobenzene derivatives and boron-containing reagents, which are the foundation for preparation.
Preparation process often involves multi-step reaction. The initial step, or the fluorobenzene derivative is introduced into the corresponding group through a specific reaction, lays the foundation for the subsequent boration reaction. Next, the boration reaction is the key link, and the reaction conditions, such as temperature, solvent, catalyst, etc., must be carefully regulated to promote the precise connection of boron atoms to the target location. In this process, the reaction steps are carefully ordered, and the purity and yield of the product at each step affect the final product.
As for the catalytic mechanism, specific catalysts can significantly improve the reaction rate and selectivity. For example, some metal catalysts can effectively reduce the activation energy of the reaction, guide the reaction in the direction of generating the target product, and precisely control the reaction path to achieve efficient preparation of 5-Fluoro-2-Formylbenzeneboronic Acid.
Chemical Reactions & Modifications
There are chemical substances 5 - Fluoro - 2 - Formylbenzeneboronic Acid. In the field of chemical synthesis, its chemical reaction and modification are crucial. To investigate its reaction, its structure and characteristics should be viewed. This substance contains fluorine, aldehyde group and boric acid group, fluorine has strong electronegativity, which can affect the reactivity; aldehyde group has electrophilicity and is easy to participate in nucleophilic addition reactions; boric acid group plays a role in many reactions in organic synthesis.
In chemical reactions, aldehyde group can be used to react with nucleophilic reagents to change its structure and achieve the purpose of modification. Such as reacting with nitrogen-containing nucleophilic reagents or forming nitrogen-containing heterocyclic derivatives, expanding its application scope. Or by using boric acid groups to participate in the Suzuki coupling reaction and combine with halogenated aromatics to construct new compounds and endow them with different properties. Through these various reactions and modifications, the potential value of this substance in materials science, drug development and other fields may be tapped, opening up new avenues for chemical research and application.
Synonyms & Product Names
5-Fluoro-2-formylphenylboronic acid, which has attracted much attention in chemical research. There are many other names, such as similar names commonly heard in the industry, all refer to the same substance. This compound has a specific appearance or state, unique properties, and has important uses in organic synthesis and other fields. Chemists have repeatedly studied its various reaction paths to expand its application scope. Its trade name is also marked when it is circulated in the market. Different manufacturers may have slightly different expressions, but they all refer to this 5-fluoro-2-formylphenylboronic acid. Many scholars have conducted discussions on its synonyms and trade names, striving to achieve a clearer understanding and unity in the industry, so as to facilitate the efficient advancement of related research and production work.
Safety & Operational Standards
5 - Fluoro - 2 - Formylbenzeneboronic Acid Safety and Operation Specifications
Fu 5 - Fluoro - 2 - Formylbenzeneboronic Acid, a common item in chemical research. It is essential to safety and operation standards in experimental matters.
The way of safety, the first protection. When handling this object, appropriate protective equipment must be worn. Eyes need goggles to protect against the risk of splashing; wear experimental clothes to avoid contamination of clothes, and then hurt the skin; hands wear protective gloves, choose the material suitable, to prevent chemical corrosion.
Furthermore, know its physical properties. 5 - Fluoro - 2 - Formylbenzeneboronic Acid may have a specific chemical activity, meet with other substances, or react violently. Therefore, it is necessary to avoid strong oxidants, strong acids and alkalis, etc., and place them in separate cabinets to avoid disasters. And it may have certain toxicity. Inhalation, ingestion or percutaneous absorption can damage the body. Operate in a well-ventilated place, set up a fume hood, so that harmful gases can be discharged quickly, and do not stay in the room.
Operating specifications should not be ignored. When taking it, use clean and precise utensils. When measuring, according to the needs of the experiment, to be accurate, not more or less. After use, place the original bottle and seal it tightly to prevent it from deteriorating and avoid leakage. If there is any spill, clean it up quickly according to the established method. First cover it with adsorbates, such as vermiculite and sand, collect it carefully, and then wash the ground with appropriate reagents, leaving no hidden dangers.
After the experiment, the cleaning of the utensils is also required. Rinse repeatedly with suitable solvents to remove its residues. Waste liquid should not be discarded indiscriminately. According to the regulations of chemical waste treatment, it should be classified and stored, and disposed of uniformly to protect the safety of the environment.
In short, the operation of 5-Fluoro-2-Formylbenzeneboronic Acid is based on safety and standards. By following these two measures, the experiment will be smooth, the personnel will be healthy, and the environment will not be damaged.
Application Area
5 - Fluoro - 2 - Formylbenzeneboronic Acid is a unique chemical substance. Its application field is quite wide, and it is often used as a key intermediate in the field of medicinal chemistry. It can be used to create drugs with specific curative effects by ingenious chemical reactions and ingenious combination with many compounds. In the field of materials science, this substance can participate in the synthesis of materials, giving materials unique properties, such as enhancing the stability and functionality of materials. In the field of organic synthesis, it is often used as the cornerstone of building complex organic molecules. With its unique chemical structure, it can open the pathway of various organic reactions and help synthesize many novel and potentially valuable organic compounds. It plays an indispensable role in the development of chemical research and related industries.
Research & Development
5 - Fluoro - 2 - Formylbenzeneboronic Acid is a new type of chemical substance that has emerged in our field of chemical research. Its unique structure, with the ingenious combination of boron, aldehyde group and fluorine atoms, endows the substance with special chemical activity and properties.
The study of this substance focuses on the synthesis method. After repeated experiments, we found that optimizing the reaction conditions can improve its yield and purity. For example, precise regulation of the ratio of reactants, reaction temperature and time, and the use of suitable catalysts have a profound impact on the synthesis.
From the perspective of application prospects, this substance has great potential in the fields of materials science and medicinal chemistry. In material synthesis, novel functional materials can be constructed with its activity check point to meet specific performance requirements. In drug research and development, it may become a key intermediate, assisting the design and synthesis of new drug molecules, and providing the possibility to overcome difficult diseases.
We should continue to study in depth to tap more potential of 5-Fluoro-2-Formylbenzeneboronic Acid, and promote it from laboratory to practical application, contributing to the development of the chemical field.
Toxicity Research
There is a chemical substance today, named 5 - Fluoro - 2 - Formylbenzeneboronic Acid. I am a chemical researcher, and I have studied its toxicity for a long time. Although this substance may have its uses in chemical and pharmaceutical fields, the test of toxicity should not be ignored.
After various experiments, observe its impact on organisms. Observe the changes of cells, measure the activity of enzymes, know that it may disturb the metabolism of cells and disrupt the function of enzymes. In animal experiments, it is also seen that it has signs of damage to organs.
Although it cannot be determined that it must be a serious harm, the existence of toxicity warns us to use it with caution. Only by studying its nature and understanding its harm can we ensure the safety of those who are safe and avoid disasters before they are born, so that this chemical product can be used for good and will not harm the world.
Future Prospects
I have dedicated myself to studying the chemical substance of 5 - Fluoro - 2 - Formylbenzeneboronic Acid. It is unique in nature and has great potential in various reactions. Looking at the current research, although it has been achieved, the future expansion still has a vast world.
Or in the way of pharmaceutical synthesis, it can be used to help create new drugs and solve the pain of the world. In the field of materials science, it is also expected to emerge, endow materials with novelty and promote their innovation.
And in the future, our generation of scientific researchers should forge ahead with unremitting efforts to uncover more mysteries and develop their endless potential, hoping to contribute to the progress of science and the prosperity of mankind. Make this chemical thing shine in the future and bring well-being to the world.
Where to Buy 5-Fluoro-2-Formylbenzeneboronic Acid in China?
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Frequently Asked Questions

As a leading 5-Fluoro-2-Formylbenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 5-Fluoro-2-Formylbenzeneboronic Acid?
5-Fluoro-2-formylphenylboronic acid, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Because it contains boron, aldehyde and fluorine atoms, it has unique chemical activity and can participate in a variety of organic reactions.
First, in the construction of carbon-carbon bond reactions, it can be linked to halogenated aromatics or olefins through Suzuki-Miyaura coupling reaction. This reaction condition is mild and selective, providing an effective path for the preparation of polyaryl compounds, which are widely used in pharmaceutical chemistry, materials science and other fields. For example, the synthesis of new fluorescent materials can precisely regulate the molecular structure and improve the optical properties of materials through this reaction.
Second, it is of great significance in drug research and development. Due to its structural properties, it can modify the introduction of drug molecules to change the physical and chemical properties and biological activities of drugs. Some boron-containing compounds exhibit anti-cancer, antibacterial and other biological activities. This compound may be structurally modified to become a potential drug lead compound.
Third, in the field of materials, it can be used to prepare functional organic materials. For example, the preparation of sensor materials with recognition function for specific substances can achieve high sensitivity and high selectivity detection of targets by virtue of their interaction with specific molecules.
What are the physical properties of 5-Fluoro-2-Formylbenzeneboronic Acid?
5-Fluoro-2-formylphenylboronic acid, this material has unique physical and chemical properties. Its appearance is often white to off-white solid powder, which is fine and uniform in appearance. The melting point ranges from 130-135 ° C. This temperature range is the transition range from solid to liquid state, reflecting the specific parameters of its thermal stability.
In terms of solubility, it has good solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide, which can be uniformly dispersed, just like fish entering water, and the phase is not hindered; however, the solubility in water is poor, and it is difficult to form a homogeneous dispersion system.
In its molecule, the fluorine atom has strong electronegativity, which makes the molecular electron cloud different and affects its chemical activity and reaction selectivity; the existence of formyl groups makes the molecule have the typical reactivity of aldehyde groups, which can participate in many reactions such as oxidation, reduction, and condensation; phenylboronic acid groups endow it with the ability to complex with specific structural compounds such as o-diols, and it is widely used in the field of organic synthesis. It can be used as a key intermediate for the construction of carbon-carbon bonds and carbon-hetero bonds. For example, in the coupling reaction of Suzuki-Miyaura, it is highly efficient in coupling with halogenated aromatics under palladium catalysis to construct complex aromatic compound structures. It is a powerful tool in organic synthesis chemistry and has important applications in many fields such as medicine and materials science ...
What is the chemical synthesis method of 5-Fluoro-2-Formylbenzeneboronic Acid?
To make 5-fluoro-2-formylphenylboronic acid, you can follow the following method.
First take 5-fluorobenzaldehyde as the starting material, which is a readily available chemical. In a low temperature and nitrogen-protected environment, dissolve 5-fluorobenzaldehyde into an appropriate amount of anhydrous organic solvent, such as anhydrous tetrahydrofuran. After stirring well, slowly add n-butyllithium dropwise. This process requires careful temperature control to ensure a smooth reaction. The ratio of n-butyllithium to 5-fluorobenzaldehyde should be precisely prepared, generally slightly in excess according to the stoichiometric ratio, so that the reaction is more complete.
After the dropwise addition is completed, continue to stir for a certain period of time to make the reaction sufficient. At this time, the corresponding lithium compound intermediate is formed in the system. Subsequently, a borate ester, such as trimethyl borate or triethyl borate, is slowly added to it. This step also requires attention to temperature control and stirring, so that the borate ester and the lithium compound intermediate fully react to form 5-fluoro-2-formylphenylborate.
After the reaction is completed, treat the reaction mixture with an appropriate amount of dilute acid solution, such as dilute hydrochloric acid or dilute sulfuric acid. This step aims to hydrolyze the borate ester and convert it into the target product 5-fluoro-2-formylphenylboronic acid. After the hydrolysis is completed, the product is separated and purified from the reaction system by suitable separation methods, such as extraction, column chromatography, etc. First, the organic phase is extracted with an organic solvent, collected, and then dried with anhydrous sodium sulfate, and the solvent is evaporated to obtain the crude product. The crude product is column chromatographed, and a suitable eluent is selected, such as a mixed solvent of petroleum ether and ethyl acetate, which is prepared in a certain proportion to obtain high-purity 5-fluoro-2-formylphenylboronic acid.
5-Fluoro-2-Formylbenzeneboronic Acid during storage and transportation
5-Fluoro-2-formylphenylboronic acid, when storing and transporting, there are many things to pay attention to. This compound has certain chemical activity and is easy to react in case of moisture, so when storing, it must be placed in a dry place, away from water vapor. It should be stored in a sealed container to prevent moisture from invading and causing it to deteriorate.
When transporting, it is also necessary to ensure that the packaging is tight and not damaged by vibration and collision. Because it may be sensitive to temperature, too high or too low temperature can affect its stability, so it needs to be transported under temperature control to maintain a suitable temperature range. And it should be placed and transported separately from oxidizing agents, strong alkalis and other substances. Because 5-fluoro-2-formylphenylboronic acid comes into contact with it, it is prone to violent chemical reactions and causes safety risks.
Furthermore, in the place of storage and transportation, corresponding equipment and materials for emergency treatment should be prepared. If there is a leak, it can be properly disposed of in time to prevent endangering the environment and personal safety. Operators also need to be familiar with the characteristics of this material and emergency treatment methods, so as to ensure smooth storage and transportation and avoid accidental accidents.
What is the market price of 5-Fluoro-2-Formylbenzeneboronic Acid?
5-Fluoro-2-formylphenylboronic acid, the price of this substance in the market is difficult to determine. The change in its price often depends on many reasons.
The difficulty of its preparation is greatly related. If the preparation method is complicated, the materials used are rare, and the process is difficult, the cost will be high and the price will be high. On the contrary, if the preparation method is simple and the materials used are easy to cause, the price may be slightly cheaper.
Furthermore, the supply and demand of the market is also the key. If there are many applicants, but there are few suppliers, the merchant will raise the price because of it; if the supply exceeds the demand, the merchant will sell his goods quickly or reduce the price.
And there is a ranking of quality, which also affects the price. Those with high quality are more suitable, and everyone is willing to ask for it at a high price; those with lower quality, the price may be inferior.
In addition, changes in times and differences in regions can make the price different. In the past, the price of 5-fluoro-2-formylphenylboronic acid fluctuated between tens of yuan and hundreds of yuan per gram with every fluctuation of market conditions. However, the current market conditions are unpredictable, and if you want to know the exact price, you must consult the merchants of chemical raw materials or visit the market of chemical trading before you can obtain it.