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5-Chloro-4-Fluoro-2-Methylnitrobenzene

5-Chloro-4-Fluoro-2-Methylnitrobenzene

Hongda Chemical

Specifications

HS Code

985503

Chemical Formula C7H5ClFNO2
Molecular Weight 191.57
Appearance Solid (Typical description, actual may vary)
Odor Characteristic (but exact may need experimental determination)
Melting Point Data may vary, check literature
Boiling Point Data may vary, check literature
Density Data may vary, check literature
Solubility In Water Low (organic nitro - halobenzene usually has low water solubility)
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene etc.
Flash Point Data may vary, check literature
Stability Stable under normal conditions but may react with strong oxidizing/reducing agents
Hazard Class May be classified as a hazardous chemical due to nitro and halogen groups

As an accredited 5-Chloro-4-Fluoro-2-Methylnitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 kg of 5 - chloro - 4 - fluoro - 2 - methylnitrobenzene in sealed chemical - resistant containers.
Storage 5 - chloro - 4 - fluoro - 2 - methylnitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly - sealed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and incompatible substances to avoid chemical reactions. Adequate labeling indicating its hazardous nature is also crucial.
Shipping 5 - chloro - 4 - fluoro - 2 - methylnitrobenzene is a chemical. Shipments must comply with hazardous material regulations. It should be properly packaged, labeled, and transported by carriers experienced in handling such chemicals.
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5-Chloro-4-Fluoro-2-Methylnitrobenzene 5-Chloro-4-Fluoro-2-Methylnitrobenzene
General Information
Historical Development
In the field of chemistry, there is a thing called 5-chloro-4-fluoro-2-methylnitrobenzene. The beginning of this substance was first encountered by various sages on the road of research and pursuit. At that time, all the gongs worked hard to deduce its properties, using the image of the end. At the beginning of this synthesis method, although the road is difficult and blocked, the ambition has not changed.
Since its inception, it has gradually become useful in the genus of medicine and materials. The way of medicine, with its characteristics, assists in the research of new agents and heals various diseases; the way of materials, relying on its performance, assists in the production of new substances and increases its advantages.
The years have passed, and the research has deepened, and its nature and production methods have been improved. The difficulties of the past have gradually broken down, and the field of its application has become more and more extensive. Looking at its course, it is like the beginning of the stars, gradually shining in the sky, adding bricks and tiles to the progress of chemistry, and making remarkable achievements.
Product Overview
5-Chloro-4-fluoro-2-methylnitrobenzene is also an organic compound. Its color is light yellow, if crystalline, it has a specific rationalization. The melting point is suitable, and the stable state is maintained at a specific temperature.
This compound plays an important role in the field of organic synthesis. It can be used as a key intermediate to prepare a variety of high-value organic compounds. Due to the ingenious combination of chlorine, fluorine, methyl and nitro groups in the molecule, it is endowed with unique reactivity.
Synthesis involves multiple specific organic reactions. Through halogenation, nitrification and other steps, the reaction conditions are finely regulated to achieve high purity products. However, when preparing, it is also necessary to pay attention to the precise control of various reaction conditions, such as temperature, reagent ratio, etc., in order to obtain the ideal yield and purity.
When storing, it should be placed in a cool, dry and well-ventilated place to avoid mixing with strong oxidants, strong bases, etc., to prevent accidental reactions. In this way, the stability of this product can be guaranteed for scientific research and industrial applications.
Physical & Chemical Properties
5-Chloro-4-fluoro-2-methylnitrobenzene is also an organic compound. Its physical properties, at room temperature, are in a solid state, color or light yellow, and have a special odor. Its melting point is about [X] ° C, and its boiling point is around [X] ° C, because the exact value varies depending on the experimental environment.
In terms of its chemical properties, it is quite active because it contains functional groups such as chlorine, fluorine, and nitro. Nitro has strong electron absorption, which reduces the density of the electron cloud of the benzene ring, making it difficult for electrophilic substitution reactions to occur. Although chlorine and fluorine atoms also have electron-absorbing effects, the differences in atomic radius and electronegativity have different effects on the distribution of the electron cloud of the benzene ring. When encountering nucleophiles, chlorine atoms are more easily replaced because the carbon-chlorine bond energy is relatively low. And under certain conditions, nitro groups can be reduced and converted into other functional groups such as amino groups, showing rich chemical changes and being widely used in the field of organic synthesis.
Technical Specifications & Labeling
Today there is 5-chloro-4-fluoro-2-methyl nitrobenzene, and its process specifications and identification (product parameters) are the key. The process specifications are related to the production method. From the selection of raw materials, it must be pure and refined, to the reaction conditions, such as temperature, pressure, duration, etc., must be precisely controlled. If the temperature is too high, the product is variable, and if it is too low, the reaction is slow. The pressure also affects the reaction process, and the duration determines the purity and yield of the product.
Labeling (product parameters) indicates its characteristics, such as appearance, or crystalline state, white or yellowish; the purity must reach a specific standard, and the impurity content must be strictly limited. And its physical and chemical properties, melting point, solubility, etc., should be clearly labeled so that users can make good use of it according to its characteristics to ensure that it can be used in the chemical industry and play its role.
Preparation Method
The method of making 5-chloro-4-fluoro-2-methylnitrobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism.
First take an appropriate amount of chlorinated aromatic hydrocarbons as raw materials, which is the starting material of the reaction. With a specific fluorination reagent, this step needs to be controlled at a suitable range, such as 40 to 60 degrees Celsius, so that the fluorine atoms gradually replace the chlorine atoms and form a preliminary intermediate.
Then, add a methylation reagent, and in an alkaline environment, the methylation reaction can proceed smoothly. This environment is suitable for weak bases to create conditions conducive to the introduction of methyl groups, and another intermediate is obtained.
As for the catalytic mechanism, a specific metal catalyst is selected to promote the efficient occurrence of the reaction by means of its activity check point, reduce the activation energy required for the reaction, so that each step of the reaction can be completed quickly. After each step of the reaction, impurities are removed by a suitable separation and purification method to obtain high-purity products. In this way, 5-chloro-4-fluoro-2-methylnitrobenzene can be prepared by this process.
Chemical Reactions & Modifications
5-Chloro-4-fluoro-2-methylnitrobenzene, the chemical reaction and modification of this compound are related to the gist of chemical research. In the field of chemistry, it is crucial to explore its reaction characteristics. The reaction may be affected by many factors, such as temperature, solvent, and the ratio of reactants.
When the temperature increases, the reaction rate is often accelerated, but if it is too high, it may cause frequent side reactions. The properties of the solvent also have a significant impact. Polar solvents or co-ionic reactions, non-polar ones are conducive to certain specific reactions. The proportion of reactants affects the direction and degree of reaction.
As for modification, it is designed to optimize its performance. Or through the transformation of substituents, adjust its physical and chemical properties to suit different needs. For example, in material science, modification may improve its stability, solubility, or endow it with special optical and electrical properties. This is the direction of unremitting exploration by chemical researchers, hoping to expand the application of compounds and gain the progress of science.
Synonyms & Product Names
5-Chloro-4-fluoro-2-methyl nitrobenzene, the synonym and trade name of this substance are quite important. In chemical research, our generation often encounters a situation of more than one thing. 5-chloro-4-fluoro-2-methyl nitrobenzene, or another name, to meet the needs of different fields and different uses. Its synonyms, or according to its chemical structure characteristics, show its composition and structure relationship in other expressions. Trade names take into account marketing activities, application scenarios and other factors. In chemical production, different manufacturers give their unique trade names to highlight product characteristics. However, whether synonyms or trade names refer to this specific chemical substance. Researchers need to be familiar with their various terms in order to accurately understand and apply them in activities such as literature review and experimental exchange, so as to avoid confusion and facilitate the smooth advancement of chemical research and industrial practice.
Safety & Operational Standards
5-Chloro-4-fluoro-2-methylnitrobenzene Safety and Operating Specifications
For those with 5-chloro-4-fluoro-2-methylnitrobenzene, it is also a research product. Its properties are special, so it is very important to operate safely.
#First, the key to survival
This product should be stored in a dry, dry and good place. Do not be near fire sources or sources, in order to prevent it from causing reactions and endangering the life of the animal. Where it is stored, it is difficult to oxidize, oxidize, and other substances, and the meeting of these substances, or cause strong reactions, endangering safety.
#Second, the operation of the
operation of the
operation, the
must be appropriate to prevent the
. Such as anti-clothing, can block the body and directly connect the
; anti-gloves, can help the hand; gas mask, can avoid its steaming and inhalation
. In the environment of operation, it is necessary to pass well, so that the steaming can not be polymerized.
and the operation is appropriate, do not make strong shock, collision. Because 5-chloro-4-fluoro-2-methylnitrobenzene is affected by strong external force, or there is no resistance. When mixing the solution, according to a specific ratio and order, add it to the solution, and do not mix, so that the uniform dispersion, must not reverse the order, in order to prevent the reaction out of control.
#3. Urgent measures
If the skin is accidentally connected, quickly wash it with a large amount of water, and wash it with soap. If inhaled, immediately move to a fresh air to keep the respiratory tract open. If breathing is sleepy, immediately give oxygen and call for emergency assistance. If you eat, do not urge vomiting, send it for treatment quickly.
Therefore, in the research and use of 5-chloro-4-fluoro-2-methylnitrobenzene, etc., you must follow safety procedures to ensure people's safety and avoid accidents.
Application Area
5-Chloro-4-fluoro-2-methyl nitrobenzene is also an organic compound. Its application field is quite wide. In the field of pharmaceutical synthesis, it is often a key intermediate. Based on this, it can make special drugs, treat various diseases, and save patients from pain. In the field of pesticide creation, it also plays an important role. With its unique chemistry, it can develop high-efficiency pesticides, protect crops from pests, and maintain a bumper harvest. And in the field of material science, it can be used as a raw material for synthesizing special materials, giving materials novel properties, and expanding the boundaries of application. The application of this compound is like a starry night, shining and heating in many fields, promoting the progress of technology and industry.
Research & Development
The chemical industry is changing with each passing day, and the research and creation of various compounds is related to the national economy and people's livelihood. Today, there is 5-chloro-4-fluoro-2-methyl nitrobenzene, which is of great value in the field of scientific research.
We have worked hard to study its properties and study its synthesis method. At the beginning, there were many twists and turns, and the synthesis process was full of thorns. However, everyone worked together, tried repeatedly, and improved the process. Or adjust the temperature of the reaction, or change the amount of reagents, and finally get a delicate method, so that the yield gradually increased.
View its application, in medicine, materials and other fields, emerging. It can be used as a pharmaceutical intermediate to assist in the research and development of new drugs; it can also add its unique properties to the preparation of materials. Looking forward to the future, continued research will surely expand its use, make its contribution to the development of scientific research and industry, and add brilliance to the pursuit of our generation.
Toxicity Research
There is a substance today, named 5-chloro-4-fluoro-2-methylnitrobenzene. I am a chemical researcher, focusing on its toxicity research. This substance has a unique structure, and chlorine, fluorine, methyl and nitro coexist, or cause it to have special toxicity.
According to experimental observations, its role in living organisms is quite complex. When it enters the animal body, it can disturb the metabolism of cells and cause physiological disorders. At the cellular level, it affects the activity of enzymes and blocks normal biochemical reactions. And it may be accumulative, and it will accumulate in the body for a long time, and the harm will gradually appear.
Although current research is limited, signs of toxicity have emerged. In the future, we should deeply study its mechanism of action, dose-effect relationship, etc., in order to prevent its harm, protect the ecology and human well-being, and exhaust our efforts to explore the mystery of its toxicity and find a good solution.
Future Prospects
I have tried to research the chemical industry, and I am particularly concerned about 5-chloro-4-fluoro-2-methylnitrobenzene. Looking at its properties, it has unique properties and can be used in many fields. Although there is still unfinished business in the current research, I am looking forward to the future.
I expect that this product will make progress in the road of medicine. It may become a raw material for a new type of medicine to solve the pain of people's diseases. In the field of materials, it can also emit light and heat, adding to the production of new materials. Although there may be thorns in the road ahead, I uphold my determination, use my reason, and explore its path. I firmly believe that in the future, I will be able to make the best use of 5-chloro-4-fluoro-2-methylnitrobenzene, contribute to the progress of the world, and develop unlimited possibilities in the future.
Where to Buy 5-Chloro-4-Fluoro-2-Methylnitrobenzene in China?
As a trusted 5-Chloro-4-Fluoro-2-Methylnitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 5-Chloro-4-Fluoro-2-Methylnitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 5-chloro-4-fluoro-2-methylnitrobenzene?
5-Bromo-4-chloro-2-methylbenzoylpyridine is an important organic compound with critical uses in many fields.
In the field of medicinal chemistry, its role is significant. In the process of many drug development, the compound can be used as a key intermediate. Due to its unique chemical structure, it can participate in a variety of organic reactions and help build complex drug molecular structures. For example, in the synthesis of some antibacterial drugs, it can combine with other chemical groups by means of specific reactions to form molecular structures with antibacterial activity, providing the possibility for the creation of new antibacterial drugs, which is of great significance for the resistance to drug-resistant bacterial infections.
In the field of materials science, it is also indispensable. It can be used to prepare functional materials, such as some materials with special photoelectric properties. After appropriate chemical modification and processing, the compound can impart unique optical or electrical properties to the material. In the research and development of organic Light Emitting Diode (OLED), solar cells and other materials, it can be used as a basic raw material to improve material properties and promote technological progress in related fields.
In the field of organic synthetic chemistry, it is an extremely important synthetic building block. Organic chemists can use various organic reactions, such as nucleophilic substitution reactions, coupling reactions, etc., to connect them with other organic molecules to construct rich and diverse organic compounds, expanding more paths for organic synthetic chemistry, enabling scientists to synthesize compounds with novel structures and functions, and promoting the continuous development of organic chemistry.
What are the physical properties of 5-chloro-4-fluoro-2-methylnitrobenzene?
5-Bromo-4-chloro-2-methylbenzoyl benzene, this substance is an organic compound with very unique physical properties.
Looking at its morphology, it is mostly solid at room temperature and pressure. Due to the strong intermolecular forces, it has a relatively stable structure, so it exists in the world as a solid state. Its melting point value is crucial in measuring the thermal stability and phase transition of the substance. After many experiments, its melting point is within a specific range, which fluctuates slightly depending on the measurement conditions and purity. When the external temperature reaches the melting point, the substance gradually melts from solid to liquid, and the arrangement of molecules also changes.
In addition to its solubility, this substance exhibits a certain solubility in organic solvents. Organic solvents such as common ethanol and ether can interact with 5-bromo-4-chloro-2-methylbenzoyl benzene because their molecular structure has a similar polarity or intermolecular force, so they can interact with it to dissolve the substance. However, in water, its solubility is poor. Water is a strong polar solvent, while the molecular polarity of 5-bromo-4-chloro-2-methylbenzoyl benzene is relatively weak, and it is difficult to form an effective interaction with water molecules, so it is difficult to dissolve in water.
Its density is also one of the important physical properties. The density reflects the mass per unit volume of the substance, and its density value can be known by accurate measurement. This value is not only related to the weight characteristics of the substance, but also has important guiding significance in practical applications such as separation and mixing.
In addition, the volatility of 5-bromo-4-chloro-2-methylbenzoyl benzene is weak. Due to its large intermolecular force, it is difficult for molecules to break away from the solid surface and enter the gas phase, so the volatilization rate is low at room temperature and pressure. This characteristic makes it relatively stable during storage and use, and it is not easy to be lost due to volatilization or cause other problems.
What are the chemical properties of 5-chloro-4-fluoro-2-methylnitrobenzene?
5-Alkane-4-ene-2-methylcarbonyl benzyl ethers are particularly important in their chemical properties, which are related to many chemical reactions and applications. This compound has a unique structure, in which the carbon-carbon double bond, carbonyl and ether bond all give it specific chemical activity.
Carbon-carbon double bonds are rich in electron clouds and are highly vulnerable to attack by electrophilic reagents, so addition reactions can occur. For example, when added to hydrogen halide, halogen atoms will be added to carbon atoms with less hydrogen in the double bond, following the Markov rule. In the presence of suitable catalysts such as platinum, palladium or nickel, the double bond can be saturated with hydrogen and converted into an alkane structure, which is a common way to prepare saturated compounds. The presence of
carbonyl groups makes the compound nucleophilic. Due to the difference in electronegativity between carbon and oxygen in carbonyl groups, carbon is partially positive and vulnerable to nucleophilic attack. If it is used with alcohols in acidic catalysts, acetal or semi-acetal structures can be formed. This reaction is often used in organic synthesis to protect carbonyl groups from unnecessary changes in subsequent reactions. It can also react with Grignard reagents to form new carbon-carbon bonds, thereby increasing the carbon chain and expanding the structural complexity of compounds, which is of great significance in the field of organic synthesis.
The ether bond is relatively stable, but under certain conditions, in case of strong acid, the ether bond can be broken. Generally speaking, hydrohalic acids (such as hydroiodic acid) can break the ether bond to form corresponding halogenated hydrocarbons and alcohols. This property is crucial in some reactions that require selective cleavage of ether bonds to obtain specific products. 5-Alkane-4-ene-2-methylcarbonyl benzyl ether has shown a wide range of application potential in organic synthesis, pharmaceutical chemistry and other fields due to the synergistic effect of these structural units. Its chemical properties provide chemists with various approaches and strategies for constructing more complex and unique molecules.
What are the synthesis methods of 5-chloro-4-fluoro-2-methylnitrobenzene?
The synthesis method of 5-bromo-4-chloro-2-methylpyridinoyl indole covers a variety of pathways.
First, it can be started from a compound containing a pyridine structure. First take the appropriate pyridine derivative, which needs to have a substitutable group at a specific position of the pyridine ring, such as a halogen atom. Place this pyridine derivative with a compound containing an indole structure and a suitable substituent under suitable reaction conditions. For example, choose a suitable organic solvent, such as toluene, dichloromethane, etc., so that the two can be fully dissolved and mixed. Then add an appropriate amount of alkali, such as potassium carbonate, sodium carbonate, etc. The function of the base is to promote the reaction and adjust the pH of the reaction system. Warm to a certain temperature, for example 60-80 degrees Celsius, through nucleophilic substitution reaction, the pyridine ring is connected to the indole structure to form a preliminary product. After purification by column chromatography, recrystallization, etc., the target product can be obtained 5-bromo-4-chloro-2-methylpyridineformyl indole.
Second, indole is used as the starting material. Indole is modified by introducing a suitable functional group on the indole ring for subsequent reaction with pyridine derivatives. First, indole is reacted with a certain reagent to activate the indole at a specific position, and a group that is easy to leave can be introduced. Then the compound containing 5-bromo-4-chloro-2-methylpyridine structure is taken, and the two are synthesized in a suitable reaction environment, such as N, N-dimethylformamide as a solvent, and a suitable catalyst, such as some transition metal catalysts, is added to react at an appropriate temperature. This reaction may go through a complex intermediate process to finally construct the structural framework of the target product. The product needs to be purified by extraction, distillation, crystallization and other steps to improve the purity of the product.
Third, the target molecule can be constructed through a multi-step reaction. First, the pyridine fragment and the indole fragment are synthesized separately, and the activity check points that can react with each other are reserved on the two. For example, the pyridine fragment may contain a halogen atom, a carbonyl group, etc., and the indole fragment may contain an amino group, a hydroxyl group, etc. Subsequently, the two are spliced together by means such as amidation and alkylation reactions. During the reaction, appropriate reaction conditions, such as reaction solvent, temperature, catalyst, etc. need to be selected according to specific activity checking points. Finally, after multi-step reaction and product purification, a purified 5-bromo-4-chloro-2-methylpyridinyl indole is obtained.
What should be paid attention to when storing and transporting 5-chloro-4-fluoro-2-methylnitrobenzene?
5-% N-4-ene-2-methylheptyl ether is a special chemical compound. For storage, it is necessary to pay attention to the general requirements in order to ensure its safety and integrity.
The first thing to do is to store it, and it will be stored in a good and dry place. Due to this, the material may have poor performance. If it is in a humid or high-pressure environment, it may cause chemical reactions, cause changes in its properties, and even pose a safety risk. If it is placed in a dense and high-pressure room, it is like a fire bucket, and if it is slightly careless, it will end.
Furthermore, the storage container is also very important. It is advisable to use materials with good corrosion resistance and sealing properties, such as specific glass or plastic materials. Due to the reaction of 5-% N-4-ene-2-methylheptyl ether or some materials, if the container is not resistant to corrosion, it may leak, pollute the environment, and endanger the surrounding.
As a result, the animal must follow the phase method. People need to be familiar with the characteristics and emergency treatment methods of the product. The product also needs to be equipped with necessary safety measures, such as fire installation, emergency treatment tools, etc. In the event of an accident such as leakage on the way, it can be quickly and properly treated to avoid harm.
In addition, whether it exists or not, it needs to be labeled. The name, characteristics, and danger warnings of the product are clear at a glance, so that the receiver can take preventive measures in advance. In this way, it is possible to avoid accidental generation in the storage process of 5-%-4-ene-2-methylheptyl ether.