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What is the main use of 5-chloro-3-fluorobenzene-1,2-diol?
5-Bromo-3-allyl-1,2-diol, which is an important compound in organic chemistry, has key uses in many fields.
In the field of organic synthesis, it often acts as a key intermediate. The cap has both bromine atoms and allyl, diol and other active functional groups in its molecular structure. Bromine atoms can interact with various nucleophilic reagents through nucleophilic substitution reactions, and then introduce different functional groups; allyl groups have higher reactivity and can participate in various reactions such as olefin metathesis reactions, so as to realize the construction of carbon-carbon bonds and the expansion of molecular skeletons; diol structures can not only participate in esterification reactions to form esters with specific functions, but also form cyclic compounds through condensation reactions with alcaldes, ketones, etc., which greatly enriches the strategies and paths of organic synthesis.
In the field of materials science, 5-bromo-3-allyl-1,2-diol also has extraordinary performance. Polymer materials with special properties can be prepared by appropriate chemical modification and polymerization. For example, copolymerization with other monomers can endow the polymer with unique solubility, thermal stability and mechanical properties. At the same time, because its structure contains double bonds, which can improve the hardness and wear resistance of the material through cross-linking reaction, it is often used in the preparation of high-performance coatings, adhesives and composites.
In the field of medicinal chemistry, the compound also shows potential application value. Because it contains a variety of functional groups that can specifically interact with targets in organisms, it can be used as a lead compound for structural optimization and modification. By introducing different substituents, adjusting their properties such as fat solubility, water solubility, and affinity with targets, it is expected to develop new drugs with specific pharmacological activities and contribute to human health.
What are the synthesis methods of 5-chloro-3-fluorobenzene-1,2-diol?
To prepare 5-bromo-3-allyl-1,2-diphenol, you can follow the following ancient methods.
First, use allyl phenol as the starting material, and introduce bromine atoms by halogenation. In a suitable reaction vessel, put allyl phenol and dissolve it with an appropriate amount of solvent, such as dichloromethane. Cold to a suitable temperature, generally about 0 ° C to 5 ° C, slowly drop the bromine solution, and stir at the same time to ensure that the reaction system is uniform. During this process, pay attention to the control of temperature to prevent side reactions from being too high. Add it dropwise, gradually raise it to room temperature, and continue stirring for a few times to ensure complete reaction. After the reaction is completed, the mixture containing the target product is obtained by conventional separation and purification methods, such as extraction, column chromatography, etc., and then refined to obtain pure 5-bromo-3-allyl-1,2-diphenol.
Second, catechol is used as the starting material. First, catechol is alkylated with allyl halides, such as allyl bromide, in the presence of bases. Take catechol, dissolve it in a suitable organic solvent, such as N, N-dimethylformamide (DMF), add an appropriate amount of base, such as potassium carbonate, and stir it to dissolve. Next, slowly add allyl bromide and heat it up to a suitable temperature, such as 60 ° C - 80 ° C, when the reaction number is. After the reaction is completed, the impurities are removed by washing with water, extraction and other steps. Then this mixture containing allyl products is used as material for halogenation reaction. Similar to the above halogenation steps using allyl phenol as raw material, bromine atoms are introduced at the appropriate position, and 5-bromo-3-allyl-1,2-diphenol can also be obtained. After fine separation and purification, a pure product is obtained. These two ancient methods have their own advantages and disadvantages, and they need to be used according to the actual situation, such as the ease of access of raw materials, the conditions of the reaction, and the purity requirements of the product.
What are the physical properties of 5-chloro-3-fluorobenzene-1,2-diol?
5-Alkane-3-enheptyl-1,2-diol is an organic compound with unique physical properties, detailed as follows:
1. ** Properties **: Under normal conditions, this compound may be a colorless to light yellow viscous liquid. Due to the structure of both alkanes, olefins and diols in the molecule, the intermolecular force is complex, resulting in such a property.
2. ** Melting point and boiling point **: Since the diol part of the molecule can form hydrogen bonds and enhance the attractive force between molecules, its melting point and boiling point are relatively high. The specific value will vary depending on factors such as the length of the carbon chain and the position of the double bond in the molecular structure. Roughly speaking, the boiling point is between 200 and 300 degrees Celsius, which requires more energy to overcome the intermolecular forces and realize the transition from liquid to gaseous state. The melting point is between -10 and 20 degrees Celsius, which makes it mostly liquid at room temperature.
3. ** Solubility **: The diol part of the molecule contains hydrophilic hydroxyl groups, so the compound can be soluble in polar solvents such as water, ethanol, and acetone. However, alkanes and olefin parts have certain hydrophobicity, resulting in limited solubility in water and not infinite miscibility. For example, it can be well dissolved in ethanol, because ethanol can form hydrogen bonds with hydroxyl groups and has certain similarities with hydrocarbon groups in the molecule.
4. ** Density **: The density may be slightly higher than that of water, about 1.0 - 1.2 g/cm ³. Because the molecule contains many atoms and the structure is relatively compact, the mass per unit volume is large.
5. ** Volatility **: Because of its high boiling point, strong intermolecular forces and low volatility. At room temperature and pressure, the volatilization rate is slow, and it can remain liquid for a long time in a sealed container.
What are the precautions for storing and transporting 5-chloro-3-fluorobenzene-1,2-diol?
5-Bromo-3-allyl-1,2-diol is an organic compound. When storing and transporting, the following numbers should be paid attention to:
First, the storage environment. This compound should be placed in a cool, dry and well-ventilated place. Because of its certain chemical activity, high temperature and humidity can easily cause it to deteriorate. If it is in a high temperature environment, or causes the activity of chemical bonds in the molecule to increase, it will initiate reactions such as decomposition and polymerization; while in a humid environment, moisture or interaction with the compound will cause side reactions such as hydrolysis, which will damage its purity and quality. At the same time, it should be kept away from fire and heat sources to avoid uncontrolled reactions due to heat and danger.
Second, the method of packaging. It needs to be packaged in a sealed and corrosion-resistant container. The bromine atom in 5-bromo-3-allyl-1,2-diol reacts with allyl and other structures, or reacts with some packaging materials. For example, it cannot be packaged with ordinary metal materials, because the bromine atom has certain oxidizing properties, or reacts with active metals, causing the packaging container to corrode and cause the compound to deteriorate. Appropriate packaging materials such as glass and specific plastics should be selected to ensure good sealing and prevent leakage.
Third, when transporting. The transportation process should be protected from vibration and impact. The allyl group in this compound structure is an unsaturated structure, which is subject to severe vibration, impact, or triggers reactions such as intramolecular rearrangement and polymerization, changing its chemical properties. And the means of transport also need to be kept dry, cool, temperature and humidity control equipment is complete to maintain a stable transportation environment. In addition, in accordance with the relevant provisions of hazardous chemicals, warning signs should be posted to ensure that transport personnel and surrounding personnel are aware of their latent risks and take protective measures.
What are the safety risks associated with 5-chloro-3-fluorobenzene-1,2-diol?
5-Alkane-3-enyne-1,2-diol, this substance has many risks related to safety. It has the risk of explosion, because its chemical structure contains alkyne bonds, high chemical activity, in case of open flame, hot topic or strong oxidant, it is easy to cause combustion and even explosion, such as in chemical production, if the operation is improper, in case of ignition source will cause instant disaster.
Furthermore, it may pose a health hazard. It can endanger the human body through respiratory tract, skin contact or accidental ingestion. Inhalation of its volatile gas can cause respiratory irritation, such as coughing, asthma, and even damage to lung tissue; skin contact, or cause allergies, burns; if accidentally ingested, it will damage the digestive system, causing nausea, vomiting, abdominal pain and other symptoms.
Environmental hazards should not be underestimated. If it flows into the environment, it may cause damage to water bodies and soil ecosystems due to its active chemical properties. In water bodies, it can affect the survival and reproduction of aquatic organisms, change the chemical properties of water bodies; in soil, or affect soil microbial activity and plant growth.
Extreme caution is also required when transporting and storing. During transportation, if the package is damaged and leaks, it will cause a disaster if it encounters surrounding dangerous factors; when storing, if it is not in accordance with the regulations, mixed with contraindicated substances, or the ambient temperature and humidity are out of control, it can cause safety accidents. Therefore, this substance must be strictly controlled from production, use to transportation and storage to reduce safety risks.