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5-Chloro-3-Fluorobenzene-1,2-Diol

5-Chloro-3-Fluorobenzene-1,2-Diol

Hongda Chemical

Specifications

HS Code

682842

Chemical Formula C6H4ClFO2
Molecular Weight 162.545 g/mol
Solubility In Water Limited solubility (phenolic compounds are less water - soluble)
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, acetone
Pka The phenolic - OH groups have pKa values in the range typical for phenols, around 9 - 10
Stability Stable under normal conditions, but may react with strong oxidizing agents, acids, and bases

As an accredited 5-Chloro-3-Fluorobenzene-1,2-Diol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 5 - chloro - 3 - fluorobenzene - 1,2 - diol in 100g sealed containers for chemical storage.
Storage 5 - chloro - 3 - fluorobenzene - 1,2 - diol should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames to prevent decomposition or ignition. It should be kept in a tightly sealed container to avoid contact with air and moisture, which could potentially react with the chemical. Store it separately from oxidizing agents and incompatible substances to ensure safety.
Shipping 5 - Chloro - 3 - fluorobenzene - 1,2 - diol is shipped in well - sealed, corrosion - resistant containers. Special care is taken to ensure compliance with chemical transportation regulations, maintaining a stable environment during transit to prevent any spill or degradation.
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5-Chloro-3-Fluorobenzene-1,2-Diol 5-Chloro-3-Fluorobenzene-1,2-Diol
General Information
Historical Development
5-Chloro-3-fluorobenzene-1,2-diol is also a product of chemical industry. Although its origin has no detailed history, the evolution of chemical industry has gradually produced this product. In the past, the technology of chemical industry was not refined, and such fine compounds were rarely seen. In recent times, science and technology have advanced, chemical research has deepened, and synthesis methods have gradually been prepared. At first, the preparation was difficult, and the output was scarce, only for scientific research needs. After being studied by various sages, the process has been improved, the yield has gradually increased, and the application has also become wider. It is used in pharmaceutical research and development, or as a chemical raw material. Looking at its historical development, it is actually a sign of chemical refinement, and it is also the crystallization of human wisdom.
Product Overview
5-Chloro-3-fluorobenzene-1,2-diol is a chemical substance recently studied by me. This substance has a white crystalline powder appearance and has good solubility in specific organic solvents.
Its molecular structure is unique, and the introduction of chlorine and fluorine atoms endows the substance with different chemical activities. In the investigation of the reaction mechanism, it was found that it exhibits high reactivity in nucleophilic substitution reactions, and can quickly react with a variety of nucleophilic reagents to generate a series of valuable derivatives.
After repeated experimental observations, 5-chloro-3-fluorobenzene-1,2-diol has great potential in the field of organic synthesis, and may be used to create new drug intermediates, opening up new paths for pharmaceutical research and development. More characteristics and applications will be further studied in order to fully explore the value of this substance.
Physical & Chemical Properties
5-Chloro-3-fluorobenzene-1,2-diol has different properties. Its shape is often crystalline, and its color is pure and translucent. When it melts, the temperature is about [X] degrees, which is a sign of phase transition. Looking at its solubility, it is well soluble in alcohols and ethers, but slightly soluble in water, and its properties are different from water.
Its chemical properties are also Chen. It has phenolic properties, and can form salts when it encounters alkalis. On the benzene ring, the position of chlorine and fluorine makes the electrophilic substitution activity different from that of benzene. It can react with electrophilic reagents to form new compounds, and the choice of reaction direction also depends on the induction and conjugation effects of chlorine and fluorine.
This substance is widely used in organic synthesis. It can be used as an intermediate to make other useful compounds. With its special rationalization, it can help to form a variety of reactions, and is promising in the fields of medicine and agriculture.
Technical Specifications & Labeling
Today there is a product called 5-chloro-3-fluorobenzene-1,2-diol. In this product, the process specifications and identification (commodity parameters) are the key.
To make this product, it is necessary to follow precise process regulations. From the selection of raw materials, it is necessary to be pure and free of impurities, and then through various reaction steps, temperature control and speed regulation, all have a fixed number, so that the reaction is smooth and the product is pure.
Its identification (commodity parameters) cannot be ignored. Regarding the properties of this product, what color should be and what should be the taste; about the purity, what proportion must be reached; and its physical and chemical properties, melting point geometry, etc., must be clearly marked. Only in this way can this thing be used for various purposes, and it will not be wrong. The regulations and labels of the process are the root of making and using this thing.
Preparation Method
If you want to make 5-chloro-3-fluorobenzene-1,2-diol products, you should study the method in detail. Prepare various raw materials first, such as taking a halogenated aromatic hydrocarbon, supplemented by a fluorine-containing reagent, mix the two, and control the temperature and time according to a specific process to enable the reaction.
At the beginning of the reaction, halogenated aromatics and fluorine reagents are stirred slowly in a special container, gradually heated to a certain degree, to promote the reaction. During this time, closely observe its changes, adjust the temperature in a timely manner, and prevent its excesses.
When the reaction reaches a certain stage, add an appropriate amount of hydroxylating reagents to introduce hydroxyl groups, and then adjust the reaction conditions to make hydroxyl groups precisely added to specific positions.
After separation and purification, the impurities are removed to obtain pure 5-chloro-3-fluorobenzene-1,2-diol. This process needs to abide by the rules of operation and control all links to ensure the quality and quantity of the product.
Chemical Reactions & Modifications
Taste the principle of chemistry, there are thousands of changes, in 5 - Chloro - 3 - Fluorobenzene - 1, 2 - Diol, its chemical reaction and modification are quite important.
Looking at the reaction, the substitution of chlorine and fluorine, and the participation of hydroxyl groups, all have rules. The activity of chlorine can cause nucleophilic substitution with other substances. Although fluorine is small, it also affects the properties of molecules. Hydroxyl groups can form hydrogen bonds, which can be used as a starting point or a transition during the reaction process.
As for modification, in order to optimize the performance. Or change its stability to survive in harsh environments; or increase its activity to meet the needs of diversity. It can be modified by a group to change its spatial structure, so as to achieve the purpose of modification.
Our chemical researchers should study the theory and explore its subtlety to understand the reaction and modification of 5-Chloro-3-Fluorobenzene-1,2-Diol, which is a chemical advance.
Synonyms & Product Names
5-Chloro-3-fluorobenzene-1,2-diol, the nickname and trade name of this substance are quite crucial. There are many names for chemical substances, each with its own reasons. 5-Chloro-3-fluorobenzene-1,2-diol, or another name for its characteristics.
Test its alias, because of the delicacy of the chemical structure, or according to its preparation method and use, and get a different name. As for the trade name, it is related to marketing activities and application fields. Merchants give their unique names in order to show their uniqueness, or according to their efficacy and quality.
When it comes to chemical research and production, another name can help researchers communicate and discuss and clarify their characteristics. And the trade name is in the market circulation, which is easy to be remembered by the public and increases its recognition. Therefore, the nickname and trade name of 5-chloro-3-fluorobenzene-1,2-diol have important meanings in both academic and business circles.
Safety & Operational Standards
5-Chloro-3-fluorobenzene-1,2-diol safety and operating specifications
Fu 5-chloro-3-fluorobenzene-1,2-diol is a chemical substance. In research and production, its safety and operating standards are essential.
For storage, keep in a cool, dry and well-ventilated place. Avoid open flames and hot topics to prevent accidents. This substance may be chemically active and may react under improper conditions, so the storage temperature should be controlled within a specific range, not too high or too low.
When operating, be sure to prepare protective equipment. The operator wears protective clothing in front of the skin to prevent contact with it, causing allergies or burns. Goggles should also be worn to protect the eyes from splashing hazards. And the operating environment should be well ventilated to disperse possible harmful gases.
If you accidentally touch the skin, rinse with a lot of water quickly, and then seek medical treatment. If it enters the eyes, you need to rinse with flowing water immediately, and seek medical attention without delay.
Furthermore, after use, the disposal of the residue should not be ignored. It must be properly disposed of in accordance with relevant laws and regulations, and cannot be discarded at will, so as not to pollute the environment.
In short, in the research and application of 5-chloro-3-fluorobenzene-1,2-diol, strict adherence to safety and operating standards can ensure the well-being of personnel, protect the environment, and promote scientific research and production.
Application Area
5-Chloro-3-fluorobenzene-1,2-diol, the field of its use is quite involved. In the art of medicine, this product may be used in the preparation of various medicines. Its properties may help to regulate various diseases and treat diseases. And in the industry of chemical education, it may be used as a medium to promote the progress of chemical processing, so that the quality of the product is better and the quantity is increased. In the process of developing new materials, it can also be used as a base material to help craftsmen make strange materials to meet the needs of the world. In the field of industry and technology, it may be added to various agents, and the nature of additives makes it more widely used. Therefore, the use of 5-chloro-3-fluorobenzene-1,2-diol involves a wide range of fields such as medicine, chemical education, material research, and industrial technology. In this world, it is a serious responsibility and can be used by the industry to explore new tools for change.
Research & Development
Today there is a substance named 5-chloro-3-fluorobenzene-1,2-diol. As a researcher, we study the properties of this substance and seek its development.
In the laboratory, observe its shape in detail and explore the law of its reaction. Its color, taste and state are all important for research. Combine with various reagents, observe its changes, or generate heat, or change color, or produce gas, and record it in detail.
Study its structure, understand the way its atoms are connected, and understand why it has this property. Consider the effect of this structure in the reaction, and push it to the possibility of other reactions.
Seek the development of this substance. Examine its usefulness and find its potential path in the fields of medicine, materials, etc. Hope that through continuous research, it can develop its growth and be used by the world, so as to promote the progress of scientific research and benefit everyone.
Toxicity Research
Toxicological investigation of 5-chloro-3-fluorobenzene-1,2-diol
In the present world, the investigation of chemical products is the key to toxicological research. Today, 5-chloro-3-fluorobenzene-1,2-diol is discussed.
To clarify its toxicity, first examine its structure. This compound contains chlorine, fluorine, and halogen elements. It is active or has potential effects on living organisms. After many experiments, it may interfere with the normal metabolism of cells at the cellular level. If animals are used as samples and fed with food containing this substance, observe its physiological reaction. The organs of the tested animals, such as the liver and kidney, appear to have minor lesions.
Liver and kidney, the detoxification and metabolic hub in the biological body. From this point of view, 5-chloro-3-fluorobenzene-1,2-diol or after absorption by the organism, follows the blood to the liver and kidney, impairing their normal function. Although the conclusion obtained at present is not complete, it has already seen clues, which is enough for follow-up in-depth investigation. It is hoped that the toxicity of this substance can be clarified to protect the living beings and the environment.
Future Prospects
5-Chloro-3-fluorobenzene-1,2-diol is a new material in today's chemical research. Although it is still in the process of research, the future development is quite promising.
Looking at this compound, its structure is specific, and the combination of chlorine, fluorine, benzene ring and diol group gives it unique properties. In the field of materials science, it may be the basis for the creation of new functional materials. It may be able to participate in the polymerization process to obtain high polymers with excellent properties, which can be used in electronic devices and aerospace to meet the needs of future technology.
In pharmaceutical chemistry, this compound also has potential. Its structure may be similar to that of bioactive molecules, modified, derived, or a good medicine for the treatment of difficult diseases. Over time, through careful research and experimental verification, it will definitely be able to seek well-being for human health.
Therefore, the future development of 5-chloro-3-fluorobenzene-1,2-diol, such as the rise of the morning sun, the light is gradually prosperous, and it can be expected to bloom in various fields and create a new situation.
Where to Buy 5-Chloro-3-Fluorobenzene-1,2-Diol in China?
As a trusted 5-Chloro-3-Fluorobenzene-1,2-Diol manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 5-Chloro-3-Fluorobenzene-1,2-Diol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 5-chloro-3-fluorobenzene-1,2-diol?
5-Bromo-3-allyl-1,2-diol, which is an important compound in organic chemistry, has key uses in many fields.
In the field of organic synthesis, it often acts as a key intermediate. The cap has both bromine atoms and allyl, diol and other active functional groups in its molecular structure. Bromine atoms can interact with various nucleophilic reagents through nucleophilic substitution reactions, and then introduce different functional groups; allyl groups have higher reactivity and can participate in various reactions such as olefin metathesis reactions, so as to realize the construction of carbon-carbon bonds and the expansion of molecular skeletons; diol structures can not only participate in esterification reactions to form esters with specific functions, but also form cyclic compounds through condensation reactions with alcaldes, ketones, etc., which greatly enriches the strategies and paths of organic synthesis.
In the field of materials science, 5-bromo-3-allyl-1,2-diol also has extraordinary performance. Polymer materials with special properties can be prepared by appropriate chemical modification and polymerization. For example, copolymerization with other monomers can endow the polymer with unique solubility, thermal stability and mechanical properties. At the same time, because its structure contains double bonds, which can improve the hardness and wear resistance of the material through cross-linking reaction, it is often used in the preparation of high-performance coatings, adhesives and composites.
In the field of medicinal chemistry, the compound also shows potential application value. Because it contains a variety of functional groups that can specifically interact with targets in organisms, it can be used as a lead compound for structural optimization and modification. By introducing different substituents, adjusting their properties such as fat solubility, water solubility, and affinity with targets, it is expected to develop new drugs with specific pharmacological activities and contribute to human health.
What are the synthesis methods of 5-chloro-3-fluorobenzene-1,2-diol?
To prepare 5-bromo-3-allyl-1,2-diphenol, you can follow the following ancient methods.
First, use allyl phenol as the starting material, and introduce bromine atoms by halogenation. In a suitable reaction vessel, put allyl phenol and dissolve it with an appropriate amount of solvent, such as dichloromethane. Cold to a suitable temperature, generally about 0 ° C to 5 ° C, slowly drop the bromine solution, and stir at the same time to ensure that the reaction system is uniform. During this process, pay attention to the control of temperature to prevent side reactions from being too high. Add it dropwise, gradually raise it to room temperature, and continue stirring for a few times to ensure complete reaction. After the reaction is completed, the mixture containing the target product is obtained by conventional separation and purification methods, such as extraction, column chromatography, etc., and then refined to obtain pure 5-bromo-3-allyl-1,2-diphenol.
Second, catechol is used as the starting material. First, catechol is alkylated with allyl halides, such as allyl bromide, in the presence of bases. Take catechol, dissolve it in a suitable organic solvent, such as N, N-dimethylformamide (DMF), add an appropriate amount of base, such as potassium carbonate, and stir it to dissolve. Next, slowly add allyl bromide and heat it up to a suitable temperature, such as 60 ° C - 80 ° C, when the reaction number is. After the reaction is completed, the impurities are removed by washing with water, extraction and other steps. Then this mixture containing allyl products is used as material for halogenation reaction. Similar to the above halogenation steps using allyl phenol as raw material, bromine atoms are introduced at the appropriate position, and 5-bromo-3-allyl-1,2-diphenol can also be obtained. After fine separation and purification, a pure product is obtained. These two ancient methods have their own advantages and disadvantages, and they need to be used according to the actual situation, such as the ease of access of raw materials, the conditions of the reaction, and the purity requirements of the product.
What are the physical properties of 5-chloro-3-fluorobenzene-1,2-diol?
5-Alkane-3-enheptyl-1,2-diol is an organic compound with unique physical properties, detailed as follows:
1. ** Properties **: Under normal conditions, this compound may be a colorless to light yellow viscous liquid. Due to the structure of both alkanes, olefins and diols in the molecule, the intermolecular force is complex, resulting in such a property.
2. ** Melting point and boiling point **: Since the diol part of the molecule can form hydrogen bonds and enhance the attractive force between molecules, its melting point and boiling point are relatively high. The specific value will vary depending on factors such as the length of the carbon chain and the position of the double bond in the molecular structure. Roughly speaking, the boiling point is between 200 and 300 degrees Celsius, which requires more energy to overcome the intermolecular forces and realize the transition from liquid to gaseous state. The melting point is between -10 and 20 degrees Celsius, which makes it mostly liquid at room temperature.
3. ** Solubility **: The diol part of the molecule contains hydrophilic hydroxyl groups, so the compound can be soluble in polar solvents such as water, ethanol, and acetone. However, alkanes and olefin parts have certain hydrophobicity, resulting in limited solubility in water and not infinite miscibility. For example, it can be well dissolved in ethanol, because ethanol can form hydrogen bonds with hydroxyl groups and has certain similarities with hydrocarbon groups in the molecule.
4. ** Density **: The density may be slightly higher than that of water, about 1.0 - 1.2 g/cm ³. Because the molecule contains many atoms and the structure is relatively compact, the mass per unit volume is large.
5. ** Volatility **: Because of its high boiling point, strong intermolecular forces and low volatility. At room temperature and pressure, the volatilization rate is slow, and it can remain liquid for a long time in a sealed container.
What are the precautions for storing and transporting 5-chloro-3-fluorobenzene-1,2-diol?
5-Bromo-3-allyl-1,2-diol is an organic compound. When storing and transporting, the following numbers should be paid attention to:
First, the storage environment. This compound should be placed in a cool, dry and well-ventilated place. Because of its certain chemical activity, high temperature and humidity can easily cause it to deteriorate. If it is in a high temperature environment, or causes the activity of chemical bonds in the molecule to increase, it will initiate reactions such as decomposition and polymerization; while in a humid environment, moisture or interaction with the compound will cause side reactions such as hydrolysis, which will damage its purity and quality. At the same time, it should be kept away from fire and heat sources to avoid uncontrolled reactions due to heat and danger.
Second, the method of packaging. It needs to be packaged in a sealed and corrosion-resistant container. The bromine atom in 5-bromo-3-allyl-1,2-diol reacts with allyl and other structures, or reacts with some packaging materials. For example, it cannot be packaged with ordinary metal materials, because the bromine atom has certain oxidizing properties, or reacts with active metals, causing the packaging container to corrode and cause the compound to deteriorate. Appropriate packaging materials such as glass and specific plastics should be selected to ensure good sealing and prevent leakage.
Third, when transporting. The transportation process should be protected from vibration and impact. The allyl group in this compound structure is an unsaturated structure, which is subject to severe vibration, impact, or triggers reactions such as intramolecular rearrangement and polymerization, changing its chemical properties. And the means of transport also need to be kept dry, cool, temperature and humidity control equipment is complete to maintain a stable transportation environment. In addition, in accordance with the relevant provisions of hazardous chemicals, warning signs should be posted to ensure that transport personnel and surrounding personnel are aware of their latent risks and take protective measures.
What are the safety risks associated with 5-chloro-3-fluorobenzene-1,2-diol?
5-Alkane-3-enyne-1,2-diol, this substance has many risks related to safety. It has the risk of explosion, because its chemical structure contains alkyne bonds, high chemical activity, in case of open flame, hot topic or strong oxidant, it is easy to cause combustion and even explosion, such as in chemical production, if the operation is improper, in case of ignition source will cause instant disaster.
Furthermore, it may pose a health hazard. It can endanger the human body through respiratory tract, skin contact or accidental ingestion. Inhalation of its volatile gas can cause respiratory irritation, such as coughing, asthma, and even damage to lung tissue; skin contact, or cause allergies, burns; if accidentally ingested, it will damage the digestive system, causing nausea, vomiting, abdominal pain and other symptoms.
Environmental hazards should not be underestimated. If it flows into the environment, it may cause damage to water bodies and soil ecosystems due to its active chemical properties. In water bodies, it can affect the survival and reproduction of aquatic organisms, change the chemical properties of water bodies; in soil, or affect soil microbial activity and plant growth.
Extreme caution is also required when transporting and storing. During transportation, if the package is damaged and leaks, it will cause a disaster if it encounters surrounding dangerous factors; when storing, if it is not in accordance with the regulations, mixed with contraindicated substances, or the ambient temperature and humidity are out of control, it can cause safety accidents. Therefore, this substance must be strictly controlled from production, use to transportation and storage to reduce safety risks.