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5-Chloro-3-Fluoro-2-Methoxynitrobenzene

5-Chloro-3-Fluoro-2-Methoxynitrobenzene

Hongda Chemical

    Specifications

    HS Code

    633629

    Chemical Formula C7H5ClFNO3
    Molecular Weight 207.57
    Appearance Solid (usually)
    Color Off - white to pale yellow
    Odor Typical organic chemical odor
    Solubility In Water Low solubility (organic nitro - aromatic compound)
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, ethyl acetate
    Stability Stable under normal conditions, but may react with strong oxidizing/reducing agents

    As an accredited 5-Chloro-3-Fluoro-2-Methoxynitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 5 - chloro - 3 - fluoro - 2 - methoxynitrobenzene: Packed in 1 - kg bottles for chemical storage.
    Storage 5 - Chloro - 3 - fluoro - 2 - methoxynitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent moisture and air exposure, which could potentially degrade the chemical. It should be segregated from incompatible substances to avoid reactions.
    Shipping 5 - Chloro - 3 - fluoro - 2 - methoxynitrobenzene, a chemical, is shipped in sealed, corrosion - resistant containers. It adheres to strict hazardous material shipping regulations to ensure safe transport due to its potentially harmful nature.
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    5-Chloro-3-Fluoro-2-Methoxynitrobenzene 5-Chloro-3-Fluoro-2-Methoxynitrobenzene
    General Information
    Historical Development
    5-Chloro-3-fluoro-2-methoxynitrobenzene is also an organic compound. Tracing back to its origin, at the beginning of organic chemistry in the past, Zhu Xian Da studied the properties and changes of substances and explored the synthesis of compounds.
    At the beginning, chemists could only analyze common substances. With the improvement of technology and equipment, there were more and more synthesis methods. The development of 5-chloro-3-fluoro-2-methoxynitrobenzene has gone through the efforts of several generations of scholars. In the early years, the synthesis of such compounds containing halogenated and nitro groups was difficult and the yield was low. However, chemists adhere to the spirit of research, constantly adjust the conditions of the reaction and change the reagents used. After long-term grinding and optimization of the synthesis path, the preparation of this compound becomes mature, laying the foundation for subsequent applications in medicine, materials and other fields.
    Product Overview
    5-Chloro-3-fluoro-2-methoxynitrobenzene is also a chemical developed by me. Its color is light yellow, crystalline, and its properties are relatively stable. The preparation of this product requires a multi-step fine reaction. It starts with a specific aromatic hydrocarbon, is halogenated, chlorine and fluorine atoms are introduced, and then methoxylated, followed by nitrification, and finally obtains this product.
    It is widely used in the field of organic synthesis. It can be used as a key intermediate to prepare a variety of biologically active compounds, and is of great significance in the research and development of medicines and pesticides. However, when preparing, it is necessary to strictly control the reaction conditions, such as temperature, pH, reactant ratio, etc. A slight difference will affect the yield and purity. We should study it carefully and strive to improve it, so as to expand its application field and seek more benefits in the world.
    Physical & Chemical Properties
    5-Chloro-3-fluoro-2-methoxynitrobenzene is an organic compound. Its physical properties, at room temperature, are solid, with a yellowish color and a slightly specific odor. The melting point is about [X] ° C, and this value varies slightly due to the difference in pure impurities. The boiling point is at [X] ° C, and its density is [X] g/cm ³.
    In terms of its chemical properties, it has nitro groups and is strongly oxidizing. Under appropriate conditions, nitro groups can be reduced to amino groups and new compounds can be derived. The presence of methoxy groups changes the density of electron clouds in the benzene ring, which affects the activity and location of electrophilic substitution reactions. Chlorine and fluorine atoms, due to their electronegativity differences, also have unique performance in chemical reactions, or participate in substitution, or affect the interaction between molecules, making this compound widely used in the field of organic synthesis and a key intermediate for the preparation of many fine chemicals.
    Technical Specifications & Labeling
    5-Chloro-3-fluoro-2-methoxynitrobenzene, its technical specifications and identification (product parameters) are the key. The preparation of this product needs to follow a precise process. First take an appropriate amount of reaction raw materials and place them in a clean vessel according to a specific ratio. The temperature, humidity and pressure of the reaction environment need to be strictly controlled to ensure the smooth progress of the reaction.
    In terms of its identification, the product name, chemical formula, content and other parameters should be clearly marked on the prominent part of the package. The appearance needs to be a specific color and shape, and there should be no impurities. In this way, the quality of the product can be guaranteed to meet the standards. When it is circulated in the market, its characteristics and uses can be understood by all parties according to the identification parameters, and the preparation process can also follow strict technical specifications.
    Preparation Method
    If you want to make 5-chloro-3-fluoro-2-methoxynitrobenzene now, you need to study the method in detail. Its raw materials and production process are crucial to success or failure.
    First of all, you need to choose suitable raw materials, such as a halogenated benzene as a base, supplemented by reagents containing fluorine, chlorine and methoxy. The reaction step is also the key. First, the halogenated benzene and the fluorine-containing reagent are substituted according to specific reaction conditions to introduce fluorine atoms. Then, react with the chlorine-containing reagent and add chlorine atoms.
    As for the access of methoxy groups, you need to choose a suitable methoxylating reagent and react at an appropriate acid-base environment and temperature.
    The catalytic mechanism cannot be ignored. Selecting a high-efficiency catalyst can promote the rate of reaction and increase the yield of products. Such as metal catalysts or specific organic catalysts, which can precisely regulate the process of the reaction. In this way, careful management of raw materials, steps and catalytic mechanisms is expected to produce high-purity 5-chloro-3-fluoro-2-methoxynitrobenzene.
    Chemical Reactions & Modifications
    5-Chloro-3-fluoro-2-methoxynitrobenzene, the chemical reaction and modification of this compound are related to the gist of our chemical research. In previous experiments, the reaction path was observed, and the conventional method was mostly followed, but the effect was not high.
    If you want to improve it now, think about it again. After careful study, it is found that changing the reaction conditions, such as temperature, solvent properties, or can cause its chemical reaction to be unique. Changes in temperature can make the molecular activity different, or promote its rapid reaction, or slow down its process, so as to achieve precise control. Solvents are also the key, different solvents have different solubility and intermolecular interaction of compounds, or help the reaction move towards the expected direction.
    If these two can be carefully debugged, the chemical reaction of 5-chloro-3-fluoro-2-methoxynitrobenzene can be made according to our wishes, showing better modification effect, opening up new paths for chemical research, opening up unknown areas, and increasing scientific knowledge.
    Synonyms & Product Names
    5-Chloro-3-fluoro-2-methoxynitrobenzene, this substance is very important in chemical research. Its synonyms and trade names have their own wonderful meanings.
    Guanfu synonyms are derived from its chemical structure characteristics. For example, the combination of atoms and groups in the structure gets various nicknames, which are all used to accurately describe its chemical essence. This contains chemical principles and highlights its unique properties in professional terms.
    As for the trade name, the merchants are different from the other products, or take the name of easy to remember, or contain auspicious meaning, or highlight the advantages of the product, so that it is easy to recognize and remember, which is conducive to the promotion of the market. However, they all refer to this 5-chloro-3-fluoro-2-methoxynitrobenzene. Synonyms emphasize chemical essence, and trade names emphasize market dissemination. The two complement each other and help this product become known and used by everyone in the field of chemical industry.
    Safety & Operational Standards
    5-Chloro-3-fluoro-2-methoxynitrobenzene is also one of the chemical products. Safety and operating standards are of paramount importance during its experimental preparation and application.
    To prepare this product, the experimental site must be well ventilated to disperse harmful gases, so as not to cause the experimenter to inhale and damage health. All kinds of instruments should be carefully checked before use to ensure that they are intact to prevent leakage and cracking during the experiment.
    When using raw materials, the exact amount must be used, and there must be no slight error. The raw materials of 5-chloro-3-fluoro-2-methoxynitrobenzene are mostly toxic and corrosive. When taking them, protective equipment is required, such as gloves, goggles, protective clothing, etc., to avoid contact with the skin and eyes. If you come into contact inadvertently, you should rinse with water immediately, and if it is serious, seek medical attention immediately.
    The reaction process, temperature, pressure and other conditions must be strictly controlled. The reaction of this product may cause a violent reaction due to improper conditions, which may cause danger. Therefore, monitoring equipment should be set up to detect the reaction situation in real time, and there are abnormal immediate measures.
    When storing, it should be placed in a cool, dry and ventilated place to avoid co-storage with oxidants, acids, alkalis, etc., to prevent reactions. The container must be well sealed to prevent leakage.
    The operating specifications should not be ignored. The experimenter must be professionally trained and familiar with the operation process, and must not change the steps without authorization. After the experiment, the instrument should be washed and returned to its place, and the residual products should be disposed of in accordance with regulations, and should not be disposed of at will.
    In short, in the preparation, use and storage of 5-chloro-3-fluoro-2-methoxynitrobenzene, all aspects should strictly abide by safety and operating standards, so as to ensure the safety of personnel, avoid accidents, and enable scientific research and production to proceed smoothly.
    Application Area
    5-Chloro-3-fluoro-2-methoxynitrobenzene, this substance is widely used in the field of chemical industry. In the process of pharmaceutical synthesis, it can be a key intermediate to help create new drugs, or treat serious diseases, or relieve diseases. In the preparation of pesticides, it can be turned into high-efficiency pesticides through delicate reactions, ensuring a bumper harvest of grains, and preventing the invasion of diseases and pests. And in the context of materials science, it is also possible to improve the properties of materials through specific processes, such as enhancing their stability and optimizing their optical properties. With its unique structure, this compound has extraordinary potential in various application fields, and is an important object of chemical research. It has attracted countless researchers to study and explore, so as to exert its maximum function and benefit the world.
    Research & Development
    Today there is a chemical thing called 5 - Chloro - 3 - Fluoro - 2 - Methoxynitrobenzene. I am a researcher of chemistry, and I am concerned with the research and progress of this thing.
    At the beginning, explore its properties, analyze its structure, and understand its molecular structure and bonds. Then, study the method of making it, and seek the way of high efficiency and purity. Between experiments, observe the change of conditions, temperature, pressure, and amount of agent, and study it carefully.
    And think about the use of this thing, it may be useful in the fields of medicine and materials. It is hoped that unremitting research can benefit the public, promote the progress of chemistry, and contribute to the development of the world. In the future, it can expand its new territory and make this chemical thing radiant and beneficial to the world.
    Toxicity Research
    Today, there is a substance named 5-chloro-3-fluoro-2-methoxynitrobenzene. In our chemical research, the investigation of its toxicity is crucial. This substance has a unique structure, and the coexistence of chlorine, fluorine, methoxy and nitro groups may cause it to have special toxicity.
    Looking at past studies, such compounds containing halogen atoms and nitro groups have a lot of toxicity. Halogen atoms can enhance the lipid solubility of compounds and make them easy to enter living bodies; nitro groups are often oxidizing or damage biological macromolecules.
    We should carefully investigate the effects of 5-chloro-3-fluoro-2-methoxynitrobenzene on organisms, starting from the cellular level, to explore its effects on cell proliferation and apoptosis. It is also necessary to study the animal body to observe its acute and chronic toxicity. After rigorous research, the complete picture of the toxicity of this substance can be obtained, which will lay the foundation for future application and protection.
    Future Prospects
    I have dedicated myself to the preparation of 5-chloro-3-fluoro-2-methoxynitrobenzene. This compound has unique properties and potential applications in many fields.
    Looking at the current research, although there have been gains, the road ahead is still long. We hope that in the future, its synthesis process can be achieved to a simpler and more efficient environment. Or new catalysts can be found to make the reaction conditions milder, reduce energy consumption and improve yield.
    Furthermore, its application scope is also expected to expand. In the field of medicine, new specific drugs may be developed; in materials science, new materials with excellent performance may be prepared. I firmly believe that with time and unremitting research, 5-chloro-3-fluoro-2-methoxynitrobenzene will be able to shine brightly, contributing to our lives and technological progress, and bringing endless well-being.
    Where to Buy 5-Chloro-3-Fluoro-2-Methoxynitrobenzene in China?
    As a trusted 5-Chloro-3-Fluoro-2-Methoxynitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 5-Chloro-3-Fluoro-2-Methoxynitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 5-Chloro-3-Fluoro-2-Methoxynitrobenzene?
    5-Chloro-3-fluoro-2-methoxynitrobenzene, which has a wide range of uses in the chemical industry.
    First, it is often used as a key intermediate in the process of organic synthesis. Chlorine, fluorine, methoxy and nitro groups in the molecules have unique reactivity. Chlorine atoms can be nucleophilic substitution reaction to introduce multiple functional groups to the benzene ring. Such as meeting with nucleophiles such as alcohols and amines, it can form ether and amine derivatives, which is of great significance for the construction process of complex organic compounds. The addition of fluorine atoms can significantly change the physical and chemical properties of compounds, such as improving fat solubility and enhancing stability. In the field of medicinal chemistry and materials science, new materials and new drug molecules with specific properties can be synthesized with this property.
    Second, it is valuable in the field of pharmaceutical research and development. Due to its unique chemical structure, it can become a starting material for the design and synthesis of new drugs. By modifying the substituents on the benzene ring, the interaction between the compound and the biological target can be adjusted, and then the lead compounds with high activity and high selectivity can be screened. For example, for specific disease-related enzymes or receptors, after rational structural modification, it is expected to create therapeutic drugs with excellent efficacy.
    Third, it is also indispensable in the path of material preparation. Its structure endows the material with special electrical and optical properties. It can be used to synthesize optoelectronic materials, and it can be used as a key functional material in the manufacture of organic Light Emitting Diode (OLED), solar cells and other devices, contributing to the improvement of device performance.
    In short, 5-chloro-3-fluoro-2-methoxynitrobenzene, with its unique structure, occupies an important position in many fields such as organic synthesis, pharmaceutical research and development, and material preparation, promoting the continuous development of related fields.
    What are the physical properties of 5-Chloro-3-Fluoro-2-Methoxynitrobenzene?
    5-Chloro-3-fluoro-2-methoxynitrobenzene is a kind of organic compound. Its physical properties are particularly important and are related to many chemical and scientific research purposes.
    The first word about its properties, under normal conditions, or in a crystalline state, it has a certain color when viewed, often in a white or yellowish color. This color varies, or due to the presence and amount of impurities. The crystalline shape is either needle-like or flake-like. Upon closer inspection, it can be felt that its texture is delicate, but the touch and appearance vary depending on the preparation and preservation.
    The melting point is described again. It has been scientifically determined that its melting point is in a specific temperature range. The determination of the melting point is crucial for the identification and purity determination of the substance. If impurities are mixed in, the melting point may drop, and the melting range becomes wider. The exact value of the melting point of this substance provides an important basis for precise temperature control and separation and purification of substances in chemical production.
    Furthermore, the boiling point is also an important physical property. Under a specific pressure, when it reaches the boiling point, it changes from liquid to gaseous state. The value of the boiling point is related to the setting of conditions for separation operations such as distillation and fractionation. Knowing the boiling point can reasonably adjust the temperature in the chemical process to achieve efficient separation and obtain high-purity products.
    In terms of solubility, 5-chloro-3-fluoro-2-methoxynitrobenzene behaves differently in different solvents. In organic solvents such as ethanol and acetone, it may have a certain solubility, which is due to the interaction between the molecular structure of the organic solvent and the molecules of the organic solvent. In water, the solubility is usually low, because water is a polar solvent, and the molecular polarity of the substance is quite different from that of the substance. According to the principle of "similar miscibility", it is difficult to dissolve. Solubility characteristics play a great role in the extraction, purification and choice of reaction medium of the substance.
    In addition, density is also one of the physical properties of the substance. The density data can help to determine its position in the mixture, and provide basic information for the selection of suitable separation methods in liquid-liquid separation and other operations.
    In summary, the physical properties of 5-chloro-3-fluoro-2-methoxynitrobenzene, such as properties, melting point, boiling point, solubility, density, etc., are of indispensable value in the preparation, separation and identification of substances in chemical production and scientific research experiments.
    What is 5-Chloro-3-Fluoro-2-Methoxynitrobenzene synthesis method?
    The synthesis of 5-chloro-3-fluoro-2-methoxynitrobenzene is an important topic in the field of organic synthesis. To synthesize this substance, several routes are often followed.
    First, halogenated aromatics are used as starting materials. First, a suitable halogenated benzene is taken, and a methoxy group is introduced under specific reaction conditions. In this step, a nucleophilic substitution reaction can be used to react with halogenated benzene with a strong base such as sodium methoxide, so that the halogen atom is replaced by a methoxy group to form an aromatic hydrocarbon containing methoxy groups. Subsequently, fluorine atoms are introduced into aromatic hydrocarbons, and fluorination reagents such as potassium fluoride can be used through nucleophilic fluorination reactions. In the presence of suitable solvents and catalysts, the substitution of fluorine atoms Finally, by using nitrification reaction, mixed acid (mixture of nitric acid and sulfuric acid) is used as nitrifying reagent to introduce nitro groups at suitable positions of aromatic hydrocarbons. After a series of regulation and optimization of reaction conditions, the target product 5-chloro-3-fluoro-2-methoxynitrobenzene can be obtained.
    Second, phenolic compounds are used as starting materials. First, phenolic hydroxyl is methylated, and methylation reagents such as dimethyl sulfate are commonly used to obtain methoxyphenol. After that, chlorine atoms and fluorine atoms are introduced through halogenation reaction, and suitable halogenation reagents and reaction conditions can be used to achieve the substitution of halogen atoms at specific positions of phenolic derivatives. Finally, the nitro group is introduced through the nitrification step to synthesize 5-chloro-3-fluoro-2-methoxynitrobenzene.
    During the synthesis process, each step of the reaction requires fine regulation of reaction conditions, such as temperature, time, ratio of reactants, solvent selection, etc., to improve the reaction yield and selectivity, and reduce the occurrence of side reactions, in order to obtain a pure target product 5-chloro-3-fluoro-2-methoxynitrobenzene.
    What are the precautions in storage and transportation of 5-Chloro-3-Fluoro-2-Methoxynitrobenzene?
    5-Chloro-3-fluoro-2-methoxynitrobenzene is an organic compound. When storing and transporting, there are many key considerations that need to be taken with caution.
    One is related to storage. This compound should be stored in a cool, dry and well-ventilated place. Do not place it in a high temperature or humid place. High temperature will increase its chemical reactivity or cause changes such as decomposition. Humid environment may cause it to react with moisture and cause quality damage. Store it away from fire and heat sources. Because it has certain chemical activity, there is a risk of open flame, hot topic or combustion explosion. At the same time, it should be stored separately from oxidizing agents, reducing agents, acids, alkalis, etc., and must not be mixed. Because the compound and these substances may have violent chemical reactions, it will cause danger. In addition, the storage area should be equipped with suitable materials to contain the leakage, in case of leakage, it can be dealt with in time to avoid greater harm.
    Second, for transportation. Be sure to ensure that the packaging is intact before transportation. The packaging material must be able to effectively prevent the compound from leaking and volatilizing, and can withstand certain external shocks. During transportation, it is necessary to ensure that the container does not leak, collapse, fall or damage. The transportation vehicle should also be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. The choice of driving route should not be ignored. Sensitive areas such as densely populated areas, schools, and hospitals should be avoided to prevent accidents during transportation and cause serious harm to the public. During transportation, the speed should not be too fast, and sudden braking should be avoided to prevent package damage and leakage due to collision and vibration. And transportation personnel must be professionally trained to be familiar with the dangerous characteristics of the compound and emergency treatment methods, so as to properly deal with various emergencies during transportation and ensure transportation safety.
    What is the market outlook for 5-Chloro-3-Fluoro-2-Methoxynitrobenzene?
    5-Chloro-3-fluoro-2-methoxynitrobenzene, an important intermediate in organic synthesis, is widely used in medicine, pesticides, dyes and other fields. Looking at its market prospects, there seem to be many things to be said.
    In the field of medicine, today, there is an increasing demand for new drugs. Among the synthesis pathways of many drugs, 5-chloro-3-fluoro-2-methoxynitrobenzene can be a key starting material. With the increasing emphasis on health, the pharmaceutical industry is booming, and the demand for it is expected to rise. For example, in the research and development process of anti-cancer drugs and anti-infective drugs, its unique chemical structure may provide an opportunity for the creation of special new drugs, so in the field of pharmaceutical synthesis, its market prospect is quite promising.
    The field of pesticides cannot be ignored. At present, high-efficiency, low-toxicity and environmentally friendly pesticides are the trend of development. 5-chloro-3-fluoro-2-methoxy nitrobenzene may be used as an important raw material for the synthesis of such new pesticides, and can be used to prepare pesticide products with unique insecticidal, bactericidal and herbicidal properties. With the advancement of agricultural modernization, the demand for high-quality pesticides is stable, and it is also expected to occupy a certain market share in the pesticide industry.
    In the dye industry, the development of new dyes has always been a hot topic. 5-Chloro-3-fluoro-2-methoxynitrobenzene, due to its special structure, may endow dyes with novel color and light, good dyeing properties and color fastness. With the increasing demand for high-quality dyes in textile, printing and dyeing industries, there is also room for development of this intermediate in dye synthesis.
    However, although the market prospect is good, it also faces challenges. Optimization of the synthesis process and cost control are crucial. If more efficient and green synthesis methods can be developed to reduce production costs, it will surely enhance its market competitiveness. In addition, environmental regulations are increasingly stringent, and the production process must meet strict environmental requirements, which is also a problem for manufacturers to deal with. But in general, if the challenges can be properly met, the market prospect of 5-chloro-3-fluoro-2-methoxynitrobenzene may be brighter, and there are development opportunities in various application fields.