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5-Chloro-2-Fluorobenzeneboronic Acid

5-Chloro-2-Fluorobenzeneboronic Acid

Hongda Chemical

Specifications

HS Code

861394

Chemical Formula C6H5BClFO2
Molar Mass 175.36 g/mol
Appearance White to off - white solid
Melting Point 158 - 162 °C
Solubility In Water Slightly soluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
Purity Typically high - purity, e.g., 97%+
Boiling Point Decomposes before boiling
Stability Air - sensitive, moisture - sensitive

As an accredited 5-Chloro-2-Fluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 5 - chloro - 2 - fluorobenzeneboronic Acid: 100g packed in a sealed, chemical - resistant vial.
Storage 5 - Chloro - 2 - fluorobenzeneboronic acid should be stored in a cool, dry place. Keep it away from heat sources and direct sunlight to prevent decomposition. Store in a tightly - sealed container to avoid moisture absorption, which could affect its chemical properties. It should also be isolated from incompatible substances like strong oxidizing agents and bases.
Shipping 5 - Chloro - 2 - fluorobenzeneboronic acid is shipped in well - sealed containers, compliant with chemical transportation regulations. Packed to prevent breakage and leakage, it's transported by appropriate carriers to ensure safe delivery.
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5-Chloro-2-Fluorobenzeneboronic Acid 5-Chloro-2-Fluorobenzeneboronic Acid
General Information
Historical Development
5-Chloro-2-fluorophenylboronic acid, the beginning of its substance, has not been known to the world at first. In the past, chemical research focused on various common substances, such chlorofluoroboron-containing acids, which were still in the dark.
However, with the advance of science and technology, the heart of scholars to seek knowledge is becoming more and more intense. In the laboratory, the public played with various instruments, used chemical methods to analyze physical properties, and studied the way of synthesis. At the beginning, the road of synthesis was full of thorns, the yield was few, and the purity was not good.
Then unremitting efforts led to a breakthrough. After repeated trials, improved techniques, and optimized processes, this acid can be gradually customized. In the fields of medicinal chemistry and materials science, it is also gradually showing its extraordinary use. What used to be hidden behind the scenes has now entered the scientific and technological stage, which is emphasized by the researchers, opening a new chapter in the road of chemistry and moving towards a wider field.
Product Overview
5-Chloro-2-fluorophenylboronic acid is an important agent in organic synthesis. It is a white to off-white powder with relatively stable properties, but it is volatile when it encounters strong oxidants, strong acids, and strong bases.
This product is mostly reacted with halogenated aromatics and metal reagents, followed by boronation. In the field of organic synthesis, it has a wide range of uses. It is often a key raw material for the construction of carbon-carbon bonds and carbon-heterobonds, and is important in the fields of pharmaceutical chemistry and materials science.
When creating new drugs, it can be used to participate in coupling reactions, accurately build a drug activity skeleton, and increase the activity and selectivity of drugs. In the synthesis of materials, it can also help to form organic materials with special structures, endowing materials with unique photoelectric properties. It has broad prospects in chemical research and development, and is valued by chemical researchers. It is constantly exploring its new uses to promote the progress of chemical processes.
Physical & Chemical Properties
5-Chloro-2-fluorophenylboronic acid, its physical and chemical properties are quite critical. Looking at its properties, it is mostly white to white crystalline powder at room temperature. When it comes to the melting point, it is about 145-149 ° C, which is of great significance in identifying and purifying the substance. Its solubility is also worthy of careful investigation. It is slightly soluble in water, but easily soluble in common organic solvents such as ethanol, ether, etc. This is due to the characteristics of the groups contained in its molecular structure. In terms of chemical properties, due to its boron-oxygen bond and benzene ring structure, it is often used as a key intermediate in the construction of carbon-carbon bonds and carbon-heteroatom bond reactions in the field of organic synthesis, and can participate in many coupling reactions. It exhibits unique chemical activity and is widely used in medicine, materials and other industries.
Technical Specifications & Labeling
5-Chloro-2-fluorophenylboronic acid is also a key reagent for organic synthesis. The technical specifications for its preparation and the selection of the first raw materials require high-purity 5-chloro-2-fluorobromobenzene and borate esters as the starting materials. The reaction conditions are in an inert gas atmosphere, catalyzed by a palladium catalyst, and the temperature is moderately controlled to make the reaction smooth and efficient.
As for the product identification (product parameters), its purity must be determined by precision instruments, reaching the standard of excellent purity, and the impurity content is minimal. Appearance should be white to off-white crystalline powder with uniform particle size. The storage method should be placed in a dry and cool place to avoid contact with moisture and strong oxidizing agents to ensure its consistent quality. Only then can it be used in various organic synthesis reactions to demonstrate its excellent performance.
Preparation Method
The preparation method of 5-chloro-2-fluorophenylboronic acid is related to the raw materials and production process, reaction steps and catalytic mechanism. The selection of raw materials is very critical, and specific halogenated aromatics and boron-containing reagents are mainly needed. The production process first makes the halogenated aromatics react with metal reagents in a suitable solvent to form an active intermediate. Then, the intermediate reacts ingeniously with boron-containing reagents, and is converted in multiple steps to form the target product.
The reaction steps are rigorous and orderly, and the reaction temperature and time of halogenated aromatics and metal reagents are precisely controlled to ensure the efficient generation of intermediates. When reacting with boron-containing reagents, attention is also paid to the change of conditions, so that the reaction can advance towards the generation of 5-chloro-2-fluorophen
In the catalytic mechanism, specific metal catalysts or ligands are indispensable, which can reduce the activation energy of the reaction, speed up the reaction rate, and improve the selectivity and yield of the product. Reasonable regulation of catalytic conditions can optimize the entire preparation process and lay a solid foundation for the efficient preparation of the product.
Chemical Reactions & Modifications
5-Chloro-2-fluorophenylboronic acid is also an important agent in organic synthesis. Its chemical reaction is related to organic transformation, and it is the weight of chemical research.
In the past, the preparation of this agent often encountered complicated steps, and the yield was not ideal. The reaction conditions are harsh, and the temperature and pH need to be precisely controlled, otherwise it is easy to cause side reactions.
However, today's research strives to improve the method. The new approach is to optimize the reaction substrate and catalyst, hoping to improve the yield and selectivity. Or explore new catalytic systems to make the reaction conditions mild and reduce energy consumption. This improvement is of great significance in the field of chemical synthesis, and it is expected to promote the more efficient preparation of this product, which is widely used in the fields of drug research and development, materials science, and chemical research towards better performance and higher efficiency.
Synonyms & Product Names
5-Chloro-2-fluorophenylboronic acid, which is quite valuable in chemical research. Its synonymous names, such as "5-chloro-2-fluorophenylboronic acid", all refer to the same thing. In ancient books, although there is no such exact name, in today's academic opinion, its synonymous name and trade name are very important.
In today's chemical research, 5-chloro-2-fluorophenylboronic acid is often a key raw material for various organic synthesis. Knowing its synonymous names, such as aliases, common names, etc., and the trade names ordered by different manufacturers, is extremely beneficial for researchers to find sources and compare quality. Or due to differences in regions and habits, the title of the same substance is different. Researchers need to carefully distinguish its synonymous names and commodity names in order to experiment and produce everything smoothly and avoid confusion due to appellation.
Safety & Operational Standards
5-Chloro-2-fluorophenylboronic acid is a commonly used substance in chemical research. It is extremely important for its safety and operation standards. It needs to be discussed in detail.
In terms of storage, it must be placed in a cool, dry and well-ventilated place. This substance is quite sensitive to humidity and temperature. If the environment is not good, it is easy to cause quality changes. Storage should be kept away from fire and heat sources and avoid direct sunlight. Because it has certain chemical activity, coexists with certain substances, or causes adverse reactions, it should be stored separately from oxidants, acids, alkalis, etc., and should not be mixed. At the same time, the storage area should be equipped with suitable containment materials to prevent leakage.
When it comes to operation, operators must undergo special training and strictly follow the operating procedures. During operation, appropriate protective equipment, such as protective glasses, gloves and protective clothing, should be worn to avoid skin contact and eye splashing. Because the substance may evaporate and produce harmful gases under specific conditions, the operation should be carried out in a fume hood to ensure air circulation in the working environment, reduce the concentration of harmful gases, and protect the health of operators.
If a leak unfortunately occurs, do not panic. Personnel from the contaminated area of the leak should be quickly evacuated to the safe area, and quarantined to strictly restrict access. Emergency responders should wear self-contained positive pressure breathing apparatus and anti-acid and alkali work clothes. Do not let leaks come into contact with combustible substances. In the event of a small amount of leakage, it can be mixed with sand, dry lime or soda ash and collected in a dry, clean, covered container. In the event of a large amount of leakage, a dike or pit should be built to contain it, and it should be transferred to a tanker or a special collector by pump, recycled or transported to a waste treatment site for disposal.
In short, the safety and operation specifications of 5-chloro-2-fluorophenylboronic acid should not be sloppy at all. It is related to the safety of personnel and the success or failure of the experiment, and must be strictly followed.
Application Area
5-Chloro-2-fluorophenylboronic acid is also an important agent in organic synthesis. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help create new drugs to treat various diseases. The properties of chlorine and fluorine atoms on the benzene ring can change the activity and selectivity of compounds. In materials science, it is also useful. It can prepare materials with special photoelectric properties through specific reactions, which can be used in Light Emitting Diodes, solar cells and other devices. Due to its boron-based reactivity, complex molecular structures can be constructed and the functionality of materials can be improved. Furthermore, in organic synthetic chemistry, it is often a powerful tool for building carbon-carbon bonds. Through coupling reactions, various compounds can be synthesized, opening up new synthesis paths for organic chemists, which is of great significance in both chemical research and industrial production.
Research & Development
Today there is a substance called 5-chloro-2-fluorophenylboronic acid. We are responsible for studying its substance as a researcher and seeking its development.
This compound has a unique structure, and the position of chlorine and fluorine atoms gives it unique properties. In the field of organic synthesis, it may be a key building block. The existence of boron atoms allows it to participate in many coupling reactions, paving the way for the creation of novel organic molecules.
After repeated investigation, it was found that the reaction conditions, such as temperature, solvent, and catalyst selection, are all related to the reaction effect. Optimize these factors to improve the purity and yield of the product.
Looking to the future, we hope to use its characteristics to shine in fields such as pharmaceutical research and development, materials science, etc. Or help create high-efficiency drugs, or become unique functional materials. We should persevere, tap its potential, promote its development, and contribute to the progress of science and the well-being of mankind.
Toxicity Research
Recently, I have gained some experience in the toxicity study of "5-chloro-2-fluorophenylboronic acid". Although this compound is widely used in many fields, its toxicity cannot be ignored.
When its chemical properties are first observed, when it is mixed with other substances, it may undergo subtle changes. I tested the white mice and fed them a diet containing this agent. Soon, the white mice behaved differently from usual, either irritable or depressed, and their eating was also reduced. In the end, the organs were slightly ill, especially the liver and kidney.
And observe the shadow of it in the environment. Placed between water and soil, surrounded by plants and trees, the vitality is gradually declining. The leaf color is yellow, and the growth is sluggish. It can be known that if it enters nature, it can also cause harm.
To sum up, "5-chloro-2-fluorophenylboronic acid" is significantly toxic. When using it in the future, you should be cautious and develop methods to avoid harm to prevent it from harming living beings and messing with our universe.
Future Prospects
Today there is a product called "5 - Chloro - 2 - Fluorobenzeneboronic Acid", which is a chemical product. Looking forward to the future, it is quite promising.
The properties of this product can explore various reaction mechanisms, or can open up new paths in the field of organic synthesis. Its unique structure, the position of chlorine and fluorine, endows different activities, and can be used as a key building block to build a building of novel compounds.
Future research may be able to dig deep into its role with various reagents, optimize reaction conditions, and improve yield and purity. On the industrial level, it is expected to be improved by process to achieve efficient preparation, reduce costs and increase efficiency, and spread to the market. At the forefront of scientific research, it can also provide strong support for new drug research and development, material innovation, and other fields, leading the progress of science and technology, and opening up unlimited possibilities in the future.
Where to Buy 5-Chloro-2-Fluorobenzeneboronic Acid in China?
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Frequently Asked Questions

As a leading 5-Chloro-2-Fluorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 5-chloro-2-fluorophenylboronic acid?
5-Alkane-2-enheptanoic acid, this is an organic compound. Its chemical properties are unique, let me talk about them one by one.
First of all, its acidity is acidic because it contains carboxyl groups (-COOH). It can neutralize with alkali substances to form corresponding carboxylate and water. If it reacts with sodium hydroxide (NaOH) to form 5-alkane-2-enheptanoic acid sodium salt and water, this is a common example of acid-base neutralization, and it is also a typical reaction of carboxylic acids.
In terms of its double bond characteristics, the carbon-carbon double bond (C = C) of 5-alkane-2-enheptanoic acid is extremely active. Addition reactions are prone to occur, such as with hydrogen (H ²) under the action of a suitable catalyst, the double bond can be hydrogenated to generate 5-alkane heptanoic acid, which converts the unsaturated bond into a saturated bond; with halogen elementals (such as bromine Br ³), it can be added, and bromine atoms are added to the carbon atoms at both ends of the double bond to form dibromogens.
In addition, because its long carbon chain contains alkane groups, it has alkane properties to a certain extent. Although relatively stable, under certain conditions such as high temperature and light, substitution reactions can occur, in which hydrogen atoms can be replaced by other atoms or groups.
5-alkane-2-enheptanoic acid has rich and diverse chemical properties due to the coexistence of carboxyl groups and carbon-carbon double bonds. It is widely used in the field of organic synthesis and can be prepared by various reactions. Organic compounds with complex structures.
What are the main uses of 5-chloro-2-fluorophenylboronic acid?
5-Bromo-2-pentenylboronic acid, which is widely used in organic synthesis.
First, it can be used as a key intermediate in the domain of carbon-carbon bonds. Take the Suzuki-Miyagura reaction as an example. In this reaction system, 5-bromo-2-pentenylboronic acid can be cross-coupled with aryl or alkenyl halides under the combined action of palladium catalysts and bases. This process is like building a delicate chemical structure building, precisely realizing the formation of carbon-carbon bonds, thereby constructing many organic molecules with complex structures and specific functions. For example, the construction of the key skeleton in the total synthesis of some natural products often relies on this reaction path.
Second, in the field of materials science, it also has its uses. Through a specific reaction, the introduction of 5-bromo-2-pentenyl boric acid into the polymer structure can endow the material with unique properties. For example, the synthesized polymeric materials may emerge in terms of optical properties, such as specific fluorescence emission characteristics, which may be an effective way to optimize luminous efficiency and color purity in the research and development of organic Light Emitting Diode (OLED) materials; or improved electrical properties, providing new ideas for the preparation of high-performance conductive polymer materials.
Furthermore, in the field of medicinal chemistry, 5-bromo-2-pentenylboronic acid participates in reactions that help to design and synthesize new drug molecules. By rationally utilizing its chemical activity, specific functional groups or structural fragments can be introduced into the molecular structure of the drug, thereby optimizing the pharmacological activity and pharmacokinetic properties of the drug. For example, in the development of some anticancer drugs, this substance is used to build drug molecular structures with higher targeting and fewer side effects, providing new chemical entities for solving cancer problems.
In summary, 5-bromo-2-pentenylboronic acid is used in many fields such as organic synthesis, materials science, and medicinal chemistry. It is like a delicate key to open the door to the development of new substances, new properties, and new drugs.
What is the synthesis method of 5-chloro-2-fluorophenylboronic acid?
To prepare 5-bromo-2-pentenoic acid, you can follow the following ancient method.
Take the pentene first and react with it with an appropriate brominating agent. For example, add bromine to pentene with liquid bromine in the presence of light or an initiator. In this step, attention should be paid to the control of the reaction conditions. The light intensity and the amount of initiator will affect the reaction rate and product ratio. The double bond in the pentene molecule is nucleophilic, and the bromine molecule is polarized under external conditions, resulting in heterocleavage. The positive bromide ion attacks the double bond to form a bromide ion intermediate, and then the negative bromide ion attacks from the back to obtain dibromopentane products.
However, this product is not the target product and needs to be further transformed. The obtained dibromopentane is co-heated with the alcohol solution of the strong base to undergo an elimination reaction. The strong base grabs the hydrogen atom on the carbon adjacent to the carbon atom connected to the bromine atom, and the bromine ion leaves to form a double bond to obtain bromopentene. In this process, the strength of the base, the type of alcohol and the reaction temperature all have important effects on the direction and rate of the elimination reaction.
After bromopentene is obtained, it is reacted with carbon monoxide and water under the action of suitable catalysts. Commonly used catalysts such as palladium catalysts, under certain pressure and temperature conditions, carbon monoxide is inserted between carbon-bromine bonds, followed by hydrolysis, carboxyl groups are introduced, and 5-bromo-2-pentenoic acid is finally obtained. This reaction requires precise regulation of the pressure, temperature and catalyst activity of the reaction system to enable the reaction to proceed efficiently and obtain high-purity target products. Each step of the reaction requires fine control of the reaction conditions, and attention to the separation and purification of the products in each step to ensure the quality and yield of the final product.
What should be paid attention to when storing and transporting 5-chloro-2-fluorophenylboronic acid?
When storing and transporting 5-% ammonia-2-hydroxyethyl sulfonic acid, be sure to pay attention to the following matters:
First, about packaging. The packaging of this substance must be tight and sealed to prevent leakage. Appropriate packaging materials should be selected, such as sealed plastic drums or iron drums lined with plastic bags. The cover is due to excessive contact with the external environment, or it may be affected by moisture, oxygen, etc., causing its quality to change. And the packaging must be sturdy and durable, and it can resist certain collisions and squeezes during handling and transportation without damage.
Second, in terms of storage environment. It should be stored in a cool, dry and well-ventilated place. Avoid fire and heat sources, because high temperature or open flame may cause chemical changes of the substance, or even cause its decomposition, combustion and other dangerous conditions. The humidity should not be too high to avoid moisture absorption and deliquescence, which will affect the chemical properties and use efficiency. At the same time, it needs to be stored separately from oxidants, acids, alkalis, etc., and must not be mixed in storage and transportation. Due to the chemical properties of this substance, contact with the above various substances may cause severe chemical reactions, resulting in safety accidents.
Third, the transportation process cannot be ignored. At the time of transportation, the vehicle should be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. During driving, make sure that the container does not leak, collapse, fall, or damage. During transportation, the transportation vehicle should be equipped with leakage emergency treatment equipment. And during transportation, it should be protected from exposure to the sun, rain, and high temperature. It is best to transport in the morning and evening in summer.
Fourth, operation and personnel protection. Personnel engaged in storage and transportation need to be professionally trained and strictly abide by the operating procedures. Appropriate protective equipment should be worn during operation, such as protective glasses, gloves, etc., to prevent the substance from contacting the skin and eyes and causing injury. In case of accidental leakage, corresponding emergency measures should be taken immediately, such as evacuating personnel, sealing off the scene, and properly cleaning up the leakage.
What is the market price of 5-chloro-2-fluorophenylboronic acid?
5-Bromo-2-pentenylboronic acid is an important reagent in the field of organic synthesis. Its market price varies due to many factors.
First, the purity of the product has a significant impact on the price. High-purity 5-bromo-2-pentenylboronic acid is usually expensive because of its more complicated preparation process, higher technology and cost. If the purity is above 98%, the price per gram may be in the hundreds of yuan spectrum. If the purity is slightly lower, it can also be used in specific application scenarios where the purity requirements are not extremely strict, and the price may be reduced accordingly.
Second, the market supply and demand relationship determines the price. If a certain period, many chemical companies and scientific research institutions have strong demand for 5-bromo-2-pentene boric acid, but the supply is relatively insufficient, the price will rise. On the contrary, if the market demand is weak and the supply is sufficient, the price will decline.
Third, the different manufacturers also cause the price to be different. Well-known large factories rely on advanced production processes and strict quality control systems to ensure stable and reliable product quality, and the price may be high. Although the price of some small factories may be low, the quality stability may be questionable.
Fourth, the purchase quantity is also related to the price. Generally speaking, bulk purchase can reduce the cost of transportation and packaging per unit product, and manufacturers may give a certain discount, and the unit price will be lower than the price of a small purchase.
Overall, the market price of 5-bromo-2-pentene boronic acid fluctuates between tens of yuan and hundreds of yuan per gram. The specific price needs to be combined with the above factors, and detailed inquiries and comparisons can be made in order to obtain a suitable price.