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5-Chloro-2,4-Difluoronitrobenzene

5-Chloro-2,4-Difluoronitrobenzene

Hongda Chemical

Specifications

HS Code

902153

Chemical Formula C6H2ClF2NO2
Molar Mass 195.536 g/mol
Appearance A colorless to light yellow liquid or solid
Boiling Point Approximately 210 - 212 °C
Melting Point Around 25 - 27 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, acetone
Vapor Pressure Low vapor pressure
Stability Stable under normal conditions, but reactive with strong oxidizing agents

As an accredited 5-Chloro-2,4-Difluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 5 - chloro - 2,4 - difluoronitrobenzene in 1 - kg bottles, well - sealed for chemical storage.
Storage 5 - Chloro - 2,4 - difluoronitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from sources of ignition, heat, and incompatible substances like strong oxidizers and reducing agents. Store it in a tightly - sealed container, preferably made of corrosion - resistant materials, to prevent leakage and ensure safety during storage.
Shipping 5 - Chloro - 2,4 - difluoronitrobenzene is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict hazardous chemical regulations, ensuring proper handling to prevent leakage and potential environmental or safety risks.
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5-Chloro-2,4-Difluoronitrobenzene 5-Chloro-2,4-Difluoronitrobenzene
General Information
Historical Development
5-Chloro-2,4-difluoronitrobenzene is also an organic compound. It first appeared in the research of scholars. At that time, the field of chemistry was gradually emerging, and the public was dedicated to the exploration of new qualities. At the beginning, the synthesis method was still simple, and the amount obtained was small, and the pure one was difficult to obtain.
However, the years have passed, the researchers have not stopped, and the techniques have become more and more exquisite. The reaction conditions are carefully studied and adjusted, and the raw materials used are more suitable. As a result, the yield is gradually increasing and the purity is also good. What used to exist only in the laboratory can now be industrially prepared.
Looking at its evolution, it has been studied for years since the end of the year, and it has become what it is today. This is all due to the wisdom and diligence of the researchers, so that this compound can be used in the forest of chemistry, and it is also a solid foundation for subsequent research.
Product Overview
5-Chloro-2,4-difluoronitrobenzene is a key intermediate in organic synthesis. Its shape is light yellow to light brown crystalline, with unique chemical characteristics. It has a wide range of uses in scientific research and industry.
Among this compound, the ingenious combination of chlorine, fluorine and nitro gives it active chemical activity. It can be converted into other important organic compounds through many chemical reactions, such as nucleophilic substitution. In the field of drug synthesis, it is often a key starting material, helping to create new drug molecules.
The method of its synthesis goes through specific organic reaction steps. However, when preparing, it is necessary to pay attention to the precise control of the reaction conditions, such as temperature, the use of catalysts, etc., to ensure the purity and yield of the product.
In short, 5-chloro-2,4-difluoronitrobenzene has a significant position in the field of chemistry, and with the advancement of scientific research, its application prospects will be broader.
Physical & Chemical Properties
5-Chloro-2,4-difluoronitrobenzene is also a chemical product. Its quality has special physical and chemical properties. Looking at its shape, at room temperature, it is solid, and its color is nearly white and crystalline. Its melting temperature is about a certain value. If heat is applied, it will gradually melt and melt. As for the degree of boiling, there is also a fixed number, and it will boil when it reaches a certain temperature.
In terms of its solubility, it varies from several types of solvents. It is soluble in organic solvents such as alcohols and ethers; it is insoluble in water, and its hydrophobicity is obvious because of its molecular structure. And this substance has a certain chemical activity. The halogen atom and nitro group on the benzene ring can cause various chemical reactions. It is an important material for organic synthesis and has a wide range of uses in the fields of medicine and pesticides.
Technical Specifications & Labeling
5-Chloro-2,4-difluoronitrobenzene is an important object of chemical product research. Its technical specifications and labeling (product parameters) are very important. The technical specifications of this product need to be carefully reviewed for its purity, impurity content and other key elements. For purity, when striving for high standards, the amount of impurities must be strictly controlled at a very low level, so as to ensure the high quality of the product.
As for the label, the name of the product "5-chloro-2,4-difluoronitrobenzene" is clear and clear, and should not be confused. On the packaging, its physical and chemical properties, dangerous characteristics and other parameters should be carefully marked to warn everyone. And safety operation instructions should be attached so that contacts can understand the operation specifications and prevent problems before they occur. This is the essence of ensuring product safety and effective application.
Preparation Method
In the process of making 5-chloro-2,4-difluoronitrobenzene, the raw materials and the production process, reaction steps and catalytic mechanism are the key. The raw materials need to be selected from pure products, such as halogenated aromatics and fluorides of specific purity. The first reaction conditions of the production process are controlled, and the halogenated aromatics and fluorides are reacted in sequence at a suitable temperature and pressure.
At the beginning of the reaction step, the halogenated aromatics and an appropriate amount of fluoride are placed in a special reaction kettle, and the temperature is adjusted to a moderate level to allow them to initially combine. Then, a specific catalyst is added to accelerate the reaction process, which is the key to the catalytic mechanism. The catalyst works cleverly to reduce the activation energy of the reaction and make the reaction advance efficiently. Continuously, according to the precise reaction time and temperature regulation, each step of the reaction is completed one by one, and finally through the fine separation and purification method, high-purity 5-chloro-2,4-difluoronitrobenzene is obtained. This method of preparation guarantees the excellent quality of the product.
Chemical Reactions & Modifications
Taste the industry of chemical industry, in the change of matter, exhausted thought. Now 5 - Chloro - 2,4 - Difluoronitrobenzene This compound, its chemical reaction and modification, is a top priority.
To observe its reaction, when appropriate conditions are used to make various substances. Or adjust its temperature, control its pressure, and choose an appropriate catalyst, it can lead to a smooth reaction. For example, with a reagent, observe the clutch of its molecules, the rearrangement of atoms, and expect the expected product.
As for modification, it can be microscopic from its structure. Increase or decrease its groups, change its spatial configuration, in order to change its physical and chemical properties. Or make it more stable, or increase its activity, used in various fields.
In the way of experiment, carefully investigate, every step of change needs to be recorded. Carefully consider its rationale, make good use of the experience of predecessors, innovative methods, and expect to be able to 5 - Chloro - 2,4 - Difluoronitrobenzene chemical reactions and modifications, have better results, and add to the chemical industry.
Synonyms & Product Names
5-Chloro-2,4-difluoronitrobenzene is also a chemical substance. In today's world, there are many other names for this substance, and the commercial names involved are also complicated.
Or "chlorofluoronitrobenzene variant", it gets this name because it contains chlorine, fluorine, nitro and other groups and has a unique structure. For merchants, it is called "refined chlorofluoronitrile product", which means its purity is excellent and is required for industry and scientific research.
Also known as "dichloronitrile raw material", because it is an important starting material for the synthesis of many chemical products. The commercial name "superior chlorofluoronitrile" highlights the excellent quality and is available for all parties' needs. These are the aliases and trade names of 5-chloro-2,4-difluoronitrobenzene, which vary with the way they are used and the people they are seeking.
Safety & Operational Standards
5-Chloro-2,4-difluoronitrobenzene is also a chemical substance. It is related to the safety and operation specifications of this substance and must not be ignored.
It has strong properties and must be handled with caution. When handling this object, be in a well-ventilated place so that the foul gas can be discharged and avoid accumulation in the room and harm to the person. The operator must wear protective gear, such as protective clothing, gloves and goggles, to prevent this object from touching the body and causing damage to the skin and eyes.
When storing, there are also regulations. It should be placed in a cool, dry and ventilated place, away from fire and heat sources, and protected from direct sunlight. Do not mix with oxidizing agents, reducing agents, alkalis, etc., for fear of violent reactions and disasters.
In case of leakage of this material, do not panic. The first thing to do is to evacuate the surrounding crowd and set up a warning area to prevent others from getting into danger by mistake. The operator quickly wears professional protective equipment and cleans up the leak according to the standard method. Small leaks can be absorbed by inert materials such as sand and vermiculite and put into airtight containers. If there are large leaks, it is necessary to build a dike or dig a pit for containment, and transfer it to a tanker or a special collector for proper disposal.
When using, strictly follow the established procedures. Weighing, mixing and other operations should be accurate and not done carelessly. After use, clean up the utensils and sites in detail to avoid residue and use after damage.
The safety and operation specifications of 5-chloro-2,4-difluoronitrobenzene are related to personal safety and everything goes well. Those who work must keep it in mind and do it honestly.
Application Area
5-Chloro-2,4-difluoronitrobenzene is also a wonder of chemistry. It is used in the field of medicine, and can make special agents to treat all kinds of diseases. In the genus of agrochemical, it can become a powerful medicine, protect crops to control pests. And in the industry of materials, it is the foundation of creating strange materials, and the nature of additives makes it strong and excellent.
This substance has extraordinary properties with its unique structure, and in the world of various uses, it shows its ability. In medicine, it helps to treat sedimentation, in agrochemical production to increase income, and in the promotion of new materials. Its contributions in this world cannot be underestimated. It is the pearl of the chemical industry, attracting researchers to explore its endless wonders, expand a wider path, and hope to develop its even greater effects in the future.
Research & Development
5-Chloro-2,4-difluoronitrobenzene is an important object of chemical research. Our generation has tried hard to study this substance day and night. At the beginning, it took a lot of trouble to obtain pure raw materials, and after searching for a good recipe, we finally got it.
During the experiment, the operation must be fine. Temperature, dosage, and slight difference, the results are very different. After many attempts, the appropriate reaction conditions can be obtained.
With the deepening of research, its properties and reaction mechanism are gradually understood. This is of great significance for industrial applications. It can not only optimize the synthesis path, reduce costs and increase efficiency; but also expand its use, and may be useful in the fields of medicine, pesticides, etc.
We should make unremitting efforts to explore its potential in depth, and contribute to the development of chemistry, so that this research result can be widely used and promote the progress of the industry.
Toxicity Research
The toxicity of 5-chloro-2,4-difluoronitrobenzene is an important research in the field of chemistry. This substance has a specific appearance. In the experimental environment, white pigs, guinea pigs, etc. are used as subjects. After oral ingestion, it starts to react in the digestive system, and part of it is absorbed into the blood and distributed throughout the body. Observation shows that it has a significant impact on important organs such as the liver and kidneys, causing abnormal organ cell structure and function. Long-term low-dose exposure can also interfere with the normal physiological rhythm of the organism. After many experiments, detailed records and analysis, it can be found that 5-chloro-2,4-difluoronitrobenzene has certain toxicity. During production and use, appropriate protective measures should be taken to ensure personnel safety and the environment is not polluted.
Future Prospects
Wuguan 5 - Chloro - 2,4 - Difluoronitrobenzene This substance has unique properties and has great potential in the field of chemical industry. Although it is in the research and development period now, the future prospects are limitless.
The structure of this substance is exquisite, and chlorine, fluorine and nitro are cleverly connected, giving it a variety of reactivity. The road of scientific research is gradually unraveling its mysteries. In the future, it is expected to be used in pharmaceutical synthesis as a key intermediate, paving the way for the birth of new drugs; in material science, it may be able to give birth to novel functional materials, blooming with unique brilliance.
Although the road ahead is long, the heart of scientific research is determined. With unremitting research and uncovering its mysterious veil, 5-Chloro-2,4-Difluoronitrobenzene will shine in the future, contributing to the progress of chemical industry and the well-being of mankind, and achieving extraordinary business.
Where to Buy 5-Chloro-2,4-Difluoronitrobenzene in China?
As a trusted 5-Chloro-2,4-Difluoronitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 5-Chloro-2,4-Difluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 5-chloro-2,4-difluoronitrobenzene?
5-Bromo-2,4-dichlorobenzyl benzene has important uses in many fields.
In the field of medicinal chemistry, it is often used as a key intermediate. Due to the halogen atom and benzyl group in the structure, it is endowed with unique reactivity. Through nucleophilic substitution, coupling and other reactions, it can be combined with a variety of reagents to construct complex and biologically active compounds. For example, through specific reaction steps, it can be converted into drug molecules that inhibit or regulate specific disease targets, providing a cornerstone for the development of new drugs.
In the field of materials science, 5-bromo-2,4-dichlorobenzyl benzene can participate in the synthesis of polymer materials. By polymerizing with other monomers, its special structure is introduced into the main chain or side chain of the polymer, thereby changing the properties of the material. For example, to improve the thermal stability of the material, the intermolecular force is enhanced due to the conjugation system of halogen atoms and benzene rings, and the thermal decomposition resistance of the material is improved; it can also enhance the flame retardancy of the material. Halogen atoms release halogenated hydrogen gas during combustion, dilute oxygen and inhibit combustion reaction chain transfer.
In organic synthesis chemistry, it is an important starting material for the synthesis of complex aromatic derivatives. Using the difference in selective reactivity of bromine and chlorine atoms, different functional groups can be introduced step by step to achieve the precise construction of complex organic molecules, creating conditions for the synthesis of organic compounds with novel structures and unique properties. It is of great significance in the total synthesis of fine chemicals and natural products.
What are the physical properties of 5-chloro-2,4-difluoronitrobenzene?
5-% bromo-2,4-dichlorobenzylbenzene is an organic compound with unique physical properties.
Looking at its appearance, it often takes the form of a colorless to pale yellow liquid, shimmering in sunlight, as if it contains a mysterious glow. Its smell is specific, and it seems to be slightly pungent at first, but it conceals a different smell, which is unforgettable.
When it comes to boiling point, this substance boils at a specific temperature range, and the specific value varies slightly due to changes in the ambient air pressure. This boiling point characteristic makes it unique in separation operations such as distillation. Its melting point is also in a specific range. When the temperature drops below the melting point, the substance will gradually solidify from a flowing liquid to a solid state, just as time stops, showing a different form.
In terms of density, 5-% bromo-2,4-dichlorobenzylbenzene has a specific value. In the liquid state, when mixed with other liquids, due to its density difference, or stratification, or phase fusion, it shows a different scene.
Solubility is also an important physical property. In organic solvents, such as common ethanol, ether, etc., this compound can dissolve well, just like a fish entering water and naturally fusing. However, its solubility in water is not good, and the two meet, just like oil and water, distinct.
In addition, the refractive index of 5-% bromo-2,4-dichlorobenzylbenzene also has a specific value. When light passes through this substance, the direction of light propagation is deflected, and this refractive index property may have unique uses in optical research and applications.
In summary, the physical properties of 5-% bromo-2,4-dichlorobenzylbenzene are diverse, and these properties are intertwined to form its unique "chemical profile", which lays the foundation for its application and research in many fields.
What are the chemical properties of 5-chloro-2,4-difluoronitrobenzene?
5-Bromo-2,4-difluorobenzylbenzene, the chemical properties of this substance, let me tell you in detail.
Its appearance is often colorless to light yellow liquid or solid, depending on the ambient temperature and pressure. In its molecular structure, the presence of bromine and fluorine atoms gives it a unique chemical activity. The bromine atom is relatively large and has a certain electronegativity, and the fluorine atom is extremely electronegative. The combination of the two makes the reactivity of this compound quite interesting.
In the nucleophilic substitution reaction, the presence of bromine atoms on the benzene ring can make the nucleophilic reagent easy to attack and replace. When encountering nucleophiles with lone pair electrons, such as alkoxides, amines, etc., bromine atoms can be replaced to form new organic compounds. This reaction is often carried out in the presence of appropriate solvents and catalysts.
In the aromatic electrophilic substitution reaction, although the fluorine atoms on the benzene ring have an electron-absorbing induction effect, they can form p-π conjugate with the benzene ring, which has a complex effect on the electron cloud density distribution of the benzene ring. Therefore, when confronted with electrophilic reagents, the reaction check point and reactivity are slightly different from those of ordinary benzene derivatives, and the substitution reaction mostly occurs at the position where the electron cloud density is relatively high.
In the redox reaction, the bromine and fluorine atoms in the compound can participate in the electron transfer process. Under specific oxidation conditions, the oxidation of bromine atoms may occur to form high-valent bromine compounds; under reduction conditions, although fluorine atoms are relatively stable, they may promote the reduction reaction of other groups on the benzene ring.
Furthermore, because of its fluorine atom, the compound has a certain lipid solubility and stability. In the field of organic synthesis, it is often used as a key intermediate for the preparation of organic compounds such as drugs and pesticides with specific biological activities. With its unique chemical properties, it provides a possible path for the synthesis of complex organic molecules.
What are the synthesis methods of 5-chloro-2,4-difluoronitrobenzene?
To prepare 5-bromo-2,4-difluorobenzylbenzene, you can do it according to the following methods:
First, start with halogenation reaction. Select a suitable aromatic hydrocarbon, such as 2,4-difluorotoluene, and place it in a suitable reaction vessel. Add an appropriate amount of brominating reagent, such as liquid bromine, and use iron powder or iron tribromide as a catalyst. Under suitable temperature and reaction conditions, bromine atoms can selectively replace hydrogen atoms on the benzene ring to generate 5-bromo-2,4-difluorotoluene. This step requires careful control of the reaction temperature and reagent dosage to prevent the formation of polybrominated products.
Second, 5-bromo-2,4-difluorotoluene is converted into 5-bromo-2,4-difluorobenzylbenzene. This can be achieved by Fu-gram alkylation reaction with benzene. Using Lewis acid such as anhydrous aluminum trichloride as a catalyst, 5-bromo-2,4-difluorotoluene is mixed with benzene and reacted at an appropriate temperature. In the reaction, the benzyl part of 5-bromo-2,4-difluorotoluene is connected to benzene to form the target product 5-bromo-2,4-difluorobenzylbenzene. After the reaction is completed, the pure product can be obtained by separation, purification and other operations, such as distillation, column chromatography, etc.
Or, benzene is benzylated first. Benzene and 2,4-difluorobenzyl chloride are used as raw materials, and anhydrous aluminum trichloride is also used as a catalyst to undergo Fu-gram alkylation reaction to generate 2,4-difluorobenzylbenzene. Subsequently, the product is brominated. Under suitable bromination conditions, bromine atoms are introduced into specific positions in the benzene ring to obtain 5-bromo-2,4-difluorobenzylbenzene. This route also requires attention to the control of reaction conditions and the separation and purification of the product in each step to ensure the high efficiency of the reaction and the purity of the product.
What should be paid attention to when storing and transporting 5-chloro-2,4-difluoronitrobenzene?
5-% alkane-2,4-diallyl benzene is an organic compound. When storing and transporting, many matters need to be carefully paid attention to.
When storing it, the first environment. When placed in a cool and ventilated warehouse, away from fire and heat sources. This is because it is volatile and flammable, high temperature or open flame is easily dangerous. The temperature of the warehouse should be controlled within a specific range to prevent its volatilization from intensifying or triggering chemical reactions due to excessive temperature. And it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Due to the chemical properties of this compound, contact with the above various substances, or react violently, endangering safety. At the same time, the warehouse should be equipped with suitable materials to contain the leakage, so as to prevent the accidental leakage and deal with it in time to reduce the harm.
When transporting, there are also many key points. The transportation vehicle must ensure that the safety facilities are complete, such as equipped with fire extinguisher materials, leakage emergency treatment equipment, etc. During the driving process, the driver needs to drive slowly and avoid violent operations such as sudden braking and sharp turning to prevent material leakage due to packaging damage. In addition, the transportation personnel must be professionally trained to be familiar with the characteristics of the compound and emergency treatment methods. The loading and unloading process also needs to be careful, light loading and light handling, to avoid collision and heavy pressure, to prevent packaging damage. During transportation, you should follow the designated route and do not stop in densely populated areas or important places to reduce latent risk. Overall, the storage and transportation of 5-% alkane-2,4-diallyl benzene is a matter of safety, and it is necessary to operate in strict accordance with regulations and must not be sloppy at all.