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5-(Bromomethyl)-1,2,3-Trifluorobenzene

5-(Bromomethyl)-1,2,3-Trifluorobenzene

Hongda Chemical

    Specifications

    HS Code

    826847

    Chemical Formula C7H4BrF3
    Molar Mass 225.005 g/mol
    Appearance Liquid (predicted from similar compounds)
    Solubility In Water Low (organic halide, non - polar nature)
    Solubility In Organic Solvents Good (in common organic solvents like dichloromethane, toluene)
    Vapor Pressure Likely relatively high due to low molar mass and volatile groups

    As an accredited 5-(Bromomethyl)-1,2,3-Trifluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 5-(bromomethyl)-1,2,3 -trifluorobenzene in a sealed chemical - grade bottle.
    Storage 5-(Bromomethyl)-1,2,3 -trifluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container, preferably made of a material resistant to chemical corrosion like glass or certain plastics, to prevent leakage and maintain its stability.
    Shipping 5-(Bromomethyl)-1,2,3 -trifluorobenzene, a chemical, is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict hazardous material regulations, ensuring proper handling during transit to prevent leakage and ensure safety.
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    5-(Bromomethyl)-1,2,3-Trifluorobenzene 5-(Bromomethyl)-1,2,3-Trifluorobenzene
    General Information
    Historical Development
    In the past, there were people who studied chemistry, specializing in the study of a substance, named 5 - (Bromomethyl) - 1, 2, 3 - Trifluorobenzene. This compound was first discovered in the academic world, but its nature was unknown. However, the scholars were diligent and dedicated for many years, taking experiments as the path, and theory as the key link. At the beginning, they explored the method of preparation, tried and made mistakes again and again, but their determination remained unchanged. Gradually, they have obtained exquisite recipes, and the yield has also increased. Its use in the field of organic synthesis is gradually emerging. It may be the basis for the development of new drugs, or help the innovation of materials. After years, this substance has been little known, and it has become important to the academic community. On the road of chemistry, it has taken a solid step, becoming the brilliance of past research and a new course of future exploration.
    Product Overview
    5- (bromomethyl) -1,2,3 -trifluorobenzene, a product of organic chemistry. Its shape and color, at room temperature or colorless to light yellow liquid, with a special smell. The structure of this product is unique, containing bromomethyl and trifluorobenzene groups.
    Its properties are active, and the bromine atom of bromomethyl has high reactivity, which can participate in many nucleophilic substitution reactions. The part of trifluorobenzene gives it certain chemical stability and special physical properties.
    In the field of organic synthesis, it has a wide range of uses. It can be used as a key intermediate to build complex organic molecular structures through chemical reactions, providing important raw materials for the creation of medicines, pesticides, etc., assisting researchers in exploring novel compounds, expanding the boundaries of chemical synthesis, and playing a pivotal role in the process of chemical research.
    Physical & Chemical Properties
    5- (Bromomethyl) -1,2,3-Trifluorobenzene, an organic compound. It has unique physical and chemical properties. Looking at its physical properties, under normal temperature, or as a colorless liquid, it has a special odor. Its boiling point and melting point are all inherent characteristics of the substance. As for the chemical properties, because it contains bromomethyl and trifluorophenyl, it is active. At bromomethyl, it is prone to nucleophilic substitution and can be replaced by other groups to form new compounds. Trifluorophenyl gives it certain stability and special reactivity. This compound has a wide range of uses in the field of organic synthesis. It can be used as a key intermediary to assist in the construction of many complex organic molecules. It can be used in drug research and development, material creation, etc.
    Technical Specifications & Labeling
    5- (Bromomethyl) -1,2,3-Trifluorobenzene, an organic compound. The process specification for its preparation, the fine selection of the first heavy raw materials, the need to take pure starting materials, the proportion must be accurate. When reacting, temperature control is very important, with moderate temperature, to promote its orderly combination, and the duration also needs to be appropriate, not slightly more.
    As for the product identification (commodity parameters), the appearance should be a colorless liquid, and the smell also has its own characteristics. The judgment of purity needs to reach a very high standard, and the impurities must be minimal. Its density, boiling point and other parameters are the key to identification, accurate determination, to ensure the best quality. According to this process specification and marking, the best quality 5- (Bromomethyl) -1,2,3-Trifluorobenzene products can be obtained.
    Preparation Method
    The preparation of 5- (bromomethyl) -1,2,3-trifluorobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism.
    First take an appropriate amount of 1,2,3-trifluorobenzene and use it as the starting substrate. Place it in a clean reactor and add a certain proportion of paraformaldehyde, which is the key raw material for introducing methyl. Then add an appropriate amount of hydrobromic acid as a brominating reagent. Under mild heating conditions, maintain the temperature at about 50-60 degrees Celsius, start the stirring device, and mix the materials thoroughly.
    At the beginning of the reaction, the benzene ring activity of 1,2,3-trifluorobenzene is synergistically acted by hydrobromic acid and paraformaldehyde, and gradually initiate an electrophilic substitution reaction. Polyformaldehyde is depolymerized to formaldehyde, and formaldehyde reacts with hydrobromic acid to form bromomethanol intermediate, which is then replaced with 1,2,3-trifluorobenzene to form 5- (hydroxymethyl) -1,2,3-trifluorobenzene.
    Then, the temperature is raised to 80-90 degrees Celsius, and an appropriate amount of concentrated sulfuric acid is added as a dehydrating agent and catalyst to promote the dehydration of hydroxyl groups into bromomethyl groups. After a series of complex reaction processes, the final product of 5- (bromomethyl) -1,2,3-trifluorobenzene is obtained. After the reaction, the product is purified by cooling, extraction, distillation and other steps to achieve high purity.
    Chemical Reactions & Modifications
    Nowadays, there is a chemical substance called 5- (Bromomethyl) -1,2,3-Trifluorobenzene. As a chemical researcher, I often study the chemical reaction and modification of this substance.
    View its reaction, or under specific conditions, combine with other substances to form a new product. In this reaction, changes in conditions, such as temperature, pressure, and catalyst, can affect its direction and rate.
    As for modification, if you want to change its properties, you can use chemical means to adjust its molecular structure. Or increase a group, or change its bonding, in order to obtain the desired properties, such as enhancing stability, changing solubility, etc. In this way, the application of this substance in various fields can be extended, adding to the progress of chemistry, so that this substance can be better applied to all parties and benefit the world.
    Synonyms & Product Names
    The chemical substance, 5- (Bromomethyl) -1,2,3-Trifluorobenzene, is also known as a synonymous name and a commodity. This substance is very important in the process of my chemical inquiry.
    Its synonymous name may vary depending on the process of inquiry and the habits of various places. However, they all refer to this specific compound. As for the name of the product, the merchant will also give it a unique name for the convenience of identification and promotion.
    Our chemical researchers, when exploring the properties and uses of this product, need to clarify its synonymous name and the name of the product. In this way, the relevant information can be obtained, and there is no risk of confusion in experiments and research, so as to promote the matter of inquiry smoothly, and add bricks and tiles to the field of chemistry and related applications.
    Safety & Operational Standards
    Safety and Operation Specifications for 5- (Bromomethyl) -1,2,3-Trifluorobenzene
    Fu 5- (Bromomethyl) -1,2,3-trifluorobenzene is an important substance in chemical research. If you want to use it, you must clarify its safety and operation specifications, so as to ensure the smooth operation of the experiment and the safety of personnel.
    On the safe side, this substance is dangerous. Its bromomethyl and trifluoro groups may cause harm. Smell it, or hurt the respiratory tract, enter the eyes, and can damage the eyes. And it may be flammable, and it may be dangerous in case of open flames and hot topics. When it is stored, choose a cool and ventilated place, keep away from fire and heat sources, and store it separately from oxidants and alkalis. Do not mix it.
    As for the operation, the experimenter must wear appropriate protective equipment. Wear goggles to prevent liquid splashing and damage the eyes; wear protective clothing to prevent it from contacting the skin; wear a gas mask to avoid inhaling harmful gases. The operation room needs to be well ventilated, with perfect ventilation facilities, so that the volatile gas can be discharged in time.
    When taking it, the action should be slow and careful. Use clean and dry appliances to avoid impurities from mixing in, which will affect the quality. If it is accidentally splashed on the skin, rinse quickly with a lot of water, followed by medical treatment. If it enters the eyes, rinse quickly with water and seek medical treatment.
    The reaction process, strictly control the conditions. According to the reaction mechanism and requirements, adjust the temperature, pressure, time, etc. Stir well to ensure that the reaction is sufficient. And closely observe, if there is any abnormality, stop disposal immediately.
    After the experiment, properly dispose of the waste. Do not discard it at will. According to relevant regulations, collect it by classification and hand it over to professional institutions for treatment, free of pollution environment.
    In summary, use 5- (bromomethyl) -1,2,3-trifluorobenzene when following safety and operating specifications. This is the key to ensure the success of the experiment, personnel safety and environmental cleanliness.
    Application Area
    Today, there is a product called 5- (Bromomethyl) -1,2,3-Trifluorobenzene. It has considerable advantages in various application fields. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create new medicines and cure various diseases. In material science, it can contribute to the development of new materials with specific properties, such as improving the stability and conductivity of materials. In the field of fine chemicals, it can be used to prepare high-end fine chemicals to increase the quality and performance of their products. Therefore, this compound plays a pivotal role in many application fields, and its prospects are broad, which can inject vigorous vitality into the development of various industries.
    Research & Development
    Recently, in the research room, I focused on the research of 5- (Bromomethyl) -1,2,3-Trifluorobenzene. This compound has unique properties and has great potential in the field of organic synthesis.
    Initially explored its synthesis path, and after several attempts, adjusted the reaction conditions, such as temperature, catalyst dosage, etc. Despite encountering many obstacles, he adhered to the heart of research and made unremitting exploration. Finally, a better synthesis method was obtained, and the yield was also improved.
    Looking to the future, it is planned to expand its application scope. It is hoped that this compound will be integrated into the creation of new materials, or used in the field of biomedicine, to help develop special drugs. Continue to conduct in-depth research, and strive to promote its practical application from the laboratory, and contribute to the development of the chemical field. Continuously make progress and pioneer innovation in the scientific research journey.
    Toxicity Research
    Toxicity studies of 5- (bromomethyl) -1,2,3-trifluorobenzene
    In recent years, I have made a lot of efforts in the toxicity research of chemical products, and now I focus on 5- (bromomethyl) -1,2,3-trifluorobenzene.
    At first, looking at its physicochemical properties, 5- (bromomethyl) -1,2,3-trifluorobenzene has a special structure, and bromomethyl is connected to trifluorophenyl. According to common sense, bromomethyl is active, or easy to react with other substances. Experiments have found that it can quickly combine with nucleophiles in specific environments, and this activity may involve its toxicity.
    Times to explore its effects on organisms. Mice were treated with an appropriate amount of 5- (bromomethyl) -1,2,3-trifluorobenzene. Soon, mice were seen to have abnormal behavior, reduced activity, and convulsions from time to time. According to dissection, the organs were damaged, especially the liver and kidneys. The cell structure of the liver is disordered, and the filtration function of the kidneys is also disturbed.
    Then investigate the mechanism of its toxicity, or due to the incorporation of 5- (bromomethyl) -1,2,3-trifluorobenzene into the body, the bromomethyl group combines with the nucleophilic check points of biological macromolecules such as intracellular proteins and nucleic acids, resulting in changes in the structure and function of biological macromolecules, and then the physiological function of the cells is disordered, and the sign of toxicity eventually appears.
    In summary, 5- (bromomethyl) -1,2,3-trifluorobenzene is significantly toxic, and when it is produced and used, care should be taken to prevent its harm to life and the environment.
    Future Prospects
    Looking at the world today, science and technology are changing day by day, and in the field of chemistry, new things are coming out frequently. Today there is 5- (Bromomethyl) -1,2,3-Trifluorobenzene, which has extraordinary characteristics and has unlimited potential in the chemical and pharmaceutical industries.
    The future prospect must depend on the in-depth investigation of this material. Its synthesis method may be more subtle and efficient, reducing energy consumption, reducing pollution, and reaching the realm of green chemistry. At the application end, it may become a key raw material for the development of new drugs, healing all kinds of difficult diseases; or in the manufacture of high-tech materials, adding a touch of bright color to help the performance of materials stand out.
    We chemical researchers, with an enterprising heart, should explore the mysteries of this object, and hope that in the future, we can use the power of this object to create a magnificent new chapter for the well-being of mankind and open up endless possibilities.
    Where to Buy 5-(Bromomethyl)-1,2,3-Trifluorobenzene in China?
    As a trusted 5-(Bromomethyl)-1,2,3-Trifluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 5-(Bromomethyl)-1,2,3-Trifluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 5- (Bromomethyl) -1,2,3-Trifluorobenzene?
    5- (bromomethyl) -1,2,3-trifluorobenzene is an important intermediate in organic synthesis. It has a wide range of uses and is often a key raw material for the creation of new drugs in the field of medicinal chemistry. Due to its unique structure, it can endow drugs with specific biological activities and pharmacological properties, help drugs to act precisely on targets, improve efficacy and reduce side effects.
    In the field of pesticide chemistry, it also plays a pivotal role. By introducing this compound, pesticides with high insecticidal, bactericidal or herbicidal properties can be prepared. Its special chemical structure can enhance the interaction between pesticides and target organisms, enhance drug efficacy, and optimize its environmental compatibility, reducing adverse effects on the ecological environment.
    In addition, in the field of materials science, 5- (bromomethyl) -1,2,3-trifluorobenzene also shows great potential. It can be used to synthesize polymer materials with special properties, such as those with excellent thermal stability, chemical stability or optical properties. Such materials are widely used in many high-end technical fields such as electronics, optics and aerospace.
    To sum up, 5- (bromomethyl) -1,2,3-trifluorobenzene, with its unique chemical structure and reactivity, is an indispensable and important substance in many fields such as medicine, pesticides and materials science, and has made great contributions to promoting technological progress and innovation in various fields.
    What are the physical properties of 5- (Bromomethyl) -1,2,3-Trifluorobenzene
    5- (bromomethyl) -1,2,3-trifluorobenzene is one of the organic compounds. Its physical properties are quite important, related to many chemical processes and practical applications.
    First of all, its appearance, under room temperature and pressure, is mostly colorless to light yellow liquid, clear and transparent, shiny. This color state is easy to observe and identify in actual operation. If there are impurities mixed in, the color or state change can be used as a warning.
    times and boiling point, about within a specific temperature range. The value of the boiling point is closely related to the intermolecular force. Due to the existence of fluorine and bromine atoms, the intermolecular force of this compound has its own uniqueness, which makes its boiling point suitable for specific separation and purification processes. For example, distillation can effectively separate it from the mixture according to the difference in boiling point.
    Melting point is also an important physical property. The state of its melting point reflects the arrangement and interaction of the molecular lattice. The specific melting point makes the molecules arranged in an orderly manner in the solid state, which has a profound impact on crystallization, storage and some solid-phase reactions.
    Furthermore, the density is different from that of water. When it comes to operations such as liquid-liquid extraction, the density difference determines the relationship between its upper and lower positions with the water phase, which is crucial to the separation process.
    In terms of solubility, it exhibits good solubility in common organic solvents, such as ethanol and ether. Due to the principle of similar miscibility, its organic structure has an affinity with organic solvent molecules. However, the solubility in water is poor, because of its hydrophobic molecular structure, it has a weak interaction with water molecules.
    The volatility of 5- (bromomethyl) -1,2,3-trifluorobenzene is moderate. Moderate volatility In chemical production workshops, there are certain safety hazards because of its vapor or flammable and explosive; it also provides convenience, such as in some reactions that require the participation of its gas phase, it is more volatile and enters the reaction system.
    The above physical properties are of great significance in the fields of organic synthesis, drug development, and materials science, and researchers must consider them carefully in order to make good use of this compound.
    What are the chemical properties of 5- (Bromomethyl) -1,2,3-Trifluorobenzene?
    5- (bromomethyl) -1,2,3-trifluorobenzene, this is an organic compound. Its chemical properties are particularly important and have many applications in the field of organic synthesis.
    In terms of its physical properties, it is mostly liquid at room temperature and has a certain volatility. Looking at its appearance, it is often a colorless to light yellow transparent liquid, which smells or has a special smell. Its density may be different from that of water. In organic solvents, its solubility is also unique. It is easily soluble in many common organic solvents, such as ether and dichloromethane, but its solubility in water is quite limited.
    In terms of chemical properties, the bromomethyl functional group in this compound is very active. Bromine atoms have strong electronegativity, which makes the carbon-bromine bond polar and prone to nucleophilic substitution reactions. In the case of nucleophilic reagents, such as alcohols and amines, bromine atoms are easily replaced, and then new carbon-oxygen and carbon-nitrogen chemical bonds are formed. This is a key step in the synthesis of complex organic molecular structures.
    The trifluoromethyl on the benzene ring also gives the compound unique properties. The fluorine atom has extremely high electronegativity, which can affect the electron cloud density distribution of the benzene ring through induction effects, resulting in a decrease in the electron cloud density of the benzene ring. In this way, the electrophilic substitution activity of the benzene ring is different from that of the ordinary benzene ring, and the reaction check point and reaction conditions also need to be carefully considered.
    In addition, 5- (bromomethyl) -1,2,3-trifluorobenzene contains fluorine atoms and may also have certain special properties, such as high chemical stability and biological activity. In the field of medicinal chemistry, fluorinated organic compounds often exhibit unique pharmacological activity and metabolic stability due to the introduction of fluorine atoms, so the compound may have potential application value in the development of new drugs.
    Overall, 5- (bromomethyl) -1,2,3-trifluorobenzene has rich and unique chemical properties, and has important research value and application prospects in many fields such as organic synthesis and medicinal chemistry.
    What are the preparation methods of 5- (Bromomethyl) -1,2,3-Trifluorobenzene?
    5- (bromomethyl) -1,2,3-trifluorobenzene is also an organic compound. There are various ways to prepare it, and this is the case.
    First, it can be prepared by the bromination reaction of the corresponding benzaldehyde derivative. Take benzaldehyde containing trifluoride and place it in an appropriate reaction vessel with a specific brominating agent, such as a combination of hydrobromic acid and an oxidizing agent, or N-bromosuccinimide (NBS). Under suitable reaction conditions, such as inert gas atmosphere, heating or light, the methyl of benzaldehyde is brominated to replace the hydrogen atom on it, and then 5- (bromomethyl) -1,2,3-trifluorobenzene is obtained. In this reaction, NBS is often the preferred brominating agent because of its mild reaction, good selectivity and few side reactions.
    Second, halogenated aromatics are used as starting materials. Select halogenated aromatics containing suitable substituents, and then introduce methyl through a reaction mediated by metal-organic reagents, and then brominate. For example, using Grignard's reagent or lithium reagent to react with halogenated aromatics, methyl is introduced to form the corresponding methylated aromatics, and then treated with a brominating agent to achieve methyl bromide substitution to obtain the target product. This approach requires attention to the preparation and use conditions of metal-organic reagents. Because of their sensitivity to the reaction environment, an anhydrous and oxygen-free environment is required to ensure the smooth progress of the reaction.
    Third, the method of diazonium salt intermediates can be used. First, the aniline compound containing trifluoride is prepared into diazonium salt through diazotization reaction, and then the diazonium group is converted into methyl group with suitable reagents, and then the bromination step is used to obtain 5- (bromomethyl) -1,2,3-trifluorobenzene. In this process, the diazotization reaction needs to be carried out under low temperature and acidic conditions to ensure the stability of the diazonium salt. The subsequent conversion steps also need to precisely control the reaction conditions to improve the yield and purity.
    All kinds of preparation methods have their own advantages and disadvantages. It is necessary to choose the appropriate one according to the actual situation, such as the availability of raw materials, the difficulty of reaction, and the consideration of cost, so as to achieve the purpose of preparing 5- (bromomethyl) -1,2,3 -trifluorobenzene.
    What are the precautions for 5- (Bromomethyl) -1,2,3-Trifluorobenzene during storage and transportation?
    5 - (bromomethyl) - 1,2,3 -trifluorobenzene is an important raw material for organic synthesis. Many matters should be paid attention to during storage and transportation.
    First storage. Because of its certain chemical activity, it needs to be placed in a cool, dry and well-ventilated place. If placed in a high temperature and humid place, it is easy to cause its chemical reaction and cause damage to its quality. For example, high temperature can promote its decomposition, humid environment or hydrolysis and other side reactions occur. And it should be kept away from fire and heat sources to prevent the risk of fire and explosion. Because of its flammability and reactivity, it may be exposed to open flames, hot topics or cause violent reactions. At the same time, it should be stored separately from oxidants and strong bases to avoid mixed storage. Due to its active chemical properties, the cover may come into contact with oxidants, strong alkalis, etc., or cause severe chemical reactions, endangering safety.
    As for transportation, it is necessary to ensure that the packaging is in good condition. The packaging must be able to withstand certain external forces to prevent leakage due to damage during transportation. The packaging materials used should have good corrosion resistance and sealing. During transportation, vibration, impact and friction should also be avoided. Violent vibration, impact or friction may cause damage to the packaging, or cause chemical reactions between materials. And the transportation vehicle should be equipped with corresponding fire protection equipment and leakage emergency treatment equipment. If a leak unfortunately occurs, it can be dealt with in time to reduce the harm. When transporting, relevant regulations and standards must be followed to ensure legal compliance of transportation and ensure the safety of personnel and the environment.