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5-Bromo-1,3-Difluoro-2-Iodobenzene

5-Bromo-1,3-Difluoro-2-Iodobenzene

Hongda Chemical

Specifications

HS Code

787815

Chemical Formula C6H2BrF2I
Molar Mass 329.886 g/mol
Appearance likely a colorless to pale yellow liquid or solid (predicted based on similar halo - benzenes)
Solubility In Water low, as halogen - substituted benzenes are generally hydrophobic
Solubility In Organic Solvents soluble in common organic solvents like dichloromethane, chloroform (due to non - polar nature of the benzene ring)
Vapor Pressure low at room temperature because of large and heavy halogen - containing structure
Stability stable under normal conditions, but can react with strong nucleophiles or reducing agents due to presence of reactive halogens

As an accredited 5-Bromo-1,3-Difluoro-2-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 5 - bromo - 1,3 - difluoro - 2 - iodobenzene packaged in a sealed glass bottle.
Storage 5 - Bromo - 1,3 - difluoro - 2 - iodobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container, preferably made of glass or a suitable chemical - resistant plastic, to prevent leakage and exposure to air or moisture, which could potentially lead to decomposition or reactivity issues.
Shipping 5 - bromo - 1,3 - difluoro - 2 - iodobenzene is shipped in specialized, well - sealed containers. They are carefully packed to prevent breakage. Shipments follow strict chemical transportation regulations to ensure safety during transit.
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5-Bromo-1,3-Difluoro-2-Iodobenzene 5-Bromo-1,3-Difluoro-2-Iodobenzene
General Information
Historical Development
5-Bromo-1, 3-Difluoro-2-Iodobenzene is an important chemical compound in chemical research. Tracing its historical development, early chemical research began, and scholars devoted themselves to exploring the synthesis and properties of various compounds. At that time, the field of organic chemistry continued to expand, and many scientists devoted themselves to the study of halogenated aromatics.
For 5-Bromo-1, 3-Difluoro-2-Iodobenzene, the synthesis process has undergone a long evolution. At first, the synthesis method was simple and the yield was low. With the progress of science and technology, new reaction mechanisms were revealed, and more efficient synthesis paths were developed. Researchers worked tirelessly to optimize the reaction conditions, adjusting the ratio of reactants, temperature, catalysts and other factors to make its synthesis more accurate and efficient, gradually meeting the diverse needs of scientific research and industrial fields, and playing an important role in the development of organic synthetic chemistry.
Product Overview
5-Bromo-1, 3-Difluoro-2-Iodobenzene, organic compounds are also. Its color is pure and uniform, and it has unique chemical properties. The molecular structure is exquisite, and the coordination of bromine, fluorine and iodine atoms is orderly, which is quite valuable in the field of organic synthesis.
This compound can be used as a key intermediate and participates in various organic reactions. It can help to form carbon-carbon bonds or cause the transformation of functional groups, and has potential applications in many fields such as medicinal chemistry and materials science.
When preparing, it is necessary to follow precise processes, control temperature, speed, and select appropriate reagents and solvents to ensure the purity and yield of the product. However, there are also challenges. Due to the activity of halogen atoms, the reaction conditions need to be carefully regulated to avoid side reactions.
In summary, although 5-Bromo-1, 3-Difluoro-2-Iodobenzene is tiny, it cannot be underestimated in chemical research and industrial production.
Physical & Chemical Properties
5 - Bromo - 1,3 - Difluoro - 2 - Iodobenzene is an organic compound. In terms of physical properties, it is mostly solid at room temperature, and its color may be white to light yellow. Due to the introduction of bromine, fluorine and iodine atoms, the intermolecular forces and arrangements are affected, resulting in the melting and boiling point being affected. The melting point reflects the strength of intermolecular bonding according to experimental data, or in a specific range.
Chemically, the compound is active due to the presence of halogen atoms. Bromine, fluorine and iodine atoms can participate in many reactions, such as nucleophilic substitution reactions. Under appropriate conditions, nucleophilic reagents can attack benzene rings, replace halogen atoms, and generate new derivatives. Due to the electron-withdrawing property of halogen atoms, the electron cloud density of benzene ring changes, which is conducive to the attack of nucleophiles.
Technical Specifications & Labeling
Nowadays, there are chemical substances 5 - Bromo - 1,3 - Difluoro - 2 - Iodobenzene. In the preparation of the technology, it is necessary to clarify its process specifications and identification (product parameters). The synthesis of this substance should follow a delicate method, temperature control and agent selection are all important. The purity of the reaction environment and the accuracy of the material ratio are related to the quality.
As for the label, you must specify its name to correct the audio and video; list its ingredients to make people know its quality; standard characteristics, showing the characteristics of color state; clear purity, indicating the advantages and disadvantages; remember the method of storage to keep its stability. In this way, the process specifications are rigorous, the identification is accurate and correct, and you can get a good product, which can run smoothly in all things chemical.
Preparation Method
5 - Bromo - 1,3 - Difluoro - 2 - Iodobenzene is an important organic compound. The preparation method is crucial.
The selection of raw materials should be based on suitable organic reagents containing bromine, fluorine and iodine. The preparation process is as follows: First, the benzene series compounds containing bromine and fluorine are substituted with iodine-containing reagents under specific conditions. This reaction requires precise regulation of temperature, pressure and reaction time. In the initial stage of the reaction, slowly heat up to a suitable range to ensure that the reactants are fully contacted and activated. When the reaction is stable and maintained for a certain period of time, the substitution reaction can be fully carried out.
Follow-up treatment is also critical. After the reaction, the target product is isolated by extraction, distillation and other means. In order to improve the purity of the product, the purification operation can be repeated. The reaction mechanism of this preparation process is complex, involving the change of electron cloud distribution, chemical bond breaking and recombination. Many details need to be further explored and perfected to achieve an efficient and stable preparation level.
Chemical Reactions & Modifications
5-Bromo-1, 3-Difluoro-2-Iodobenzene is a very important compound in organic synthesis. In chemical reactions, its chemical properties are special and the reactivity is worth studying.
The bromine, fluorine and iodine atoms of this compound give it a unique reaction tendency. Bromine atoms have moderate activity and can be replaced by other nucleophilic reagents in nucleophilic substitution reactions, thereby introducing multiple functional groups to expand the molecular structure. Fluorine atoms have high electronegativity and can significantly change the distribution of molecular electron clouds, affecting the reactivity and selectivity. Although iodine atoms have high activity, they can participate in coupling reactions under specific conditions to form important chemical bonds such as carbon-carbon bonds.
In order to optimize the reaction effect, the reaction conditions can be cut in. Such as precise regulation of temperature, moderate heating or cooling, or can speed up the reaction rate, or can improve product selectivity. It can also screen suitable catalysts, with the unique activity of the catalyst checking point, reduce the activation energy of the reaction, promote the efficient reaction, and improve the yield and purity of the product. It can also finely adjust the proportion of reactants to avoid side reactions and achieve the best stoichiometric ratio of the reaction, so that the compound can play a greater role in the field of organic synthesis.
Synonyms & Product Names
I have heard that there is a thing called 5 - Bromo - 1,3 - Difluoro - 2 - Iodobenzene. This is a chemical product and has many other names in the industry. Its synonyms are all taken by industry insiders for their own purposes.
or because of the characteristics of its chemical structure, there are those who call it by the name of its atomic combination, and there are those who call it by its characteristics in the synthesis path. Although the various aliases are called differently, they all refer to the same thing.
The name of this thing is crucial in academic exchanges, production and manufacturing scenarios. Only with accurate appellation can all parties communicate correctly and promote the progress of chemical research and industrial production.
Safety & Operational Standards
5 - Bromo - 1,3 - Difluoro - 2 - Iodobenzene is an important chemical substance. Safety and operating standards are of paramount importance during its experimental operation and use.
Anyone who comes into contact with this substance must wear appropriate protective equipment, such as laboratory clothes, protective gloves and goggles. Due to its potential chemical risk, if it is slightly inadvertent, it may cause skin contact damage, eye irritation, and even inhalation harm to health.
The operating environment should ensure that it is well ventilated, and it is best to perform related operations in a fume hood. This can effectively disperse harmful gases that may be generated and reduce the risk of the experimenter being exposed to dangerous environments.
Storage of this substance requires following specific specifications. It should be placed in a cool, dry place away from sources of ignition and oxidants. Proper storage conditions can prevent the substance from deteriorating or dangerous reactions due to environmental factors.
When using this substance, accurate measurement and operation steps should not be ignored. Strictly follow the experimental protocol and use appropriate instruments for measurement and transfer to avoid material leakage or uncontrolled reaction due to improper operation.
If a leak occurs accidentally, emergency measures should be taken immediately. Small leaks can be collected with inert adsorption materials and properly placed in specific containers; in the event of a large leak, evacuate personnel quickly, seal the scene, and deal with it in accordance with relevant regulations.
In this way, following safety and operating practices can ensure the safe use of 5-Bromo-1, 3-Difluoro-2-Iodobenzene and the smooth progress of the experiment.
Application Area
5 - Bromo - 1, 3 - Difluoro - 2 - Iodobenzene is a delicate chemical substance. Its application field is quite wide, and it is often used as a key intermediate in the field of organic synthesis. The unique activity of the gainhalogen atom can lead all functional groups into organic molecules, so it is the cornerstone of the synthesis of complex organic structures.
In the field of pharmaceutical chemistry, this compound can participate in the construction of many drug molecules. Due to its structural properties, it may endow drugs with unique pharmacological activities, help drugs to act precisely on targets, and provide rich possibilities for the development of new drugs.
In the field of materials science, it has also emerged. Or through specific reactions, polymer materials can be incorporated to improve the properties of materials, such as optical and electrical properties, paving the way for the creation of new materials. From this perspective, 5-Bromo-1, 3-Difluoro-2-Iodobenzene has extraordinary potential and application value in many fields.
Research & Development
There is a chemical substance today, called 5 - Bromo - 1,3 - Difluoro - 2 - Iodobenzene. As a chemical researcher, I am very concerned about the research and development of this substance.
The structure of this substance is unique, and the atoms of bromine, fluorine and iodine are located in their respective positions on the benzene ring, giving it different chemical properties. After repeated experiments and investigations, its reactivity was observed, and it showed specific performance in many organic synthesis reactions.
In order to promote its development, we have tried various synthesis paths, striving to optimize the process and increase the yield. We also explore its potential use in the research and development of new materials, hoping to open up new fields. Although the process is arduous, I firmly believe that with time and unremitting research, it will be able to make it shine in the field of chemistry and contribute to scientific progress.
Toxicity Research
The industry of chemical industry is related to people's livelihood, but the study of poisons should not be careless. Today there is a substance name 5 - Bromo - 1,3 - Difluoro - 2 - Iodobenzene, and the study of its toxicity is quite important.
This substance contains bromine, fluorine, and iodine elements, and has a unique structure. Or due to the nature of halogens, it is in the biological body and may disturb the biochemical process. Halogen atoms are active and easily react with body molecules, disrupting cell metabolism and enzyme functions.
To demonstrate its toxicity, it should be studied by various methods. Observe its effect on cells, measure cell vitality and morphological changes. Also use animals as models to observe differences in their physiology and behavior. Record weight gain and loss, visceral lesions, analyze the data in detail, and judge the toxicity and toxicity of the pathway, which can be used as evidence for protection and application, and ensure that people are content with the benefits of chemical industry.
Future Prospects
I try to study chemical products. In this product 5 - Bromo - 1,3 - Difluoro - 2 - Iodobenzene, I observe its characteristics and think about its future development. This product is specific and may be a key material in organic synthesis. Although it is not widely used at present, it has infinite potential.
In the future world, science and technology will advance, and the field of organic synthesis will become more profound. 5 - Bromo - 1,3 - Difluoro - 2 - Iodobenzene may shine in the development of new drugs and material innovation. Its unique structure can lead to various reactions to prepare novel compounds. With time, it can become a treasure in the medical industry, a good prescription for treating diseases and saving people; or it can be a newcomer in the material industry, creating materials with extraordinary performance. Yu firmly believes that this product will definitely emerge in the future exhibition and live up to the expectations of our researchers.
Where to Buy 5-Bromo-1,3-Difluoro-2-Iodobenzene in China?
As a trusted 5-Bromo-1,3-Difluoro-2-Iodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 5-Bromo-1,3-Difluoro-2-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 5-Bromo-1, 3-Difluoro-2-Iodobenzene?
5-Bromo-1,3-difluoro-2-iodobenzene is one of the organic compounds. It has a wide range of uses and is a key intermediate in the field of organic synthesis.
First, in the field of medicinal chemistry, it can be used to prepare drug molecules with specific biological activities. Due to the presence of halogen atoms in its structure, other functional groups can be introduced through many organic reactions, such as nucleophilic substitution reactions, to construct drug precursors with diverse structures, laying the foundation for the development of new drugs.
Second, in the field of materials science, it can be integrated into the structure of polymer materials through specific chemical reactions. Due to its halogen atom properties, it may endow materials with unique electrical and optical properties, such as improving the conductivity and fluorescence properties of materials, so it also has potential application value in optoelectronic materials.
Furthermore, in the field of fine chemicals, it is often used to synthesize fine chemicals with special structures. For example, as a starting material, high-value added flavors, dyes and other products are synthesized through multi-step reactions to help improve the quality and performance of fine chemical products.
Overall, 5-bromo-1,3-difluoro-2-iodobenzene plays an important role in many fields due to its unique structure, providing key support for the development of organic synthetic chemistry and the progress of related industries.
What are the physical properties of 5-Bromo-1 3-Difluoro-2-Iodobenzene?
5-Bromo-1,3-difluoro-2-iodobenzene is one of the organic compounds. Its physical properties are quite important, and I will describe them in detail today.
First of all, its appearance, under room temperature and pressure, this substance is mostly colorless to light yellow liquid, clear and transparent, and looks quite fluid. It has a special smell, although not pungent and unpleasant, it is also different from ordinary odorless things, with a slightly unique smell.
When it comes to melting point, the melting point of 5-bromo-1,3-difluoro-2-iodobenzene is relatively low, between -10 ° C and 10 ° C. This property makes the substance easy to appear liquid in an environment slightly higher than normal temperature without excessive temperature changes.
In terms of boiling point, it is between 180 ° C and 200 ° C. This boiling point value shows that in order to change from liquid to gaseous state, a considerable amount of heat needs to be applied to allow the molecules to obtain enough energy to break free from each other's forces.
Solubility is also one of the key properties. This compound exhibits good solubility in organic solvents, such as common ethanol, ether, dichloromethane, etc. However, in water, its solubility is poor. Due to the molecular structure of the substance, the interaction between it and water molecules is weak, and it is difficult to dissolve in the water phase with strong polarity.
On the density, 5-bromo-1,3-difluoro-2-iodobenzene is heavier than water, and its density is about 2.3-2.5 g/cm ³. This characteristic makes it sink to the bottom when mixed with water. This phenomenon is of great reference value in related chemical operations and studies.
In addition, the stability of 5-bromo-1,3-difluoro-2-iodobenzene is acceptable under conventional conditions. However, it contains bromine, fluorine, iodine, and other halogen atoms. Under specific chemical reaction conditions, halogen atoms can participate in many reactions. Therefore, when storing and using them, one should also pay attention to their environment and conditions to prevent unnecessary reactions from occurring.
What is the synthesis method of 5-Bromo-1,3-Difluoro-2-Iodobenzene
To prepare 5-bromo-1,3-difluoro-2-iodobenzene, you can do it by the following method. First, take a suitable aromatic compound, such as 1,3-difluorobenzene, as the starting material for the reaction.
The first step is to react 1,3-difluorobenzene with a brominating reagent. This brominating reagent can be selected from bromine (Br _ 2) and accompanied by a suitable catalyst, such as iron powder (Fe) or iron tribromide (FeBr _ 3). Under suitable reaction conditions, such as heating and in an inert solvent, bromine atoms will selectively replace hydrogen atoms at specific positions on the benzene ring to generate 5-bromo-1,3-difluorobenzene. This step is based on the electrophilic substitution reaction of the benzene ring. Bromine forms an electrophilic reagent under the action of a catalyst, attacking the higher electron cloud density of the benzene ring.
In the next step, 5-bromo-1,3-difluorobenzene is reacted with an iodizing reagent. The iodizing reagent can be iodine (I _ 2) and an appropriate oxidizing agent such as hydrogen peroxide (H _ 2O _ 2) or nitric acid (HNO _ 3) is added. In a suitable reaction environment, such as a specific temperature and solvent system, iodine atoms will replace the hydrogen atoms at the target position on the benzene ring to obtain 5-bromo-1,3-difluoro-2-iodobenzene. This step of the reaction is also an electrophilic substitution process. The role of the oxidant is to promote the formation of electrophilic active species of iodine to realize the substitution of iodine to the benzene ring.
During the reaction process, it is necessary to pay attention to the precise control of the reaction conditions at each step, such as temperature, reaction time, reagent dosage, etc., in order to obtain higher yield and purity. And after each step of the reaction, it often needs to be separated and purified, such as extraction, distillation, recrystallization and other means to remove by-products and unreacted raw materials, and finally obtain pure 5-bromo-1,3-difluoro-2-iodobenzene.
What is the market price of 5-Bromo-1,3-Difluoro-2-Iodobenzene
I have not obtained the market price of 5 - Bromo - 1,3 - Difluoro - 2 - Iodobenzene. The market situation is changing rapidly, and the price often varies according to the source, quality, purchase quantity, time and place. To know the exact price, you should consult the chemical raw material supplier, the chemical trading platform, or visit the relevant industry exhibition. At the chemical raw material supplier, he can tell the exact price according to the real-time inventory and market supply and demand. On the chemical trading platform, there are also quotations from various companies, which can be compared. In the industry exhibition, you can negotiate with the industry, and you may get preferential prices and opportunities for cooperation. Therefore, in order to obtain the market price of this product, you need to explore and compare it in detail to get a suitable price.
5-Bromo-1, 3-Difluoro-2-Iodobenzene What are the precautions in storage and transportation?
5-Bromo-1,3-difluoro-2-iodobenzene is an organic compound. When storing and transporting, many things must be paid attention to.
First words storage. This compound is more sensitive to light and air, so it should be stored in a cool, dry and well-ventilated place, away from heat sources and open flames to prevent fire. Be sure to use dark packaging, such as dark glass bottles, to prevent light intrusion and cause decomposition. Because of its certain chemical activity, it should be stored separately from oxidants, acids, bases, etc., and must not be mixed, otherwise it may cause violent chemical reactions. At the same time, the storage area should be equipped with suitable containment materials to prevent leakage accidents from being dealt with in time.
Second talk about transportation. During transportation, the packaging must be sturdy to ensure that it will not be damaged or leaked under normal transportation conditions. It needs to be implemented in accordance with the relevant regulations on the transportation of hazardous chemicals, and the transportation vehicles should be equipped with corresponding fire protection equipment and leakage emergency treatment equipment. Transportation personnel should also be professionally trained to be familiar with the characteristics of the compound and emergency treatment methods. During transportation, avoid high temperatures and bumpy road sections to prevent material leakage caused by damage to the packaging. In the event of leakage, the surrounding people should be evacuated immediately. After taking protective measures, clean up and dispose of it in time to prevent environmental pollution.
Only in this way can the storage and transportation of 5-bromo-1,3-difluoro-2-iodobenzene be ensured to the greatest extent and accidents can be avoided.