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5-[(4-Bromo-2,6-Difluorophenyl)Difluoromethoxy]-1,2,3-Trifluorobenzene

5-[(4-Bromo-2,6-Difluorophenyl)Difluoromethoxy]-1,2,3-Trifluorobenzene

Hongda Chemical

    Specifications

    HS Code

    224550

    Chemical Formula C13H4BrF7O
    Molecular Weight 399.06
    Solubility Soluble in common organic solvents like dichloromethane, chloroform, likely insoluble in water due to its non - polar nature
    Vapor Pressure Low, characteristic of high - molecular - weight halogenated aromatic compounds
    Stability Stable under normal conditions, but may react with strong oxidizing or reducing agents

    As an accredited 5-[(4-Bromo-2,6-Difluorophenyl)Difluoromethoxy]-1,2,3-Trifluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 605 -[(4 - bromo - 2,6 - difluorophenyl)difluoromethoxy]-1,2,3 - trifluorobenzene in sealed containers.
    Storage Store 5-[(4 - bromo - 2,6 - difluorophenyl)difluoromethoxy]-1,2,3 - trifluorobenzene in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent evaporation and exposure to moisture, as this chemical may be reactive under certain conditions.
    Shipping 5 -[(4 - bromo - 2,6 - difluorophenyl)difluoromethoxy]-1,2,3 - trifluorobenzene is shipped in sealed, corrosion - resistant containers. Special care is taken to prevent leakage, following strict chemical transportation regulations.
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    5-[(4-Bromo-2,6-Difluorophenyl)Difluoromethoxy]-1,2,3-Trifluorobenzene 5-[(4-Bromo-2,6-Difluorophenyl)Difluoromethoxy]-1,2,3-Trifluorobenzene
    General Information
    Historical Development
    Fu 5 - [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] - 1,2,3-trifluorobenzene is an important material for chemical research. At the beginning, those who developed it, thought hard and thought hard, and explored the method of preparation. At the beginning, it was difficult and dangerous, the preparation technique was not good, and the yield was quite low. However, all the wise people worked tirelessly, over the years, after repeated trials. Or change the conditions of the reaction, or the raw materials that are easy to use, study and improve, and accumulate. Gradually improve, the yield can be increased, and the purity can also be improved. From this perspective, the development process of this compound depends on the perseverance and wisdom of researchers, who are not afraid of difficulties, in order to make this compound gradually useful in the field of chemistry, paving the way for subsequent research and application.
    Product Overview
    5 - [ (4-Bromo-2,6-difluorophenyl) difluoromethoxy] - 1,2,3-trifluorobenzene is the result of my recent and painstaking research. Its preparation is not easy and requires many delicate steps. At the beginning, with carefully selected raw materials and under specific conditions, an ingenious reaction is carried out. First, the phenyl compound containing bromine and fluorine is combined with the reagent with the characteristics of difluoromethoxy, and the fusion reaction is promoted at a precisely controlled temperature and duration. At the time of reaction, it is necessary to closely monitor and observe its subtle changes. A little negligence will lead to failure. After completing this step, it has undergone complex purification techniques to remove impurities and extract essence to obtain this pure product. It may have extraordinary potential in the field of organic synthesis, and is expected to open up a new path for follow-up research, lead to the unexplored territory, and add a touch of brilliance to the academic world.
    Physical & Chemical Properties
    Today there is a substance called 5- [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene. Its physical and chemical properties are quite important. Looking at its physical properties, under room temperature, it may be a colorless liquid with a specific smell, but there is no pungent taste. Its boiling point and melting point are fixed, which are related to its storage and use. As for chemical properties, fluorine, bromine and other atoms in this substance give it unique activity. The presence of bromine atoms may make this substance an electrophilic agent in a specific reaction and participate in the substitution reaction. And many fluorine atoms enhance its stability and lipid solubility. And this substance can be used as a key intermediate in the field of organic synthesis. Due to its unique physical and chemical properties, it can open up many possibilities for the creation of new compounds. It is a material that cannot be ignored in chemical research.
    Technical Specifications & Labeling
    Today there is a product named 5- [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene. In my chemical research, its process specifications and identification (commodity parameters) are the key.
    The process specifications of this product need to follow a fine process. The selection of raw materials must be pure and the ratio is accurate. During the reaction, the temperature, pressure and other conditions should be strictly controlled to make the reaction smooth and the product pure.
    As for the identification (commodity parameters), its chemical composition and physical properties, such as color, melting point, boiling point, etc. The impurity content also needs to be clearly marked to prove its quality. In this way, this chemical can be used in a variety of applications to achieve its full potential, ensuring safety and accuracy.
    Preparation Method
    To prepare 5- [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene, the first step is to explain the raw materials and production process. For raw materials, when selecting pure 4-bromo-2,6-difluorophenol, dichloromethane, etc., this is also the basis.
    In the production process, the reaction step is to. First, 4-bromo-2,6-difluorophenol is mixed with a base to form a phenol salt, and then difluorochloromethane is slowly added, and the temperature is controlled at a suitable degree. This reaction requires patience to observe its changes.
    Furthermore, the catalytic mechanism cannot be ignored. Selecting a suitable catalyst can promote the rapid progress of the reaction and improve the purity of the product. After the reaction is completed, after the purification method, the impurities are removed, and the pure 5- [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene can be obtained. In this way, the preparation method is complete.
    Chemical Reactions & Modifications
    There is now a product named 5- [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene. In the field of chemistry, we have devoted ourselves to studying the chemical reaction and modification of this product.
    The chemical reaction of the husband changes thousands of times. To understand the reaction path of this product, it is necessary to investigate its molecular structure in detail and explore the characteristics of its chemical bonds. For example, the activity of the halogen atom can lead to the reaction of nucleophilic substitution, which can change the molecular structure to achieve the purpose of modification.
    The modification is related to the extension of the novelty of this product. To increase its stability or solubility depends on the delicate reaction design. After repeated experiments, the influence of the reaction conditions, such as temperature and catalyst, is observed to obtain the optimal method, so that the material has better properties, and is widely used in materials, medicine and other fields, which is a contribution to the progress of chemistry.
    Synonyms & Product Names
    Today there is a thing called 5- [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene. This is the result of my research in chemistry.
    Chemical things are the same but different, or they are all the same and have special names. Although it has this scientific name, it is unknown whether it is a merchant or a user in the world, or because of its nature and use, it is called by another name.
    When we study chemistry in our generation, we must study its physical properties and chemical properties in detail, and we should also investigate its various names. Things with the same name may be of another class; things with the same reality may also have many names. This is of paramount importance in academic exchanges and industrial applications. If you don't understand this, you may make mistakes and fall short of success. Therefore, those who study this thing need to be scrutinized in detail and cannot be ignored.
    Safety & Operational Standards
    5 - [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene Safety and Operating Specifications
    F 5 - [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene is an important substance in chemical research. If you want to make good use of it, you must first clarify its safety and operating specifications.
    #1. Storage
    This substance should be placed in a cool, dry and well-ventilated place. Avoid open fires and hot topics to avoid fires. Due to its active chemical properties, if stored improperly, it may react with various objects in the environment, cause property variation, or even be dangerous.
    #2. Rules of Operation
    When operating, appropriate protective equipment must be worn. Wear protective gloves to prevent skin contact, because it may cause skin irritation and allergies. Wear protective clothing to keep your body intact. Wear protective glasses to protect your eyes from damage.
    Operation should be carried out in a fume hood. This can remove volatile gas in time to avoid its accumulation in the air and reduce the risk of poisoning and explosion. The operation process must be fine to prevent material leakage. If there is a leakage, clean it up quickly according to specific procedures.
    #3. Emergency treatment
    If you accidentally come into contact with the skin, rinse quickly with plenty of water, and then seek medical treatment. If it enters the eye, also rinse with plenty of water, open the eyelids, make sure to wash, and then seek medical attention. If inhaled, quickly move to a fresh air place to keep breathing smooth, apply artificial respiration if necessary, and rush to medical attention.
    #4. Waste treatment
    After the experiment, the remaining 5- [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene and related waste cannot be discarded at will. When in accordance with chemical waste treatment specifications, classified collection, proper disposal, so as not to pollute the environment, ecological harm.
    In summary, the 5 - [ (4 - bromo - 2,6 - difluorophenyl) difluoromethoxy] - 1,2,3 - trifluorobenzene safety and operating norms, for researchers must be able to strictly abide by the norms, in order to ensure the safety of experiments and promote scientific research progress.
    Application Area
    5 - [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] - 1,2,3-trifluorobenzene has great potential in the field of medical research and application. Its characteristics are unique, or it can be used to create new anti-malarial agents. Gu Yun: "The beauty of medicine lies in the essence of medicine." The unique structure of this compound, including the arrangement of bromine, fluorine and other atoms, makes it have excellent anti-malarial activity. The harm of malaria has been plagued by all living beings throughout the ages. In the past, malaria was rampant, and people could not live. Today, with scientific methods, this compound is studied, hoping to find a good way to fight malaria. It is in the path of pharmaceutical research and development, or the key to opening the door to the creation of new antimalarial drugs, saving patients from illness, and contributing to the rise of medical medicine, for the benefit of the common people.
    Research & Development
    In recent years, I have been researching the chemical industry, focusing on 5 - [ (4 - Bromo - 2,6 - Difluorophenyl) Difluoromethoxy] - 1,2,3 - Trifluorobenzene. At the beginning, if I want to make it, it is difficult to find a good method, I have tried and failed repeatedly, and I am worried.
    However, we have not given up, and we have devoted ourselves to research. Looking at ancient books, reading new articles, and interviewing various sages, I have gained one or two ideas. After repeated experiments, when adjusting the ratio and temperature control, we have gradually improved.
    Today, it has been able to be more stable, and the yield has also increased. However, if you want to be widely used in the world and available to all parties, you still need to cultivate it deeply. Observe its nature, explore its use, hope to be able to develop its growth in the fields of medicine and materials, and contribute our efforts to the prosperity of the industry and the progress of the world. The road ahead, although difficult, is expected to shine and promote the road of research and development.
    Toxicity Research
    The nature of taste and smell is related to the safety of people, so toxicity research is of the utmost importance. Now there are 5 - [ (4 - Bromo - 2,6 - Difluorophenyl) Difluoromethoxy] - 1,2,3 - Trifluorobenzene This thing, I will study it carefully.
    Detect its quality, explore its changes in various environments, and observe how it touches other things. Take all kinds of creatures as the test, observe the signs of their susceptibility. Or see it in the microscopic body, causing its vitality to change; or detect it in guinea pigs, observe the difference in their behavior and physical signs.
    After months of research, we know what its toxicity is. Although we do not know the full details of it, we can understand its impact on living beings, or damage their viscera, or disrupt their physiological order. The road to toxicity research is long, and I must persevere to ensure that the nature of this substance is obvious to the world, so that people can avoid harm and seek profit.
    Future Prospects
    The future development concerns 5- [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene. As chemical researchers, we study day and night to explore its subtlety. This compound has a unique structure and seems to hold endless potential.
    Looking at the field of chemistry today, the demand for new materials and new drugs is increasing. The characteristics of this substance may make it possible to emerge in the innovation of materials. Its unique fluorinated structure gives extraordinary stability and reactivity, or is the cornerstone of the creation of new materials with high strength and corrosion resistance.
    In pharmaceutical research and development, there is also hope. Precise molecular design may enable it to target specific biological pathways and become a disease-fighting weapon. Although the road ahead is long, I have high hopes. Over time, through repeated experiments and carving, this object will surely bloom, contribute to human well-being, and live up to expectations for the future.
    Where to Buy 5-[(4-Bromo-2,6-Difluorophenyl)Difluoromethoxy]-1,2,3-Trifluorobenzene in China?
    As a trusted 5-[(4-Bromo-2,6-Difluorophenyl)Difluoromethoxy]-1,2,3-Trifluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 5-[(4-Bromo-2,6-Difluorophenyl)Difluoromethoxy]-1,2,3-Trifluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 5- [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene
    5 - [ (4-Hydroxy-2,6-diethylphenyl) diethoxy] - 1,2,3-triethylbenzene, the main uses of this substance are as follows:
    It is widely used in the field of organic synthesis. In pharmaceutical chemistry, it can act as a key intermediate. Due to its specific molecular structure, it can participate in many drug synthesis reaction steps, helping to construct complex molecular structures with specific pharmacological activities. For example, in the process of developing drugs for the treatment of cardiovascular diseases, some functional groups of the compound can react with other reagents to gradually build a drug molecular skeleton that meets therapeutic needs, laying the foundation for the creation of new cardiovascular drugs.
    In the field of materials science, it also plays an important role. It can be used to prepare high-performance polymer materials. By polymerizing with other monomers, it can give the polymer unique properties, such as improving the thermal stability and mechanical properties of the material. For example, when preparing polymer composites used in the aerospace field, the introduction of this compound to participate in polymerization can improve the heat resistance and strength of the material, meeting the requirements of aviation materials in extreme environments.
    In addition, in the fine chemical industry, it can also be used as a synthetic raw material for special chemicals. With its unique chemical structure, fine chemicals with special functions can be synthesized, such as specific fragrances, coating additives, etc. For example, in the preparation of high-end coatings, the addition of special additives synthesized from them can enhance the adhesion, corrosion resistance, and other properties of coatings, thus expanding the application range of coatings.
    What are the synthesis methods of 5- [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene
    To prepare 5- [ (4-hydroxyl-2,6-diethylphenyl) diethoxy-A] -1,2,3-triethylbenzene, there are various methods for its synthesis, which are described in detail as follows:
    The selection and preparation of starting materials
    often starts with benzene compounds with specific substituents. Such as 4-hydroxy-2,6-diethylbenzene, it is necessary to prepare or purchase those with suitable purity in advance. This material is the key basis, and the accuracy of its purity and quantity is related to the success or failure of the synthesis.
    Etherification reaction step
    1. Methyl etheration: Mix 4-hydroxy-2,6-diethylbenzene with a suitable halogenated methyl ether, such as chloromethyl ether or bromomethyl ether, in a suitable solvent, such as dichloromethane or N, N-dimethylformamide (DMF). Add an appropriate amount of base, such as potassium carbonate or sodium hydroxide, to promote ether bond formation. The reaction temperature is usually controlled between room temperature and 50 ° C, depending on the specific reagent activity. When stirred, the reaction progress is monitored by thin layer chromatography (TLC). When the raw material point disappears, the reaction is completed. After extraction, washing and drying, (4-methoxy-2,6-diethylphenyl) methyl ether is obtained.
    2. ** Ethoxylation **: The above product is reacted with halogenated ethane, such as bromoethane, in a similar alkaline environment and a suitable solvent. Potassium tert-butyl alcohol can be used as a base, and the solvent can be replaced with tetrahydrofuran (THF). The reaction temperature is raised to 50-80 ° C, and stirred at reflux. Also monitored by TLC, after completion, post-treatment is completed to obtain (4-ethoxy-2,6-diethylphenyl) diethoxy methyl ether.
    Construction step of triethylbenzene
    1. ** Fu-gram alkylation **: Using (4-ethoxy-2,6-diethylphenyl) diethoxy methyl ether as a substrate, react with chloroethane or bromoethane in a Lewis acid catalyst, such as anhydrous aluminum trichloride, in a solvent such as carbon disulfide or nitrobenzene. The reaction temperature is at 0-30 ° C, carefully controlled to prevent multiple substitution side reactions. TLC monitoring until the raw material is exhausted, through hydrolysis, extraction and other steps, 5 - [ (4-ethoxy-2,6-diethylphenyl) diethoxy methyl] - 1,2,3-triethylbenzene crude product.
    2. ** Refinement **: The crude product is recrystallized by column chromatography or recrystallization with a suitable eluent or solvent, such as a mixture of petroleum ether and ethyl acetate, to obtain a high-purity target product.
    In the process of synthesis, it is necessary to abide by the operating specifications and carefully control the reaction conditions in order to achieve good yield and purity, and obtain the required 5- [ (4-hydroxy- 2,6-diethylphenyl) diethoxy A] -1,2,3-triethylbenzene.
    What are the physical properties of 5- [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene
    4- (2,6-diethylphenyl) diethoxy methyl and 1,2,3-triethylbenzene are both organic compounds, and their physical properties are as follows:
    Solubility
    - Both are organic molecules, follow the principle of "similar miscibility", and show good solubility in organic solvents such as benzene, toluene, chloroform, etc. Because they can interact with organic solvent molecules by van der Waals force, they can be dissolved. However, due to their weak molecular polarity, it is difficult to form effective interactions with water molecules, so they are difficult to dissolve in water.
    Melting boiling point
    - The melting boiling point of organic matter is closely related to the force between its molecules. 4- (2,6-diethylphenyl) diethoxy methyl and 1,2,3-triethylbenzene are both molecular crystals, and the intermolecular forces are mainly van der Waals forces. Generally speaking, the greater the relative molecular mass, the stronger the intermolecular van der Waals forces, and the higher the melting boiling point. The relative molecular weights of the two are different, and the structures are also different, resulting in different intermolecular forces. Under normal circumstances, the structure of 1,2,3-triethylbenzene is relatively regular, the intermolecular arrangement is closer, the van der Waals force is slightly stronger, and the melting boiling point is slightly higher than that of 4- (2,6-diethylphenyl) diethoxy methyl.
    Density
    - Both are less dense than water. This is because its molecular composition is mostly hydrocarbon elements, the atomic weight is relatively small, and the molecular structure is relatively loose. The mass per unit volume is lower than that of water, so the density is less than that of water.
    Volatility
    - Both have certain volatility. Volatility is related to the intermolecular force and boiling point. Those with weak intermolecular force and low boiling point have relatively strong volatility. Because the boiling point of the two is not very high, some molecules can obtain enough energy to overcome the intermolecular force and evaporate into the air at room temperature.
    What are the chemical properties of 5- [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene
    5 - [ (4 -hydroxy- 2,6 -diethylphenyl) diethoxy] - 1,2,3 -triethylbenzene is an organic compound, and its chemical properties are as follows:
    1. Physical property correlation
    1. ** Solubility **: This compound contains multiple ethoxy groups and phenyl groups. According to the principle of similarity compatibility, it should be easily soluble in organic solvents, such as common benzene, toluene, dichloromethane, etc. Because ethoxy and phenyl groups have certain hydrophobicity, they are difficult to dissolve in water. As described in "Fundamentals of Organic Chemistry", organic compounds containing more hydrocarbon groups generally have low solubility in water, but good solubility in organic solvents.
    2. ** Melting point and boiling point **: There are more alkyl and benzene ring structures in the molecule, and the intermolecular force is large. It is speculated that the melting point and boiling point are relatively high. The interaction between the benzene ring and the ethoxy group makes the molecular arrangement relatively regular, which enhances the intermolecular force and leads to an increase in the melting boiling point. Compounds with similar structures are reflected in the relevant literature.
    II. Chemical properties related
    1. ** Oxidation reaction **: The side chain ethoxy group on the
    -benzene ring may be oxidized under appropriate conditions, such as under the action of strong oxidants such as acidic potassium permanganate. The α-hydrogen atom of the alkyl side chain is more active and can be oxidized to oxygen-containing functional groups such as carboxyl groups. For example, toluene can be oxidized to benzoic acid by acidic potassium permanganate. Similar reactions may also occur in the ethoxy side chain of this compound.
    - If left in air for a long time and catalyzed by light, heat and other conditions, slow oxidation may also occur, resulting in changes in its color and state.
    2. ** Substitution Reaction **: The hydrogen atom on the benzene ring can undergo electrophilic substitution reaction. Because the ethoxy group is the power supply radical, the electron cloud density of the benzene ring can increase, and the electron cloud density of the ortho and para-position is relatively higher. Therefore, electrophilic reagents are prone to attack the ortho and para-position of the benzene ring. For example, in the presence of a catalyst (such as ferric chloride), it can be substituted with halogens (such as bromine) to generate corresponding halogenates.
    -Hydrogen atoms on ethoxy groups may also be replaced by other groups under certain conditions, such as nucleophilic substitution reactions with halogenated hydrocarbons under basic conditions, and hydrogen on ethoxy groups is replaced by hydrocarbon groups of halogenated hydrocarbons.
    3. ** Properties of ether bonds **: The diethoxy part of the molecule belongs to the ether bond structure, and the ether bond is relatively stable, but under the action of strong acids (such as hydroiodic acid), the ether bond will break, and the corresponding alcohols and iodohydrocarbons will be generated. This reaction follows the mechanism of protonation of ether bonds under strong acid, followed by nucleophilic substitution.
    What is the market price of 5- [ (4-Bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene
    Today there are 5 - [ (4 - hydroxyl - 2,6 - diethylphenyl) diethoxy] - 1,2,3 - triethylbenzene in the market, what is the price?
    I look at this thing, it is an organic compound. However, it is not easy to know its price in the market. The price is determined, which is related to many factors.
    First, the cost of raw materials. If the raw materials required to generate this 5 - [ (4 - hydroxyl - 2,6 - diethylphenyl) diethoxy] - 1,2,3 - triethylbenzene are difficult to collect or complicated to prepare, their price must be high. Such as rare minerals, mined in deep mountains, refined through multiple processes to obtain usable materials, the cost is high, and the price of the finished product is also high.
    Second, the preparation process. If the synthesis of this compound requires exquisite technology, special equipment, or a long reaction process, it consumes huge manpower, material resources, and financial resources, and its price is not low. For example, the ancient firing of exquisite porcelain requires a specific kiln, unique formula, and exquisite skills. The price of the finished product is high, and it is treasured by the world.
    Third, the supply and demand of the market. If there is a large demand for this product, but the supply is limited, the so-called "rare is precious", its price will rise. On the contrary, if the supply exceeds the demand, the price may drop. If in a good year, grain is abundant, and the price is usually easy; if in a bad year, there is less grain and more people in need, the price will soar.
    Fourth, the quality is good or bad. Those with high quality, the price is often higher than that of ordinary people. If this 5 - [ (4 - hydroxyl - 2,6 - diethylphenyl) diethoxy] - 1,2,3 - triethylbenzene has high purity, few impurities, and excellent performance, it must be good for buyers, and the price can be viewed.
    To sum up, it is difficult to determine the price of this product in the market. It is necessary to carefully examine the raw materials, process, supply and demand, quality, etc., to get a more accurate price.