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What is the main use of 5- [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene
5 - [ (4-Hydroxy-2,6-diethylphenyl) diethoxy] - 1,2,3-triethylbenzene, the main uses of this substance are as follows:
It is widely used in the field of organic synthesis. In pharmaceutical chemistry, it can act as a key intermediate. Due to its specific molecular structure, it can participate in many drug synthesis reaction steps, helping to construct complex molecular structures with specific pharmacological activities. For example, in the process of developing drugs for the treatment of cardiovascular diseases, some functional groups of the compound can react with other reagents to gradually build a drug molecular skeleton that meets therapeutic needs, laying the foundation for the creation of new cardiovascular drugs.
In the field of materials science, it also plays an important role. It can be used to prepare high-performance polymer materials. By polymerizing with other monomers, it can give the polymer unique properties, such as improving the thermal stability and mechanical properties of the material. For example, when preparing polymer composites used in the aerospace field, the introduction of this compound to participate in polymerization can improve the heat resistance and strength of the material, meeting the requirements of aviation materials in extreme environments.
In addition, in the fine chemical industry, it can also be used as a synthetic raw material for special chemicals. With its unique chemical structure, fine chemicals with special functions can be synthesized, such as specific fragrances, coating additives, etc. For example, in the preparation of high-end coatings, the addition of special additives synthesized from them can enhance the adhesion, corrosion resistance, and other properties of coatings, thus expanding the application range of coatings.
What are the synthesis methods of 5- [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene
To prepare 5- [ (4-hydroxyl-2,6-diethylphenyl) diethoxy-A] -1,2,3-triethylbenzene, there are various methods for its synthesis, which are described in detail as follows:
The selection and preparation of starting materials
often starts with benzene compounds with specific substituents. Such as 4-hydroxy-2,6-diethylbenzene, it is necessary to prepare or purchase those with suitable purity in advance. This material is the key basis, and the accuracy of its purity and quantity is related to the success or failure of the synthesis.
Etherification reaction step
1. Methyl etheration: Mix 4-hydroxy-2,6-diethylbenzene with a suitable halogenated methyl ether, such as chloromethyl ether or bromomethyl ether, in a suitable solvent, such as dichloromethane or N, N-dimethylformamide (DMF). Add an appropriate amount of base, such as potassium carbonate or sodium hydroxide, to promote ether bond formation. The reaction temperature is usually controlled between room temperature and 50 ° C, depending on the specific reagent activity. When stirred, the reaction progress is monitored by thin layer chromatography (TLC). When the raw material point disappears, the reaction is completed. After extraction, washing and drying, (4-methoxy-2,6-diethylphenyl) methyl ether is obtained.
2. ** Ethoxylation **: The above product is reacted with halogenated ethane, such as bromoethane, in a similar alkaline environment and a suitable solvent. Potassium tert-butyl alcohol can be used as a base, and the solvent can be replaced with tetrahydrofuran (THF). The reaction temperature is raised to 50-80 ° C, and stirred at reflux. Also monitored by TLC, after completion, post-treatment is completed to obtain (4-ethoxy-2,6-diethylphenyl) diethoxy methyl ether.
Construction step of triethylbenzene
1. ** Fu-gram alkylation **: Using (4-ethoxy-2,6-diethylphenyl) diethoxy methyl ether as a substrate, react with chloroethane or bromoethane in a Lewis acid catalyst, such as anhydrous aluminum trichloride, in a solvent such as carbon disulfide or nitrobenzene. The reaction temperature is at 0-30 ° C, carefully controlled to prevent multiple substitution side reactions. TLC monitoring until the raw material is exhausted, through hydrolysis, extraction and other steps, 5 - [ (4-ethoxy-2,6-diethylphenyl) diethoxy methyl] - 1,2,3-triethylbenzene crude product.
2. ** Refinement **: The crude product is recrystallized by column chromatography or recrystallization with a suitable eluent or solvent, such as a mixture of petroleum ether and ethyl acetate, to obtain a high-purity target product.
In the process of synthesis, it is necessary to abide by the operating specifications and carefully control the reaction conditions in order to achieve good yield and purity, and obtain the required 5- [ (4-hydroxy- 2,6-diethylphenyl) diethoxy A] -1,2,3-triethylbenzene.
What are the physical properties of 5- [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene
4- (2,6-diethylphenyl) diethoxy methyl and 1,2,3-triethylbenzene are both organic compounds, and their physical properties are as follows:
Solubility
- Both are organic molecules, follow the principle of "similar miscibility", and show good solubility in organic solvents such as benzene, toluene, chloroform, etc. Because they can interact with organic solvent molecules by van der Waals force, they can be dissolved. However, due to their weak molecular polarity, it is difficult to form effective interactions with water molecules, so they are difficult to dissolve in water.
Melting boiling point
- The melting boiling point of organic matter is closely related to the force between its molecules. 4- (2,6-diethylphenyl) diethoxy methyl and 1,2,3-triethylbenzene are both molecular crystals, and the intermolecular forces are mainly van der Waals forces. Generally speaking, the greater the relative molecular mass, the stronger the intermolecular van der Waals forces, and the higher the melting boiling point. The relative molecular weights of the two are different, and the structures are also different, resulting in different intermolecular forces. Under normal circumstances, the structure of 1,2,3-triethylbenzene is relatively regular, the intermolecular arrangement is closer, the van der Waals force is slightly stronger, and the melting boiling point is slightly higher than that of 4- (2,6-diethylphenyl) diethoxy methyl.
Density
- Both are less dense than water. This is because its molecular composition is mostly hydrocarbon elements, the atomic weight is relatively small, and the molecular structure is relatively loose. The mass per unit volume is lower than that of water, so the density is less than that of water.
Volatility
- Both have certain volatility. Volatility is related to the intermolecular force and boiling point. Those with weak intermolecular force and low boiling point have relatively strong volatility. Because the boiling point of the two is not very high, some molecules can obtain enough energy to overcome the intermolecular force and evaporate into the air at room temperature.
What are the chemical properties of 5- [ (4-bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene
5 - [ (4 -hydroxy- 2,6 -diethylphenyl) diethoxy] - 1,2,3 -triethylbenzene is an organic compound, and its chemical properties are as follows:
1. Physical property correlation
1. ** Solubility **: This compound contains multiple ethoxy groups and phenyl groups. According to the principle of similarity compatibility, it should be easily soluble in organic solvents, such as common benzene, toluene, dichloromethane, etc. Because ethoxy and phenyl groups have certain hydrophobicity, they are difficult to dissolve in water. As described in "Fundamentals of Organic Chemistry", organic compounds containing more hydrocarbon groups generally have low solubility in water, but good solubility in organic solvents.
2. ** Melting point and boiling point **: There are more alkyl and benzene ring structures in the molecule, and the intermolecular force is large. It is speculated that the melting point and boiling point are relatively high. The interaction between the benzene ring and the ethoxy group makes the molecular arrangement relatively regular, which enhances the intermolecular force and leads to an increase in the melting boiling point. Compounds with similar structures are reflected in the relevant literature.
II. Chemical properties related
1. ** Oxidation reaction **: The side chain ethoxy group on the
-benzene ring may be oxidized under appropriate conditions, such as under the action of strong oxidants such as acidic potassium permanganate. The α-hydrogen atom of the alkyl side chain is more active and can be oxidized to oxygen-containing functional groups such as carboxyl groups. For example, toluene can be oxidized to benzoic acid by acidic potassium permanganate. Similar reactions may also occur in the ethoxy side chain of this compound.
- If left in air for a long time and catalyzed by light, heat and other conditions, slow oxidation may also occur, resulting in changes in its color and state.
2. ** Substitution Reaction **: The hydrogen atom on the benzene ring can undergo electrophilic substitution reaction. Because the ethoxy group is the power supply radical, the electron cloud density of the benzene ring can increase, and the electron cloud density of the ortho and para-position is relatively higher. Therefore, electrophilic reagents are prone to attack the ortho and para-position of the benzene ring. For example, in the presence of a catalyst (such as ferric chloride), it can be substituted with halogens (such as bromine) to generate corresponding halogenates.
-Hydrogen atoms on ethoxy groups may also be replaced by other groups under certain conditions, such as nucleophilic substitution reactions with halogenated hydrocarbons under basic conditions, and hydrogen on ethoxy groups is replaced by hydrocarbon groups of halogenated hydrocarbons.
3. ** Properties of ether bonds **: The diethoxy part of the molecule belongs to the ether bond structure, and the ether bond is relatively stable, but under the action of strong acids (such as hydroiodic acid), the ether bond will break, and the corresponding alcohols and iodohydrocarbons will be generated. This reaction follows the mechanism of protonation of ether bonds under strong acid, followed by nucleophilic substitution.
What is the market price of 5- [ (4-Bromo-2,6-difluorophenyl) difluoromethoxy] -1,2,3-trifluorobenzene
Today there are 5 - [ (4 - hydroxyl - 2,6 - diethylphenyl) diethoxy] - 1,2,3 - triethylbenzene in the market, what is the price?
I look at this thing, it is an organic compound. However, it is not easy to know its price in the market. The price is determined, which is related to many factors.
First, the cost of raw materials. If the raw materials required to generate this 5 - [ (4 - hydroxyl - 2,6 - diethylphenyl) diethoxy] - 1,2,3 - triethylbenzene are difficult to collect or complicated to prepare, their price must be high. Such as rare minerals, mined in deep mountains, refined through multiple processes to obtain usable materials, the cost is high, and the price of the finished product is also high.
Second, the preparation process. If the synthesis of this compound requires exquisite technology, special equipment, or a long reaction process, it consumes huge manpower, material resources, and financial resources, and its price is not low. For example, the ancient firing of exquisite porcelain requires a specific kiln, unique formula, and exquisite skills. The price of the finished product is high, and it is treasured by the world.
Third, the supply and demand of the market. If there is a large demand for this product, but the supply is limited, the so-called "rare is precious", its price will rise. On the contrary, if the supply exceeds the demand, the price may drop. If in a good year, grain is abundant, and the price is usually easy; if in a bad year, there is less grain and more people in need, the price will soar.
Fourth, the quality is good or bad. Those with high quality, the price is often higher than that of ordinary people. If this 5 - [ (4 - hydroxyl - 2,6 - diethylphenyl) diethoxy] - 1,2,3 - triethylbenzene has high purity, few impurities, and excellent performance, it must be good for buyers, and the price can be viewed.
To sum up, it is difficult to determine the price of this product in the market. It is necessary to carefully examine the raw materials, process, supply and demand, quality, etc., to get a more accurate price.