4-(Trifluoromethyl)Iodobenzene

Hongda Chemical

Specifications

HS Code	732022
Chemical Formula	C7H4F3I
Molar Mass	286.006 g/mol
Appearance	Colorless to light yellow liquid
Boiling Point	193 - 195 °C
Melting Point	N/A
Density	1.94 g/cm³
Solubility	Insoluble in water, soluble in organic solvents like ethanol, ether
Flash Point	79 °C
Refractive Index	1.532 (20 °C)
Purity	Typically high - purity, e.g., 98%+ in commercial products
Cas Number	402 - 45 - 9

As an accredited 4-(Trifluoromethyl)Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	500g of 4-(trifluoromethyl)iodobenzene packaged in a sealed glass bottle.
Storage	4-(Trifluoromethyl)iodobenzene should be stored in a cool, dry place, away from direct sunlight. Keep it in a well - ventilated area, preferably in a tightly sealed container to prevent leakage. As it is a chemical, store it separately from incompatible substances, such as oxidizing agents, to avoid potential reactions. Ensure storage conditions comply with safety regulations.
Shipping	4-(Trifluoromethyl)iodobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper handling to prevent spills and environmental or safety risks during transit.

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General Information

Historical Development

I will study the historical development of 4- (Trifluoromethyl) Iodobenzene. In the past, organic synthesis was not yet developed, and such fluoroaryl halides were little known. However, science and technology were progressive, and chemists studied them more and more. At first, the synthesis method was cumbersome and the yield was meager.
In recent years, new catalytic systems have come out, which has improved its synthesis. The refinement of palladium-catalyzed coupling reactions has made the preparation of 4- (Trifluoromethyl) Iodobenzene easier and the yield has also been improved. This progress is of great use in the fields of materials science and drug research and development, and can be used as a key intermediate to make special materials and new drugs. Its historical development is one of the evidence of chemical progress. From difficulty to ease, it opens up a broad future for various applications.

Product Overview

Today, there is a substance named 4 - (trifluoromethyl) iodobenzene. Its color is pure and complete, and its properties are specific. This substance is cleverly synthesized from various elements, fluorine, carbon, iodine, etc. as a body.
Looking at its structure, the stability of the benzene ring, the activity of the auxiliary trifluoromethyl group, and the uniqueness of the iodine atom. The benzene ring is a six-membered ring with a strong structure. Trifluoromethyl is connected to the benzene ring, giving it strong electronegativity, which makes the reaction activity of this substance unique. Iodine atoms are attached to it, increasing the weight and polarity of its molecules, and also affecting its chemical behavior.
During the synthesis process, through many steps, temperature control, pressure regulation, and agent selection are used to achieve precise combination. Or use nucleophilic substitution and halogenation methods. All conditions need to be carefully controlled before high-purity 4- (trifluoromethyl) iodobenzene can be prepared. It is a key raw material in the field of organic synthesis, and the birth of new compounds has broad prospects and functions cannot be underestimated.

Physical & Chemical Properties

4- (trifluoromethyl) iodobenzene, an organic compound. Its physical and chemical properties are important for chemical research. Looking at its properties, at room temperature, it may be a colorless to light yellow liquid with a special odor. Its boiling point, melting point and other physical constants are the keys to identifying this substance. The boiling point is about a certain temperature, which is the boundary point at which it changes from liquid to gaseous state. The melting point is related to the transition between solid and liquid states.
Discusses chemical properties, it contains trifluoromethyl and iodine atoms, and its activity is special. Trifluoromethyl has strong electronegativity, which affects the polarity and reactivity of molecules. Iodine atoms can participate in many chemical reactions, such as nucleophilic substitution. In the field of organic synthesis, it can be used as an important intermediate. Due to its unique physical and chemical properties, it provides the possibility for the creation of new compounds. It plays an indispensable role in the process of chemical research.

Technical Specifications & Labeling

4- (trifluoromethyl) iodobenzene, an organic compound. The process specification for its preparation, and the fine selection of the first raw materials. The required reactants must be pure and flawless, and the proportions must be accurate. In the reaction vessel, control its temperature and pressure, and follow a specific time sequence to make the various substances react.
The identification of its products (product parameters) is related to the judgment of purity. When using precision instruments, such as chromatography, to measure the impurity content, the purity must reach an extremely high level. Looking at its color and shape is also important for identification. Normal 4- (trifluoromethyl) iodobenzene should have a specific color state. And its physical and chemical properties, such as melting point, solubility, etc., are the key to identification and must be determined in detail to comply with the regulations of high-quality products before they can be used in various scientific research and industrial processes.

Preparation Method

To prepare 4 - (trifluoromethyl) iodobenzene, the raw materials and production process, reaction steps and catalytic mechanism are the key. First, take an appropriate amount of aromatic hydrocarbon raw materials containing trifluoromethyl and mix them with iodine sources in a certain ratio. This is the basis for the reaction.
The reaction steps are as follows: In a special reactor, create a suitable temperature and pressure environment, about [X] degrees Celsius, [X] kPa, and add a specific catalyst, which can effectively promote the reaction and accelerate the fracture and recombination of intermolecular bonds.
The catalytic mechanism is that the catalyst activity check point interacts with the reactant molecules to weaken the specific carbon-hydrogen bond in the aromatic hydrocarbon, making it easier for iodine atoms to combine with it, so as to achieve the formation of the target product. After such a series of operations, 4- (trifluoromethyl) iodobenzene can be obtained, but the parameters of each link need to be precisely controlled in the process to ensure the purity and yield of the product.

Chemical Reactions & Modifications

The research of chemistry is related to the change of substances, and the reaction and modification of the product of 4- (Trifluoromethyl) Iodobenzene are of great importance.
In the past, the preparation of this product, the reaction conditions were harsh, and the yield was not ideal. The method used may take a long time, or require special reagents, and it is often unfavorable to the environment.
At present, scholars are trying their best to improve the reaction method. Optimize the reaction conditions and select the appropriate catalyst to make the reaction milder and the yield can be improved. For example, use a new catalytic system to reduce the reaction temperature and pressure and reduce the generation of side reactions.
Furthermore, pay attention to the modification of the product. By means of chemical modification, the functional group is added to 4- (Trifluoromethyl) Iodobenzene to expand its application domain. It can be used to create new drugs, develop new materials, and contribute greatly to the progress of the chemical industry and science and technology. This is the unremitting exploration of chemical researchers to form reactions and modifications.

Synonyms & Product Names

Today there is a product called 4- (trifluoromethyl) iodobenzene. It has a wide range of uses in the field of chemistry. Although the name is unique, they all refer to the same product.
or "4- (trifluoromethyl) iodobenzene", which is named after its chemical structure. Also known as its trade name, it also represents this chemical product. Although the name is different, it is actually the same thing.
This 4- (trifluoromethyl) iodobenzene is a key material for chemical research. It can be used in various synthetic reactions and is an important part of the preparation of special compounds. Chemists often rely on this substance for their research purposes when experimenting and exploring. Its synonyms are like all things in the world. Although the title has changed, the essence has not changed, all of which are to help the research of chemistry and promote the progress of science.

Safety & Operational Standards

4- (trifluoromethyl) iodobenzene, the safe production and operation of this chemical is related to the priority of our chemical researchers.
In the preparation of this chemical, the selection and disposal of the first raw materials. All raw materials used must be strictly inspected to determine their purity and quality before they can be put into use. When taking out the material, it is necessary to follow the precise measurement and operate carefully to prevent the reaction disorder caused by errors.
During the reaction process, the control of temperature, pressure and other conditions is the key. Precise temperature control and pressure control devices should be set up to maintain the appropriate conditions according to the needs of the reaction. If the temperature is too high, it may cause the reaction to be too fast and cause danger; if the temperature is too low, the reaction will be slow and affect the yield.
Furthermore, the reaction environment must be kept clean to avoid impurities mixing, interfering with the reaction process, or causing the product to be impure.
The separation and purification of the product also have its own specifications. The selection of appropriate separation methods, such as distillation, extraction, etc., depends on the characteristics of the product. When operating, strictly follow the procedures to ensure the purity and quality of the product.
Store this chemical in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent it from decomposing by heat and causing safety accidents. The storage container must also be firmly sealed to prevent leakage.
During use, the experimenter must wear professional protective equipment, such as protective clothing, gloves, goggles, etc., to prevent chemicals from coming into contact with the skin and eyes. In case of accidental contact, you should immediately follow the emergency treatment procedures, quickly rinse and seek medical attention.
In short, the safe production and operation of 4- (trifluoromethyl) iodobenzene must be carried out through the whole process of preparation, storage and use, and every link should not be ignored, so as to ensure the safety of personnel and the smooth operation of the experiment.

Application Area

Today, there is a substance called 4- (Trifluoromethyl) Iodobenzene. It is quite capable in various application fields.
In the field of organic synthesis, this substance is often the key raw material. With its unique structure, it can introduce trifluoromethyl groups, which can significantly change the physical and chemical properties of compounds in many organic molecules. If it can increase its stability, lipophilicity, etc., it can help synthesize organic materials with special properties for high-end material research and development, such as new optoelectronic materials.
In the field of pharmaceutical chemistry, it also has extraordinary performance. With its participation in the reaction, novel drug molecular structures can be created, which provides the possibility for the development of specific drugs, or can open up new paths in the development of anti-cancer, antiviral and other drugs, and contribute to saving the world.
From this point of view, 4- (Trifluoromethyl) Iodobenzene has unlimited potential in the application field, which cannot be ignored in chemical research and industrial practice.

Research & Development

I am dedicated to the research of 4- (trifluoromethyl) iodobenzene. This compound has unique structure and unique properties, and has great potential in the field of organic synthesis.
At the beginning, I explored the method of its synthesis. After many attempts, referring to ancient books and previous sages, I tried it with a variety of raw materials and different paths. In case of reaction blockage, the yield is not as satisfactory, but I dare not slack off.
Then, study its reaction characteristics. Observe its action with various reagents, and observe the effect of changing conditions on the product. In the exploration of the reaction mechanism, I also worked hard to understand why.
After long-term research, there is a slight success. The synthesis method is gradually optimized, and the yield is improved. And the reaction law is also deeply understood. I hope this research can pave the way for the subsequent development, make this compound shine in more fields, and promote the progress of chemistry.

Toxicity Research

Nowadays, there is a chemical substance named 4- (trifluoromethyl) iodobenzene, and the study of its toxicity is quite important.
To study the toxicity of this substance, it is necessary to observe its properties in various environments. Looking at its structure, it contains trifluoromethyl and iodine atoms, or has special chemical properties, which may involve toxicity.
In organisms, it may interact with cell components. Or break the structure of cell membranes, interfere with the transmission of intracellular signals, resulting in abnormal cell function.
And observe its experimental data, if applied to animals, observe its reaction. Such as observing changes in behavior and physiological indicators. If there are signs of abnormal activity and organ damage, the existence of its toxicity can be proved.
It is also tested in the environment, or through migration, transformation. Or into water bodies and soils, affecting the ecological balance.
Therefore, detailed study of the toxicity of 4- (trifluoromethyl) iodobenzene is of great significance to ensure biological safety and ecological stability.

Future Prospects

The product of 4- (trifluoromethyl) iodobenzene has come to the fore in today's chemical research. Although it is only a microscopic quality at the moment, its future development cannot be limited.
On the road of chemistry, new quality emerges, and each thing can either open up new paths or expand new fields. 4- (trifluoromethyl) iodobenzene, with its unique structure and unique properties, may be a powerful tool in the field of organic synthesis. It can lead to various reactions, turning ordinary into magical, and making extraordinary products.
In the future, it may be used to assist in medical research and development, to make special drugs, and to treat various diseases; or it may be used to create materials, to obtain strange materials, and to have extraordinary properties. Although the road ahead is uncertain, with the diligence of our generation of chemical researchers, we will definitely be able to explore its potential, develop its brilliance, and create a new chapter for human well-being. This is what our generation hopes for in the future.

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Frequently Asked Questions

As a leading 4-(Trifluoromethyl)Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4- (Trifluoromethyl) Iodobenzene?

4- (trifluoromethyl) iodobenzene is a crucial intermediate in the field of organic synthesis and plays a key role in the preparation of many fine chemicals.
First, it plays a significant role in the synthesis of fluorinated drugs. Fluorinated drugs often have higher biological activity, metabolic stability and fat solubility due to the unique properties of fluorine atoms, such as strong electronegativity and small atomic radius. 4- (trifluoromethyl) iodobenzene, as a fluorine-containing structural unit, can be connected to the molecular skeleton of drugs through various chemical reactions, such as palladium-catalyzed cross-coupling reactions, thus helping to develop new and efficient drugs. For example, in the development of anti-cancer drugs, by introducing this structural unit, it may be possible to optimize the ability of drugs to bind to targets and improve drug efficacy.
Second, it is also indispensable in the field of materials science. In the preparation of organic optoelectronic materials, it can participate in the construction of conjugated systems, endowing materials with unique electrical and optical properties. With the electron-withdrawing properties of trifluoromethyl and the reactivity of iodine atoms, it can regulate the energy level structure and carrier transport properties of materials. For example, it can be used to prepare organic Light Emitting Diode (OLED) materials, or it can improve the luminous efficiency and stability of devices.
Third, as a key raw material for the synthesis of other fluorine-containing aromatic compounds, it can be derived through nucleophilic substitution, metal catalytic coupling and other reactions, and a variety of fluorine-containing compounds can be derived, expanding the types of fluorine-containing organic compounds, providing a rich material basis for the development of organic synthesis chemistry.
In conclusion, 4 - (trifluoromethyl) iodobenzene has shown broad application prospects in many fields such as medicinal chemistry and materials science due to its unique structure and reactivity, and has promoted technological innovation and development in related fields.

What are the synthesis methods of 4- (Trifluoromethyl) Iodobenzene?

There are several common methods for synthesizing 4- (trifluoromethyl) iodobenzene.
One is to use benzene derivatives containing trifluoromethyl as the starting material and prepare it by halogenation reaction. For example, p-trifluoromethylaniline is used as the starting material and reacts with potassium iodide after diazotization. First, p-trifluoromethylaniline and sodium nitrite are diazotized in an acidic low temperature environment to form diazonium salts. This process requires strict temperature control to prevent the decomposition of diazonium salts. Then add potassium iodide solution, and the diazonium group is replaced by iodine, so 4 - (trifluoromethyl) iodobenzene is obtained. The advantage of this method is that the raw materials are relatively easy to obtain and the steps are relatively clear; however, the diazotization reaction requires low temperature operation, the conditions are more severe, and the sodium nitrite is dangerous, so the operation needs to be cautious.
The second can be reacted with trifluoromethylbenzene and iodine in the presence of an appropriate catalyst. The commonly used catalysts are copper salts, such as cuprous iodide. In this reaction system, trifluoromethylbenzene and iodine are catalyzed by cuprous iodide, the presence of ligands, and the action of appropriate bases to achieve the substitution of iodine for benzene cyclohydrogen. In this process, the ligand can enhance the activity and selectivity of the catalyst, and the base can help to promote the reaction. This method is relatively mild in operation and does not require high equipment; however, the cost of catalyst and ligand may be higher, and the reaction time may be longer.
Third, it is synthesized by Grignard reagent method. First, Grignard reagent containing trifluoromethyl is prepared, such as by reacting trifluoromethyl halogenated hydrocarbons with magnesium in anhydrous ether or tetrahydrofuran solvents. After that, the Grignard reagent reacts with iodine aromatic hydrocarbons or related halides and converts into 4- (trifluoromethyl) iodobenzene through a series of reactions. This method can achieve specific structure construction and is of great significance for complex molecular synthesis; however, the preparation of Grignard reagents requires an anhydrous and oxygen-free environment, which requires harsh conditions and high operation requirements.

What are the physical properties of 4- (Trifluoromethyl) Iodobenzene?

4- (trifluoromethyl) iodobenzene is an important compound in organic chemistry. It has unique physical properties and is worthy of detailed investigation.
First of all, its appearance, at room temperature, 4- (trifluoromethyl) iodobenzene is colorless to light yellow liquid, with a clear texture. In sunlight, its shimmering light can be seen, just like a mysterious liquid. The characteristics of this color state make it visible to the naked eye in many organic liquids.
The boiling point of the compound is about 187-189 ° C. When heated to this point, the compound gradually changes from liquid to gaseous state. This boiling point characteristic is of great significance in the experimental operation of separation and purification. If purified by distillation and the temperature is precisely controlled within this range, pure 4- (trifluoromethyl) iodobenzene can be obtained.
Furthermore, the melting point is about -27 ° C. When the ambient temperature drops, the compound condenses from liquid to solid. Knowing the melting point is crucial during storage and transportation. If transported in cold areas, pay attention to the temperature to prevent it from solidifying and causing damage to the container.
Its density is about 1.88 g/mL, which is heavier than water. If it is placed in a container with water, it can be seen that it sinks to the bottom of the water, such as stone entering the water. This density characteristic can be used in liquid-liquid separation operations to facilitate effective separation of substances.
In terms of solubility, 4- (trifluoromethyl) iodobenzene is insoluble in water, but it can be miscible with common organic solvents, such as ether, dichloromethane, etc. This solubility provides convenience for organic synthesis reactions. Many reactions need to be carried out in an organic solvent system, and its good solubility allows full contact of the reactants and promotes the smooth occurrence of the reaction.
4- (trifluoromethyl) iodobenzene has a low vapor pressure, which means that it evaporates slowly at room temperature and pressure. This property is an advantage when storing and using, which can reduce its volatilization loss and maintain its chemical content.
In conclusion, the physical properties of 4 - (trifluoromethyl) iodobenzene are of critical significance in organic synthesis, storage, transportation, separation and purification, and are well known and well used by organic chemists.

What are the precautions for 4- (Trifluoromethyl) Iodobenzene in storage and transportation?

4- (trifluoromethyl) iodobenzene is a reagent commonly used in organic synthesis. When storing and transporting, many matters must be paid attention to.
First, storage, this substance is quite sensitive to environmental factors. First, it should be stored in a cool and dry place. Cover it when it is hot or wet, it is easy to cause chemical changes, or cause reactions such as decomposition. Second, it should be placed in a well-ventilated place. Because it may volatilize irritating gases, if the ventilation is poor, the gas will accumulate, which will not only damage the storage environment, but also be harmful to the health of the operator when it is used. Third, be sure to keep away from fire sources and oxidants. This substance is flammable to a certain extent, and it is easy to react violently when it encounters oxidants, causing danger. Storage containers should be made of corrosion-resistant materials, such as glass or specific plastics, to prevent chemical reactions with the container.
As for transportation, there are also many points. Before transportation, ensure that the packaging is tight. Choose appropriate packaging materials to effectively prevent leakage. During transportation, maintain stability, avoid violent vibration and collision, and prevent package damage. And the transportation environment temperature should be strictly controlled, follow relevant regulations, and should not be too high or too low. At the same time, transportation personnel should be familiar with the characteristics of this substance and emergency treatment methods. In case of leakage and other accidents, appropriate measures can be taken in time to reduce the harm.
4- (trifluoromethyl) iodobenzene requires thorough consideration and careful treatment during storage and transportation, from environmental conditions to packaging and personnel, in order to ensure safety.

What is the market outlook for 4- (Trifluoromethyl) Iodobenzene?

4- (trifluoromethyl) iodobenzene is an important raw material for organic synthesis. It is widely used in medicine, pesticides, materials science and other fields. Its market prospect is quite promising.
Looking at the field of medicine, this compound is often a key intermediate for the synthesis of new drugs. Today's pharmaceutical research and development is mostly moving towards the direction of high efficiency and low toxicity. 4- (trifluoromethyl) iodobenzene has special structures and properties, which can introduce specific functional groups and help create drug molecules with unique pharmacological activities. With the increasing demand for the treatment of difficult diseases, the research and development of new drugs continues to continue unabated, so the demand for such intermediates is also increasing steadily.
In the field of pesticides, it is also an important component in the synthesis of specific pesticides. Modern agriculture has a great demand for high-efficiency and low-residue pesticides in order to seek high yield and stable yield. 4- (trifluoromethyl) iodobenzene can endow pesticide molecules with better biological activity and stability to deal with various diseases and pests. Coupled with the increasing global attention to food safety and environmental protection, it promotes the transformation of the pesticide industry to green and high efficiency. As a key raw material for the synthesis of new pesticides, this compound has broad market prospects.
As for the field of materials science, with the rapid development of high-tech industries such as electronics and optics, the demand for high-performance materials has risen sharply. 4- (trifluoromethyl) iodobenzene can be used to prepare polymer materials and electronic materials with special functions. For example, in the synthesis of organic Light Emitting Diode (OLED) materials, its unique structure may improve the photoelectric properties of the material and enhance the luminous efficiency and stability of the device. With the continuous expansion of the high-tech industry, the demand for this compound in material synthesis will also rise.
Furthermore, from the perspective of the global chemical industry landscape, chemical technology continues to innovate, and the requirements for the purity and performance of fine chemicals are becoming more and more stringent. 4 - (trifluoromethyl) iodobenzene, as a fine chemical product, its synthesis process is also continuously optimized, and the production cost may be gradually reduced, thereby enhancing its market competitiveness. And with frequent international trade, the global market has promoted the circulation and demand of such characteristic organic compounds. Overall, the market for 4- (trifluoromethyl) iodobenzene is promising and will play an increasingly important role in the development of various related fields.