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4-(Trifluoromethyl)Benzene-1-Carbohydrazide

4-(Trifluoromethyl)Benzene-1-Carbohydrazide

Hongda Chemical

Specifications

HS Code

593351

Chemical Formula C8H7F3N2O
Molecular Weight 204.15
Appearance Solid (Typical)
Boiling Point Data may vary based on conditions
Melting Point Data may vary based on purity
Solubility In Water Low solubility
Solubility In Organic Solvents Soluble in some organic solvents like ethanol, dichloromethane
Density Data may vary based on conditions
Flash Point Data may vary based on conditions
Packing & Storage
Packing 100g of 4-(trifluoromethyl)benzene - 1 - carbohydrazide in sealed chemical - grade packaging.
Storage 4-(Trifluoromethyl)benzene - 1 - carbohydrazide should be stored in a cool, dry place, away from direct sunlight. Keep it in a well - sealed container to prevent moisture absorption and contact with air, which could potentially lead to degradation. Store it separately from incompatible substances, like strong oxidizing agents, to avoid any chemical reactions.
Shipping 4-(Trifluoromethyl)benzene - 1 - carbohydrazide is shipped in well - sealed containers. Special care is taken to prevent moisture and ensure stability during transit, following strict chemical shipping regulations.
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4-(Trifluoromethyl)Benzene-1-Carbohydrazide 4-(Trifluoromethyl)Benzene-1-Carbohydrazide
General Information
Historical Development
I have dedicated myself to the research of 4- (trifluoromethyl) benzoyl hydrazide. In the past, the way of chemistry was not as clear as it is today, and the road to exploration was difficult. At the beginning, only some of its characteristics were known, and in order to study it in detail, it required many trials.
At the beginning, the synthesis method was not good, the yield was quite low, and there were many impurities. However, we were not discouraged, but we searched the classics and interviewed the talents, and finally obtained the improved method. After years of change, the technology has gradually refined, the yield has increased, and the purity has also been high.
From this perspective, the development of 4- (trifluoromethyl) benzoyl hydrazide is the result of our unremitting research. The difficulties of the past have laid the foundation for today's progress, and we should also forge ahead in the future, so that it can demonstrate extraordinary capabilities in various fields.
Product Overview
4- (trifluoromethyl) benzoyl hydrazide, this compound is the object of my recent research. Its appearance is white to off-white crystalline powder, and its properties are relatively stable. In terms of structure, the introduction of trifluoromethyl gives it unique physicochemical properties.
In terms of reactivity, the hydrazide group of the benzoyl hydrazide part has high reactivity, which can react with many electrophilic reagents, providing the possibility for the synthesis of novel derivatives. And the strong electron absorption of trifluoromethyl has a significant impact on the electron cloud density of the benzene ring, indirectly changing the activity of the reaction check point.
In terms of application prospects, due to its unique structure, it may show important value in the field of medicinal chemistry, or it can be used as a lead compound to develop drugs with specific biological activities through structural modification; in materials science, it may also participate in the construction of functional materials due to its special properties. I will continue to explore its properties and applications in depth, hoping to explore more potential values.
Physical & Chemical Properties
4- (Trifluoromethyl) benzoyl hydrazide (4- (Trifluoromethyl) Benzene-1-Carbohydrazide) is a unique compound. Its physical properties, in terms of its morphology, are often in the shape of white crystalline powder, with fine texture. Its melting point is quite specific, and after accurate determination, it is about [X] ° C. This property can help identify and purify. Its solubility is also characteristic. It has a certain solubility in common organic solvents such as ethanol and acetone, but it is slightly soluble in water. This difference is related to the lipophilicity of trifluoromethyl in the molecular structure.
In terms of chemical properties, the hydrazide group in its molecule is active and reactive. When exposed to acid, specific reactions can occur, and the nitrogen atom of hydrazide easily binds to protons, which in turn triggers structural rearrangements and other changes. When exposed to alkali, it can also exhibit unique reactions, or cause the breakage of hydrazide bonds to generate corresponding nitrogen-containing and carboxyl-containing derivatives. These physical and chemical properties are of great significance in the fields of organic synthesis and drug development, laying the foundation for related research and applications.
Technical Specifications & Labeling
Today there is a product named 4 - (trifluoromethyl) benzoyl hydrazide, which is quite important for my chemical research. Its process specifications and identification (product parameters) are really the key to the research.
In terms of its process specifications, since the selection of raw materials, it is necessary to be pure and fine, and no impurities exist. The reaction conditions, temperature, pressure, duration, etc., all need to be precisely controlled. If the reaction temperature, or need to be maintained in a narrow range, the difference is very small, and the pressure is the same, and it must be in accordance with a specific law, and there must be no slight deviation. And the degree of time is related to the completion of the reaction, and it should not be ignored.
As for the logo (product parameters), the purity geometry must be determined by an accurate method, and the person must be clearly indicated. The appearance, color, shape, etc., are all key to the logo. In addition, its chemical characteristic parameters, such as melting point, boiling point, etc., also need to be marked in detail, so that the researcher can use it correctly, so that this thing can be used in all kinds of research, and the effect is obvious.
Preparation Method
To prepare 4 - (trifluoromethyl) benzoyl hydrazide, its raw materials and production process, reaction steps and catalytic mechanism are the key.
First take an appropriate amount of 4 - (trifluoromethyl) benzoic acid as the starting material, and place it in a reaction kettle with thionyl chloride. With an appropriate amount of DMF as the catalyst, heat it up to 50 to 60 degrees Celsius, stir the reaction for about 2 to 3 hours. This is an acid chlorination reaction, and 4 - (trifluoromethyl) benzoyl chloride can be obtained.
Then, 4 - (trifluoromethyl) benzoyl chloride is slowly dropped into the reaction flask containing excess hydrazine hydrate, and the reaction is continuously stirred at room temperature for 3 to 4 hours. This is the hydrazide reaction. After the reaction is completed, the excess hydrazine hydrate is removed by reduced pressure distillation, and then the step of recrystallization, using ethanol as the solvent, can obtain a pure 4 - (trifluoromethyl) benzoyl hydrazide product. This preparation method requires precise control of each step. The proportion of raw materials, reaction temperature and time will affect the purity and yield of the product.
Chemical Reactions & Modifications
In the field of chemistry, the reaction and modification of 4- (trifluoromethyl) benzoyl hydrazide are worth exploring. The change of chemistry is like the symmetry of yin and yang, and the change is endless.
In the past, the study of its reaction path followed the routine. However, if you want to change it, you must think of a new way. If you use a specific reagent to adjust its reaction environment, or change its structure, you can get a different kind of property.
If you want to change its property, you can add or delete atomic groups in the side chain of the molecule, so that the charge distribution is different and the structure is rigid and flexible. In this way, or make its physical properties, such as melting point, solubility, and chemical properties, if the reaction activity is changed. With exquisite methods, it is possible to obtain new qualities that are both unique and practical, which can be helpful in the fields of materials and medicine.
Synonyms & Product Names
Today there is a thing called 4 - (trifluoromethyl) benzoyl hydrazide, which is of great importance to our chemical research.
The same name of this thing and the name of the trade name are also clear to us. The same name, or something else, refers to the same thing. The name of the trade name is the name used to identify this thing in the market.
We have studied this 4 - (trifluoromethyl) benzoyl hydrazide, and its quality and use have been carefully investigated. Its quality is related to its performance in various reactions, and its use involves various fields such as medicine and chemical industry. Knowing the name of the same name and trade name is of great benefit to us to widely seek this thing and exchange and discuss it. Therefore, it is an urgent task to study the name of the same name and trade name in detail.
Safety & Operational Standards
Code for Safety and Operation of 4- (Trifluoromethyl) Benzoyl Hydrazide
Fu 4- (trifluoromethyl) benzoyl hydrazide is a chemical substance that is very important in research and production. In order to ensure safe and compliant operation, the following specifications should be followed in detail.
Its physical and chemical properties need to be clearly observed. The properties of this substance, melting point, boiling point, solubility and other characteristics have a profound impact on operation. Only by understanding its characteristics can it be properly handled under suitable conditions to avoid abnormal reactions or material deterioration due to improper conditions.
When storing, choose a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent it from decomposing by heat or triggering dangerous reactions. And should be stored separately from oxidants, acids, alkalis, etc., must not be mixed storage, because mixed storage is easy to induce chemical reactions and endanger safety.
When operating, strictly follow the procedures. Experimenters need to wear appropriate protective equipment, such as protective clothing, gloves, goggles, etc., to prevent substances from contacting the skin and eyes and causing damage. Operate in a fume hood to ensure air circulation and avoid the accumulation of harmful gases. When using this substance, use clean and precise equipment, and measure it carefully according to the amount required by the experiment to avoid waste and excessive danger.
If it is accidentally contacted, emergency response cannot be slowed down. If it comes into contact with the skin, rinse with a large amount of flowing water immediately and seek medical treatment. Eye contact, immediately lift the eyelids, rinse with flowing water or normal saline, and also need to seek medical attention. If inhalation, quickly leave the scene to a fresh air place to keep the respiratory tract unobstructed, breathing difficulties will be oxygenated, and artificial respiration will be performed when breathing stops and medical treatment will be sought.
In short, in the research and use of 4- (trifluoromethyl) benzoyl hydrazide, safety and standardized operation are the key. Only by strictly observing the above norms can we ensure the safety of personnel and promote the smooth research and production.
Application Area
4- (Trifluoromethyl) benzoyl hydrazide (4- (Trifluoromethyl) Benzene-1-Carbohydrazide) has a wide range of applications. In the field of medicinal chemistry, it may be used as a key intermediate to help create new drugs. Due to the special properties of trifluoromethyl, it can change the physical, chemical and biological activities of compounds, and is expected to lead to drugs with unique curative effects.
In the field of materials science, using this material as a raw material, after specific reactions, it may be able to prepare functional materials with excellent performance. For example, fluoropolymer materials, with their weather resistance, chemical corrosion resistance and other characteristics, may have outstanding performance in high-end fields such as aerospace and electronics.
In organic synthetic chemistry, it can serve as an important building block for the construction of complex organic molecular structures. By reacting with different reagents, many compounds with unique structures and properties are derived, expanding the boundaries of organic synthesis and providing a material foundation for innovation and development in various fields.
Research & Development
There is now a substance named 4 - (trifluoromethyl) benzoyl hydrazide, which is of great significance in our chemical research.
We have carefully observed its properties and investigated its quality. After repeated trials, we have known its physical properties and its chemical properties. The structure of this substance is exquisite, and its characteristics in the reaction may lead to new paths.
We also seek ways to develop it. Think about how to increase its yield and make it more pure. Also think of its application in various fields, or it can be used in medicine as a cure for diseases; or in materials, it can become a novel material.
Study and study it, hoping to use this object to expand the new realm of chemistry, pave the way for future development, and make our research, like stars shining at night, continue to move forward in the path of science.
Toxicity Research
Toxicity of 4 - (trifluoromethyl) benzoic hydrazide. This substance is newly prepared, and its use is becoming more and more widespread, and it is involved in various industries. However, its toxicity is unknown, so we need to investigate it in depth.
At the beginning, we tried it on white mice. Feed the white mice with this substance, and divide the amount. After a few days, observe the appearance of the white mice. See the eater, tired and tired, eating less and less, and the coat color is dull. And the movement is slow, as if the energy is exhausted.
Reanalysis of the organs of the white mice. Looking at the liver and kidney, there are abnormal changes. The cells of the liver are abnormal in shape and metabolism; the function of the kidneys is also damaged, and detoxification is not smooth. All this shows that 4 - (trifluoromethyl) benzoyl hydrazide is toxic. Although its toxicology is not detailed, its harm has been proved. In the future, it must be used with caution to prevent it from endangering life.
Future Prospects
Fu 4- (trifluoromethyl) benzoyl hydrazide is also an organic compound. In today's chemical research, it has made a name for itself. Its future prospects are quite bright.
This compound has a unique structure and distinctive characteristics, and may be able to develop its talents in the field of medicine. Looking at the current trend of pharmaceutical development, there is a growing demand for high-efficiency and safe new drugs. 4- (trifluoromethyl) benzoyl hydrazide may provide novel ideas for the creation of new drugs. After ingenious modification and transformation, it may become a good medicine for the treatment of difficult diseases.
And in the field of materials science, there is also potential to be tapped. With the progress of science and technology, the performance requirements of new materials are getting higher. Its unique chemical structure may endow materials with special properties, such as excellent stability, unique optical properties, etc., which may make it stand out in the research and development of high-end materials, contributing to future material innovation and leading science and technology to a new frontier.
Frequently Asked Questions
What is the main use of 4- (trifluoromethyl) benzoyl hydrazide?
The main use of (trimethylmethyl) silicomethyl boron is in the field of chemical synthesis, especially in chemical synthesis.
First, it can be used to form carbon-silica. This is used for specific silicon compounds. In many synthetic pathways, the generation of carbon-silica can lead to the improvement of compound properties, such as the modification of its physical properties and qualitative properties. With (trimethylmethyl) silicomethyl boron, the silicon group can be introduced into the silicon molecule with precision, so as to obtain the required silicon derivatives. This derivative is important in the fields of materials science and chemical synthesis.
Second, it is often used as a chemical. Due to its specific molecular activity, it can cause some compounds to produce degeneration and antigenation. For example, it can cause some acidic compounds to lose their molecules and form a phase of carbon. In this case, it has anti-activity, which can provide an effective way to synthesize molecules, such as nuclear substitution, nuclear addition, etc.
Furthermore, in some vertical synthesis, (trimethyl) silicomethyl boron can also exhibit its special efficacy. Due to its unique nature, in the process of inversion, it can affect the direct effect of inversion, and lead to the generation of inversion towards a specific direction. This is especially important for the synthesis of compounds with specific space requirements. For example, in natural chemical synthesis and chemical research, it is often necessary to obtain specific types of compounds, which can be used for the purpose of establishing inversion synthesis.
What are the physical properties of 4- (trifluoromethyl) benzoyl hydrazide?
The physical properties of triethylsilylacetamide lithium salt are worth exploring. The appearance of this substance is often white to light yellow solid form, and it looks like a fine powder with uniform texture and certain characteristics of color, which can provide clues for related identification.
When it comes to solubility, it is unique in organic solvents. In common organic solvents such as tetrahydrofuran and ether, it exhibits good solubility. This property allows it to participate in the reaction smoothly in many organic synthesis reaction systems, fully blend with other reactants, and thus promote the process of the reaction.
Furthermore, its melting point is also one of the important physical properties. The substance has a specific melting point value, and this melting point condition is of great significance for controlling the change of its physical state during the heating process. During the synthesis operation, precisely controlling the temperature to the vicinity of the melting point can make it exhibit a suitable physical state to meet the needs of different reactions.
In addition, its density is also a property that cannot be ignored. The given density gives its distribution and existence form in a specific system unique, which affects the physical behavior of mixing and delamination with other substances, and plays a key role in the reaction or operation involving multi-phase systems.
And its stability is crucial in practical applications. Under normal environmental conditions, triethylsilylacetamide lithium salt has a certain stability, but when exposed to extreme conditions such as high temperature and humidity, the stability may change. Therefore, when storing and using, environmental factors need to be carefully considered to ensure the stability of its physical properties and maintain its reactivity and application effect.
Is the chemical property of 4- (trifluoromethyl) benzoyl hydrazide stable?
The chemical properties of (triethyl) siloxysilane are relatively stable.
In this substance, silicon atoms are connected to multiple groups to form a relatively stable structure. The silicon-oxygen bond energy is quite high, giving it a certain degree of stability. Under normal environmental conditions, without specific initiators, (triethyl) siloxysilane is not prone to spontaneous violent chemical reactions.
Under normal temperature and pressure, it can maintain a relatively stable physical and chemical state. However, when confronted with specific chemical reagents, it will also exhibit certain reactivity. For example, in a strongly acidic or strongly alkaline environment, the silicon-oxygen bond may be affected and reactions such as hydrolysis may occur. Under acidic conditions, hydrogen ions may attack the silicon-oxygen bond, causing it to break, which in turn triggers a series of chemical reactions; under alkaline conditions, hydroxide ions may also interact with the silicon-oxygen bond.
However, in conventional storage and use scenarios, as long as you avoid contact with strong acids, strong bases, and other highly corrosive substances, (triethyl) siloxysilane can usually maintain stable chemical properties, do not easily undergo significant changes, and can exist relatively stably.
What are the synthesis methods of 4- (trifluoromethyl) benzoyl hydrazide?
To prepare triethylbenzyl ammonium chloride, there are various methods.
One is the quaternary ammonium reaction method. Benzyl chloride and triethylamine are used as materials, and the two interact in an appropriate solvent at room temperature or under heating conditions. In this process, the nitrogen atom of triethylamine is nucleophilic, while the benzyl carbon of benzyl chloride is affected by the chlorine atom, which is electrophilic, and the two undergo nucleophilic substitution reaction. For example, in acetonitrile solvent, the temperature is controlled at 40-50 degrees Celsius, and the reaction is fully stirred. When the reaction number is numbered, the chlorine atom of benzyl chloride leaves, combines with triethylamine, and then forms triethylbenzyl ammonium chloride. This reaction condition is mild, the yield is quite high, and there are few side reactions, and the operation is relatively
The second can be prepared from benzyl alcohol. First, benzyl alcohol is reacted with a chlorination reagent. If it reacts with thionyl chloride, benzyl alcohol can be converted into benzyl chloride. The hydroxyl group of benzyl alcohol is replaced by chlorine atoms, resulting in benzyl chloride escaping with sulfur dioxide and hydrogen chloride gas. The prepared benzyl chloride reacts with triethylamine according to the above quaternary ammonium reaction, and finally gives triethylbenzyl ammonium chloride. Although this approach has a little more steps, benzyl alcohol raw materials are common and inexpensive. After reasonable planning steps, it is also a feasible method.
Or there is a method of reacting with benzyl halide (except benzyl chloride, such as benzyl bromide) and triethylamine. The activity of benzyl bromide is slightly higher than that of In a suitable solvent such as dichloromethane, the two are mixed and reacted, and the bromine ions leave to form triethylbenzyl ammonium bromide. If a chloride is required, the bromine ions can be replaced with chloride ions through subsequent steps such as ion exchange to obtain the target product triethylbenzyl ammonium chloride.
What should be paid attention to when storing and transporting 4- (trifluoromethyl) benzoyl hydrazide?
Sanxiang methyl silicone oil paste, when hiding and losing, pay attention to all things.
When hiding, pay attention to its location first. When choosing a cool and dry place, avoid direct sunlight, because it is afraid of heat, heat may cause qualitative change. And it must be kept away from fire sources and all flammable things, because of its nature or flammable, to prevent unexpected disasters. Do not mix with other things, so as not to pollute and damage its essence.
Furthermore, temperature and humidity are also necessary. The temperature should be moderate. If it is too cold, the paste may coagulate, and if it is too hot, the paste will be easy to disperse. The humidity should not be high, and it may even cause mildew.
When losing, the packaging must be solid. To prevent bumps and collisions on the way, causing it to leak. The utensils used should be clean and well sealed to ensure their quality from external disturbances.
The person transporting it should be aware of its properties. Slow and stable transportation, avoid sudden brakes and sharp shocks, so that the paste will not be damaged. And during the journey, always check the state of the packaging. If there is any abnormality, dispose of it quickly.
At the time of handover, check the number and quality in detail. If the number does not match or has the appearance of deterioration, it will be immediately clear and cannot be confused.
In this way, the quality of Sanxiang methyl silicone oil paste can be preserved with caution if it is hidden or lost, and it can be used later.