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4-(Trifluoromethyl)-2-Methyl-1-Nitrobenzene

4-(Trifluoromethyl)-2-Methyl-1-Nitrobenzene

Hongda Chemical

    Specifications

    HS Code

    846037

    Chemical Formula C8H6F3NO2
    Molar Mass 205.134 g/mol
    Appearance liquid (presumably, based on similar compounds)
    Solubility In Water low solubility (due to non - polar aromatic and fluorinated groups, and a polar nitro group, but overall hydrophobic nature)
    Solubility In Organic Solvents soluble in common organic solvents like dichloromethane, chloroform, toluene
    Vapor Pressure low vapor pressure at room temperature (due to relatively high molar mass and polar groups)

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    Packing & Storage
    Packing 1 kg of 4-(trifluoromethyl)-2 - methyl - 1 - nitrobenzene in a sealed chemical - grade drum.
    Storage 4-(Trifluoromethyl)-2 - methyl - 1 - nitrobenzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and bases to prevent potential reactions. Ensure proper labeling for easy identification.
    Shipping 4-(Trifluoromethyl)-2 -methyl-1 -nitrobenzene, a chemical, should be shipped in well - sealed, corrosion - resistant containers. Follow proper hazardous material shipping regulations, ensuring secure packaging to prevent leaks during transit.
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    4-(Trifluoromethyl)-2-Methyl-1-Nitrobenzene 4-(Trifluoromethyl)-2-Methyl-1-Nitrobenzene
    General Information
    Historical Development
    Fu 4- (trifluoromethyl) -2-methyl-1-nitrobenzene is also an organic compound. The process of its research and development is really meaningful. At the beginning, Zhu Xian was diligent in exploring the field of chemistry, expecting to make progress in organic synthesis.
    At that time, chemical technology was still in the stage of development, and all kinds of synthesis methods were not perfect. However, the determination of scholars was strong, and they worked tirelessly. After years of work, various reaction mechanisms have been gradually clarified, and material selection and control conditions have become more accurate.
    In recent years, with the increasing technology and sophisticated instruments, the method of synthesizing this compound has become more and more mature. From the refining of raw materials to the precise regulation of reaction conditions, there have been improvements. Its development process relies on the wisdom and hard work of chemists of all ages to achieve today's achievements and gain a place in the field of organic chemistry.
    Product Overview
    Description of 4- (trifluoromethyl) -2-methyl-1-nitrobenzene
    V 4- (trifluoromethyl) -2-methyl-1-nitrobenzene is an important intermediate in organic synthesis. Its color is yellowish, like an oil, and has a special odor. In the chemical industry, it has a wide range of uses.
    The preparation of this product often follows a specific chemical path. It can only be obtained by starting with the corresponding aromatic hydrocarbon and undergoing various reactions such as halogenation, nitrification, and fluorination, and fine regulation conditions. In the reaction, temperature, reagent ratio, and catalyst are all key, and a slight deviation or change in yield and purity.
    Its properties are stable, and it can also undergo delicate transformations when encountering specific reagents. In pharmaceutical research and development, it may be the cornerstone of the synthesis of special drugs; in materials science, it may help the birth of new materials. And because of its unique chemical structure, it has potential in many fields, attracting the attention of chemical researchers, hoping to explore more applications to benefit human society.
    Physical & Chemical Properties
    4- (trifluoromethyl) -2-methyl-1-nitrobenzene, this compound has unique physical and chemical properties. Its appearance is light yellow to light brown liquid, which is relatively stable at room temperature and pressure. The boiling point is about 230-235 ° C. Due to the presence of trifluoromethyl in the molecule, it has certain hydrophobicity. The density is about 1.35-1.40 g/cm ³, and it is heavier than water.
    From a chemical point of view, the presence of nitro groups makes the compound have certain oxidation and reactivity, and can participate in many organic reactions, such as nucleophilic substitution reactions. Under suitable conditions, nitro groups can be reduced to amino groups. Methyl and trifluoromethyl affect the electron cloud distribution and spatial structure of molecules, which in turn affect their chemical behavior. Trifluoromethyl has strong electron-absorbing ability, which will enhance the inhomogeneity of electron cloud density on the benzene ring, and affect the reaction check point and activity.
    Technical Specifications & Labeling
    There is now a technique for making 4- (trifluoromethyl) -2-methyl-1-nitrobenzene. The technique needs to follow a certain rule, which is related to the distribution of materials, the control of the heat, and the order of the process. The materials are carefully selected and the proportions are accurate. Such as the amount of various ingredients, are all key parameters.
    When operating, put materials into a specific device in sequence. First heat up with a slow fire, wait until a specific temperature, stabilize it, and observe the reaction. The changes in color and smell during this period are all characteristics and need to be observed in detail. Then adjust the heat to the fire, and urge it to respond quickly, but do not be too hasty to prevent it from getting out of control.
    After the reaction is completed, purify it by various methods. Or filter it to remove its insolubility; or steam it to divide it into different boiling points. The resulting product should meet all standards. Looking at its color, it should be pure and free of impurities; measuring its degree, the value should be within a certain limit. In this way, it can be obtained in the specification of 4 - (trifluoromethyl) - 2 - methyl - 1 - nitrobenzene.
    Preparation Method
    The method of making 4 - (trifluoromethyl) - 2 - methyl - 1 - nitrobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. First take an appropriate amount of 2 - methyl benzene, put it in the reactor, add trifluoromethylation reagent, adjust the reaction temperature to an appropriate temperature, control the pressure and flow steady, so that the two are combined. This is the initial step. After the initial application, slowly add the nitrifying reagent, finely adjust the reaction conditions, so that the nitro can be accurately connected to the predetermined position, and the addition of the catalyst can promote the reaction to accelerate and optimize the yield. Each step of the reaction requires close observation of its progress. By means of a variety of testing methods, it is confirmed that the reaction proceeds as expected. After the completion of the process, the pure 4 - (trifluoromethyl) - 2 - methyl - 1 - nitrobenzene product can be obtained through the process of separation and purification.
    Chemical Reactions & Modifications
    In the field of chemistry, the reaction and modification of Guanfu 4- (trifluoromethyl) -2-methyl-1-nitrobenzene are particularly crucial.
    The method of the past, in order to make this product, the reaction path is often complicated. The reaction conditions are harsh, the selection of raw materials is also laborious, and the yield is not ideal.
    Today is different from the past, the researchers have devoted themselves to the study of the reaction mechanism. Optimize the reaction environment and select the appropriate catalyst, so that the reaction can be carried out in a milder environment. The way of modification has also been improved. After delicate molecular modification, the distribution of its electron cloud has been adjusted, which has greatly changed the properties of the substance. The stability is increased, the activity can be controlled, and it has better application prospects in many fields. This is a good example of the reaction and modification of 4- (trifluoromethyl) -2-methyl-1-nitrobenzene.
    Synonyms & Product Names
    There is a substance named 4 - (trifluoromethyl) - 2 - methyl - 1 - nitrobenzene. This substance is widely used in the field of chemical industry. Its aliases also exist.
    or trifluoromethyl nitrobenzene, which is known for its structural characteristics. This name is concise, indicating its key components, so that the wearer can have a brief overview of its molecules.
    It is also called fluoromethyl nitrobenzene, emphasizing the important position of fluorine in it. The characteristics of fluorine often give substances unique properties, and this name is also known for its characteristics.
    As for the name of the product, it may be based on its use, performance, or market positioning. Or excellent fluoro-nitro agent, "excellent" indicates its excellent quality; "fluorine" refers to fluorine element, "nitro" indicates its chemical properties, and "agent" indicates its application form. All of these are for the convenience of the industry to identify and use, so as to help this substance in the chemical industry.
    Safety & Operational Standards
    4- (trifluoromethyl) -2-methyl-1-nitrobenzene, this chemical is related to safety and operating standards, and is extremely important and needs to be explained in detail.
    In terms of safety, 4- (trifluoromethyl) -2-methyl-1-nitrobenzene is dangerous. It is flammable and can easily cause combustion and explosion in case of open flames and hot topics. Therefore, fireworks must be strictly prohibited in storage and use places, and perfect fire extinguishing facilities must be equipped. At the same time, the substance is also harmful to the human body. If it touches the skin inadvertently, it should be rinsed with a large amount of flowing water immediately. If it still feels uncomfortable after rinsing, it is necessary to seek medical attention in time. If it touches the eyes, it should be rinsed with a large amount of water quickly, open the eyelids, and ensure thorough rinsing. Then seek medical treatment immediately. Inhalation of volatile gases from this substance may also damage the respiratory tract. The working environment should be well ventilated, and the operator should wear an effective gas mask if necessary.
    In terms of operating specifications, when taking 4- (trifluoromethyl) -2-methyl-1-nitrobenzene, be sure to handle it with care to avoid leakage caused by damage to the container. The operation process should strictly follow the established procedures. Before experiment or production, the operator should be familiar with the operation steps and emergency treatment methods. After use, the remaining chemicals should be properly stored in designated containers, disposed of according to regulations, and must not be discarded at will. It should also be stored in a cool, dry and well-ventilated place, away from fire and heat sources, and stored separately from oxidants and food chemicals. Do not mix storage, and make corresponding labels for easy identification and management. In this way, the safety of 4- (trifluoromethyl) -2-methyl-1-nitrobenzene during use can be ensured and accidents can be avoided.
    Application Area
    4- (trifluoromethyl) -2-methyl-1-nitrobenzene has a wide range of application fields. In the field of medicinal chemistry, it can be used as a key intermediate to help create new special drugs, fight difficult diseases, and save patients from pain. In the field of materials science, it can contribute to the synthesis of special functional materials, so that the materials have unique properties, such as excellent stability and special optical properties. In terms of pesticide research and development, based on this, it is expected to develop high-efficiency and low-toxicity pesticides to protect crops from pests and diseases and ensure a bumper harvest. The application of this compound in various fields is like a shining star, illuminating the road of scientific and technological progress, adding luster to human well-being, and will also bloom more splendid in the future, injecting majestic impetus into the development of various fields.
    Research & Development
    The product of 4- (trifluoromethyl) -2-methyl-1-nitrobenzene is becoming increasingly important in the chemical industry. We have dedicated ourselves to studying its synthesis path and strive to improve it. In the past, the synthesis method may have complicated steps or the yield was not ideal. After repeated trials, we have improved the process to improve the yield and better product purity.
    This product has great application potential in materials science, medical chemistry and other fields. In materials science, it can be used as a key component of new materials to improve the special properties of materials; in pharmaceutical chemistry, or an important intermediate for the development of specific drugs.
    However, the road to research and development still faces challenges. During the synthesis process, some reaction conditions are severe, which requires extremely high equipment and operation. In the future, we should continue to explore and optimize the conditions, hoping to achieve more efficient and greener production, and promote the wide application of this product to promote the development of the chemical industry.
    Toxicity Research
    Fu 4- (trifluoromethyl) -2-methyl-1-nitrobenzene This substance is of great importance to toxicity studies. We have carefully observed its properties to understand its effects on living beings.
    At first, looking at its chemical structure, trifluoromethyl is combined with nitro and methyl in the benzene ring, or causes its properties to be different. Take animals as tests, and observe their oral, percutaneous and inhalation. During oral tests, the subject is seen, or has a digestive system disorder, lazy diet, and also abnormal. Where it is percutaneous, the skin may appear red, swollen, and allergic. When inhaled, the respiratory tract is disturbed, and the cough is short of breath.
    Also explore its effect at the cell level, and observe its effect on cell proliferation and apoptosis. See that it may prevent normal cell proliferation, disrupt its cycle, and induce apoptosis.
    In summary, 4- (trifluoromethyl) -2-methyl-1-nitrobenzene is toxic and potentially dangerous to the health of living beings. In the future, we should study its toxicology system as a preventive measure.
    Future Prospects
    Looking at this 4- (trifluoromethyl) -2-methyl-1-nitrobenzene, which is a chemical product, contains unique structures and properties. Looking forward to the future, its application has great potential.
    It may be able to shine in the field of materials. With its characteristics, the research and development of new functional materials, such as those with special optical and electrical properties, will inject new energy into the development of electronic devices and optical instruments.
    In the field of medicine, it is also expected to emerge. After in-depth research, its biological activity may be discovered, and it may become a key raw material for the creation of new drugs, contributing to human health and well-being.
    Or in agricultural chemistry, play a role. Or it can be developed as an efficient and low-toxicity pesticide to help the green and sustainable development of agriculture.
    In short, 4- (trifluoromethyl) -2-methyl-1-nitrobenzene has a bright future in the future. It is waiting for our scientific researchers to explore it in depth and open a new chapter.
    Where to Buy 4-(Trifluoromethyl)-2-Methyl-1-Nitrobenzene in China?
    As a trusted 4-(Trifluoromethyl)-2-Methyl-1-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-(Trifluoromethyl)-2-Methyl-1-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4- (trifluoromethyl) -2-methyl-1-nitrobenzene?
    4- (triethylmethyl) -2-methyl-1-propylnaphthalene, this is an organic compound. Its main uses are quite extensive and its contributions to the chemical industry are outstanding.
    First, it can be used as a key raw material for the synthesis of new materials. Through a series of chemical reactions, it can be cleverly combined with other compounds to prepare polymer materials with special properties. Such materials may have excellent heat resistance and can be used in the manufacture of parts in high temperature environments; or have excellent flexibility and are suitable for the manufacture of products that require frequent bending.
    Second, it also occupies an important position in the field of fine chemical products. It can be used as an important starting material for the synthesis of special fragrances and pharmaceutical intermediates. In the synthesis of fragrances, it endows fragrances with unique odor and stability, providing more possibilities for perfumers to create novel aromas; in the synthesis of pharmaceutical intermediates, it builds a key bridge for the synthesis of many drugs and helps to synthesize drug molecules with specific pharmacological activities.
    Third, in the study of organic synthesis reactions, it is often used as a model compound. With the help of in-depth investigation of the reactions they participate in, researchers can gain insight into the reaction mechanism, optimize the reaction conditions, and then promote the development of organic synthesis chemistry theory and technology, providing a solid theoretical foundation and practical experience for the efficient synthesis of more complex organic compounds.
    In summary, 4- (triethyl) -2-methyl-1-propylnaphthalene plays a key role in many fields of chemical industry due to its unique chemical structure, which is of great significance for promoting the progress of materials science, fine chemistry and organic synthetic chemistry.
    What are the physical properties of 4- (trifluoromethyl) -2-methyl-1-nitrobenzene?
    4- (trimethylphenyl) -2-methyl-1-naphthylbenzene, this is an organic compound with unique physical properties.
    Looking at its morphology, it is mostly solid at room temperature and pressure. Due to the strong force between molecules, the molecules are closely arranged, so it exists in a solid state. Its melting point value has been determined by many experiments and is within a certain range. This property plays a key role in its physical state change in a specific temperature environment.
    When it comes to solubility, this compound exhibits a certain degree of solubility in organic solvents. Organic solvents such as common benzene and toluene have good compatibility with them. This is due to the similarity between the molecular structure of the compound and the molecular structure of the organic solvent. According to the principle of "similarity and miscibility", the two can be mixed with each other. However, in water, its solubility is extremely poor and almost insoluble. This is due to the significant difference between the polarity of the water molecule and the molecular polarity of the compound, and it is difficult for the two to interact and dissolve each other.
    Its density is also one of the important physical properties. After precise measurement, it can be known that its density is larger or smaller than that of water, and the specific value is a specific value. This density characteristic determines its sinking and floating state in different media.
    Furthermore, the volatility of the compound is weak, because of the large intermolecular force, the energy required for the molecule to break away from the solid surface and enter the gas phase is higher This property makes it not easy to evaporate into the air at room temperature, and the stability is relatively high.
    In summary, the physical properties of 4- (trimethylphenyl) -2-methyl-1-naphthylbenzene, such as morphology, melting point, solubility, density and volatility, are essential for in-depth understanding of its chemical behavior, participation in chemical reactions, and performance in practical applications.
    Is the chemical property of 4- (trifluoromethyl) -2-methyl-1-nitrobenzene stable?
    The chemical properties of Futetra- (Sanxiang methyl) -2 -methyl-1 -cyanonaphthalene, related to its stability, need to be investigated in detail.
    Looking at the structure of this compound, tetra- (Sanxiang methyl) -2 -methyl-1 -cyanonaphthalene contains specific functional groups. Cyanyl groups have strong electronegativity, which can cause electron cloud migration and affect molecular chemical activity. The presence of methyl groups, although alkyl groups, can change the density of surrounding electron clouds and play a role in overall stability.
    In terms of reactivity, cyanyl groups can participate in many reactions, such as nucleophilic addition. Due to the partial positive electricity of carbon atoms, they are vulnerable to attack by nucleophilic reagents. The electricity supply of methyl groups may slightly reduce the positive electricity of cyanocarbon, which affects the nucleophilic reaction rate to a certain extent.
    In terms of stability, the bonding mode between atoms in a molecule and the distribution of electrons are the key. Each atom is connected by a covalent bond, and the bonding electron pair maintains the atomic bond. However, the interaction between cyanyl groups and methyl groups may cause uneven distribution of electron clouds, resulting in a certain tension in the molecule.
    Under normal conditions, if there is no strong external interference, this compound may remain relatively stable. However, in case of high temperature, strong acid or base or specific catalysts, the stability may be destroyed. High temperature can intensify the thermal movement of molecules, enhance the vibration of covalent bonds, and to a certain extent, the bonds are easy to break. Strong acids and bases can provide protons or hydroxide ions to react with functional groups in the molecule and change its structure.
    In summary, the stability of tetra- (Sanxiang methyl) -2-methyl-1-cyanonaphthalene is not absolute and is restricted by many factors. It is relatively stable under mild conditions, but under certain extreme environments or chemical reaction conditions, the stability will be challenged.
    What are the synthesis methods of 4- (trifluoromethyl) -2-methyl-1-nitrobenzene?
    To prepare 4 - (triethylamino) -2 - ethyl - 1 - naphthalonitrile, the method is as follows:
    First, 4 - bromo - 2 - ethyl - 1 - naphthalonitrile and triethylamine are used as raw materials, and the two are added to appropriate solvents, such as acetonitrile, N, N - dimethylformamide (DMF), etc., with an appropriate amount of base, potassium carbonate, sodium carbonate can be heated and refluxed for several hours. This reaction is the mechanism of nucleophilic substitution. The nitrogen atom in triethylamine is rich in electrons, launching a nucleophilic attack on the check point of the bromine atom of 4-bromo-2-ethyl-1-naphthalonitrile, and the bromine ion leaves, so it becomes the target product. After the reaction, the pure 4- (triethylamino) -2-ethyl-1-naphthalonitrile can be obtained by conventional separation and purification methods, such as column chromatography and recrystallization.
    Furthermore, 2-ethyl-1-naphthalonitrile can be used as a starting point. After halogenation, bromine or N-bromosuccinimide (NBS) is used as a halogenating agent. Under appropriate reaction conditions, the naphthalene ring is brominated at a specific position to obtain 4-bromo-2-ethyl-1-naphthalonitrile. The follow-up operation is as described above, and the target product can also be obtained. The key to this approach is the precise control of the halogenation step, so that the bromine atom is precisely located at the fourth position of the naphthalene ring.
    Another approach is to construct the naphthalene ring and the corresponding substituent through a multi-step reaction with appropriate starting materials. For example, first, the prototype of the naphthalene ring is constructed by means of a suitable aromatic hydrocarbon derivative and a reagent containing acetonitrile and ethyl group, and acetonitrile and ethyl are introduced, and then bromine atoms are introduced at specific positions in the naphthalene ring, and then reacted with triethylamine to finally obtain 4- (triethylamino) -2 -ethyl-1 -naphthalonitrile. Although this method has many steps, if the reaction conditions of each step are properly controlled, it is also a feasible method.
    What are the precautions for 4- (trifluoromethyl) -2-methyl-1-nitrobenzene in storage and transportation?
    Futetra- (triethyl alkyl) -di-ethyl-one-benzyl ether, there are several points to be paid attention to during storage and transportation.
    First, this substance is quite sensitive to changes in temperature and humidity. If the temperature is too high, the molecular movement will intensify, or its chemical structure will change, affecting its properties. If the humidity is too high, water molecules are easy to interact with the substance, or cause reactions such as hydrolysis, which will damage its purity and quality. Therefore, the storage place should be a cool, dry place, and put in equipment with temperature and humidity regulation to keep the environment stable.
    Second, this substance has a certain chemical activity. In case of strong oxidants, it is easy to cause violent oxidation reactions, or even risk combustion and explosion. When transporting, it must not be packed with strong oxidizing agents. Storage should also be separated from oxidizing agents, and clear signs and isolation measures should be set up in the warehouse to prevent accidental mixing.
    Third, its volatility should not be underestimated. In a closed space, the volatile gas gradually accumulates, or reaches flammable or harmful concentrations. Therefore, the storage place and transportation vehicles must be well ventilated to dissipate the volatile gas. And corresponding gas detection devices should be prepared to monitor the gas concentration of the substance in the environment in real time to prevent accidents.
    Fourth, this material has strict requirements on packaging. Packaging materials must have good sealing and corrosion resistance to prevent their leakage. During transportation, the package should also be prevented from being damaged due to bumps and collisions. If there is a leak, it should be dealt with promptly according to the established emergency measures to prevent it from spreading and causing greater harm.