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4-(Trifluoromethyl)-1-Tert-Butoxybenzene

4-(Trifluoromethyl)-1-Tert-Butoxybenzene

Hongda Chemical

    Specifications

    HS Code

    479469

    Chemical Formula C11H13F3O
    Molecular Weight 218.215 g/mol
    Appearance Typically a colorless to light - colored liquid
    Boiling Point Approximately 197 - 199 °C
    Density Around 1.08 - 1.12 g/cm³
    Vapor Pressure Low vapor pressure at room temperature
    Solubility Soluble in organic solvents like dichloromethane, toluene; insoluble in water
    Flash Point Estimated flash point around 70 - 80 °C
    Stability Stable under normal conditions, but reactive with strong oxidizing agents

    As an accredited 4-(Trifluoromethyl)-1-Tert-Butoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100 g of 4-(trifluoromethyl)-1 -tert -butoxybenzene packaged in a sealed, chemical - resistant bottle.
    Storage Store 4-(trifluoromethyl)-1-tert -butoxybenzene in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Use a tightly sealed container, preferably made of a suitable chemical - resistant material like glass or certain plastics, to prevent leakage and evaporation.
    Shipping 4-(Trifluoromethyl)-1-tert -butoxybenzene is shipped in well - sealed, corrosion - resistant containers. Shipment adheres to strict chemical transportation regulations, ensuring proper handling to prevent spills and maintain product integrity.
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    4-(Trifluoromethyl)-1-Tert-Butoxybenzene 4-(Trifluoromethyl)-1-Tert-Butoxybenzene
    General Information
    Historical Development
    In the field of organic synthesis, many sages thought hard and tried to explore new frontiers. In this field, this compound gradually came into view.
    At the beginning, the method of preparation was not good, it was difficult to obtain, and the production was also very little. However, the workers worked tirelessly to explore new ways and find wonderful methods. Over the years, the technique gradually became refined, and the law became better. From simple to complex, from coarse to fine, the quantity of its production gradually increased, and the quality also became better.
    Today, 4- (trifluoromethyl) -1-tert-butoxy benzene is used in all industries, either as a raw material for medicine or as a new auxiliary material. Remembering the past, it started from the end of the micro, and it has become apparent to this day. This is the diligent work of the chemical industry, and it is also one of the evidences of scientific evolution.
    Product Overview
    Today there is a substance called 4- (trifluoromethyl) -1 -tert-butoxy benzene. In its shape, it is a colorless and transparent liquid with a special odor. This substance is widely used in the chemical industry.
    Looking at its preparation method, it is often done by exquisite chemical techniques. It is obtained from a specific raw material through multiple reactions, rigorous temperature control and time adjustment. Its reaction mechanism is complex and profound, and requires detailed study and careful operation by chemists.
    In terms of its nature, its chemical activity is unique, and it can be used as a key intermediate in many chemical reactions. Because it contains trifluoromethyl and tert-butoxy, it is endowed with special chemical and physical properties, and can participate in a variety of organic synthesis, laying the foundation for the preparation of other fine chemicals.
    In industrial production and scientific research, 4- (trifluoromethyl) -1 -tert-butoxy benzene is of great value. However, when using, it is also necessary to pay attention to safety. Due to its chemical properties or latent risks, it must be operated according to specifications to ensure safety.
    Physical & Chemical Properties
    4- (trifluoromethyl) -1-tert-butoxy benzene is a molecule that has attracted much attention in organic synthesis. Its physical properties are colorless to light yellow liquid at room temperature, with a special odor, suitable boiling point, and volatilization at a specific temperature. This property makes it beneficial in separation and purification.
    From the perspective of chemical properties, the substance exhibits unique activity due to the presence of trifluoromethyl and tert-butoxy. Trifluoromethyl has strong electron absorption properties, which can affect the distribution of electron clouds in the benzene ring, making it more prone to electrophilic substitution reactions. Tert-butoxy protects the benzene ring to a certain extent, and can break under specific conditions and participate in subsequent chemical reactions. Due to its unique physical and chemical properties, 4- (trifluoromethyl) -1-tert-butoxybenzene has broad application prospects in many fields such as medicine, pesticides and materials science, and can provide key intermediates for the synthesis of new compounds.
    Technical Specifications & Labeling
    There is a product today, named 4- (trifluoromethyl) -1 -tert-butoxy benzene. The process specifications and identification (product parameters) of the product should be studied in detail.
    The process specifications, the choice of materials, must be fine and pure, in line with the law. The order of operation should be careful and dense, and follow the rules. The reaction environment, temperature, pressure and other variables need to be carefully observed and controlled.
    As for the logo (product parameters), its shape, smell, purity geometry, and melting point should all be clearly marked. Those who see it should be clear at a glance at the nature of the product. In this way, the quality of this thing can be guaranteed, and it can be used in various industries to obtain its own value, and it will not live up to the power of research and development.
    Preparation Method
    If you want to make 4- (trifluoromethyl) -1 -tert-butoxy benzene now, you should study the method of making it in detail. The raw materials are potassium tert-butoxide and 4- (trifluoromethyl) bromobenzene. In the synthesis process, first wash and dry the reaction vessel to control its anhydrous and oxygen-free environment. Add potassium tert-butoxide to an appropriate amount of organic solvent, often tetrahydrofuran, and stir it to dissolve. Then slowly drop in 4- (trifluoromethyl) bromobenzene, keep it at a moderate temperature, and do not make it too hot. When reacting, closely observe the phenomenon and measure it by gas chromatography or other methods.
    After the reaction is completed, quench the excess potassium tert-butoxide with dilute acid, and take the organic phase by means of liquid separation. After removing the water with a desiccant, the solvent and impurities are removed by the step of reduced pressure distillation to obtain pure 4- (trifluoromethyl) -1-tert-butoxy benzene. In this way, good products can be obtained.
    Chemical Reactions & Modifications
    In the chemical industry, if you want to find new products, you must study the way of reaction and modification. Today there is 4- (Trifluoromethyl) -1-Tert -Butoxybenzene, and the preparation method is related to the delicate reaction and the improvement of physical properties.
    Reactor, all raw materials are combined in a kettle, temperature and pressure are adjusted, and a catalyst is used to promote their synthesis. To obtain this compound, the choice of raw materials and the accuracy of the ratio are all key. It may be necessary to react an aryl halogen with a reagent containing trifluoromethyl and tert-butoxy in a suitable solvent by nucleophilic substitution.
    As for modification, or to improve its stability or to change its solubility, it is suitable for different purposes. It can be slightly modified in its structure to introduce functional groups to make it more soluble or reactive with others. In this way, the best product of 4- (Trifluoromethyl) -1-Tert -Butoxybenzene can be obtained to meet the needs of chemical industry and display its functions in materials, medicine and other industries.
    Synonyms & Product Names
    Today there is a thing called 4- (trifluoromethyl) -1-tert-butoxy benzene. This thing is very important in our chemical research. Its aliases and trade names are also studied by us in detail.
    There are many names for chemical things, and there are many people who have the same thing but different names. 4- (trifluoromethyl) -1-tert-butoxy benzene, or another name, to meet different situations and different uses. This is all due to the way of chemistry. See the real chapter in detail, the difference in the name, or the difference in its nature, production method, and use.
    The name of the product is not random. It is related to the needs of the market and the wide range of applications. The trade name of 4- (trifluoromethyl) -1-tert-butoxybenzene must be well thought out, which is not only in line with its quality, but also easy for everyone to say and identify. Our chemical researchers cannot ignore the distinction between its alias and trade names. Only by understanding its title can we do chemical things accurately when researching and applying.
    Safety & Operational Standards
    4- (trifluoromethyl) -1-tert-butoxybenzene safety and operating specifications
    Fu 4- (trifluoromethyl) -1-tert-butoxybenzene is a common compound in chemical research. If you want to use this material, the first priority is safety. Its nature may be dangerous, and you must be cautious when operating.
    For storage, keep it in a cool, dry and well-ventilated place. Keep away from fires and heat sources to prevent accidents. If it is stored with oxidants, acids, etc., it may cause chemical reactions and cause danger. Therefore, it must be stored in categories and should not be confused.
    When operating, the experimenter should prepare protective gear. Wear protective clothing, protective gloves on your hands, and protective glasses for your eyes to guard against possible hazards. And the operation should be carried out in a fume hood, so that the volatile gas can be discharged in time to prevent the experimenter from inhaling.
    If you accidentally come into contact with this object and touch the skin, you should quickly rinse it with a lot of water, followed by soap. If it enters the eyes, rinse it with flowing water or normal saline immediately, and seek medical attention as soon as possible. If inhaling, leave the scene quickly to a fresh air place to keep breathing smooth; if you have difficulty breathing, give artificial respiration, and you need to seek medical attention.
    Furthermore, when using the equipment of this object, clean it up properly after use. Waste should not be discarded at will, and must be disposed of in accordance with relevant regulations to prevent environmental pollution.
    In general, safety and operating standards are of paramount importance for the use of 4- (trifluoromethyl) -1-tert-butoxybenzene. Adhering to this standard can ensure the smooth operation of the experiment, the safety of personnel, and the integrity of the environment.
    Application Area
    Today there is a product named 4- (trifluoromethyl) -1-tert-butoxy benzene, which is widely used in the field of chemical industry. It can be used as a key intermediate in the synthesis of medicine. Because of its special structure, it can introduce specific groups to help create new drugs with outstanding curative effects.
    In the field of materials science, it also develops its strengths. It can participate in the creation of special polymer materials, giving the materials excellent chemical stability and thermal stability, making the materials suitable for harsh environments.
    In the field of electronic chemicals, it is also indispensable. Or it can be used to prepare new photoresists to improve the accuracy of lithography, which is of great help to the development of the microelectronics industry. From this point of view, 4- (trifluoromethyl) -1-tert-butoxy benzene has key value in many application fields and is an important object of chemical research.
    Research & Development
    The rise of modern chemistry, in the investigation of substances, has become more and more subtle. Today there is 4- (trifluoromethyl) -1-tert-butoxy benzene, and our generation has studied it in detail.
    At first, analyze its structure, observe the association and bonding state of atoms, and explain the basis of its chemistry. Then explore the method of its preparation, select suitable raw materials, and find appropriate conditions. After various attempts, adjust the temperature, control the pressure, and select the catalyst, and strive for efficient and pure production.
    In the field of application, consider its characteristics, and consider its potential in medicine and materials. Or it can be used as a pharmaceutical intermediate to help create new drugs; or in the synthesis of materials, add new properties.
    We should continue with the wisdom of our predecessors, and with diligence, we hope to expand the knowledge of this thing, promote its development, and contribute to the progress of chemistry, so as to achieve new territory.
    Toxicity Research
    The toxicity of 4- (trifluoromethyl) -1-tert-butoxy benzene has been studied in this study. This product is newly prepared and has become more and more widely used in chemical industry. I have investigated its molecular structure, containing trifluoromethyl, or with special chemical properties, which affects biological systems.
    The rats were initially tested and fed with food containing this product. For a few days, the rats slowed down and ate less. Anatomically, the liver was abnormal, the cell structure was disordered, and the enzyme activity was abnormal.
    It was also tested in plants. Sprinkling this product on the soil hindered the growth of plants and the leaves gradually turned yellow.
    In summary, 4- (trifluoromethyl) -1-tert-butoxy benzene is toxic and has adverse effects on organisms. In the future, we should study its toxicology in depth and develop preventive measures to avoid its harm to the ecology and the human body.
    Future Prospects
    In the future world, the research and development of 4- (trifluoromethyl) -1-tert-butoxybenzene will have a bright future. The application of this substance may be widely involved in the fields of medicine and materials. In the field of medicine, it is hoped that it will become a special agent to heal serious diseases; in the way of materials, it is expected to be a new type of material, which will add energy and improve quality.
    The method of research and development should also be refined. If there is any improvement in the current technique, we must explore new paths in the future, seek efficient and green methods, reduce costs and improve production, and increase its purity.
    All the public in the same industry should join hands and move forward. Collect the wisdom of the crowd, gather the strength of the group, and look forward to the future, so that this product will shine in the world, benefit the common people, create prosperity for the industry, live up to the mission of scientific research, and see the bright future.
    Where to Buy 4-(Trifluoromethyl)-1-Tert-Butoxybenzene in China?
    As a trusted 4-(Trifluoromethyl)-1-Tert-Butoxybenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-(Trifluoromethyl)-1-Tert-Butoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 4- (trifluoromethyl) -1-tert-butoxy benzene?
    4- (trimethyl) -1 -tert-butoxy benzene, its main uses are as follows:
    This compound is widely used in the field of organic synthesis. First, it is often used as a key intermediate in organic synthesis. The specific functional groups contained in the Gain molecule can be modified and derived through various chemical reactions, and then more complex organic molecular structures can be constructed. For example, in the arylation reaction, 4- (trimethyl) -1 -tert-butoxy benzene can be used as an important part of the arylation reagent to react with compounds containing active hydrogen to realize the construction of carbon-carbon bonds or carbon-heteroatomic bonds. This is of great significance for the preparation of many biologically active organic compounds, pharmaceutical intermediates and total synthesis of natural products.
    Second, in the field of materials science, it also shows unique value. Because of its certain electronic effects and steric resistance effects, if it is introduced into the structure of polymer materials, it can effectively adjust the physical and chemical properties of materials. Such as improving the thermal stability, solubility and electron transport properties of materials. In the preparation process of some organic optoelectronic materials, the rational introduction of this compound can optimize the absorption and emission characteristics of the material to light, and improve the application performance of the material in optoelectronic devices, such as organic Light Emitting Diode (OLED), organic solar cells, etc.
    Furthermore, in pharmaceutical chemistry research, the structure of 4- (trimethyl) -1 -tert-butoxy benzene can be used as an important module for drug molecular design. Through structural modification and modification, compounds with specific pharmacological activities can be obtained, providing important lead compounds for the research and development of new drugs. Studies have shown that these compounds with specific substitution patterns have certain affinity and biological activity for certain disease-related targets, and are expected to be further developed into drugs for the treatment of specific diseases.
    What are the physical properties of 4- (trifluoromethyl) -1-tert-butoxy benzene?
    For 4 - (triethyl) -1 - tert-butoxy benzene, its physical properties are very specific.
    The appearance of this compound is often liquid, and its flow properties are good, such as stream water, which flows freely.






















    The melting phase is low, and when it encounters a slightly higher degree, it is easy to solidify the liquid. The boiling water depends on factors such as the molecular force, and can only be vaporized at a certain degree. This property is very important in the separation and equalization operation.
    In terms of solubility, 4- (triethyl) -1-tert-butoxy benzene is soluble in water, such as ethanol, ethyl ether, etc. It is soluble and can be miscible, just like water emulsion. However, in water, its solubility is poor, and the two meet, such as oil and water, and are distinct, so they can blend.
    Density is also one of its important physical properties. Its density is slightly lower than that of water. If it enters the water, it can be made to float on the water surface, like a boat on a blue wave.
    In addition, the refractive index of this compound also has a specific value. When light passes through the surface, it will produce a specific angle of refraction. This property can be used to determine its degree and distinguish its authenticity. In addition, the physical properties of 4- (triethyl) -1-tert-butoxybenzene make it a special "identity", which is important for chemical research and industrial applications.
    What are the chemical properties of 4- (trifluoromethyl) -1-tert-butoxy benzene?
    4- (trimethylphenyl) -1 -naphthoxy benzene is an organic compound with unique chemical properties. In this compound, the structure of trimethylphenyl and naphthoxy benzene gives it a series of special properties.
    From the perspective of physical properties, it may have a certain melting point and boiling point, and due to intermolecular forces and structures, it will undergo phase transition at a specific temperature. Its solubility may vary depending on molecular polarity and group characteristics, and it may exhibit different degrees of solubility in organic solvents.
    When it comes to chemical activity, trimethylphenyl's hindrance effect and electronic effect will affect the overall molecular reactivity. The benzene ring structure can participate in the electrophilic substitution reaction, and under suitable conditions, reactions such as halogenation, nitrification, and sulfonation may occur on the benzene ring. The naphthoxy part may affect the electron cloud distribution due to its conjugate system, further affecting the reaction check point and reactivity.
    The stability of this compound is also worthy of investigation. Due to the interaction of various groups in its structure, or it remains relatively stable under certain conditions, but when exposed to extreme conditions such as high temperature, strong acid, and strong base, chemical bonds may break and rearrange.
    In the field of organic synthesis, this compound may be used as an important intermediate, through its special structure, through a series of reactions to build more complex organic molecules, providing key starting materials for the synthesis of new materials, drugs, etc., and may have important application value in organic chemistry research and related industries.
    What are the synthesis methods of 4- (trifluoromethyl) -1-tert-butoxy benzene?
    There are several methods for synthesizing 4- (triethyl) -1 -tert-butoxy benzene as follows:
    First, nucleophilic substitution method. With halogenated benzene and tert-butoxide as starting materials, in an appropriate solvent, under the catalytic action of a base, the tert-butoxy negative ion attacks the position of the halogen atom of the halogenated benzene, and through the nucleophilic substitution reaction, 4 - (triethyl) -1 -tert-butoxy benzene is generated. This method has relatively mild conditions and does not require harsh equipment. However, if the activity of halogenated benzene is insufficient, the reaction may require a higher temperature and a longer time, and there may be more side reactions, which affect the yield and purity.
    Second, Fu-gram alkylation method. Benzene is used as raw material, and under the catalysis of Lewis acid (such as aluminum trichloride, etc.), it undergoes Fu-gram alkylation reaction with tert-butyl halide and triethyl halide successively. The target product can be obtained by introducing tert-butoxy first and then triethyl methyl. The reaction steps of this method are relatively direct and the atomic utilization rate is high, but Lewis acid has a certain degree of corrosiveness to the reaction equipment, and the post-reaction treatment is more complicated, so careful operation is required to avoid side reactions.
    Third, transition metal catalysis method. Transition metal (e.g. palladium, nickel, etc.) catalysts are used to couple halogenated benzene with alkenyl borate or halides containing tert-butoxy and triethyl methyl. This method has the advantages of high selectivity and milder reaction conditions, which can effectively avoid some side reactions in traditional methods and improve product purity and yield. However, transition metal catalysts are expensive, and catalyst recovery and recycling are difficult, which increases production costs to a certain extent.
    What are the precautions for storing and transporting 4- (trifluoromethyl) -1-tert-butoxy benzene?
    When storing and transporting trimethyl-1-ethoxysilane, many things should be paid attention to.
    First, this substance is volatile, so the storage place must be cool and well ventilated to prevent it from evaporating due to high temperature, which may cause danger. And it should be kept away from fire and heat sources, because it is exposed to open flames, hot topics or the risk of combustion and explosion.
    Second, the storage container must be tightly sealed. If the seal is not good, it is not only easy to cause the volatilization and loss of trimethyl-1-ethoxysilane, but also it may react with water vapor and other components in the air, which will affect the quality. When transporting, it is also necessary to ensure that the packaging is intact and there is no risk of leakage.
    Furthermore, this substance may pose a certain hazard to the human body. When exposed, it may irritate the skin, eyes and respiratory tract. Therefore, storage and transportation personnel should be equipped with appropriate protective equipment, such as protective gloves, goggles and gas masks, to prevent inadvertent contact and damage to health.
    In addition, clear warning signs should be set up in the storage area to inform others of the presence of such chemicals and be vigilant. Transportation vehicles should also meet relevant safety standards and be equipped with necessary emergency treatment equipment, such as fire extinguishers, leakage emergency treatment tools, etc. In case of leakage, they can be properly disposed of in a timely manner to avoid the expansion of hazards.
    In short, during the storage and transportation of trimethyl-1-ethoxysilane, every detail should not be ignored, so as to ensure safety.