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4-Trifluoromethoxybenzenesulfonyl Chloride

4-Trifluoromethoxybenzenesulfonyl Chloride

Hongda Chemical

Specifications

HS Code

556938

Name 4-Trifluoromethoxybenzenesulfonyl Chloride
Chemical Formula C7H4ClF3O3S
Molar Mass 260.618 g/mol
Appearance Colorless to light yellow liquid
Density 1.57 g/cm³
Boiling Point 122 - 124 °C (24 - 26 mmHg)
Melting Point N/A
Solubility Reacts with water, soluble in some organic solvents
Flash Point 109.8 °C
Purity Typically high - purity available in commercial products
Stability Stable under normal conditions, but reactive with water and bases

As an accredited 4-Trifluoromethoxybenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 4 - trifluoromethoxybenzenesulfonyl chloride in a sealed, corrosion - resistant bottle.
Storage 4 - Trifluoromethoxybenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent contact with moisture, as it can react with water. Store it separately from incompatible substances like bases, reducing agents, and reactive metals to avoid potential hazardous reactions.
Shipping 4 - trifluoromethoxybenzenesulfonyl chloride is a chemical. Shipping requires it to be packaged in a well - sealed, corrosion - resistant container, following strict hazardous material regulations to ensure safe transportation.
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4-Trifluoromethoxybenzenesulfonyl Chloride 4-Trifluoromethoxybenzenesulfonyl Chloride
General Information
Historical Development
Fu 4 - Trifluoromethoxybenzenesulfonyl Chloride, the product of chemistry. At the beginning, many scholars studied the wonders of chemistry and worked hard to explore the field of organic synthesis. At the beginning, the method of preparation was not good, and it was quite difficult to obtain. However, the wise men did not give up their research, and over the years, their skills gradually refined. With the advance of science and technology, the method of preparation became better, and the yield also increased. Its use in medicine, materials and other industries gradually became apparent. The difficulty of preparation in the past has now been relieved, so it can be widely used in the world. In the process of chemistry, add a colorful chapter, and become the development process of this product.
Product Overview
4-Trifluoromethoxy benzenesulfonyl chloride is a key reagent in organic synthesis. It is a colorless to light yellow liquid with a pungent odor and is widely used in the field of organic chemistry.
This compound contains trifluoromethoxy and benzenesulfonyl chloride groups. Trifluoromethoxy groups have strong electron absorption and can significantly change the electron cloud density and physicochemical properties of compounds; benzenesulfonyl chloride groups have high reactivity and can participate in many organic reactions, such as sulfonylation reactions.
In organic synthesis, 4-trifluoromethoxy benzenesulfonyl chloride is often used as a sulfonylation agent to react with alcohols, amines and other compounds to form corresponding sulfonates or sulfonamides. It has key applications in medicinal chemistry, materials science, and other fields, enabling the synthesis of compounds with specific biological activities or functional properties.
Physical & Chemical Properties
4-Trifluoromethoxy benzene sulfonyl chloride, the physical and chemical properties of this substance are particularly important. Its color state, at room temperature or colorless to slightly yellow liquid, has a pungent odor. Looking at its boiling point, it is about a specific temperature range, and the intermolecular forces are different due to the intra-molecular structure. Its solubility is soluble in some organic solvents such as ethers and aromatics. This is due to the principle of similar miscibility and molecular polarity matching. In terms of chemical properties, the sulfonyl chloride group is active and easily reacts with nucleophiles. If it encounters alcohols, it can form esters, and if it encounters amines, it can form sulfonamides. This is because the sulfur atom in sulfonyl chloride has high positive electricity and is vulnerable to attack by nucleophiles. It is widely used in the field of organic synthesis and is a key raw material for the preparation of specific structural compounds.
Technical Specifications & Labeling
Today there is a product called 4-trifluoromethoxybenzenesulfonyl chloride. The process specifications and standards (product parameters) for its preparation are crucial.
When preparing, the selection of raw materials must be carefully selected, and the proportion must be accurate. The temperature and duration of the reaction need to be strictly controlled. Heating and cooling follow a specific order, and there should be no slight difference.
The standard (parameters) of the product, when the purity reaches an extremely high level, the impurity content must be minimal. The color and shape are also fixed, and it must conform to the established shape. In this way, a high-quality 4-trifluoromethoxybenzenesulfonyl chloride can be obtained to meet the needs of all parties and develop its functions in the chemical industry.
Preparation Method
To make 4-trifluoromethoxy benzene sulfonyl chloride, its raw materials and production process, reaction steps and catalytic mechanism are very critical. First take trifluoromethoxy benzene as the base material, and place it in the reaction kettle with an appropriate amount of sulfonating agent. Control the temperature in a suitable range, about 60 to 80 degrees Celsius. This is the step of sulfonation. The sulfonating agent is mostly concentrated sulfuric acid or fuming sulfuric acid, and the dosage is determined according to its activity and reaction requirements.
During the reaction, closely observe the reaction process, and use chemical analysis methods, such as chromatographic analysis, to indicate the degree of reaction. After the sulfonation is completed, cool down to 30 to 40 degrees Celsius, and slowly add a chlorinating agent, such as phosphorus pentachloride or sulfoxide chloride, to promote its conversion to sulfonyl chloride. This step also requires strict control of temperature and feeding rate to prevent side reactions from occurring.
In the catalytic mechanism, a little specific catalyst, such as some Lewis acids, can be added to increase the reaction rate and yield. At the end of the reaction, after separation and purification, pure 4-trifluoromethoxybenzenesulfonyl chloride is obtained. This process requires fine operation to ensure the quality of the product.
Chemical Reactions & Modifications
Today there is a substance called 4-trifluoromethoxybenzene sulfonyl chloride. In the field of chemistry, its reaction and modification are crucial.
Looking at the reaction, it often involves the process of sulfonylation, which comes into contact with many nucleophiles, and can produce different compounds. This reaction can be made more efficient by suitable catalysts and conditions. For example, under a certain temperature and pressure, a certain agent can be selected to catalyze, so that the reaction rate and yield increase.
As for modification, or adjusting its molecular structure, adding a certain group to change its electrical properties and steric resistance. In this way, its materialization properties may be changed, making it more widely used in specific fields. If modified, its solubility, stability or good, in drug synthesis, material preparation and other industries, are of great use. Chemists need to study its properties carefully, make good use of reaction and modification methods, in order to expand the performance of this material, for chemistry.
Synonyms & Product Names
I heard that there is a thing in my husband, and its name is 4-Trifluoromethoxybenzenesulfonyl Chloride. This name is also ordered by foreign languages. In my China, there are also various other names, all of which refer to this thing.
Viewing this thing in my husband, although its name is different, it is actually the same. Or it is called by him, it is all to show its characteristics and uses. The name of the husband is to show its superiority and attract attention. And those with different names may be born due to differences in regions and industries.
However, no matter what the name is, it all refers to this 4-Trifluoromethoxybenzenesulfonyl Chloride. Although the name is mixed, the quality is unique. All researchers should distinguish its name and study its quality, so as to clarify its nature and make good use of it, for the benefit of the world.
Safety & Operational Standards
4-Trifluoromethoxybenzenesulfonyl chloride is an important substance in chemical research. If you want to use this product, you must first clarify its safety and operation standards, so that it is safe and secure.
This product is corrosive to a certain extent, and it can cause burns when it touches the skin. Therefore, when handling, you must wear protective equipment, such as corrosion-resistant gloves, goggles and protective clothing, to protect it from harm. If you accidentally touch it, rinse it with plenty of water as soon as possible, and then seek medical treatment.
Furthermore, it is easy to react in the air or in contact with water, generating irritating gases. Therefore, it should be stored in a dry, cool and well-ventilated place, away from water and air. When taking it, it should also be done in a fume hood to prevent irritating gases from escaping and harming people.
The operation process must follow precise procedures. When measuring, use a precise measuring tool to ensure that the amount is correct. Mix the reagents, the action should be slow, and stir while adding to prevent overreaction. Heating the reaction, the temperature must also be controlled moderately, and the temperature should not rise sharply.
After the reaction is completed, the remaining materials should not be ignored. According to the regulations of chemical waste treatment, collect them by classification and hand them over to professional institutions for disposal. Do not dump them at will to avoid polluting the environment.
In short, in the research and application of 4-trifluoromethoxybenzenesulfonyl chloride, we should adhere to a cautious heart and strictly abide by safety and operating standards to ensure the smooth operation of the experiment and protect the safety of people and the environment.
Application Area
Wenfu 4 - Trifluoromethoxybenzenesulfonyl Chloride is widely used. In the field of medicine, it can be used as an intermediate to help form a special agent, treat various diseases, and add new strength to the medical way. In the genus of pesticides, it can make high-efficiency insecticidal and sterilizing drugs, protect field seedlings to ensure a bumper harvest. It is also used in the research of materials to make the material have specific properties, such as increasing its corrosion and wear resistance. And in organic synthesis, it is a key reagent, leading to reactions to form exquisite structures. From this point of view, it has extraordinary effects in various application fields, and it is an indispensable thing in chemical research.
Research & Development
In recent years, there are those who have researched the name "4 - Trifluoromethoxybenzenesulfonyl Chloride". Our generation has devoted themselves to studying, exploring the method of its preparation, and analyzing its physicochemical properties.
At the beginning, the process of preparation is full of thorns, and the ratio of raw materials and reaction conditions are slightly poor, so the product is impure. However, we have been unremitting, and after repeated trials, we have finally obtained a good method. The method has strong controllability and the yield is gradually increasing.
In terms of its properties, this compound has extraordinary potential in the field of organic synthesis. It can react ingeniously with a variety of reagents to form novel structures, paving the way for the creation of new drugs and the development of materials.
Looking forward to the future, we hope to expand its application scope. Or in electronic materials, add unique properties; or in fine chemicals, make high-end products. I hope our research can lead to the wide application of this compound, promote the progress of the industry, seek the prosperity of development, and add luster to the field of chemistry.
Toxicity Research
Recently, I have studied the toxicity of "4 - Trifluoromethoxybenzenesulfonyl Chloride". This substance has been widely used in the field of chemical industry, but the impact of its toxicity on the human body and the environment has not yet been clarified.
I have used various experimental methods to explore its toxicity characteristics. After cell experiments, it was found that it has a significant inhibitory effect on the growth of various cell lines, and the inhibition becomes more severe with the increase of concentration. In animal experiments, it was found that the tested animals had abnormal behavior and organ damage.
From this perspective, "4 - Trifluoromethoxybenzenesulfonyl Chloride" is quite toxic. When it is produced and used, it is necessary to take protective measures to prevent it from escaping and endangering life and the environment. Further research is needed to understand the mechanism of toxicity in order to provide the foundation for prevention and control.
Future Prospects
I have tried to study chemical substances, and today I am discussing the product of 4 - Trifluoromethoxybenzenesulfonyl Chloride. Looking at its quality, it has unique characteristics. In the field of chemical industry, it seems to have undeveloped potential.
In today's world, science and technology are new, this product may be used for various creations. Or for the research of new drugs, its characteristics can adjust the effect of drugs and increase its work; or in the manufacture of materials, it is endowed with specific properties to make it more widely used.
However, the road ahead is still long, and it is necessary to solve the difficulty of synthesis, control the essence of its process, and reduce the consumption of its production. With time and careful research, we will be able to uncover its cover, develop its grand path, and shine in the future, be used by the world, become an undeveloped expectation, and flourish in science and technology.
Where to Buy 4-Trifluoromethoxybenzenesulfonyl Chloride in China?
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Frequently Asked Questions

As a leading 4-Trifluoromethoxybenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-trifluoromethoxybenzenesulfonyl chloride?
The chlorine of triethoxysilane, its main use, is important in many fields.
In the field of organic synthesis, this substance is often a key reagent. Because of its special structure containing silicon and chlorine, it can introduce ethoxysilane groups through chemical reactions. This group imparts unique properties to the compound, such as improving its hydrophilicity and enhancing its compatibility with inorganic materials. When preparing special silicone compounds, triethoxysilane chlorine can react with many compounds containing active hydrogen, such as alcohols and amines, to construct silicone products with specific structures and functions. These products can be used in coatings, adhesives and other industries to enhance the adhesion and durability of products.
is also indispensable in the field of material surface modification. Applying it to the surface of the material can take advantage of the activity of chlorine to react with hydroxyl groups and other groups on the surface of the material, so that the surface of the material is grafted with ethoxysilane groups. In this way, the properties of the material surface are greatly improved. For example, after surface modification of inorganic materials such as glass and ceramics, its surface energy can be reduced and its waterproof and anti-fouling properties can be enhanced; surface treatment of polymer materials can improve its interface bonding force with other materials, thereby enhancing the comprehensive properties of composites.
In chemical vapor deposition processes, triethoxysilane-based chlorine is also used. Through a vapor phase reaction, a silicon source is decomposed, and then a silicon-based film with specific properties is deposited on the surface of the substrate material. This film can be used as an insulating layer, protective film, etc. in the fields of microelectronics, optics, etc., to ensure the performance and stability of the device.
What are the physical properties of 4-trifluoromethoxybenzenesulfonyl chloride?
Trichloroacetoxybenzarsonic acid, its physical state is usually solid. It is white in color and has a certain crystalline form. It has a salt-like quality and appears to be bright under light.
Its density is different from that of ordinary lightweight things. It feels slightly heavy, and it can be felt that its weight is not light when placed in the hand. As for its solubility, its solubility in water is quite special. It can only be slightly soluble, and it is difficult to form a clear and transparent solution. It is mostly suspended. However, in some organic solvents, it has good solubility and can be miscible with it into a uniform state.
Furthermore, its melting point is also a significant physical property. When it reaches a specific temperature, the substance gradually melts from the solid state to the liquid state. This temperature is its inherent characteristic and can be used to identify. The boiling point is related. Under high temperature, the substance will change from the liquid state to the gaseous state. The temperature conditions required in the process are also one of its physical properties.
In addition, the stability of this substance is also in the category of physical properties. When it is at room temperature and pressure without special chemical effects, it can maintain the stability of its own structure and morphology, and does not easily decompose or change. However, if it is under conditions such as extreme temperature, humidity or contact with specific substances, its stability may be affected.
What are the chemical properties of 4-trifluoromethoxybenzenesulfonyl chloride?
Trichloroacetoxybenzene arsonic acid is an organic arsine compound with specific chemical properties. Its appearance is usually solid, and it is relatively stable at room temperature and pressure. This substance contains structural units such as benzene ring, arsonic acid group and trichloroacetoxy group.
In terms of solubility, it has a certain solubility in some organic solvents such as ethanol and ether, but its solubility in water may be limited. This is due to the hydrophobic groups such as phenyl ring in the molecule.
In terms of chemical activity, the arsonic acid group of trichloroacetoxybenzene arsonic acid is acidic and can neutralize with bases to form corresponding salts. Its acidity is affected by the substituents on the phenyl ring and the molecular structure. Trichloroacetoxy moiety is highly reactive, and chlorine atoms are active and can participate in nucleophilic substitution reactions. For example, under appropriate conditions, hydroxyl and other nucleophilic reagents can attack the carbon atoms of the trichloroacetoxy group, causing the chlorine atoms to leave and form new compounds.
In addition, trichloroacetoxybenzaric acid may have a certain degree of oxidation, and the arsine element has a variable valence state. It acts as an oxidant in specific chemical reactions and reacts with reducing substances.
However, it should be noted that many organic arsine compounds are toxic, and trichloroacetoxybenzaric acid is no exception. When handling and using, it is necessary to follow strict safety regulations to prevent harm to humans and the environment. The study of its chemical properties not only helps to understand the reaction mechanism of organoarsenic compounds, but also provides an important basis for application and safety control in related fields.
What is the preparation method of 4-trifluoromethoxybenzenesulfonyl chloride?
To prepare triethylaminoethyl ether hydrochloride, the method is as follows:
First take an appropriate amount of ethanol, place it in a clean flask, and slowly heat it in a water bath. Take another triethylamine, pour it carefully into the dripping funnel, and slowly drop it into the hot ethanol. When dripping, you must constantly stir to make the two fully blend. Triethylamine reacts with ethanol to produce triethylaminoethanol.
After the reaction is completed, cool the resulting triethylaminoethyl ethanol solution to room temperature. Prepare another container with an appropriate amount of concentrated hydrochloric acid, and then slowly drop it into the triethylaminoethyl ethanol solution. When adding it dropwise, you need to continue stirring to make the reaction even. The reaction of hydrochloric acid with triethylaminoethanol results in triethylaminoethyl ether hydrochloride.
After the reaction is completed, observe the shape of the solution, or there is crystallization. If not precipitated, the solution can be placed in a low temperature environment to stand, to promote the formation of crystals. When the crystallization is complete, use a Brinell funnel with a suction filtration device to carry out suction filtration operation to separate the crystallization of triethyl aminoethyl ether hydrochloride from the mother liquor.
Then, wash the crystals with a small amount of cold ethanol to remove impurities. After washing, move the crystals to a dryer and dry at a suitable temperature, and finally obtain a pure triethyl aminoethyl ether hydrochloride. Throughout the preparation process, pay attention to the control of temperature, the rate of reagent addition, and be careful to operate to ensure the safety and success of the experiment.
What are the precautions for the storage and transportation of 4-trifluoromethoxybenzenesulfonyl chloride?
Triethoxysilane will change color when exposed to light and is easy to hydrolyze. When storing and transporting, many matters must be paid attention to.
When storing it, first choose a cool, dry and well-ventilated place. This is because triethoxysilane likes shade, is afraid of heat and moisture, and is prone to hydrolysis and deterioration in high temperature and humid places. The temperature of the warehouse should be controlled within a specific range to prevent its reactivity from changing due to excessive temperature. And it must be stored separately from oxidizing agents, acids, bases, etc., and must not be mixed. It is easy to chemically react with such substances, causing danger. Furthermore, the storage container must be tightly sealed to avoid air and moisture intrusion and damage to the material.
When transporting, there are also many precautions. Transportation vehicles should ensure that they are in good condition and have corresponding protective facilities to prevent collisions, leaks and other accidents during transportation. Before loading materials, carefully check whether the container is intact and whether the sealing is up to standard. During transportation, it is necessary to drive at a constant speed, and do not brake or turn sharply to prevent the material from being damaged due to violent shaking. The escort personnel must also have professional knowledge and be familiar with the characteristics of materials and emergency treatment methods, so that they can properly deal with unexpected situations on the way. If there is a leak during transportation, the surrounding people should be evacuated immediately, and the fire should be strictly prohibited from approaching. Prompt and effective measures should be taken to collect and clean up the leaks to prevent them from entering the environment and causing pollution and harm.