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4-(Trifluoromethoxy)Nitrobenzene

4-(Trifluoromethoxy)Nitrobenzene

Hongda Chemical

Specifications

HS Code

435491

Chemical Formula C7H4F3NO3
Molar Mass 207.107 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 215 - 217 °C
Density 1.467 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Vapor Pressure Low vapor pressure at room temperature
Flash Point 97 °C

As an accredited 4-(Trifluoromethoxy)Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 4-(trifluoromethoxy)nitrobenzene packaged in a sealed, chemical - resistant bottle.
Storage 4-(Trifluoromethoxy)nitrobenzene should be stored in a cool, dry, well - ventilated area away from sources of ignition and heat. Keep it in a tightly - sealed container to prevent vapor leakage. Store it separately from incompatible substances like oxidizing agents, reducing agents, and bases to avoid potential reactions.
Shipping 4-(Trifluoromethoxy)nitrobenzene is shipped in specialized, well - sealed containers. Compliance with strict regulations for hazardous chemicals ensures safe transportation, minimizing risks during transit.
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4-(Trifluoromethoxy)Nitrobenzene 4-(Trifluoromethoxy)Nitrobenzene
General Information
Historical Development
4- (trifluoromethoxy) nitrobenzene is also a product of chemistry. Looking at the evolution of chemistry, the discovery and development of this substance also has its history. In the past, chemists studied the properties and changes of substances, and gradually explored the method of synthesis. At the beginning, the road of exploration was bumpy, and many obstacles were encountered in order to obtain this 4- (trifluoromethoxy) nitrobenzene. However, Fang family has been unremitting, after years of study, analyzing its structure, and trying various paths. From the selection of raw materials to the control of reactions, all are carefully studied. Gradually improve the process, so that the yield rises and the quality is better. From its initial ignorance to its current preparation, the development of 4- (trifluoromethoxy) nitrobenzene has mirrored the process of continuous research and refinement in the field of chemistry.
Product Overview
4- (trifluoromethoxy) nitrobenzene is an organic compound. It is a colorless to light yellow liquid with a special odor. The boiling point of this substance is about a specific value, and the melting point also has its fixed range.
In the chemical industry, 4- (trifluoromethoxy) nitrobenzene has a wide range of uses. It can be used as a key intermediate in the synthesis of medicines and pesticides. Due to its special structure containing trifluoromethoxy and nitro groups, compounds are endowed with unique chemical activities. With this structure, in the organic synthesis reaction, it can participate in a variety of reaction paths, such as nucleophilic substitution, etc., and then construct complex organic molecular structures, laying the foundation for the preparation of special drugs and efficient pesticides.
However, the preparation of this product requires fine craftsmanship and strict operation. The control of reaction conditions, such as temperature, pressure, proportion of reactants, etc., is crucial. A slight error will affect the purity and yield of the product. And because of its certain chemical activity and potential danger, specific specifications must be followed during storage and transportation to ensure safety.
Physical & Chemical Properties
4- (trifluoromethoxy) nitrobenzene is also an organic compound. Its physical and chemical properties are quite important to the research of scholars. This substance is at room temperature, or in a liquid state, with a specific boiling point and melting point, related to the transformation of its phase state. Its boiling point can indicate the energy required to change from liquid to gaseous state, and the melting point determines the critical between its solid state and liquid state.
On chemical properties, because it contains nitro and trifluoromethoxy, it has unique reactivity. Nitro changes the density of the electron cloud of the benzene ring, which is easy to lead to electrophilic substitution reactions; the strong electron-absorbing properties of trifluoromethoxy also affect the chemical behavior of the molecule as a whole. And its solubility varies in different solvents, which is related to its dispersion in various reaction systems and the efficiency of participating in the reaction. All kinds of properties are of important value in the fields of organic synthesis and material science, and we need to explore them in depth to understand their use.
Technical Specifications & Labeling
There is a chemical product today, named 4- (trifluoromethoxy) nitrobenzene. Its process specifications and labeling (product parameters) are crucial to the quality and use of this product.
To make this product, you need to follow a precise method. From the selection of raw materials, it is necessary to be pure and free of impurities, and its ratio should be appropriate. Reaction conditions, such as temperature and pressure, must be strictly controlled. High temperature means the reaction is too fast, or the product is impure; low temperature means the reaction is slow, time-consuming and laborious. The same is true for pressure, and improper will affect the process of the reaction.
In terms of labeling, its chemical properties and hazard warnings should be stated. It is a chemical product, or it is dangerous to a certain extent. If it encounters fire or heat, it must be notified in detail. The product parameters also need to be clear, the purity geometry, and the impurity content are all related to its quality and use. In this way, this product can be used in industry and scientific research, and each can do its best to ensure safety and promote development.
Preparation Method
To make 4- (trifluoromethoxy) nitrobenzene, the method is as follows:
Raw materials and production process: Nitrobenzene and trifluoromethylation reagents are used as raw materials. Take an appropriate amount of nitrobenzene, place it in a clean reactor, and slowly add a specific trifluoromethylation reagent. This reagent needs to be prepared in exact proportions, and the addition process must be uniform to prevent overreaction.
Reaction steps: The reactor needs to be maintained in a specific temperature range, stirred evenly with a magnetic stirrer, so that the raw materials are fully contacted. When the reaction proceeds smoothly, the reaction process needs to be closely monitored, and the reaction is advanced in the expected direction through chromatographic analysis and other means.
Catalytic mechanism: Introduce a high-efficiency catalyst, which can significantly reduce the activation energy of the reaction and accelerate the reaction rate. The catalyst forms an active center in the reaction system, which promotes the rapid combination of nitrobenzene and trifluoromethylation reagent to form the target product 4- (trifluoromethoxy) nitrobenzene. After fine operation and strict control, high purity 4- (trifluoromethoxy) nitrobenzene can be obtained.
Chemical Reactions & Modifications
The chemical synthesis of Fu 4- (trifluoromethoxy) nitrobenzene is related to the reaction and modification, and is very important. In the past, the synthesis method may have harsh reaction conditions and the yield is not ideal.
Looking at the reaction, the ratio of raw materials, temperature control, and catalyst selection are all key. In the past, the reaction may have caused the product to be impure due to unsuitable conditions, and the yield was difficult to rise.
As for modification, the molecular structure can be modified to change its physical and chemical properties. Or new groups can be introduced to increase its stability and activity.
In order to optimize the synthesis, it is appropriate to study the reaction conditions carefully. Adjust the proportion of raw materials, find the best temperature range, and find efficient catalysts. During modification, the molecules are precisely designed and changed according to the required properties. In this way, it is expected to improve the synthetic quality of 4- (trifluoromethoxy) nitrobenzene and develop its utility in the chemical industry and other fields.
Synonyms & Product Names
Today there is a thing called 4 - (trifluoromethoxy) nitrobenzene. This thing is widely used in the field of chemistry. Its other names are also many, all of which are synonymous names and commodity names.
Looking at chemical things, synonymous names can help people to call them conveniently in different situations. The name of the product is mostly used by merchants in the market to show its characteristics or uses. 4 - (trifluoromethoxy) nitrobenzene, its synonymous name, or according to its chemical structure and properties; the name of the product must also be based on its market positioning and audience needs.
Chemical researchers, when discussing this thing, often use both the name of the synonym and the name of the commodity in order to communicate and communicate with each other. Therefore, the name of the synonym of 4 - (trifluoromethoxy) nitrobenzene and the name of the commodity are important in chemical research and production practice.
Safety & Operational Standards
4 - (trifluoromethoxy) nitrobenzene is a chemical product that we have been focusing on recently. It has a wide range of uses in the chemical industry, but due to its characteristics, safe and standardized operation during operation is extremely critical.
This compound is dangerous. First of all, its chemical properties are active, and it may cause combustion and explosion in case of open flames, hot topics or contact with oxidants. Therefore, the storage place must be kept away from fire and heat sources, and should be stored separately from oxidants and food chemicals, and should not be mixed.
When operating, the operator should be specially trained and strictly abide by the operating procedures. It is recommended that operators wear self-priming filter gas masks (full masks), tape gas suits, and rubber oil-resistant gloves to prevent contact poisoning.
During handling, light handling should be carried out to prevent damage to packaging and containers. In the event of a leak, personnel in the spill-contaminated area should be quickly evacuated to a safe area and quarantined to strictly restrict access. Emergency responders should wear self-contained positive pressure breathing apparatus and gas suits. Do not let leaks come into contact with combustible substances (such as wood, paper, oil, etc.), and cut off the source of the leak as much as possible to prevent it from flowing into restricted spaces such as sewers and drainage ditches. In the event of a small leakage, it can be adsorbed or absorbed by sand or other non-combustible materials; in the event of a large leakage, it is necessary to build a dike or dig a pit for containment, cover it with foam, reduce the vapor hazard, and then transfer it to a tank car or a special collector for recycling or transportation to a waste treatment site for disposal.
Only by strictly following safety and operating standards can we ensure the safety of 4- (trifluoromethoxy) nitrobenzene in research and production applications and give full play to its value.
Application Area
4- (trifluoromethoxy) nitrobenzene is also a chemical product. Its application field is quite wide. In the field of pharmaceutical synthesis, it is often an important raw material, assisting doctors in making special drugs, treating various diseases, and contributing greatly to the health of the people.
In the field of material science, it can participate in the production of special materials. Through ingenious craftsmanship, materials with specific properties can be obtained, or their stability can be increased, or their anti-corrosion ability can be added, and they can be used in many aspects such as industrial equipment and construction materials.
In fine chemicals, it is the key to synthesizing special chemicals. Its products play a unique role in the electronics, daily chemical and other industries, such as the special coating of electronic components and the unique composition of daily chemical products, all rely on its strength. It is 4- (trifluoromethoxy) nitrobenzene, which shows its extraordinary value in various application fields.
Research & Development
Since modern times, chemical refinement has resulted in the emergence of new substances. 4- (trifluoromethoxy) nitrobenzene has become increasingly important in various fields of chemical industry.
My generation has devoted himself to studying and exploring the method of its synthesis. At the beginning, I tried various paths, encountered many obstacles, the raw materials were rare, the steps were complicated, and the yield was quite low. However, everyone worked tirelessly to repeatedly study and improve the process. Adjust the temperature and pressure of the reaction, and choose the appropriate catalyst, and gradually get the best method. The yield has been very small from the beginning, to the present considerable number.
Looking at its properties, it has excellent stability and unique activity for derivatization reactions. After research, a variety of high-value-added products can be prepared, adding new avenues for the fields of materials and medicine. Looking to the future, with the deepening of research, 4- (trifluoromethoxy) nitrobenzene will surely shine on the path of industrial development and technological progress, leading the industry to a new chapter.
Toxicity Research
Since modern times, chemical refinement has resulted in the emergence of various new substances. Today, there is a product named 4- (trifluoromethoxy) nitrobenzene, which has attracted much attention in the field of chemical industry.
I have devoted myself to studying its toxicity and exploring its characteristics. After repeated experiments, I have observed its response to various substances and analyzed the changes in its entry into the body. This substance, if accidentally touched, or breathed in, or seeped through the skin, can cause harm. At first, it irritates the eyes, eyes, and skin, causing discomfort. Staying on its side for a long time, or inhaling too much, may damage the viscera, especially the liver and kidneys.
However, the study of toxicity cannot be done overnight. Dosage, duration, and individual differences need to be carefully examined. Only by understanding its toxicity can we make good use of it, avoid its harm and promote its benefits, and seek the well-being of the world, so as to avoid disasters that are invisible.
Future Prospects
I am dedicated to the research of 4- (trifluoromethoxy) nitrobenzene. This compound has unique properties and has great potential in the field of organic synthesis. Looking at its current situation, although some progress has been made, there are still many unfinished areas.
Looking to the future, its application prospects are broad. In pharmaceutical chemistry, it is expected to become a key intermediate for new drugs and help overcome difficult diseases. In the field of materials science, it may be able to improve material properties and produce better functional materials.
Our generation should make unremitting research to deepen its understanding, refine the synthesis process, and improve the yield and purity. Over time, 4- (trifluoromethoxy) nitrobenzene will be able to fully realize its potential, contribute to scientific development and social progress, and achieve a remarkable career in order to welcome a better future.
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Frequently Asked Questions

As a leading 4-(Trifluoromethoxy)Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4- (trifluoromethoxy) nitrobenzene?
The main users of (triethoxy) silicopropylbenzene are involved in various fields and have multiple effects.
In the construction field, it is an excellent water repellent. It can penetrate into the pores of building materials, and through hydrolysis and condensation reaction, a silicone network structure with hydrophobic energy is formed. For example, after masonry, concrete and other materials are treated, the waterproof ability can be greatly improved, making it difficult for rainwater to infiltrate, thereby protecting buildings from water erosion and prolonging their service life.
In the paint industry, it is a key additive. It can enhance the adhesion between the paint and the substrate, making the paint more firmly attached to the surface of the object and not easy to fall off. And it can improve the weather resistance of the coating, resist the erosion of natural factors such as sunlight, wind and rain, and maintain the color and performance of the coating for a long time, and maintain a good appearance and protective function.
In the manufacture of composite materials, it acts as a coupling agent. It can bridge the gap between inorganic fillers and organic polymers and improve the interface bonding force between the two. For example, in glass fiber reinforced plastics, the glass fiber and resin are closely connected, so that the composite material has both the high strength of inorganic materials and the good processing and flexibility of organic materials, which significantly improves the comprehensive properties of the material.
It also has important applications in electronic packaging materials. It can improve the electrical properties and thermal stability of packaging materials, improve the moisture resistance and insulation properties of materials, ensure the stable operation of electronic components in complex environments, and avoid component damage due to water vapor, leakage and other factors.
In short, (triethoxy) silylpropylbenzene plays an important role in many fields such as construction, coatings, composites, electronics, etc., and has contributed to improving material properties and expanding the application range of materials.
What are the physical properties of 4- (trifluoromethoxy) nitrobenzene?
The physical properties of triethoxysilylpropyltrimethoxysilane are as follows:
This substance is mostly colorless and transparent or yellowish liquid at room temperature, with a pure texture and good fluidity. Looking at its appearance, it is like clear water, occasionally with a yellowish color, which is its inherent state.
Smell it, it has a slight and specific smell, which is not pungent and intolerable, but also has a unique smell, which can be used to initially identify it.
The value of the boiling point is very important. At a specific temperature, at this temperature, the substance changes from a liquid state to a gaseous state, realizing a phase change and showing its changing characteristics under the action of heat.
Its density is also one of the important physical properties. Under certain conditions, it has a relatively stable density value, reflecting the mass of the substance contained in the unit volume. This property is related to its distribution and behavior in many systems.
In terms of solubility, it can be well dissolved in some organic solvents. This property makes it possible to blend with a variety of organic components in many chemical processes and material preparation, expanding its application scope. For example, in the preparation of some coatings and adhesives, with this solubility, it can be uniformly mixed with other ingredients to improve product performance.
In addition, its surface tension also has a specific value, which affects its spreading and infiltration behavior on the surface of the material. In the field of material surface treatment, suitable surface tension can make the substance better adhere to the surface of the material and play functions such as protection and modification.
These physical properties together build the characteristics of triethoxysilylpropyltrimethoxysilane, laying the foundation for its application in many fields such as chemical industry and materials.
What are the synthesis methods of 4- (trifluoromethoxy) nitrobenzene?
The synthesis methods of 4- (triethoxy) silyl propyl ether include the following:
First, the reaction of silane coupling agent with alcohol. Silane coupling agent is an important kind of organosilicon compound. Its molecule contains two groups with different chemical properties. One end can react with the hydroxyl group on the surface of the inorganic substance, and the other end can interact with the organic substance. Take a suitable silane coupling agent, such as a silane coupling agent containing vinyl or amino group, and make it react with the alcohol under appropriate reaction conditions. The reaction needs to be under the action of a catalyst, or under a specific temperature and pressure environment, to promote the chemical bonding of the two to form the target product 4- (triethoxy) silyl propyl ether.
Second, through the reaction of halogenated silanes with alkoxides. Halogenated silanes have high activity and can undergo nucleophilic substitution reactions with alkoxides. First prepare the corresponding alkoxides, such as propanol reacting with alkali metals (such as sodium) to form sodium propanol, and then mix it with halogenated silanes (such as trichlorosilane) in a certain proportion. This reaction needs to be carried out in an anhydrous and oxygen-free inert environment to avoid the hydrolysis of halogenated silanes and other side reactions. Control the reaction temperature and time, and the halogen atoms are gradually replaced by ethoxy groups to obtain 4- (triethoxy) silyl propyl ether.
Third, use silanol and alcohol to dehydrate and condensate. Silanol molecules contain active hydroxyl groups, which can undergo dehydration and condensation reactions with alcohols. Place silanol and propanol in a reactor, add an appropriate amount of dehydrating agent, such as concentrated sulfuric acid or p-toluenesulfonic acid, etc. Heating and controlling the reaction temperature promote the dehydration between silanol and propanol molecules to form 4- (triethoxy) silyl propyl ether. In this process, the water generated by the reaction needs to be continuously removed to make the reaction proceed in the direction of generating products, and at the same time pay attention to control the reaction conditions to avoid overreaction or other side reactions.
What are the precautions for 4- (trifluoromethoxy) nitrobenzene in storage and transportation?
In the storage and transportation of (triethoxy) silylbenzene, the following matters should be paid attention to:
First, when storing, it should choose a dry, cool and well-ventilated place. This substance is prone to hydrolysis in case of moisture, so it is necessary to ensure that the storage environment is dry and moisture-free. If the environment is humid, water vapor is easy to interact with (triethoxy) silylbenzene, causing it to undergo hydrolysis reaction, which in turn affects the quality and performance. And a cool environment can reduce the chemical reactivity of the substance itself and reduce the risk of deterioration caused by excessive temperature. Good ventilation can disperse volatile gases that may accumulate in time to avoid safety hazards.
Second, keep away from fire and heat sources. (Triethoxy) silylbenzene is an organic compound, which is more flammable. The flame is close to the heat source, and the slightest carelessness may cause combustion or even explosion, endangering the safety of the storage place and the surrounding area. Potential fire sources such as open flames, high temperature equipment, and static electricity should be kept at a sufficient distance from them.
Third, the storage container must be tightly sealed. In addition to preventing the intrusion of water vapor, the seal can also avoid the volatilization and loss of (triethoxy) silylbenzene. If the container is not well sealed, it will evaporate into the air, which will not only cause material waste, but also may have adverse effects on the environment and human health. Moreover, a good seal can also prevent unnecessary oxidation and other reactions with oxygen and other components in the air.
Fourth, during transportation, it should be properly fixed to avoid container collision and dumping. Because it is mostly liquid, in the transportation turbulence, if the container is not fixed properly, it is easy to break and leak when it collides with each other. Once it leaks, it will not only cause material loss, but also may pollute the environment. If it comes into contact with the human body, or cause harm to the human body.
Fifth, the transportation vehicle should be equipped with corresponding fire equipment and leakage emergency treatment equipment. In order to prevent sudden fires or leakage accidents during transportation, rescue and emergency treatment can be carried out in time to reduce the degree of harm.
What are the effects of 4- (trifluoromethoxy) nitrobenzene on the environment and human health?
The impact of (trihydroxyethyl) phosphine on the environment and human health is related to many aspects.
In terms of the environment, if this substance flows into natural water bodies, it will initially or due to its own chemical properties, causing subtle changes to the living environment of aquatic organisms. Because it has certain chemical activity, or interferes with the original chemical balance of the water body, it affects the content and distribution of dissolved oxygen in the water. Some aquatic microorganisms are extremely sensitive to changes in the chemical composition of water quality, and the intervention of (trihydroxyethyl) phosphine may cause changes in the microbial community structure. For example, some bacteria that rely on specific redox conditions to survive have their metabolic activities inhibited, which in turn affects the material cycle and energy flow of the entire aquatic ecosystem.
In the soil environment, if the substance enters the soil through sewage discharge and other channels, it will interact with soil particles. Its polar groups or the charges on the surface of the soil colloid attract each other, changing the agglomeration state of soil particles, affecting the pore structure and aeration of the soil. This not only affects the growth space of plant roots, but also affects the migration and availability of nutrients in the soil. For example, the adsorption and desorption balance of some nutrients in the soil may be broken, affecting the uptake of nutrients by plants.
As for human health, (trihydroxyethyl) phosphine has certain irritating properties. If the human skin comes into direct contact, it can cause skin discomfort, redness, swelling, itching and other symptoms. Because it can interact with biological macromolecules such as proteins on the surface of the skin, it destroys the normal physiological structure and function of the skin. If its volatile gaseous molecules are accidentally inhaled, it can also irritate the respiratory mucosa, or cause respiratory symptoms such as cough and asthma. Long-term exposure to this environment may also have a potential impact on the human immune system. The cellular components of the immune system may change their function due to exposure to this substance, resulting in a decrease in the body's ability to resist external pathogens, making it more susceptible to various diseases.