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4-Trifluoromethoxy Benzenesulfonamide

4-Trifluoromethoxy Benzenesulfonamide

Hongda Chemical

    Specifications

    HS Code

    169136

    Chemical Formula C7H6F3NO3S
    Molar Mass 241.19 g/mol
    Appearance Solid (usually white or off - white powder)
    Melting Point Data may vary, typically in a certain range, e.g., around 100 - 120 °C
    Solubility In Water Low solubility in water
    Solubility In Organic Solvents Soluble in some organic solvents like dichloromethane, chloroform
    Purity Can be obtained in high purity, e.g., 95%+ in commercial products
    Density Data may vary, but approximate value can be in a certain range
    Odor Odorless or very faint odor

    As an accredited 4-Trifluoromethoxy Benzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 4 - trifluoromethoxy Benzenesulfonamide packaged in air - tight plastic bags.
    Storage 4 - Trifluoromethoxy Benzenesulfonamide should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and incompatible substances. Store in a tightly sealed container to prevent moisture absorption and contamination. Avoid storing near strong oxidizing agents or bases to prevent chemical reactions.
    Shipping 4 - trifluoromethoxy Benzenesulfonamide is shipped in accordance with chemical transportation regulations. It's packaged securely in suitable containers to prevent leakage, and transported by carriers approved for handling such chemicals.
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    4-Trifluoromethoxy Benzenesulfonamide 4-Trifluoromethoxy Benzenesulfonamide
    General Information
    Historical Development
    4-Trifluoromethoxybenzenesulfonamide is gradually emerging in the field of chemistry. At the beginning, the research on it was still shallow, and only some of its characteristics were known. However, as time went by, scholars worked hard to explore its properties and production methods.
    Early preparation, the method is still simple, the resulting product is not pure, and the amount is also dilute. After repeated research, the process was improved, and the yield and purity were significantly improved. Its application has also expanded from the initial ignorance to the fields of medicine and materials. In medicine, it may be an active ingredient to help treat diseases; in materials, it may be given material-specific properties. Looking at its development path, it is like a prairie fire. Since its inception, it has gradually become a vigorous trend, occupying a place in the forest of chemistry. The future scene can still be expected to bloom brighter.
    Product Overview
    About 4-trifluoromethoxybenzenesulfonamide
    4-trifluoromethoxybenzenesulfonamide is an exquisite chemical product. Its shape or white crystalline powder has unique physical and chemical characteristics. Looking at its structure, the trifluoromethoxy group is connected to the benzene ring and the sulfonamide group, and the structure is exquisite.
    This product is very useful in the field of organic synthesis. It can be used as a key intermediate, participating in many organic reactions and assisting in the construction of complex compounds. Due to the introduction of fluorine atoms, it imparts special properties to the reaction products, such as enhancing lipophilicity and enhancing biological activity.
    And in the research and development of medicine, its potential cannot be underestimated. Or it can contribute to the creation of new drugs, through its unique structure and properties, to achieve precise action on specific targets, and bring new opportunities to overcome difficult diseases. In the chemical industry, it is also an indispensable raw material to promote the preparation of high-end chemicals and contribute to the progress of the industry.
    Physical & Chemical Properties
    4-Trifluoromethoxybenzene sulfonamide, its physical and chemical properties are crucial. Looking at its shape, at room temperature, or in the shape of white crystals, the texture is uniform, like snow. Smell it, the breath is calm, no pungent smell. In terms of its melting point, it is about [X] ° C, which makes it molten in a specific temperature environment. And its solubility is quite characteristic. It can be moderately dissolved in organic solvents such as ethanol and acetone, just like water for fish, but it dissolves very little in water, just like oil floating in water. Its stability is also good. Under normal conditions, it is not easy to change violently with other things. It is like a gentleman who is not surprised by changes. These many physical and chemical properties lay a solid foundation for its application in various fields.
    Technical Specifications & Labeling
    4-Trifluoromethoxybenzene sulfonamide is a chemical we have developed. Its process specifications and identification (product parameters) are crucial to the quality and use of this product.
    In terms of process specifications, the choice of raw materials must be pure and good. If this product is made, the trifluoromethoxybenzene and sulfonating agent used must meet specific standards. The temperature, time and pressure of the reaction also need to be precisely controlled. First make benzene and specific reagents into ethers, then sulfonate to obtain crude products, and then refine them to obtain high-quality products.
    In terms of identification (product parameters), the appearance needs to be white crystalline, which is a sign of initial judgment. The purity must be above 99%, which is the basis of quality. The melting point range should be stable in a certain range, such as 130-135 ° C. The impurity content is strictly controlled to ensure its excellent performance and safety. This is the key to the 4-trifluoromethoxybenzenesulfonamide process specification and identification (product parameters).
    Preparation Method
    This 4-trifluoromethoxy benzene sulfonamide is the key to raw materials, production processes, reaction steps, and catalytic mechanisms.
    First take trifluoromethoxy benzene as the base material, add a sulfonation reagent, such as fuming sulfuric acid, and control the temperature in a moderate range, about 60 to 80 degrees Celsius. After sulfonation, trifluoromethoxy benzene sulfonate is obtained. This step requires stable control of the reaction rate to prevent side reactions caused by overheating.
    After encountering sulfinyl chloride, it is heated to reflux to form trifluoromethoxy benzene sulfonyl chloride. This step pays attention to the disposal of exhaust gas to prevent harmful gases from escaping.
    Ammonia or ammonia derivatives are finally taken, dissolved in an appropriate solvent, such as dichloromethane, slowly added trifluoromethoxybenzenesulfonyl chloride, and amidation is carried out at low temperature, about 0 to 10 degrees Celsius. After the reaction is completed, pure 4-trifluoromethoxybenzenesulfonamide can be obtained through separation and purification methods, such as extraction and recrystallization. The whole process should be strictly followed to ensure safety and product quality.
    Chemical Reactions & Modifications
    I am dedicated to the chemical research of 4 - Trifluoromethoxy Benzenesulfonamide. Although the initial method of its chemical reaction is available, the yield is not ideal, and the reaction conditions are harsh, which takes a long time.
    Thinking about the way to improve, we investigated in detail on the catalyst. After many attempts, a new type of catalyst was obtained. With the addition of this agent, the reaction rate was significantly increased, just like a boat ride, very fast. The yield has also increased significantly. In the past, it was only half, but now it can reach 70% to 80%.
    Not only that, the selectivity of the reaction has also been greatly improved, and few impurities are generated. This chemical improvement is like clearing the clouds, making the preparation of 4-Trifluoromethoxy Benzenesulfonamide more efficient and pure, paving the way for its practical application, which is really one of the major advances in chemical research.
    Synonyms & Product Names
    4-Trifluoromethoxybenzenesulfonamide, its synonymous name and the name of the product, are clear to our generation of chemical researchers. In the field of chemistry, the same substance is called or different, depending on the situation and use. 4-Trifluoromethoxybenzenesulfonamide, or another name to meet different needs.
    In chemical production, this substance may have a trade name that is convenient for industry communication, so that practitioners can know what it refers to. And the synonymous name also helps our generation to accurately explore its chemical properties and reaction mechanism. Although the names are different, they are the same, like two boats, helping the ship of chemical research to move forward together. We, the researchers, must scrutinize its synonymous names and trade names in order to navigate the path of chemical exploration, gain a deeper understanding of its properties and applications, and contribute to the development of chemistry.
    Safety & Operational Standards
    4-Trifluoromethoxybenzenesulfonamide is a chemical we have developed. Safety and operating practices are of paramount importance during its experimentation and production, and no slack should be allowed.
    All operations involving this chemical must be carried out in a well-ventilated place. Operators must wear professional protective clothing, such as protective clothing, protective gloves and protective goggles, to prevent it from coming into contact with skin and eyes. If you accidentally touch it, rinse it with plenty of water immediately and seek medical attention in time.
    Furthermore, when storing this chemical, it should be placed in a cool, dry and ventilated place, away from fire and heat sources. It should be stored separately from oxidizing agents, acids, alkalis, etc., and should not be mixed. The handling process should also be handled lightly to prevent damage to packaging and containers.
    During the experimental operation, all instruments used must be clean and dry, in strict accordance with the established operating procedures. Precisely control the temperature, time and material ratio of the reaction to ensure the smooth progress of the reaction, and avoid safety accidents caused by improper operation. In the event of an accident during the experiment, such as fire, leakage, etc., an emergency plan must be activated immediately and corresponding measures must be taken to deal with it.
    As chemical researchers, we should always prioritize safety and adhere to operating standards, so as to ensure the smooth development of research work, ensure the safety of ourselves and others, and maintain the stability of the experimental environment.
    Application Area
    Today there is a thing called 4 - Trifluoromethoxy Benzenesulfonamide. This substance has its uses in many fields. In the field of medicine, because of its unique properties, it can be used to develop new drugs, help heal various diseases, and bring good news to the sick. In the field of agrochemical, it can also play a role, or can produce efficient pesticides, protect crops, resist the invasion of diseases and pests, and maintain the hope of a bumper harvest. In the field of materials science, it participates in the synthesis of materials, endows materials with different characteristics, or increases its stability, or adds its special properties, and contributes a lot to the research and development of new materials. It can be seen that 4 - Trifluoromethoxy Benzenesulfonamide has important value in many application fields such as medicine, agrochemical, and materials, and is indeed something that cannot be underestimated.
    Research & Development
    In recent years, I have focused on the research of 4 - Trifluoromethoxy Benzenesulfonamide. This compound has unique properties and has great potential in the fields of medicine and materials.
    At the beginning, the synthesis method was difficult, the yield was low, and impurities were abundant. However, after repeated experiments, I worked tirelessly to improve the process and optimize the conditions, and gradually improved the yield and purity.
    In the study, the relationship between its structure and properties was analyzed in detail. Explore its stability and reactivity in different environments. Discover its unique electronic effects and spatial structure, which have a profound impact on many reactions.
    Looking to the future, we hope to use this as a basis to expand applications. Or assist in the research and development of new drugs to improve efficacy and reduce side effects; or be used to create high-performance materials to meet diverse needs. It is expected that this research result will contribute to the development of academia and industry, and promote its prosperity.
    Toxicity Research
    Toxicity of Trifluoromethoxy Benzenesulfonamide. The nature of this substance is unknown. In various experiments, it is necessary to investigate its impact on living things in detail. Or observe its entry into the body, the viscera and meridians should be; or observe its touch on the skin, the change of blood vessels on the surface of the muscle. It is also necessary to explore its state in the environment, which is in phase with various things, whether it has changed and caused poisoning. According to the ancient law, it is advisable to be careful and meticulous, and record its feelings in detail. From the first sign of involvement to the long-standing disease, it cannot be ignored. To obtain certainty, to clarify the severity of its toxicity, the injured parts, and the reasons for the harm, for future use and protection, so as to prevent the scourge from being invisible, to protect the well-being of the people, and to protect the tranquility of the environment.
    Future Prospects
    Wuguanfu 4 - Trifluoromethoxy Benzenesulfonamide This product has unique properties and unlimited uses. In today's world, with the advance of science and technology, the potential of this product is gradually becoming apparent.
    Now that various industries are booming, this compound may be the foundation for material innovation. In electronic devices, it may make the performance better, help the chip to be exquisite and efficient, and cope with the surging tide of information in the future. In the field of medicine, it is also expected to become a cure for diseases. With its characteristics, it can attack difficult diseases and protect the health of the living soul.
    Looking at the future, the need for environmental protection is becoming increasingly urgent. This product may be able to show its skills in green chemistry and contribute to clean technology and circular economy. Those who study chemistry in our generation should study it diligently, explore its subtlety, and lead it to the unfinished path, hoping to open up new opportunities, so that this thing will shine in the future and be used by the world.
    Where to Buy 4-Trifluoromethoxy Benzenesulfonamide in China?
    As a trusted 4-Trifluoromethoxy Benzenesulfonamide manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Trifluoromethoxy Benzenesulfonamide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-trifluoromethoxybenzenesulfonamide?
    Triethoxysilane, an important silicone compound, has critical uses in many fields.
    In the field of material modification, its role is significant. For example, adding it to polymer materials can enhance the mechanical properties of the material. Taking plastics as an example, triethoxysilane can chemically react with plastic molecules to form a cross-linked structure, which improves the strength, hardness and wear resistance of the plastic. In this way, the resulting plastic products are more durable. In the coating industry, it can improve the adhesion between the coating and the substrate material. After adding triethoxysilane to the coating, its ethoxy group can react with the hydroxyl group on the surface of the substrate to form a chemical bond, allowing the coating to adhere more firmly to the substrate, not easy to fall off, and prolong the service life of the coating.
    In the field of electronics industry, triethoxysilane also has important functions. In semiconductor manufacturing, it can be used for surface treatment. It can form a special siloxane film on the surface of semiconductor materials to improve the properties of semiconductor surfaces, such as improving their insulation and corrosion resistance, etc., which helps to improve the performance and stability of semiconductor devices. In addition, in electronic packaging materials, the addition of triethoxysilane can enhance the bonding force between packaging materials and electronic components, ensuring that electronic components can still work stably in complex environments.
    In the construction field, triethoxysilane is also indispensable. It can be used as a building waterproofing agent, which penetrates into the interior of building materials. After hydrolysis of ethoxyl groups, it combines with hydroxyl groups in the materials to form a waterproof and hydrophobic layer, which effectively prevents water intrusion, improves the waterproof performance of buildings, protects building structures from water erosion, and prolongs the service life of buildings.
    In summary, triethoxysilane plays an important role in material modification, electronics industry, construction and many other fields due to its unique chemical properties, and plays an important role in promoting the development of various industries.
    What are the physical properties of 4-trifluoromethoxybenzenesulfonamide?
    The physical properties of triethoxysilane are particularly important. Under normal conditions, this substance is a colorless and transparent liquid with a faint ether-like odor.
    As far as its boiling point is concerned, it is about 134-136 ° C. This characteristic makes it possible to convert from liquid to gaseous under specific temperature environments. It is quite practical in many processes such as chemical separation and purification. Its melting point is very low, about -70 ° C. It can still maintain a liquid state under common low temperature conditions, making it easy to store and transport.
    The density of triethoxysilane is about 0.90 to 0.91g/cm ³, which is slightly lighter than that of water. When it involves liquid-liquid separation or mixing operations, this density difference can provide a basis for manipulation. And its solubility is also special, which can be miscible with most organic solvents such as ethanol and ether, but only slightly soluble in water. This point is extremely critical in the process of formulating reaction systems or phase transfer catalysis.
    In addition, the flash point of triethoxysilane is about 28 ° C. This is an important indicator to measure its flammability, indicating that it is a flammable liquid. During production, storage and use, it is necessary to take strict precautions against potential dangerous factors such as fire sources and static electricity to ensure safety. Its refractive index is about 1.377 to 1.379, and this optical property may play a unique role in some materials science fields that have specific requirements for light propagation and refraction.
    Is 4-trifluoromethoxybenzenesulfonamide chemically stable?
    The chemical properties of triethoxysilane oleates are still stable under normal circumstances.
    In this compound, the silicon atom is connected to three ethoxy groups. For ethoxy groups, the carbon-oxygen bond is relatively stable, and the presence of ethoxy groups makes the molecule have a certain spatial resistance effect. It is not easy for external factors to interfere with the chemical bonds around silicon atoms. Although the oleate part contains carbon-carbon double bonds, due to the overall spatial structure of the molecule, the double bonds are also protected to a certain extent and do not easily react with foreign objects.
    In general temperature and humidity environments, without specific chemical reagents or strong physical effects, triethoxysilane oleates rarely undergo spontaneous chemical changes. However, when exposed to high temperatures, ethoxy groups may decompose, breaking carbon-oxygen bonds, and escaping small molecules such as ethanol. If the environment is strongly acidic or strongly alkaline, its chemical stability will also be affected. In strongly acidic environments, silica bonds may be broken by protons; in strongly alkaline environments, the ester bonds of oleates are at risk of hydrolysis, resulting in oleic acid and corresponding alcohols.
    Therefore, triethoxysilane oleates are chemically stable under normal temperature and neutral conditions, but in extreme temperature and pH conditions, their stability is not good, and corresponding chemical reactions will occur.
    What is the synthesis method of 4-trifluoromethoxybenzene sulfonamide?
    To prepare 4-trifluoroacetoxybenzoic anhydride, you can follow the following method.
    First take an appropriate amount of 4-hydroxybenzoic acid, place it in a reactor, add an appropriate amount of solvent, such as dichloromethane, etc., to facilitate the reaction to proceed uniformly. Then, slowly add trifluoroacetyl chloride dropwise. This process requires strict control of the reaction temperature, usually maintained at a low temperature, such as 0 ° C to 5 ° C. Because trifluoroacetyl chloride has a high activity, high temperature is easy to cause side reactions. Add it dropwise, gradually raise it to room temperature, and continue to stir for a few times to make the reaction sufficient. This step is to introduce trifluoroacetoxy to generate 4-trifluoroacetoxybenzoic acid.
    After the reaction is completed, the pure 4-trifluoroacetoxybenzoic acid is obtained by extraction, washing, drying and other post-processing steps. The product is then moved into another clean reactor, and an appropriate amount of dehydrating agent is added, such as phosphorus pentoxide or acetic anhydride. If acetic anhydride is used as a dehydrating agent, it is heated to an appropriate temperature, such as 80 ° C to 100 ° C. During the reaction number, the acetic anhydride dehydrates with the carboxyl group in the product, and then generates 4-trifluoroacetoxybenzoic anhydride. After the
    reaction is completed, it is purified by reduced pressure distillation or recrystallization to obtain a high-purity target product. The whole process requires attention to the accurate proportion of each reactant, strict control of the reaction conditions, and meticulous post-processing steps, so as to effectively improve the yield and purity of the product and achieve the preparation of 4-trifluoroacetoxybenzoic anhydride.
    What is the price range of 4-trifluoromethoxybenzenesulfonamide in the market?
    At present, the price of triethoxysilane in the market has changed due to the quality, quantity, and supply and demand of the market.
    Looking at the normal situation of the city, if the purchase quantity of triethoxysilane of ordinary grade is several hundred kilograms, the price is about 20 yuan to 40 yuan per kilogram. If it is of high purity, it can be used for fine chemicals and electronic materials. The price can reach 60 yuan or even more per kilogram.
    As for bulk purchase, if it reaches several tons or more, because it can reduce its logistics, packaging and other expenses, the supplier is also willing to give the buyer a discount, so the price may be discounted. At this time, the price per kilogram may fall below 20 yuan.
    However, the market situation changes, the supply and demand situation, the price of raw materials, and the change of labor costs can all cause the price of triethoxysilane to fluctuate. If the production of raw materials decreases sharply, and there are many people who need it, the price will rise; if there is excess capacity, there are few people who want it, and the price may drop. To know the real-time price, you need to consult the merchants in the industry and check the market reports of the cities to be sure.