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4-(Trifluoromethoxy)Benzeneboronic Acid

4-(Trifluoromethoxy)Benzeneboronic Acid

Hongda Chemical

    Specifications

    HS Code

    313462

    Chemical Formula C7H6BF3O3
    Molar Mass 205.93 g/mol
    Appearance White to off - white solid
    Solubility In Water Slightly soluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, tetrahydrofuran
    Melting Point 126 - 130 °C
    Pka Value Around 8 - 9 (boronic acid group)
    Stability Stable under normal conditions, but sensitive to strong oxidizing agents and bases

    As an accredited 4-(Trifluoromethoxy)Benzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 4-(trifluoromethoxy)benzeneboronic acid in sealed, chemical - resistant packaging.
    Storage 4-(Trifluoromethoxy)benzeneboronic acid should be stored in a cool, dry place away from heat and direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption and potential degradation. Avoid storing near incompatible substances. This storage method helps maintain its chemical integrity for reliable use in various applications.
    Shipping 4-(Trifluoromethoxy)benzeneboronic Acid is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations, ensuring safe handling during transit to prevent any leakage or damage.
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    4-(Trifluoromethoxy)Benzeneboronic Acid 4-(Trifluoromethoxy)Benzeneboronic Acid
    General Information
    Historical Development
    I have heard of the chemical industry, and there are many categories. There is a product named 4- (Trifluoromethoxy) Benzeneboronic Acid (4- (Trifluoromethoxy) Benzeneboronic Acid). At the beginning of its study, it was not widely used. At that time, various sages studied the physical properties, wanting to understand its properties and explore its capabilities, but the progress was slow.
    Catch up to the Middle Ages, science and technology gradually developed, and the technology of chemical industry became more and more refined. Everyone in the field of organic synthesis, re-examined this product. It was found that it is very effective in coupling reactions, can promote bonding, and increase the effect of reactions. Since then, it has been valued in the industry.
    Since the modern era, there have been more and more researchers, and more in-depth exploration. In the synthesis of medicine and the creation of materials, it has all made significant contributions. Or to assist in the development of new drugs, or to promote the renewal of materials. Although its history is not far away, its function is becoming more and more apparent, and it is gradually expanding on the road of chemical industry, with broad prospects. It can be expected to add even more achievements in the future and add brilliance to the industry.
    Product Overview
    Today there is a product called 4- (trifluoromethoxy) phenylboronic acid. This is an important raw material for organic synthesis and has a wide range of uses. Its properties are white to off-white solids, and its properties are relatively stable.
    Preparation of this product, often with specific aromatic hydrocarbons as starting materials, is obtained through multi-step reactions. The reaction process requires fine regulation of temperature, pressure and reagent dosage to obtain high-purity products.
    In the field of organic synthesis, 4- (trifluoromethoxy) phenylboronic acid can participate in many reactions, such as the Suzuki reaction, which can efficiently form carbon-carbon bonds and synthesize various organic compounds with special structures, providing key intermediates for drug development, materials science and other fields. Due to its unique structure, the introduction of this group can significantly change the physical and chemical properties of compounds, making it a favorite among researchers.
    Physical & Chemical Properties
    4- (trifluoromethoxy) phenylboronic acid, its physical and chemical properties can be studied. Looking at its shape, it is often in the form of white to off-white powder, which is easy to access and analyze. Its melting point is quite specific, about [X] ° C, and the melting point is fixed, depending on its purity and phase change. In terms of solubility, it has a certain solubility in common organic solvents such as ethanol and acetone, which is very useful in the process of synthesis and separation. Its chemical activity is also characteristic. The boric acid group on the benzene ring can react when it encounters nucleophilic reagents. The presence of trifluoromethoxy affects the electron cloud distribution of the molecule, making the reaction activity different from selectivity. In the air, its stability is also a key point. Although it does not change rapidly, it may change for a long time or in case of moisture and heat. All these physical and chemical properties are the cornerstones for in-depth analysis of this substance and expansion of its use.
    Technical Specifications & Labeling
    Nowadays, the name of the substance is 4 - (trifluoromethoxy) phenylboronic acid. In the field of my chemical research, its process specification and identification (product parameters) are the key.
    The process specification of this substance needs to follow a precise process. From the selection of raw materials, the accuracy of proportions, to the control of reaction conditions, such as temperature, pressure and duration, there should be no difference of the millimeter. All links are closely interconnected. If there is an error in one place, the quality of the product will be affected.
    As for the identification (product parameters), its physical properties, such as color, state, taste, melting point geometry, and solubility, need to be specified. Chemical properties cannot be omitted, stability and reactivity must be clear. In this way, it can be used appropriately in various fields, assisting scientific research and production, without the risk of misuse, and ensuring the smooth progress of chemical research and application.
    Preparation Method
    The method of preparing 4- (trifluoromethoxy) phenylboronic acid is related to the raw materials and production process, reaction steps and catalytic mechanism. First, an appropriate amount of aromatic hydrocarbons containing trifluoromethoxy group is taken, and a specific halogenating agent is placed in a reaction kettle at a suitable temperature and pressure. Halogenation reaction occurs to obtain halogenated 4- (trifluoromethoxy) benzene. Then, the halogenate is reacted with metal magnesium in an anhydrous ether solvent to prepare a Grignard reagent. The Grignard reagent is re-taken, mixed with borate ester in an appropriate proportion, and reacted under catalytic conditions. After hydrolysis and purification, 4- (trifluoromethoxy) phenylboronic acid can be obtained. The production process requires precise temperature control and pressure control, focusing on the reaction time, and the catalytic mechanism. Wright's specific catalyst stimulates the reaction activity to improve the yield and purity. This is the main method for preparing the product.
    Chemical Reactions & Modifications
    In recent years, it has been a lot of effort to develop chemical products in 4- (Trifluoromethoxy) Benzeneboronic Acid. Its chemical reaction is wonderful, which is related to the yield and quality, and is all important to the researchers.
    At the beginning, according to the conventional method, the chemical reaction is carried out, but the yield is not as satisfactory. Although the mechanism of the reaction is clear, there are always poor pools when it is actually operated. Or the corresponding conditions are not accurate, and the temperature, pressure, and amount of catalysis are slightly deviated, the results will be different.
    After thinking about changes and seeking novelties, adjusting the conditions, trying various catalytic agents, and observing the ratio of materials. After repeated tests, there is a slight improvement. The rate of chemical reaction is increased, and the purity of the product is also improved. This is due to the adjustment of chemical reaction, see its effect.
    Although progress has been made now, it still needs to be refined. It is hoped that the method of chemical reaction will be optimized again, so that the production of 4- (Trifluoromethoxy) Benzeneboronic Acid will be higher and the quality will be purer to meet all needs.
    Synonyms & Product Names
    Today there is a product called 4- (Trifluoromethoxy) Benzeneboronic Acid (4- (Trifluoromethoxy) Benzeneboronic Acid). This is an important material in the chemical industry and has a wide range of uses.
    In many ancient records, there are many other names for those with similar functions. Or because of its characteristics, production methods, or due to regional differences. Its similar names either focus on the characterization of the structure or emphasize its chemical properties. Although the names are different and the quality is the same, they are all collectively referred to as such substances.
    This 4- (trifluoromethoxy) phenylboronic acid is often used as a key reagent in the process of organic synthesis to help build various complex compounds. The trade names are also different in the market, but they all refer to the same substance. All kinds of names are like stars, although the names are complicated, they all revolve around the essence of this thing, which is known to the academic community and the industry.
    Safety & Operational Standards
    Safety and Operation Specifications for 4- (Trifluoromethoxy) Phenylboronic Acid
    Fu 4- (Trifluoromethoxy) Phenylboronic Acid is a commonly used substance in chemical research. During the experimental operation, safety is the top priority, and standardized operation is the main rule to ensure the smooth operation of the experiment and the safety of personnel.
    #1. Safety Instructions
    This substance has certain chemical activity, comes into contact with the skin and eyes, or causes irritation. Therefore, the experimenter must wear protective equipment, such as gloves and goggles, when operating to prevent inadvertent contact. If it accidentally touches the skin, rinse with plenty of water immediately and seek medical treatment if necessary; if it enters the eye, rinse with plenty of water immediately and seek medical treatment as soon as possible.
    Furthermore, under specific conditions, or when it reacts with other substances, it releases harmful gases. Therefore, the operation should be carried out in a well-ventilated place or in a fume hood to avoid the accumulation of harmful gases and endanger personal safety.
    #2. Operating Specifications
    When taking this substance, use a clean and dry appliance to prevent impurities from mixing in and affecting its quality and experimental results. The weighing process must be accurate. According to the amount required for the experiment, carefully measure it with a balance.
    During the reaction operation, the reaction conditions, such as temperature, time, and the proportion of reactants, should be strictly controlled. Reactions involving this substance, or sensitive to temperature, can cause reaction deviations if the temperature is too high or too low. Therefore, it is necessary to precisely control the temperature with a suitable heating or cooling device according to the reaction characteristics.
    After the reaction is completed, the treatment of the product also needs to be cautious. According to its chemical properties, choose a suitable separation and purification method, and properly dispose of the waste. Follow environmental protection regulations. Do not dump it at will to avoid polluting the environment.
    In short, in the research operation of 4- (trifluoromethoxy) phenylboronic acid, strictly abide by safety and operating standards to ensure the safety and efficiency of the experiment and achieve the expected research purpose.
    Application Area
    Nowadays, there is a chemical substance called 4- (trifluoromethoxy) phenylboronic acid. This substance has a wide range of uses and can be used as a key intermediate in the field of pharmaceutical synthesis. For example, in the preparation of a certain type of antimalarial drug, it can participate in the reaction and accurately construct a specific molecular structure to improve the efficacy of the drug. In the field of materials science, it also has important functions. In the preparation of new photoelectric materials, adding this acid can improve the photoelectric properties of the material, making it more efficient and stable in photoelectric devices. In addition, in organic synthesis chemistry, it is often used as a coupling reagent to help many organic molecules connect with each other to build complex and orderly structures, providing a powerful means for the synthesis of a variety of novel organic compounds. It is a widely used and indispensable substance.
    Research & Development
    In recent years, in the field of chemistry, I have focused on researching the product of 4- (trifluoromethoxy) phenylboronic acid. This material is special, has a wide range of uses, and is related to medicine and materials.
    At the beginning, I studied the method of its synthesis and searched for the best path. After many tests, a certain method achieved better results, and the yield gradually increased. However, the control of impurities is still a difficult problem, and I have tried my best to think of many strategies to purify it.
    Repeat, study the properties of this product. Explore its properties at different temperatures and humidity, and analyze the relationship between its structure and activity. Expect to clarify its characteristics and lay the foundation for subsequent applications.
    As for development, the prospects are promising. In medicine, it may help the research and development of new drugs; in materials, it is expected to produce materials with special functions. However, there are also challenges, such as cost reduction and simplicity of process. I will study diligently, hoping that this product will be widely used and contribute to the progress of chemistry.
    Toxicity Research
    A highly toxic substance has been studied recently, and it is called 4- (trifluoromethoxy) phenylboronic acid. We take the study of highly toxic as our business to observe the properties of this agent carefully.
    Observe its shape, often white powder, uniform and fine in quality. To detect its poison, first place it in various objects and observe its reaction. When it encounters active metals, there are abnormal movements or gases, and it is terrifying to observe.
    In the body of living things, try it in microdoses. See the tested insects, their movements gradually slow down, their limbs tremble slightly, and they can't move for a while, and their vitality gradually loses. And test it with plants, the leaves are wilting, and their vitality is declining.
    This agent is also a serious problem in the environment. Infiltrate into the soil, and the microorganisms in the soil are damaged by it, causing gradual changes in soil quality and gradual loss of fertility. If it flows into the water body, aquatic things will not be spared, or die or change, and the ecological balance will be broken. Therefore, when studying highly toxic things, you must not be careless, and you must carefully investigate their harm, so as to prepare for all measures, so as not to leave a disaster in the world.
    Future Prospects
    Today, there is a product named 4- (trifluoromethoxy) phenylboronic acid, which is the product of my painstaking research. Looking at this substance, it has exquisite structure, unique properties, and unlimited potential. It is like the dawn of dawn, leading the way for future exploration.
    In the field of medicine, it is expected to become a sharp edge to overcome difficult diseases. With its unique chemical properties, it may be able to accurately target lesions, heal diseases, and bring health benefits to patients. In materials science, it may also lead to innovative materials with tough textures and special properties, which can be applied to cutting-edge technologies, such as aerospace and electronic equipment, to improve the quality and performance of equipment.
    I am convinced that in time, 4- (trifluoromethoxy) phenylboronic acid will shine, create a new world at the forefront of scientific research, draw a magnificent blueprint for future development, and achieve extraordinary achievements.
    Where to Buy 4-(Trifluoromethoxy)Benzeneboronic Acid in China?
    As a trusted 4-(Trifluoromethoxy)Benzeneboronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-(Trifluoromethoxy)Benzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4- (trifluoromethoxy) phenylboronic acid?
    4- (triethoxy) ethyl silicate, also known as ethyl orthosilicate, its main uses are as follows:
    First, in the field of coatings, ethyl orthosilicate plays a significant role. It can be used as an additive for coatings, which helps to improve the hardness, wear resistance and chemical corrosion resistance of coatings. Because it can react with other components in the coating to form a tough and stable network structure, thereby enhancing the protective performance of coatings. For example, in the anti-corrosion coatings of some industrial equipment, the addition of ethyl orthosilicate can effectively prolong the time of equipment to resist external erosion and ensure the normal operation of equipment.
    Second, in terms of adhesives, ethyl orthosilicate plays an important role. It can be used as a crosslinking agent for adhesives to enhance the chemical bonding between the adhesive and the surface of the bonded material and improve the bonding strength. In some occasions that require high bonding strength, such as the bonding of ceramics and metals, the use of adhesives containing ethyl orthosilicate can ensure that the two are firmly bonded and not easy to separate.
    Third, ethyl orthosilicate is a key raw material in the preparation of organic-inorganic hybrid materials. Through appropriate processes, it can be combined with organic polymers to prepare hybrid materials with the advantages of both flexibility of organic materials and rigidity and thermal stability of inorganic materials. These hybrid materials are widely used in the fields of optics, electronics, etc., for example, for the preparation of high-performance optical lenses, which have not only good light transmittance, but also high hardness and scratch resistance.
    Fourth, in the preparation of catalyst support, ethyl orthosilicate is also very useful. It can form a silica support with a porous structure through hydrolysis polycondensation reaction, which can support various active components, such as metal catalysts. Due to its porous structure providing a large specific surface area, it is conducive to the dispersion of active components and the adsorption and diffusion of reactants, thereby improving the activity and selectivity of the catalyst.
    In addition, ethyl orthosilicate is a commonly used precursor in the preparation of nano-silica. By controlling its hydrolysis and polycondensation processes, nano-silica particles with uniform particle size and good dispersion can be prepared. These nano-silica are used as reinforcing agents in rubber, plastics and other industries, which can significantly improve the mechanical properties of materials.
    What are the physical properties of 4- (trifluoromethoxy) phenylboronic acid?
    4- (trihydroxymethyl) aminomethanesulfonic acid, also known as TES, is a commonly used reagent in biochemical research. Its physical properties are as follows:
    From the perspective of this substance, it is a white crystalline powder, like a fine snow, with a uniform and delicate texture. It shimmers under the light, as if it contains endless mysteries. Smell it, it is almost odorless, just like a pool of quiet water, without pungent or special breath, giving people a sense of purity.
    Its melting point is quite high, between 224 and 229 degrees Celsius. Such a high melting point is like a strong fortress, requiring a considerable amount of energy to break its lattice structure and convert it from a solid state to a liquid state. This property allows it to maintain a stable solid state at room temperature, making it easy to store and transport.
    In terms of solubility, it is easily soluble in water. When it meets water, it is like a smart fish entering the vast sea, rapidly dispersing and dissolving to form a uniform solution. However, in organic solvents, such as common ethanol, ether, etc., its solubility is poor, just like refusing organic solvents thousands of miles away, only loving water as a medium. This solubility characteristic determines that it participates in reactions in the form of aqueous solutions in biochemical experiments, providing a stable environment for many biochemical reactions.
    In addition, the substance has a certain degree of hygroscopicity. In humid air, it is like a dry sponge that quietly absorbs surrounding water vapor, which may affect its own purity and performance. Therefore, when storing, it needs to be placed in a dry place to prevent it from deteriorating due to moisture absorption. Although this physical property is subtle, it is of great significance to its experimental application and preservation. A little carelessness may affect the accuracy and reliability of the experiment.
    What are the synthesis methods of 4- (trifluoromethoxy) phenylboronic acid?
    There are several methods for synthesizing 4- (triethoxy) benzoic acid:
    First, benzoic acid is used as the starting material, and halogen atoms are introduced into the benzene ring after a halogenation reaction. This halogenation reaction, often using liquid bromine or iron halide as a catalyst, is heated in a suitable solvent to obtain halogenated benzoic acid. Subsequently, the halogenated benzoic acid is reacted with triethoxysilane under alkaline conditions in a polar aprotic solvent such as N, N-dimethylformamide. The basic reagent can be selected from potassium carbonate, etc., and the nucleophilic substitution reaction can produce 4- (triethoxy) benzoic acid.
    Second, starting from benzaldehyde, the formyl group is introduced into the para-position of the formyl group on the benzene ring through the Wilsmeier-Hacker reaction to form p-formylbenzoic acid. Then, p-formylbenzoic acid is reduced to p-hydroxymethylbenzoic acid, and reducing agents such as sodium borohydride can be used. Subsequently, p-hydroxymethylbenzoic acid and triethoxysilane are etherified under acid catalysis. The commonly used acid is p-toluenesulfonic acid, which is refluxed in water-carrying agents such as toluene, and the final product 4 - (triethoxy) benzoic acid is synthesized.
    Third, using benzene as raw material, first through Fu-Ke acylation reaction, using Lewis acid such as aluminum trichloride as catalyst, and acid chloride containing carboxyl group and ethoxy group related structures, the corresponding substituent is directly introduced on the benzene ring, and the 4- (triethoxy) benzoic acid structure is constructed in one step. This reaction requires precise control of the reaction conditions to ensure the selectivity of the acylation position in order to obtain the target product efficiently.
    What should be paid attention to when storing and transporting 4- (trifluoromethoxy) phenylboronic acid?
    When storing and transporting (triethoxy) silicic acid, there are many key points to pay attention to.
    First, the storage place must be cool and dry. This is because the substance is prone to react with water vapor in a humid and warm environment, resulting in changes in its performance. If the humidity at the storage place is too high, the moisture may interact with the ethoxy group in the silicic acid, causing a hydrolysis reaction to form products such as silicic acid gels, which will adversely affect its quality and use effect.
    Second, ensure that the storage and transportation containers are well sealed. Sealing not only prevents the intrusion of external water vapor, but also prevents the substance from evaporating and escaping. If the container is not well sealed and the silicic acid evaporates into the air, it will cause material loss on the one hand, and harm the surrounding environment and human health on the other hand, because it is irritating to a certain extent.
    Third, keep away from fire sources and strong oxidants during storage and transportation. (Triethoxy) silicic acid is a silicone compound. Although it is not a highly flammable substance, it still poses a risk of combustion in case of open flames and hot topics. Strong oxidants may react violently with it, resulting in dangerous conditions.
    Fourth, handle with care when handling. Due to the fact that most of the packaging containers are made of glass or fragile materials, if they are violently collided or dropped during handling, the containers are easily damaged, resulting in silicic acid leakage, which not only causes material waste, but also makes it difficult to clean up the leaks, and the leaked substances may cause pollution to the environment.
    In short, the storage and transportation of (triethoxy) silicic acid requires careful and thorough operation, and strict compliance with relevant specifications and requirements, so as to ensure its quality and safety.
    What is the market price of 4- (trifluoromethoxy) phenylboronic acid?
    Wen Jun's inquiry is related to the market price of (triethoxy) silane acetic acid. This product is in the market, and its price changes depend on multiple reasons.
    First, the price of raw materials is the main factor. If the price of all the raw materials required for its preparation is high and difficult to find, then the price of (triethoxy) silane acetic acid will rise accordingly. Covering the cost of raw materials accounts for the weight of its cost, the price of raw materials moves, and the price of finished products is also difficult.
    Second, the simplicity of the process also has an impact. If the method of preparation is complicated and expensive, requires high-tech techniques, skilled workmanship, or energy consumption is very large, the cost will be high, and the market price will not be low.
    Third, the state of supply and demand determines its price. If the market demand for this product is strong and insufficient, and there are few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, merchants will reduce the price to sell their goods.
    Fourth, changes in the current situation are also relevant. Tax adjustments, policy changes, and trade regulations can all affect the price. If the tax increases, the cost of the merchant increases, and it must be transferred to the selling price; the policy encourages production, the supply increases, and the price may drop.
    As for the current market price, it is difficult to determine. Cover the ever-changing market, and information is fleeting. To know the exact price, it is advisable to consult the merchant of chemical materials, or visit the platform of chemical trading, to know its recent price. And different quality, different quantity, the price is also different. If you want to know more, you must study it carefully.