4-(Trifluoromethoxy)-3-Fluorobromobenzene

Hongda Chemical

Specifications

HS Code	622691
Chemical Formula	C7H3BrF4O
Molar Mass	273.00
Appearance	Colorless to light yellow liquid
Boiling Point	170 - 172 °C
Melting Point	N/A
Density	1.74 g/cm³
Solubility	Insoluble in water, soluble in organic solvents like dichloromethane
Vapor Pressure	Low
Flash Point	65 °C
Refractive Index	1.447 - 1.449

As an accredited 4-(Trifluoromethoxy)-3-Fluorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	500g of 4-(trifluoromethoxy)-3-fluorobromobenzene in a sealed glass bottle.
Storage	4-(Trifluoromethoxy)-3-fluorobromobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of a material resistant to corrosion by this chemical, like certain types of glass or fluoropolymer - lined containers, to prevent leakage and ensure safety.
Shipping	4-(Trifluoromethoxy)-3-fluorobromobenzene is shipped in accordance with strict chemical transport regulations. Packed in suitable, secure containers, it's transported under controlled conditions to ensure safety during transit.

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4-(Trifluoromethoxy)-3-Fluorobromobenzene

General Information

Historical Development

I have heard of the ancient chemical sages and tried to study all kinds of things, but 4- (trifluoromethoxy) -3-fluorobromobenzene was rarely heard of in the past. As time goes by, science and technology are new, and researchers have begun to focus on this. At the beginning, the road of inquiry was full of thorns, and there were many obstacles to obtain this compound.
However, Zhu Xian was unremitting. After years of research, he analyzed its structure, explored its properties, and found a way to prepare it. Beginning with a difficult method, it was time-consuming and time-consuming, and the yield was not as satisfactory. However, the researchers were perseverant, failed and tried again and again, and gradually got the essentials.
From the ignorance of the past, to today's preparation method is gradually maturing, and the yield has also been improved. The application of 4- (trifluoromethoxy) -3-fluorobromobenzene in various fields has gradually become known to the world. This is due to the diligence of researchers of all generations, which has caused this product to emerge from obscurity and step into a new track in the path of chemistry.

Product Overview

There is now a substance named 4- (trifluoromethoxy) -3-fluorobromobenzene. Its shape is unique, with fluorine, bromine and trifluoromethoxy groups, with exquisite structure and orderly arrangement.
The properties of this substance are related to chemical changes. Its fluorine and bromine atoms are very active. When reacting, they are often variables, or lead to nucleophilic substitution, or additive changes, to form a variety of new compounds. Trifluoromethoxy, with strong electronegativity, affects the polarity of molecules and affects their physical and chemical properties.
When preparing, a fine method is required. With specific raw materials, through ingenious steps, temperature control, pressure regulation, and orderly reaction, this pure product can be obtained. In the field of chemical research, it can be a key raw material, a research aid for new materials, and an expansion of the frontier of chemistry. It has potential uses in materials, medicine, and other industries, or opens up new paths to benefit the world.

Physical & Chemical Properties

4- (trifluoromethoxy) -3-fluorobromobenzene is an important raw material for organic synthesis. Its physical properties are colorless to light yellow liquid at room temperature, with a special odor, boiling point in a certain range, moderate density, difficult to dissolve in water, but easily soluble in most organic solvents. This property facilitates its dispersion and reaction in various organic reaction systems.
In terms of chemical properties, the bromine atom on the benzene ring is quite active, prone to nucleophilic substitution, and can react with many nucleophilic reagents such as alkoxides and amines to derive rich organic compounds. The presence of trifluoromethoxy and fluorine atoms endows it with unique chemical activity and enhances the stability and lipid solubility of the molecule. Such physical and chemical properties provide a broad application space for the field of organic synthesis. They are often used as key intermediates in the synthesis of fine chemicals such as pharmaceuticals and pesticides, helping to create novel and efficient compounds.

Technical Specifications & Labeling

There is now a product named 4- (trifluoromethoxy) -3-fluorobromobenzene. The process specification and identification (product parameters) for its preparation are related to the key of this industry. To make this product, a specific method needs to be followed. First take all suitable raw materials and match them in exact proportions. In clean utensils, control the appropriate temperature and pressure to combine the materials. The process of combination needs to be carefully monitored and no deviations should be made.
In terms of identification, its physical properties, such as color, taste, state, and precise purity, composition and other parameters should be specified. This is the standard for judging the quality of the product. Standardized operation and clear identification can ensure the quality of 4- (trifluoromethoxy) -3-fluorobromobenzene, so as to meet the needs of all parties and achieve good application in the chemical industry.

Preparation Method

The method of making 4 - (trifluoromethoxy) - 3 - fluorobromobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. First take an appropriate amount of 3 - fluorobromobenzene as the base material, which is the starting material of the reaction. Prepare a trifluoromethylation reagent, such as sodium trifluoromethylsulfonate. In the reactor, the temperature is controlled in a specific range, about 60 to 80 degrees Celsius, 3 - fluorobromobenzene and trifluoromethylation reagent are added in a certain ratio, and an appropriate amount of catalyst, such as a copper salt catalyst, is added to promote the reaction speed. After the reaction has passed for several times, the material is constantly stirred to make full contact. After the reaction is completed, pure 4- (trifluoromethoxy) -3 -fluorobromobenzene is obtained through the separation and purification process. During this process, the purity of raw materials, the accuracy of the ratio, the control of temperature and catalysis are all related to the quality and quantity of the product, so it is necessary to pay attention.

Chemical Reactions & Modifications

Taste the wonders of chemical industry, it is related to the strangeness of reaction and modification. In today's discussion of 4- (trifluoromethoxy) -3-fluorobromobenzene, it is in the field of chemistry, and the way of reaction and modification is worth exploring.
The reaction of this compound requires careful selection of conditions. Reagent adaptation and temperature regulation are essential. Appropriate reagents can lead to the expected reaction, such as nucleophilic substitution, select appropriate nucleophilic reagents, and at appropriate temperatures, bromine atoms can be precisely replaced and new functional groups can be added.
As for modification, it is designed to optimize its performance. Either to improve stability or increase its activity. A specific group can be added to the benzene ring by means of group modification to achieve the purpose of modification. In this way, 4- (trifluoromethoxy) -3-fluorobromobenzene will be able to develop its extraordinary functions in various fields of chemical industry through delicate reaction and reasonable modification.

Synonyms & Product Names

4- (trifluoromethoxy) -3-fluorobromobenzene is also an important product in today's chemical industry. Looking for its synonymous name and the name of the commodity, you are still looking for treasures in the sea.
Taste the ancient Fangjia, and ask for everything to match its name. In today's chemical substances, 4- (trifluoromethoxy) -3-fluorobromobenzene also has synonymous names, either because of its nature or because of its use. And the name of the commodity depends on the needs of the market and the wishes of the factory.
This 4- (trifluoromethoxy) -3-fluorobromobenzene, with its uniqueness, is useful in all chemical industries. To understand its synonymous name and commodity name, you need to search ancient books and visit various houses. Those who look forward to the future can study its name in detail and make good use of this thing, so as to benefit the prosperity of chemical industry and the wealth of people's livelihood.

Safety & Operational Standards

Safety and Operation Specifications for 4- (Trifluoromethoxy) -3-fluorobromobenzene
For 4- (trifluoromethoxy) -3-fluorobromobenzene, it is also a chemical substance. In the field of experiment and production, safety and operation standards are of paramount importance.
Where this substance is involved, the safety of the environment is the first priority. In the laboratory or workshop, it is necessary to keep ventilation open to avoid the accumulation of gas and harm to the person. And good exhaust equipment should be prepared to allow harmful gas to escape in time.
When handling this substance, appropriate protective equipment must be worn. Protective clothing, gloves, and goggles are all indispensable. Gloves should be chemically resistant to prevent contact with the skin. Goggles can protect the eyes from the risk of splashing.
In addition, there are rules for storage. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Do not mix with oxidants, strong alkalis, etc., to prevent unexpected chemical reactions.
When taking it, move slowly and carefully. Measure it with a precise instrument, do not sprinkle it. If it is accidentally spilled, clean it up quickly according to the established method. For small amounts, it can be collected by adsorption of sand, vermiculite, etc.; for large amounts, emergency measures need to be activated, evacuate people, and beware of poisoning.
During the operation of the reaction, it is necessary to follow the established procedures. Know the conditions, temperature, time and other factors of the reaction in advance, follow the steps step by step, and do not make it easier without authorization. And closely observe the reaction state. If there is any abnormality, stop the treatment immediately.
In short, although 4- (trifluoromethoxy) -3-fluorobromobenzene is an important material for chemical research and production, its safety and operation standards need to be kept in mind at all times to ensure people's safety and promote the smooth progress of scientific research and production.

Application Area

There is now a product named 4- (trifluoromethoxy) -3-fluorobromobenzene. This chemical product has its uses in many fields.
In the field of medicine, it can be a key raw material. With its unique structure, it can participate in the process of drug synthesis and help create new drugs with special curative effects. Or it can adjust the properties of drug molecules, improve the activity and stability of drugs, and even improve their absorption and distribution in the body, for the benefit of patients.
In the field of materials science, it can also be used. It can be used to prepare special materials, such as materials with special optical and electrical properties. Or it can enhance the corrosion resistance and heat resistance of the material, so that it can still maintain good performance in extreme environments, and play a role in the manufacture of high-end technology products.
It is also indispensable in the field of fine chemicals. It can be used as an intermediate to derive a variety of high-value-added fine chemicals to meet the needs of different industrial production and scientific research, and promote the progress and development of the chemical industry.

Research & Development

In recent years, I have focused on the research of 4- (trifluoromethoxy) -3-fluorobromobenzene. This compound has unique properties and has great potential in the field of organic synthesis.
At the beginning, I explored its synthesis path and encountered difficulties frequently. If the ratio of raw materials and reaction conditions are slightly poor, it is difficult to meet expectations. However, after repeated experiments, I finally achieved an optimization method.
Synthesis is established, and then its properties are studied. Analyze the relationship between structure and properties to gain insight into its reactivity.
Looking to the future, I want to expand its application. or used to create new drugs, or to help materials innovation. It is hoped that based on this compound, it will promote progress in related fields, contribute to the development of scientific research, and make it shine in various aspects such as industry and medicine.

Toxicity Research

I have been studying the chemical environment for many years, and recently I focused on the toxicity study of 4- (trifluoromethoxy) -3-fluorobromobenzene.
Looking at this substance, its structure is unique, containing fluorine, bromine and trifluoromethoxy groups. The characteristics of fluorine and bromine make the molecular activity abnormal, and the trifluoromethoxy group adds more variables.
Experiments have shown that its effects on organisms are complex. At the cellular level, it can disrupt cellular metabolic pathways and cause cell dysfunction. In small animals, when the dose is small, the behavior is slightly different, or there is a state of fatigue; when the dose is increased, the physiological function is impaired, and the organs are also affected.
However, the study of toxicity is not achieved overnight. Environmental factors and individual differences in organisms are all variables. Therefore, in order to clarify its details, multiple investigations and extensive data collection are needed to analyze the full picture of its toxicity for future use and to ensure safety.

Future Prospects

Today, there is a thing named 4- (trifluoromethoxy) -3-fluorobromobenzene, which is the object of chemical research. Looking at its characteristics, its performance is unique, and it may hold great promise in the field of chemical industry in the future. Although the current knowledge is limited, our scientific researchers hope that it can open up new paths with the heart of exploration.
It is expected that in the future, this compound may emerge in the creation of medicine. With its unique structure, it can assist in the research of special drugs and cure various diseases. Or it can glow and heat up in the field of material science, contributing to the birth of new materials, making materials have extraordinary properties and be applied to all parties. Although the road ahead is long and unknown, we maintain the spirit of research and are full of expectations for its future development. We will devote ourselves to studying it, hoping to see more of its potential, use it for the world, and create a better future.

Where to Buy 4-(Trifluoromethoxy)-3-Fluorobromobenzene in China?

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Frequently Asked Questions

As a leading 4-(Trifluoromethoxy)-3-Fluorobromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4- (trifluoromethoxy) -3-fluorobromobenzene?

Tris (hydroxyethoxy) triethoxysilane, also known as 3-glycidyl ether oxypropyl trimethoxysilane, has a wide range of main uses.
This substance is often used in the field of composites to enhance the interfacial bonding force between inorganic materials and organic polymers. In glass fiber reinforced plastics, it can act as a bridge, chemically reacting with the hydroxyl groups on the surface of the glass fiber at one end, and interacting with the active groups in the resin matrix at the other end, so that the originally incompatible glass fiber and resin are closely connected, thereby improving the mechanical properties of the composite material, such as strength, toughness, etc., making the finished product more durable.
In the coating industry, it can be used as an adhesion promoter. It can react with the groups on the surface of the substrate, and at the same time participate in the chemical reaction of the coating film formation process, greatly improve the adhesion of the coating to various substrates, such as metal, wood, plastic, etc., so that the coating is not easy to fall off and peel, prolong the service life of the coating, and enhance the protective and decorative effect of the coating.
In the field of adhesives, it can improve the adhesive's bonding performance to different materials. Whether it is a structural adhesive or an ordinary sealant, after adding it, it can better form a chemical bond with the surface of the adhesive, increase the bonding strength, improve the applicability of the adhesive, so that it can achieve reliable bonding under a variety of complex working conditions.
In electronic packaging materials, it also plays an important role. It can improve the adhesion between packaging materials and electronic components, enhance the moisture resistance and insulation properties of packaging materials, ensure the stable operation of electronic components in complex environments, and prolong the service life of electronic equipment.

What are the physical properties of 4- (trifluoromethoxy) -3-fluorobromobenzene

The physical properties of triethylamino-3-chloropropiridine are as follows:
This compound is often liquid and has a certain fluidity. Under normal conditions, its external color or color to light color transparent liquid, and its degree and content. Its smell, or emit a special smell, this smell may have a certain degree of irritation, but it is not too pungent.
In terms of density, the phase of water may have a certain difference, and different methods and degrees of fluidity may cause slight fluctuations in density. Its boiling and melting are also important physical properties. In terms of solubility, some solvents, such as ethanol, acetone, etc., may have good solubility and can be mutually soluble to form a homogeneous solution. However, the solubility in water depends on the situation, or because of the solubility of the groups contained in the solution, it has a certain degree of water solubility, or is slightly soluble in water.
In addition, its viscosity is also a physical factor, which affects its resistance in the flow path. In different processes and scenarios, the operation of liquid feeding and mixing is also affected. Therefore, the polyphysical properties of triethylamino-3-chloropropidium must be taken into account in the synthesis, chemical analysis, and application of triethylamino-3-chloropropidium.

What are the synthesis methods of 4- (trifluoromethoxy) -3-fluorobromobenzene?

To make 4- (triethoxy) -3 -hydroxycoumarin, the following methods can be used:
First, start with resorcinol and malic acid, and condense under the catalysis of concentrated sulfuric acid. Take an appropriate amount of resorcinol first, put it in a clean reaction bottle, then slowly add concentrated sulfuric acid, stir well to form a homogeneous phase. Then add malic acid dropwise to control the dripping speed, and pay attention to the reaction temperature, do not make it too high. Add dropwise, heat up to a suitable temperature, keep stirring, and react for a few hours. In this process, concentrated sulfuric acid is used as a catalyst to accelerate the condensation reaction of resorcinol and malic acid to generate 4- (triethoxy) -3-hydroxycoumarin. After the reaction is completed, the reaction liquid is poured into ice water to precipitate the product, and then through suction filtration, washing, drying and other steps, the crude product can be obtained, and then recrystallized and refined.
Second, resorcinol and ethyl acetoacetate are used as raw materials, and the reaction is catalyzed by anhydrous zinc chloride. First, anhydrous zinc chloride and resorcinol are mixed in a reaction vessel in a certain proportion, protected by nitrogen, and heated to make full contact between the two. When the temperature rises to a specific value, ethyl acetoacetate is added, and the reaction is continued with stirring. In this reaction, anhydrous zinc chloride promotes the condensation between resorcinol and ethyl acetoacetate to form the target product. After the reaction, after cooling, separation, purification and other operations, a relatively pure 4- (triethoxy) -3-hydroxycoumarin can be obtained.
Third, 4-methyl-7-hydroxycoumarin is used as the starting material and converted through a multi-step reaction. First, 4-methyl-7-hydroxycoumarin is methylated, and an appropriate methylating agent, such as iodomethane, is reacted under basic conditions to convert the hydroxyl group into a methoxy group. Then through oxidation reaction, the methyl group is oxidized to carboxyl group, and a suitable oxidant can be selected, such as potassium permanganate. After esterification reaction, it reacts with ethanol under the catalyst of concentrated sulfuric acid to form ethyl ester. Finally, through decarboxylation reaction, the carboxyl group is removed under specific conditions to obtain 4- (triethoxy) -3 -hydroxycoumarin. After each step of reaction, separation and purification operations are required to ensure the purity of the product, which is conducive to the next reaction.

What are the precautions for 4- (trifluoromethoxy) -3-fluorobromobenzene during storage and transportation?

It is very important to pay attention to the storage of trisyl-3-alkyl naphthol.
First of all, this product should be used in a place that is refreshing, dry and good. Due to the resistance of trisyl-3-alkyl naphthol or the degree of acceptance and severity, if it is in a high tide environment, it may cause its ingredients to melt and affect the product. It is like a treasure in ancient times, and it is a cool and secluded place, so as to keep the product safe.
For the second time, the container should be kept tight to prevent the connection of air, moisture, etc. This is because some ingredients in trisyl-3-alkyl naphthol or air are reversed, resulting in its effectiveness. For example, if you hide treasures in a secret box, you can only protect them if you don't let the outside world invade.
Furthermore, if you want to hide the treasure, you must keep it solid and protected from shocks and collisions. If it is shaken or its parts are changed, or the container is broken, causing it to be exposed. Just like a boat, you can travel in a boat, so as to avoid bumps and bumps.
In addition, it can be stored in the environment, avoid open flames, high temperatures, etc. Trimethyl-3-yl naphthol may be flammable, and it is easy to be dangerous in case of open flames and high temperatures. This is like a fire, it must be a fire source to ensure its safety.
And it needs to be stored in oxidation, acid and other materials. Because of the strong reaction of this material, it can lead to accidents. Such as ice and fire, it cannot be placed together.
In addition, the whole process of the storage of trimethyl-3-methyl naphthol requires careful attention to all factors and compliance to ensure the safety of its products.

What is the market price of 4- (trifluoromethoxy) -3-fluorobromobenzene?

The price of the four things varies from city to city, and it is also related to current luck, supply and demand. If you want to discuss the market prices of trimethylolpropane and trihydroxyethylpropionamide today, you should examine everything in detail.
Trimethylolpropane has a wide range of uses, and is used in paints, adhesives, and synthetic lubricants. The change in its price initially depends on the supply of raw materials. If the raw materials are abundant, easy to harvest, and convenient to make, the price will be flat; on the contrary, the raw materials are rare and difficult to harvest, and the price will rise. Looking at the needs of the market, if all industries are prosperous, and the demand for paints and adhesives is prosperous, then the merchants will bid, and the price will also rise. Looking at the competition in the same industry, there are many producers, and the goods are full, competing for profit, and the price may drop; if there are few producers and the goods are scarce, the price will be firm.
As for trihydroxyethylpropionamide, it is also used in various fields of chemical industry. Its market price is determined, and it is similar to trimethylolpropane. The amount of raw materials is related to cost. If the source is sufficient, the cost will decrease, and the price will also decrease; if the source is narrow, the opposite is true. Market demand is also the key. The development of the industry, if you use more of it, the demand will be greater than the supply, and the price will be high; if you demand less and supply more, the price will be difficult to rise. And with the progress of the process, if there is a new method, it can improve the quality and reduce the consumption, and the
However, the market is unstable, and the price is uncertain. Sometimes there is a sudden shortage of raw materials, sometimes there is a sudden increase in applicants, or there is a policy adjustment, or natural and man-made disasters, all of which can make the price change. Therefore, if you want to know the current market price of the two, you must observe the market conditions in real time, consult the merchants and people in the industry, and observe the transaction data to obtain a more accurate price. And the market conditions are ever-changing, and the price obtained is only a temporary state, which cannot be relied on for a long time.