4-Nitro(Trifluoromethoxy)Benzene

Hongda Chemical

Specifications

HS Code	881568
Chemical Formula	C7H4F3NO3
Molecular Weight	207.106
Appearance	colorless to light yellow liquid
Boiling Point	197 - 198 °C
Melting Point	17 - 19 °C
Density	1.44 g/cm³
Vapor Pressure	0.33 hPa (20 °C)
Flash Point	83 °C
Solubility In Water	insoluble
Solubility In Organic Solvents	soluble in common organic solvents like ethanol, ether

As an accredited 4-Nitro(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	1 kg of 4 - nitro(trifluoromethoxy)benzene packaged in a sealed, corrosion - resistant drum.
Storage	4 - nitro(trifluoromethoxy)benzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition points. Keep it in a tightly - sealed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and bases as it may react with them. Ensure proper labeling for easy identification and handling.
Shipping	4 - nitro(trifluoromethoxy)benzene is shipped in specialized, properly labeled containers. It follows strict regulations for hazardous chemicals, ensuring secure transport to prevent any risks during transit.

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General Information

Historical Development

4 - Nitro (Trifluoromethoxy) Benzene is also an organic compound. At the beginning, chemists worked hard to explore it in the laboratory. At first, only a little knowledge of its basic properties, and the synthesis method was cumbersome and inefficient.
However, the years have passed, and science and technology have advanced. Many researchers have been studying the reaction mechanism in depth and improving the synthesis path. In the past, it required multiple steps and complex operations, which took a lot of time and materials, but now it is becoming more simple and efficient.
Its application field has also expanded with the deepening of research. At first, it was limited to specific experimental scenarios, and later it emerged in the fields of medicine and materials, which was the cornerstone of many innovative achievements. From this perspective, since the advent of 4-Nitro (Trifluoromethoxy) Benzene, its development process is like a pearl gradually shining brightly, blooming in the field of chemistry.

Product Overview

There is a chemical product named 4-Nitro (Trifluoromethoxy) Benzene. It is a chemical product with a colorless to light yellow liquid appearance and a special odor. This substance has a wide range of uses in the field of organic synthesis and is often used as a key intermediate.
Its unique structure contains nitro and trifluoromethoxy groups. Nitro groups are active and give the product many reactivity; trifluoromethoxy groups have high electronegativity of fluorine atoms, which affects the physical and chemical properties of the product, making it stable and special solubility.
Preparation of this product often requires delicate chemical processes, through specific reaction steps, precise control of reaction conditions, such as temperature, pressure, catalyst, etc., to obtain ideal yield and purity. However, the preparation process also poses challenges, requiring fine operation and strict control to ensure product quality.

Physical & Chemical Properties

4 - Nitro (Trifluoromethoxy) Benzene is also a chemical substance. Its physical and chemical properties are quite specific. Looking at its shape, at room temperature, or as a colorless liquid, its quality is clear and has a special odor.
In terms of its physical properties, the number of boiling points is about a specific value, reflecting the difficulty of its gasification. Its density is also fixed, and it has its unique specific gravity in liquids. As for solubility, it is more insoluble in some organic solvents or soluble in water.
In terms of autochemical properties, it has a specific reactivity because it contains nitro and trifluoromethoxy groups. Nitro can participate in reduction and other reactions, while trifluoromethoxy affects the distribution of its electron cloud, making the substance exhibit different behaviors in nucleophilic and electrophilic reactions. Chemists often explore these properties to illustrate their applications in synthesis and other fields.

Technical Specifications & Labeling

Today there is a thing called 4 - Nitro (Trifluoromethoxy) Benzene. To clarify its technical specifications and identification (product parameters), you should consider it carefully.
The shape and quality of this thing must be determined. Its color, taste and state are all important for identification. The color should be pure and free of variegated contamination; the taste should be suitable for its nature, and there should be no odor disturbance; the state must be stable and present according to its original state.
As for the technical specification, it depends on the method of preparation. The materials used must be fine, the proportion must be accurate, and the preparation process should follow a strict sequence. The temperature and duration should not be ignored. Every step is related to the quality of the product. In the
logo, product parameters are also key. Values such as purity must be accurately tested; the amount of impurities contained must be clearly marked. In this way, when this product is applied, everyone can understand its properties and make the best use of it without error.

Preparation Method

To prepare 4-Nitro (Trifluoromethoxy) Benzene, the raw materials and production process, reaction steps and catalytic mechanism are crucial.
The selection of raw materials needs to be carefully screened. High-purity initial reactants, such as specific halogenated benzene derivatives and reagents containing nitro and trifluoromethoxy groups, should be selected as the basis for the reaction.
In the production process, the reaction conditions need to be precisely controlled. Temperature, pressure and reaction time all affect the purity and yield of the product. If in a suitable organic solvent, under the catalysis of a specific catalyst, the reactants should be fully mixed and reacted.
For the reaction step, the halogenated benzene derivative is mixed with the nitro-containing reagent in a certain proportion, and the nucleophilic substitution reaction occurs under the action of the catalyst, and the nitro group is introduced. After adding the trifluoromethoxy reagent, the trifluoromethoxy group is connected under specific reaction conditions.
In terms of catalytic mechanism, the selected catalyst should be able to effectively reduce the activation energy of the reaction and accelerate the reaction process. Metal-organic complex catalysts can be selected, which can form specific intermediates with the reactants to guide the reaction to proceed smoothly, so that 4-Nitro (Trifluoromethoxy) Benzene can be efficiently prepared.

Chemical Reactions & Modifications

The chemical and reverse modification of 4-Nitro (Trifluoromethoxy) Benzene is investigated. This compound is used for its unique properties, but its anti-chemical mechanism and modification method can be explored.
In the chemical and reverse reaction, its unique characteristics lead to the same anti-chemical effect. The position of nitro trifluoromethoxy affects the reverse effect and rate. Such as the nuclear substitution, the two either promote or inhibit, and the end of the environment.

and modification, aiming to expand its use and improve its performance. It can be borrowed and modified to improve its performance and performance. Or introduce new radicals to improve its physical and chemical properties, so that it can be used in new domains and increase its efficiency.
, 4 - Nitro (Trifluoromethoxy) Benzene chemical and anti-modification, to be further studied in order to reveal its use.

Synonyms & Product Names

4 - Nitro (Trifluoromethoxy) Benzene, this substance is also a key material in chemical research. In today's chemical industry, it has a wide range of uses.
Its synonymous name, also known as "p-nitrotrifluoromethoxy benzene". The name of the product, also known as common.
This substance has unique properties. Looking at its physical properties, or it is a colorless liquid, it has a special smell. Its chemical properties are active and contain a stable state. Under specific reaction conditions, it can participate in a variety of delicate synthesis.
In the process of industrial preparation, through various reactions and precise processes, this product is obtained. Scientific researchers often rely on it as a raw material to explore new synthesis paths, seek excellent performance, and hope to make progress in the field of new materials and new drugs, in order to benefit the world.

Safety & Operational Standards

4 - Safety and Operation Specifications of Nitro (Trifluoromethoxy) Benzene
Husband 4 - Nitro (Trifluoromethoxy) Benzene is also a chemical product. Its special properties, for the purpose of engineering and engineering, must be operated with safety, so as to protect the danger.
#1. The importance of storage
This product should be stored in a place where it is dry, dry, and well-connected. Avoid fire, avoid fire, and avoid fire sources. Do not mix with oxidized materials, raw materials, and other substances to prevent chemical reactions. The device of storage must be well-packed to prevent leakage from the outside. And there is a clear warning, so that people know its danger.
#Second, when operating,
When operating, you must use anti-wear clothing, anti-wear gloves, and eye protection. If you are in a room, you must do it in the passageway to eliminate harmful effects. The operator is familiar with the operation requirements. Take it away, make it appropriate, and prevent it. If it is accidentally released, immediately isolate it and restrict the entry and exit of people. Small amounts of waste can be absorbed by inert materials such as sand and vermiculite; large amounts of waste need to be moved to the container for use by pump and properly handled.
#3. Urgent measures
If the skin is damaged, quickly wash the dyed clothes with a large amount of water and treat it immediately. If in the eyes, immediately wash with physiological water or clean water, and then remove. If inhaled, quickly move to the new air. If breathing is difficult, give oxygen, and it is necessary to perform artificial respiration.
Therefore, the safe operation of 4 - Nitro (Trifluoromethoxy) Benzene is of paramount importance. All workers should follow it to avoid harm and ensure safety.

Application Area

4 - Nitro (Trifluoromethoxy) Benzene is also a chemical substance. Its use, in the field of production, can be used as a raw material for making special effects, to help heal. In the field of production, it can be used as the basis for refining, to avoid damage. And in the field of materials, it can be used to synthesize special materials to increase their properties. It is important to synthesize. It is important to be able to do more and more reactions, to obtain exquisite compounds. Such uses are all special properties. Make this thing, more and more difficult, and it must be affected by it, and it can be used in this world.

Research & Development

I have been studying chemical products for a long time. Recently, I studied 4-Nitro (Trifluoromethoxy) Benzene carefully. Its synthesis method was originally based on traditional techniques, but the yield did not reach my expectations. Then I turned to a new path and explored a catalytic method to gain energy.
In terms of property exploration, this product has unique chemistry, high stability, and can be used as a key agent in specific reactions. Its application prospects are also quite broad, and it has applications in the fields of medicine and materials.
I will continue to study to optimize the synthesis process and improve the yield and quality. I hope this product can contribute to the development of the chemical industry and become a treasure in the industry, so as to promote the progress of the chemical industry, benefit the country and the people, and prosper the chemical industry.

Toxicity Research

Yu Yanyan Chemical Products recently focused on the toxicity study of 4-Nitro (Trifluoromethoxy) Benzene. This substance has a wide range of uses in the chemical industry, but its toxicity cannot be ignored.
At the beginning, we took all kinds of creatures as the test and observed how they were affected by 4-Nitro (Trifluoromethoxy) Benzene. See that the behavior and physiology of the tested creatures have abnormalities. Or slow movement, or physiological disorders, all of which are signs of toxicity.
Analyze the state of its dispersion in the environment and observe its harm to the surrounding water, soil and vegetation. It was found that this substance remained for a long time and was easy to enter the food chain, endangering many organisms. Although it has contributed a lot to industry, it is toxic and harmful. When used prudently, research methods to avoid harm, and seek stability in the hope of profit, so as to avoid misfortune in the world.

Future Prospects

The Prospect of the Husband, in 4 - Nitro (Trifluoromethoxy) Benzene, this product is not available for use. Its characteristics are unique, and the way of use is not limited. It can be made by engineering, or it can be the basis of new materials, so that the performance of the product is outstanding, exceeding the norm. In the field of research, it is also expected to research new technologies, overcome many diseases, and save people.
Our scientific researchers must be unremitting in our research, digging deep into its strength. Study the theory of its transformation and reverse, seek better synthesis methods, and improve it. Hope that this product can be developed in the future, promote the progress of science and technology, and benefit the well-being of people. Make this 4 - Nitro (Trifluoromethoxy) Benzene, on the stage of the generation, show the color, and achieve the work of thousands of years. This is the grand work that I have never done before.

Where to Buy 4-Nitro(Trifluoromethoxy)Benzene in China?

As a trusted 4-Nitro(Trifluoromethoxy)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 4-Nitro(Trifluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 4-Nitro (Trifluoromethoxy) Benzene?

4-Nitro (trifluoromethoxy) benzene is also widely used in the field of organic synthesis.
One of them is the key raw material for the preparation of nitrogen-containing heterocyclic compounds. In organic chemistry, nitrogen heterocyclic compounds play an important role in many fields such as medicine, pesticides and materials science. 4-Nitro (trifluoromethoxy) benzene can be converted into various nitrogen-containing heterocyclic structures through specific chemical reactions, such as nucleophilic substitution and cyclization. In this process, its nitro group and trifluoromethoxy group can play a unique role. Nitro has strong electron-absorbing properties, which can reduce the electron cloud density of the benzene ring and promote the attack of nucleophilic reagents; while trifluoromethoxy gives the product special physical and chemical properties, such as increasing the lipid solubility of the compound and affecting its biological activity.
Second, in the process of drug synthesis, this compound is also an important intermediate. In drug development, it is often necessary to build complex molecular structures to obtain specific biological activities. 4-Nitro (trifluoromethoxy) benzene can be reacted in multiple steps to introduce other functional groups to build structures that are compatible with drug targets. For example, in the synthesis of some antifungal and antiviral drugs, it is used as the starting material and carefully designed reaction routes to gradually construct drug molecules with the required activity.
Third, in the field of materials science, 4-nitro (trifluoromethoxy) benzene also contributes. The polymer materials it participates in the synthesis can have good thermal stability, chemical stability and electrical properties due to the characteristics of trifluoromethoxy. For example, the preparation of high-performance engineering plastics, electronic packaging materials, etc., adding structural units derived from this compound can significantly improve the properties of materials and meet the needs of high-end fields.
In summary, 4-nitro (trifluoromethoxy) benzene plays an indispensable role in organic synthesis, drug development and materials science, and plays an important role in promoting the development of various fields.

What are the physical properties of 4-Nitro (Trifluoromethoxy) Benzene?

4-Nitro (trifluoromethoxy) benzene, the physical properties of this substance are quite important, and it is relevant to its application in various fields. Its properties are usually colorless to light yellow liquid, and it looks quite fluid. Under light, it may have a faint luster.
When it comes to the melting point, it is between -15 ° C and -10 ° C. In this temperature range, the substance gradually solidifies from the liquid state, and the molecular arrangement changes from disorder to order, and the structure tends to be tight. The boiling point is in the range of 200 ° C to 210 ° C. When the temperature rises to the boiling point, the molecule obtains enough energy to break free from the liquid phase and transform into a gaseous state. Under this temperature condition, its gas-liquid transformation can be realized.
Its density is about 1.5 g/cm ³, which is slightly higher than that of common organic solvents, which means that it has a larger mass under the same volume. In terms of solubility, it is soluble in halogenated hydrocarbon organic solvents such as dichloromethane and chloroform, and slightly soluble in water. This solubility characteristic is derived from the characteristics of nitro and trifluoromethoxy groups in its molecular structure. The polarity and molecular structure of halogenated hydrocarbon organic solvents are in a certain agreement with 4-nitro (trifluoromethoxy) benzene, so they are miscible; while the polarity of water is strong, which does not match the intermolecular forces of the substance, resulting in slight solubility.
In addition, 4-nitro (trifluoromethoxy) benzene has a low vapor pressure and a slow volatilization rate at room temperature, which makes it relatively less susceptible to loss due to volatilization during storage and use, and also guarantees the safety of the operating environment to a certain extent. At the same time, its refractive index is about 1.47-1.48. When light passes through the substance, the direction of propagation will change at a specific angle according to this characteristic. This property may be important in optical correlation detection and analysis.

Is 4-Nitro (Trifluoromethoxy) Benzene Chemically Stable?

4-Nitro (trifluoromethoxy) benzene, this is an organic compound. The stability of its chemical properties requires many factors to balance.
Under normal conditions, the compound has a certain stability. Because the structure of the benzene ring is very stable, there is a conjugated system, which can disperse the electron cloud and reduce the molecular energy. Nitro and trifluoromethoxy are connected to the benzene ring, although it will affect the electron cloud density of the benzene ring, it does not cause a drastic change in the structure. Nitro is an electron-withdrawing group, which can reduce the electron cloud density of the benzene ring, weaken the activity of electrophilic substitution, but enhance the molecular stability to a certain extent. Trifluoromethoxy is also an electron-withdrawing group, and trifluoromethyl has high electronegativity of fluorine atoms and is connected to oxygen atoms, which can affect the distribution of molecular electrons, but it does not break its basic skeleton stability.
However, under special conditions, its stability may be destroyed. In case of strong oxidants, the nitro group may be further oxidized, causing structural changes. In case of extreme conditions such as high temperature, high pressure, and strong acid and base, the chemical bonds in the molecule may break, causing the reaction to occur. For example, under strong acidic conditions, the substituents on the benzene ring may participate in the reaction, causing the structure of the compound to change.
In summary, 4-nitro (trifluoromethoxy) benzene has certain stability under conventional conditions, but under special and extreme conditions, the stability will be challenged, or chemical reactions will occur, causing structural changes.

What is the preparation method of 4-Nitro (Trifluoromethoxy) Benzene?

The preparation method of 4-nitro (trifluoromethoxy) benzene is as follows:
One method is to use 4-nitrophenol as the starting material. In a suitable reaction vessel, first add 4-nitrophenol, and then add an appropriate amount of alkali, such as potassium carbonate, which can convert the phenolic hydroxyl group into phenoxy anion and enhance its nucleophilicity. Then, slowly add trifluoromethylation reagents, such as trifluoromethylsulfonic acid anhydride. The reaction needs to be carried out at a suitable temperature and under the protection of inert gas, generally between low temperature and room temperature, and nitrogen protection is appropriate. This reaction goes through a nucleophilic substitution process. The phenoxy negative ion attacks the sulfur atom of the trifluoromethyl sulfonate anhydride and leaves the sulfonate ion, so 4-nitro (trifluoromethoxy) benzene is obtained. After the reaction is completed, the product is purified by conventional post-processing steps such as extraction, washing, drying, and column chromatography.
The second method can start from nitrobenzene. First, a specific method, such as under the catalysis of Lewis acid, makes the nitrobenzene and the trifluoromethylating reagent undergo electrophilic substitution reaction, and the trifluoromethoxy group is introduced into the benzene ring. For example, using aluminum trichloride as a catalyst, under low temperature conditions, a trifluoromethylating reagent such as trifluoromethyliodine is slowly added In the reaction, the positive trifluoromethyl ion attacks the benzene ring as an electrophilic reagent to form an intermediate, and generates 4-nitro (trifluoromethoxy) benzene through proton transfer and other steps. After the reaction, the product also needs to be separated and purified by means such as extraction to remove impurities, water washing to remove water-soluble substances, anhydrous magnesium sulfate drying, and distillation or column chromatography to obtain high-purity 4-nitro (trifluoromethoxy) benzene.

What is the price range of 4-Nitro (Trifluoromethoxy) Benzene in the market?

4-Nitro (trifluoromethoxy) benzene, the range of the market price, it is difficult to cut off. Its price often varies due to the process, quantity, and supply conditions.
Looking at the past examples of chemical transactions, if the quantity is small, it is for laboratory use, with high purity, and the price per gram is about tens to hundreds of yuan. Cover a small amount of refining, its cost is high, and it needs special methods to maintain purity, so the price is high.
If it is for industrial use and the quantity is large, its price is measured in tons. However, in the preparation, raw materials, energy consumption, labor costs, etc. all affect its price. Raw materials are expensive, energy consumption is huge, and labor costs are high. Generally speaking, the price per ton may be between tens of thousands and hundreds of thousands.
And the trend of demand and supply also affects the price. If you ask for more and less, the price will rise; if you ask for more and less, the price will be depressed. Market conditions are fickle, and the price will follow. To know the exact price, it is advisable to consult the chemical material supplier, and depending on the current situation, you can get the accurate price.