4-Methoxyfluorobenzene

Hongda Chemical

Specifications

HS Code	759855
Chemical Formula	C7H7FO
Molar Mass	126.13 g/mol
Appearance	Colorless liquid
Boiling Point	150 - 152 °C
Density	1.107 g/cm³
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, ether
Flash Point	45 °C

As an accredited 4-Methoxyfluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100 mL of 4 - methoxyfluorobenzene packaged in a tightly - sealed glass bottle.
Storage	4 - methoxyfluorobenzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly - sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances. The storage area should be dry to avoid any potential reactions due to moisture.
Shipping	4 - methoxyfluorobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper labeling, secure packaging, and transportation by trained handlers to prevent any leakage or safety issues.

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General Information

Historical Development

4 - Methoxyfluorobenzene is an organic compound, and its historical development is quite significant. In the past, at the beginning of chemical research, many scholars devoted themselves to exploring new substances. At that time, the understanding of the structure and properties of organic compounds was still shallow.
With the passage of time, chemical technology has been continuously refined, and scientists have gradually been able to analyze and synthesize various compounds with precision. For 4 - Methoxyfluorobenzene, researchers have repeatedly experimented and studied its synthesis path. At first, the synthesis method was complex and the yield was low.
However, scientists have made unremitting efforts to continuously improve the technology. With the innovation of analytical methods, the understanding of its properties has become more and more in-depth. Today, 4 - Methoxyfluorobenzene has been applied in many fields, and its historical development has witnessed the progress of chemistry.

Product Overview

Description of 4-methoxyfluorobenzene
4-methoxyfluorobenzene is an important raw material for organic synthesis. It is a colorless and transparent liquid with a special odor. In the field of organic chemistry, it has a wide range of uses.
The structure of this product is unique, and the methoxy group and fluorine atoms are cleverly connected to the benzene ring. Because the methoxy group has a electron-absorbing effect, the fluorine atom has an electron-absorbing effect. The interaction between the two gives the compound unique chemical activity.
In the synthesis reaction, 4-methoxyfluorobenzene is often a key intermediate. With its special structure, it can participate in various reactions such as nucleophilic substitution and electrophilic substitution, and help synthesize many complex organic compounds. For example, in the field of medicinal chemistry, a molecular framework with biological activity can be constructed through a specific reaction path, providing the possibility for the development of new drugs.
Its physical properties cannot be ignored, and parameters such as boiling point and melting point need to be precisely controlled during storage and use. The colorless and transparent state makes it easy to observe its reaction process and purity. Although the special smell is not the only criterion for measuring its quality, it is an important basis for identification. In short, 4-methoxyfluorobenzene plays an important role in chemical research and industrial production.

Physical & Chemical Properties

4-Methoxyfluorobenzene is an organic compound with unique physical and chemical properties. Looking at its physical properties, under normal temperature and pressure, it often appears as a colorless and transparent liquid with a special odor. Its boiling point is about a specific value. This value is the key temperature for a substance to change from liquid to gaseous state, which is related to its existence in different environments. Furthermore, the melting point is also an important parameter, which determines its state at low temperature.
On its chemical properties, the presence of methoxy groups and fluorine atoms in the molecular structure gives it unique chemical activity. The power supply of methoxy groups and the absorption of fluorine atoms make the distribution of molecular electron clouds different and affect their chemical reactivity. For example, in the electrophilic substitution reaction, the reaction check point is mostly in the ortho-position due to the ortho-para-location effect of methoxy group, and compared with benzene, the reaction activity may be changed. These physical and chemical properties are of great significance in the fields of organic synthesis and drug development, laying the foundation for related research and applications.

Technical Specifications & Labeling

Jinyan 4 - Methoxyfluorobenzene this material, its technical specifications and identification (commodity parameters) are the key. To observe its quality, when the purity is the key, the impurities must be less, before it can be used. Viewing its shape, it should have a specific color, taste and state, colorless, transparent and pure odor is preferred. Its boiling point, melting point and other physical parameters also need to be accurately determined, in line with the established standards. On the label, the composition, content and origin must be specified. When preparing, according to specific methods, control its temperature, pressure and reaction time to ensure uniform quality. In this way, the technical specifications and identification (commodity parameters) of 4 - Methoxyfluorobenzene can be used safely and sold reliably.

Preparation Method

The method of making 4-Methoxyfluorobenzene products is as follows: First take all raw materials and make them by a specific process. For raw materials, when choosing a good one, such as [specific raw material name], the proportion is appropriate. In the preparation method, the first step is the reaction step, at a suitable temperature and pressure, so that the raw materials are combined. For example, under [specific reaction conditions], after [X] time, the intermediate product is obtained. The second is the catalytic mechanism, using [catalyst name] to promote the speed of the reaction and increase the rate of the product. When catalyzing, pay attention to temperature control and control to avoid side reactions. In this way, after multiple operations, 4-Methoxyfluorobenzene can be obtained, and its quality should meet the required standards. This is the approximate method of making this product.

Chemical Reactions & Modifications

The chemical and reverse modification of 4-Methoxyfluorobenzene compounds is an important issue in chemical research. In order to explore the chemical and reverse properties, it is necessary to improve the chemical properties, such as chemical properties, catalysis, etc. The appropriate degree of resistance can increase the rate of reaction. If the degree of resistance is high or low, the reaction or reaction will be caused, or the side reaction will be generated.
Catalysis can also reduce the activation energy of the reaction, so that the reaction will be easy to generate. The combined catalytic properties can be directed to induce reaction and improve the yield of the target compound.
and modification, aiming to give the new properties of the compound. Or functional modification, so that the 4-Methoxyfluorobenzene has better solubility and characterization. All of these need to be refined in the principle of transformation and reversed in order to realize the good environment of anti-modification and the development power of the field.

Synonyms & Product Names

4 - Methoxyfluorobenzene, this thing is also worthy of investigation by its synonymous name and commodity name. Today's chemical things have various names, and there are many people who have the same thing but different names. In the field of chemical industry, 4 - Methoxyfluorobenzene or have other names, all of which are different due to the naming convention, or stem from the method of synthesis, or according to its behavior. The name of its commodity, the merchant is its characteristic, and will also set up another title. When we study this chemical thing, we must study its synonymous name and commodity name in detail to get the whole picture. Knowing its names is beneficial to the collection of raw materials, the application of experiments, and the promotion of results. In the name of 4 - Methoxyfluorobenzene synonyms and commodities, it is the priority of chemical researchers.

Safety & Operational Standards

4 - Methoxyfluorobenzene safety and operating standards
4 - Methoxyfluorobenzene, chemical products are also. Its preparation, access and storage should strictly adhere to safety and operating standards to avoid accidents.
When preparing, all instruments must be clean and dry. The reaction vessel used must be able to withstand the temperature and pressure of the reaction to prevent rupture and leakage. The stirring device should also operate smoothly to make the reaction system uniform. The reaction temperature must be precisely controlled. If it is too high, it may cause the reaction to go out of control, and if it is too low, it will affect the yield. Measure it in real time with a thermometer, and adjust the temperature in a timely manner according to the reaction process.
When taking it, it should be in a well-ventilated environment. Wear protective gloves, the material should be resistant to erosion of 4-Methoxyfluorobenzene, so as not to contact the skin. Take it with a dropper or pipette, the amount must be accurate, and the operation should be slow to avoid its splashing. If it is accidentally splashed on the skin, quickly rinse with a lot of water, followed by an appropriate agent.
When storing, it should be placed in a cool, dry and ventilated place. Keep away from fire and heat sources to prevent fires. The reservoir must be well sealed to prevent it from evaporating and escaping. The label is clear, indicating the name, concentration, date, etc., so that it can be identified and used.
After the experiment, the remaining material should not be discarded at will. According to relevant regulations, classify it to prevent pollution to the environment. The equipment used should also be cleaned immediately for later use.
In short, in the business of 4-Methoxyfluorobenzene, we must be cautious and follow safety and operating standards to ensure the smooth operation of the experiment, the safety of personnel, and the cleanliness of the environment.

Application Area

4 - Methoxyfluorobenzene, it is also a chemical thing. Its application field can be investigated. In the field of synthesis, it can be an important raw material. With this material, it can be reversed, or it can be used to obtain special effects, so as to create general diseases. And in the field of materials, it is also useful. It can assist in the research of new materials, or with special properties, such as better performance, quality, etc. In the production of spices, if used, it can give spices a special fragrance and increase their charm. In addition, 4 - Methoxyfluorobenzene in the field of multi-use, all of them are hidden. To be explored in depth by researchers, in order to show their use and benefit the world.

Research & Development

In modern times, chemistry has flourished, and the exploration of various substances has deepened. Today's words 4 - Methoxyfluorobenzene this thing, our generation has been studying it for years. At the beginning, it was very difficult to make this thing, and the ratio of raw materials and reaction conditions needed to be carefully considered.
Beginning with common methods, repeated attempts have not worked well. Later, the poor classics, referring to the methods of the past, combined with modern equipment, adjust the reaction temperature, duration and catalyst dosage. After many attempts, it has gradually gained. The yield has been very small from the beginning, and it is quite impressive now.
Looking at its application, it has extraordinary potential in the fields of medicine and materials. It can be used as a pharmaceutical intermediate to help the research and development of new drugs; it can also add unique properties in material synthesis. We should make unremitting efforts to expand its application, so that this substance can play a greater role in the world, promote the development of the industry, and seek the well-being of future generations.

Toxicity Research

4 - Methoxyfluorobenzene, the thing that dissolves is also. It is quite important for us to study the toxicity of this thing. If this thing or the way into the body, such as breathing, skin, or ingestion.
Study its toxicity, in the body of the body, check its reaction. Inhalation of the body, or cause respiratory diseases, the lungs. The connection of the skin, or the birth of the body, the disease of the body. If eaten into the stomach, the harm of the stomach should not be ignored.
However, the depth of its toxicity is also the amount. Less harm, more heavy. We want to understand the harm, so as to protect the well-being of people, and use it to prevent the secret, so as not to suffer from poison.

Future Prospects

4 - Methoxyfluorobenzene is a chemical product that I have dedicated myself to studying. Looking at its future development, it is quite impressive. This substance may emerge in the field of pharmaceutical synthesis. With its unique chemical structure, it is expected to become a key intermediate for many new drugs, helping to overcome difficult diseases and benefit the health of the common people. In the field of materials science, there are also potential applications. It may improve the properties of materials and give rise to materials with special functions, such as high stability and strong conductivity, which can be used in high-end technology products. I firmly believe that with time, through unremitting exploration and research, 4 - Methoxyfluorobenzene will be able to shine in various fields, promote scientific and technological progress, and create a better future.

Where to Buy 4-Methoxyfluorobenzene in China?

As a trusted 4-Methoxyfluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 4-Methoxyfluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-Methoxyfluorobenzene?

4-Methoxyfluorobenzene is a class of organic compounds. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
In the field of medicinal chemistry, this compound can participate in the construction of many drug molecules. Due to the unique electronic effect and spatial structure of methoxy and fluorine atoms, it can endow the synthesized drug with specific physical and chemical properties, such as regulating the lipid solubility and water solubility of the drug, which in turn affects the biofilm permeability, absorption and distribution in the body of the drug, or enhances the interaction between the drug and the target, improves the drug activity and selectivity, and contributes greatly to the creation of new drugs.
In the field of materials science, 4-methoxyfluorobenzene can be used to synthesize special functional materials. For example, in the field of organic optoelectronic materials, with its structural characteristics, through rational design and reaction, materials with unique optoelectronic properties can be prepared, such as organic Light Emitting Diode (OLED) materials. Its structure can affect the electron transport and luminous efficiency of materials, contributing to the development of high-performance optoelectronic materials.
In pesticide chemistry, 4-methoxyfluorobenzene is also useful. It can be used as an important raw material for the synthesis of new pesticides, and its structural characteristics can be used to endow pesticides with better biological activity, environmental compatibility and durability. Its unique chemical structure helps to design efficient pesticides for specific pests or diseases, providing strong support for agricultural pest control.
In short, 4-methoxyfluorobenzene plays an indispensable role in organic synthesis, medicine, materials, pesticides and many other fields, promoting the sustainable development and progress of related fields.

What are the physical properties of 4-Methoxyfluorobenzene?

4-Methoxyfluorobenzene, its form is colorless to light yellow liquid, with a special odor. Boiling point is about 172-174 ℃, melting point is -29 ℃, relative density is 1.128 (20/4 ℃), refractive index is 1.4700. Insoluble in water, miscible in most organic solvents such as ethanol, ether, acetone, etc.
This substance is flammable and can be burned in case of open flame or hot topic. It reacts violently in contact with an oxidizing agent and decomposes and releases toxic gases in case of hot topic. Its vapor is heavier than air and can spread to a distance at a lower place. In case of fire, it will lead to backburning.
For storage, it should be placed in a cool and ventilated compartment, away from fire and heat sources, and protected from direct sunlight. It should be stored separately from oxidants. The lighting, ventilation and other facilities in the storage room should be explosion-proof, and the switch should be located outside the warehouse. Equipped with the corresponding variety and quantity of fire-fighting equipment. There should be fire-proof and explosion-proof technical measures when storing tanks. It is forbidden to use mechanical equipment and tools that are prone to sparks. When filling, attention should be paid to the flow rate, and there is a grounding device to prevent the accumulation of static electricity.
Operating 4-methoxyfluorobenzene requires strict compliance with the operating procedures. Operators should undergo special training and strictly abide by the operating regulations. It is recommended that operators wear self-priming filter gas masks (half masks), chemical safety protective glasses, anti-poison penetration work clothes, and rubber oil-resistant gloves. Keep away from fires and heat sources, and smoking is strictly prohibited in the workplace. Use explosion-proof ventilation systems and equipment. Prevent steam from leaking into the air of the workplace. Avoid contact with oxidants. Filling should control the flow rate to prevent static electricity accumulation. When handling, it should be light and unloaded to prevent damage to packaging and containers. Equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. Empty containers may remain harmful.

What is the chemistry of 4-Methoxyfluorobenzene?

4-Methoxyfluorobenzene is also an organic compound. Its chemical properties are particularly important and it has a wide range of uses in the field of organic synthesis.
In terms of its physical properties, 4-methoxyfluorobenzene is often in a colorless liquid state at room temperature, with a special odor. Its boiling point, melting point and other physical constants depend on the arrangement and interaction of atoms in the molecule. The boiling point is related to the strength of the intermolecular force. The boiling point of this compound makes it change from liquid to gaseous state at a specific temperature.
On chemical properties, methoxy (-OCH) and fluorine atoms (-F) are its key functional groups. The electron cloud density of the benzene ring can be increased by methoxy group, which in turn affects the reactivity of the benzene ring. Although the fluorine atom is small, it has a high electronegativity, which also has a deep impact on the properties of the molecule.
In the electrophilic substitution reaction, the electron cloud density of the adjacent and para-sites of the benzene ring is relatively high due to the electron-donor characteristics of the methoxy group, and the electrophilic reagents are prone to attack these two positions. For example, during the nitrification reaction, the nitro group (-NO ²) is mostly introduced into the adjacent and para-sites of the methoxy group. However, the existence of fluorine atoms, due to its electron-absorbing induction effect, will affect the regionality and rate of the reaction.
4 -methoxyfluorobenzene can also participate in When encountering suitable nucleophiles, fluorine atoms can be replaced to form new organic compounds. The rate and selectivity of this reaction depend on factors such as reaction conditions such as temperature, solvent, and the activity of nucleophiles.
In addition, it can also participate in metal-catalyzed reactions, such as palladium-catalyzed coupling reactions. In such reactions, 4-methoxyfluorobenzene can be coupled with other organic halides or olefins to form carbon-carbon bonds or carbon-hetero bonds, thereby synthesizing more complex organic molecules, which are of great value in drug synthesis, materials science, and many other fields.

What are 4-Methoxyfluorobenzene synthesis methods?

There are several common methods for the synthesis of 4-methoxyfluorobenzene.
One is to use 4-methoxyaniline as the starting material, through the diazotization reaction to obtain 4-methoxydiazonium salt, and then react with fluoroboronic acid to form 4-methoxyfluoroboronic acid diazonium salt, heat decomposition of this salt to obtain 4-methoxyfluorobenzene. In this process, the diazotization reaction needs to precisely control the reaction conditions, and the temperature should be low to prevent the decomposition of diazonium salts. And the reagents used, such as sodium nitrite, must be careful when operating, because it is dangerous.
The second is to use 4-methoxyphenol as a raw material, first convert the phenolic hydroxyl group into the corresponding halide, such as reacting with thionyl chloride to obtain 4-methoxychlorobenzene, and then carry out a halogen exchange reaction with fluorinated reagents such as potassium fluoride to obtain 4-methoxyfluorobenzene. However, in this route, the choice of halogenation reaction conditions is crucial, which will affect the yield and purity of halides. When halogen exchange reactions, the activity of fluorinated reagents and the choice of reaction solvents should be considered to improve the reaction efficiency.
In addition, anisole is used as the starting material, and the alkylation reaction of Fu-g is first carried out, and a suitable alkyl group is introduced, and then a halogen atom is introduced through the halogenation reaction. The halogen atom is replaced by a fluorine atom through a fluorination reaction, and the target product 4-methoxyfluorobenzene is obtained. This approach involves a multi-step reaction, and the separation and purification of the product at each step are crucial to avoid the accumulation of impurities affecting the quality of the final product. The reaction conditions at each step, such as the choice of catalyst, the control of reaction temperature and time, need to be carefully considered to achieve efficient synthesis.

What are the precautions in storage and transportation of 4-Methoxyfluorobenzene?

4-Methoxyfluorobenzene is an organic compound. When storing and transporting, many points must be paid attention to.
First words storage. Because of its certain chemical activity, it should be stored in a cool, dry and well-ventilated place. Avoid high temperature and near fire sources to prevent the risk of fire or explosion. This is due to high temperature or open flame or exacerbated volatilization of the compound, forming a flammable mixed gas with air, which will explode in case of fire. In addition, it needs to be stored separately from oxidants, acids, bases and other substances. Due to the violent chemical reaction of 4-methoxyfluorobenzene or with it, it may cause deterioration or produce dangerous products. And the storage container must be tightly sealed to avoid leakage. If it leaks into the environment, or pollutes the air, soil and water, it is also harmful to the human body.
Second talk about transportation. During transportation, ensure that the packaging is complete and firm to prevent leakage due to package damage caused by bumps and collisions. Transportation vehicles should also be equipped with corresponding fire equipment and leakage emergency treatment equipment for emergencies. Transportation personnel should be professionally trained to be familiar with the dangerous characteristics and emergency treatment methods of 4-methoxyfluorobenzene. During transportation, avoid sun and rain, drive according to the specified route, and do not stop in densely populated areas or traffic arteries. If a leak occurs during transportation, the surrounding population should be evacuated immediately to isolate the leakage area. Emergency responders should wear protective equipment and take appropriate treatment measures according to the leakage situation, such as absorbing with inert materials such as sand and vermiculite, or rinsing and diluting with a large amount of water.