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4-Fluoroiodobenzene

Fluorobenzene

4-Fluoroiodobenzene

Hongda Chemical

Specifications

HS Code

383648
Chemical Formula C6H4FI
Molar Mass 222.00 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 185 - 187 °C
Melting Point −13 °C
Density 1.807 g/cm³ at 25 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Flash Point 71 °C
Refractive Index 1.5920 (20 °C)

As an accredited 4-Fluoroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 4 - fluoroiodobenzene packaged in a sealed, chemical - resistant bottle.
Storage 4 - fluoroiodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor release. Store it separately from oxidizing agents and reactive chemicals. Given its potential toxicity and flammability, proper labeling is essential to ensure safe handling and storage.
Shipping 4 - fluoroiodobenzene is shipped in accordance with strict chemical transport regulations. Packed in suitable containers, it's transported by approved carriers, ensuring proper handling to prevent spills and maintain safety during transit.
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4-Fluoroiodobenzene 4-Fluoroiodobenzene
General Information
Historical Development
4 - Fluoroiodobenzene is an important compound in organic synthesis. Looking back to the past, the development of chemistry has been long and exciting. Since the dawn of chemistry, many talents have devoted themselves to material exploration.
In the early years, chemical research was still in the ignorant stage, and the understanding of various compounds was extremely limited. However, with the passage of time, experimental methods have gradually become more abundant, and researchers have deepened their research on the structure and properties of organic compounds. 4 - The birth of Fluoroiodobenzene is the result of the unremitting exploration of many chemists.
Its synthesis method has also evolved over the long history. From the initial rough attempt to the current precise and efficient synthesis path, countless wisdom has been condensed. This compound has emerged in the fields of medicine, materials and other fields, helping the development of the industry. The progress of chemistry, like a shining star, illuminates the long journey of human cognition in the material world, and 4-Fluoroiodobenzene is one of the shining stars.
Product Overview
4 - Fluoroiodobenzene is also an organic compound. It is a colorless to light yellow liquid with a special odor. In the molecular structure of this compound, fluorine atoms and iodine atoms on the benzene ring are interconnected, giving it unique chemical properties.
In the field of organic synthesis, 4 - Fluoroiodobenzene has a wide range of uses. Because of its high activity of iodine atoms, it is easy to participate in nucleophilic substitution reactions, and fluorine atoms can affect the electron cloud distribution of molecules, thereby changing the reaction activity and selectivity. It is often used as an intermediate to prepare various fluorine-containing organic compounds, such as drugs, pesticides and functional materials.
The method of preparing 4 - Fluoroiodobenzene is mostly obtained by iodization of fluorobenzene derivatives as starting materials. During the reaction, attention should be paid to the control of reaction conditions, such as temperature, catalyst selection, etc., to ensure the purity and yield of the product. When storing and using this compound, attention should also be paid to its stability to avoid contact with oxidants, strong bases and other substances to prevent dangerous chemical reactions.
Physical & Chemical Properties
4 - Fluoroiodobenzene is an organic compound, and its physical and chemical properties are worth studying. Looking at its physical properties, at room temperature, this substance is often in a liquid state with a specific density. The density is related to the mass of the substance per unit volume. This property is of great significance in many chemical processes. And its boiling point is also a key physical property. The boiling point defines the temperature at which a substance changes from liquid to gaseous state, which has a profound impact on the separation and purification steps.
On its chemical properties, the existence of fluorine and iodine atoms in 4 - Fluoroiodobenzene gives it unique reactivity. Fluoroiodobenzene atoms have high electronegativity, which changes the electron cloud density of the benzene ring and affects the activity of electrophilic substitution. Iodine atoms can participate in a variety of organic reactions due to their own characteristics, such as coupling reactions, and are widely used in the field of organic synthesis. The clarification of its physical and chemical properties lays a solid foundation for the application of this compound in chemical, pharmaceutical and other fields.
Technical Specifications & Labeling
4 - Fluoroiodobenzene is an important intermediate in organic synthesis. Its preparation process needs to be carefully controlled.
In terms of process specifications, in a dry reaction vessel, an appropriate amount of fluorobenzene is added, iodine gas is introduced, and a specific catalyst is added. The amount of this catalyst is about [X]% of the molar amount of fluorobenzene. The reaction temperature is maintained at [specific temperature] ° C, with continuous stirring. The stirring rate is [X] rpm, and the reaction time is about [X] hours.
The identification of the product (commodity parameters) is related to its quality and application. Its appearance should be colorless to slightly yellow liquid, the purity should be more than 99%, and the moisture content should not be higher than 0.1%. The boiling point is in the [specific boiling point range] ℃, and the density is [specific density value] g/cm ³. Such process specifications and product labels can ensure the quality of 4-Fluoroiodobenzene and meet various industrial needs.
Preparation Method
4 - Fluoroiodobenzene is an important compound in organic synthesis. The preparation method is as follows:
Raw materials and production process: Fluorobenzene is used as the starting material, with an appropriate amount of iodizing reagents, such as iodine elemental substance and a suitable catalyst. The reaction is carried out in an organic solvent. The organic solvent needs to have good solubility to the reactants and products, and the chemical properties are stable.
Reaction steps: First add fluorobenzene and catalyst to the reaction vessel, stir well, and slowly add iodine elemental substance. The reaction process requires strict control of temperature and reaction time, usually under mild heating conditions, the reaction takes several hours.
Catalytic mechanism: The catalyst can reduce the activation energy of the reaction and promote the substitution reaction between fluorobenzene and iodine elemental The catalyst changes the reaction pathway and increases the reaction rate and product selectivity by forming intermediates with the reactants. In this way, 4-Fluoroiodobenzene can be obtained through fine operation to meet the needs of scientific research and industry.
Chemical Reactions & Modifications
Today's research on the anti-chemical properties of 4-Fluoroiodobenzene. The reaction of this compound can be done in many ways. In the past, in order to obtain this compound, it was often encountered in many ways. The anti-chemical properties are harsh, and the rate is not as satisfactory.
However, recent research has been done. The exploration of new and new components makes the reaction more controllable. If a catalyst is used to complement it, it can promote the reaction in the desired direction, and the transformation properties have also been improved. Its activity is increased, the reaction rate is improved, and the side reaction rate is improved.
The transformation of the family is unremitting, and it is expected to be improved one step. Hope to improve the method, so that the synthesis of 4-Fluoroiodobenzene is easy and efficient, and its transformation properties can also be refined on demand, to meet the needs of multiple domains.
Synonyms & Product Names
4 - Fluoroiodobenzene, which is an important product in the chemical world. Although its name is different, it refers to the same thing. Or fluoroiodobenzene, which is called differently, is actually the same.
In the field of chemical research, 4 - Fluoroiodobenzene has a wide range of uses. Its structure is unique, and the atoms containing fluorine and iodine give it special properties. Researchers often use it to control other substances, involving medicines and materials.
Although there are many names, they all identify this product. Just as the ancient saying: "Those who are famous, so other things are also." Although the names are mixed, the essence of natural things remains unchanged. 4 - Fluoroiodobenzene has the same name, which is recognized by the student aid community. When it is used for research, its meaning should be clarified so as not to be confused, so as to promote the progress of the chemical industry.
Safety & Operational Standards
4 - Fluoroiodobenzene safety and operating practices
Fu 4 - Fluoroiodobenzene is an important compound in chemical research. When it is researched and used, safety and operating practices are of paramount importance and cannot be ignored.
#1. Storage rules
This compound should be stored in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent accidents. Because of its certain chemical activity, if it is improperly stored, it may cause deterioration, affect its quality, or even cause safety accidents. It must be stored separately from oxidants, acids and other substances, and must not be mixed in storage to avoid the risk of mutual reaction.
#Second, the operation is necessary
When operating, the experimenter must wear appropriate protective equipment. Protective clothing can prevent it from touching the skin and preventing it from corroding; goggles can protect the eyes from splashing damage; masks can filter out possible volatiles in the air to prevent them from entering the body. The operation process should be carried out in a fume hood to ensure that the volatile gas can be discharged in time and does not gather in the experimental environment.
When taking 4 - Fluoroiodobenzene, the action should be stable and accurate. Use clean and dry appliances to avoid impurities from mixing. If it is accidentally spilled, immediate measures should be taken. A small amount of sprinkling can be absorbed by inert materials such as sand and vermiculite, and properly disposed of after collection; if a large amount of sprinkling, it is necessary to evacuate personnel, seal the scene, and deal with it by professionals.
#3. Emergency measures
If the skin accidentally comes into contact with 4-Fluoroiodobenzene, it should be rinsed with a large amount of flowing water immediately, and the rinsing time should not be less than 15 minutes, and then seek medical treatment. If it splashes into the eye, it is necessary to race against time. Rinse with a large amount of water or normal saline for not less than 15 minutes, and then send it to the hospital. If it inhales its volatile gas, it should be quickly moved to a fresh air place to keep the respiratory tract unobstructed. If breathing difficulties, oxygen needs to be given. If breathing stops, artificial respiration should be performed immediately and rushed to the hospital.
In short, in the research and use of 4-Fluoroiodobenzene, strict adherence to safety and operating standards can ensure the smooth operation of the experiment and the safety of personnel.
Application Area
4 - Fluoroiodobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize specific drugs or have the ability to target treatment for specific diseases. In materials science, it can participate in the creation of novel functional materials, such as optoelectronic materials, endowing materials with unique optical and electrical properties. In the field of organic synthesis, it is an important building block for building complex organic molecules. With its unique chemical activity, it expands the structural diversity of organic compounds through various reactions. In short, 4 - Fluoroiodobenzene has significant effects in many fields. With the advance of scientific research, its application potential will be further explored and expanded.
Research & Development
In recent years, I have been researching various chemical substances, 4-Fluoroiodobenzene, which is quite important to me. Its properties are very different, and it has a wide range of uses in the field of chemical industry.
I began to investigate it, explore its origin, and observe its physical properties. After months of study, I learned the method of synthesis. At the beginning, it was based on the ancient method, but the yield did not reach my expectations. Then I repeated the research, improved the process, changed the conditions of its reaction, and adjusted the proportion of its reagents.
Looking at its application, it can be used as an intermediate in the production of medicine to help the research of new drugs; in the manufacture of materials, it can also add unique properties. I often think that if we can make good use of it, we will be able to introduce new ideas in the chemical industry.
Although I have made progress today, there is still a long way to go. I will make unremitting efforts to cultivate and develop 4-Fluoroiodobenzene, hoping to make greater progress in the research and development of 4-Fluoroiodobenzene. I will do my best for the prosperity of chemical industry.
Toxicity Research
The toxicity of 4 - Fluoroiodobenzene. The properties of this substance are related to the safety and application of experiments. Examine the classics in detail, analyze its structure and reaction, and observe its changes in different environments.
Test it by common method to observe its effect on the substance. Combine with other agents, observe its response, record its image, and analyze its effect.
After various tests, it is known that 4 - Fluoroiodobenzene has a certain toxicity. The effect on the body, or a certain mechanism, still needs to be explored in depth.
Its toxicity or the difference in its structure disturbs the order in the biochemical process. Follow-up research should focus on this, clarify its rationale, in order to reduce the risk of experimentation and use, and ensure people's safety and environmental goodness.
Future Prospects
4 - Fluoroiodobenzene is a chemical product that we have dedicated ourselves to studying. In the current research, this product has emerged, revealing extraordinary characteristics and potential.
Looking to the future, its development prospects can be described as bright. In the field of organic synthesis, with its unique structure, it may become a key building block for the construction of many complex organic molecules, helping to create new drugs and functional materials. With the rapid advancement of science and technology, analysis and detection methods are becoming more and more accurate, and the purity and quality of 4 - Fluoroiodobenzene will definitely be able to be improved to meet the increasingly stringent industrial needs.
With the trend of green chemistry on the rise, it is the trend to develop more environmentally friendly and efficient preparation processes. We, the scientific researchers, should forge ahead and strive to make breakthroughs, so that 4-Fluoroiodobenzene can bloom more brilliantly on the future chemical stage, contribute to human well-being, and lead the chemical industry to a new height.
Where to Buy 4-Fluoroiodobenzene in China?
As a trusted 4-Fluoroiodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 4-Fluoroiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the physical properties of 4-Fluoroiodobenzene?
4-Fluoroiodobenzene, or 4-fluoroiodobenzene, is an important compound in organic chemistry. Its physical properties are particularly critical and have applications in many fields of chemistry.
First of all, 4-fluoroiodobenzene is usually in a colorless to light yellow liquid state, which is easy to observe and identify in experiments and industrial production. Looking at its color and texture, its purity and reaction process can be preliminarily determined.
Second, the boiling point of 4-fluoroiodobenzene is quite high, about 185-187 ° C. A higher boiling point indicates strong intermolecular forces, and its stability can be guaranteed in high temperature environments. In distillation, separation and other operations, the boiling point characteristics are crucial, and can be separated and purified according to the difference between its boiling point and other substances.
Furthermore, the melting point is about -27 ° C. The lower melting point makes 4-fluoroiodobenzene liquid at room temperature, which is easy to handle and transport. And the melting point characteristics have a significant impact on crystallization, recrystallization and other operations, which can help control crystal formation conditions and improve product purity.
The density of 4-fluoroiodobenzene is greater than that of water, which is about 1.98 g/mL. This density characteristic is useful for liquid-liquid separation. If mixed with solvents with different densities such as water, it will be stratified due to density difference, providing convenience for separation.
Its solubility is also worthy of attention. 4-fluoroiodobenzene is insoluble in water, but soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. This solubility characteristic plays a significant role in organic synthesis. According to the reaction requirements, a suitable organic solvent can be selected to provide a good environment for the reaction and promote the reaction.
In addition, 4-fluoroiodobenzene is volatile. In a poorly ventilated environment, its volatilization can cause the concentration in the air to rise. Pay attention to ventilation when using to ensure the safety of experimenters and avoid potential safety hazards.
To sum up, the physical properties of 4-fluoroiodobenzene, such as its color state, melting boiling point, density, solubility and volatility, have far-reaching implications for its applications in organic synthesis, drug development, materials science and other fields. Researching and mastering these properties will help to better utilize 4-fluoroiodobenzene and promote the development of related fields.
What are the common synthesis methods of 4-Fluoroiodobenzene?
4-Fluoroiodobenzene is a compound commonly used in organic synthesis. The common synthesis methods are roughly the following.
First, it is formed by halogen exchange reaction. Usually 4-fluorobromobenzene and iodide are used as raw materials, and a catalyst is added in an appropriate solvent to promote the reaction. For example, acetone is used as a solvent, potassium iodide and an appropriate amount of copper catalyst are added, and heated to reflux. In this reaction, bromine and iodine are exchanged to obtain 4-fluoroiodobenzene. Its advantage is that the raw materials are relatively easy to obtain, and the reaction conditions are not extremely harsh. However, there are also deficiencies, and the yield may be affected by various factors, such as the amount of catalyst, reaction time and temperature.
Second, it is prepared by diazotization reaction. First, 4-fluoroaniline is reacted by diazotization to obtain diazonium salts, and then reacts with iodine sources such as potassium iodide. Specifically, 4-fluoroaniline reacts with sodium nitrite in a low-temperature acidic environment to form diazonium salts, and then potassium iodide is added. The diazonium group is replaced by iodine to generate 4-fluoroiodobenzene. This method requires strict control of the reaction temperature, and low temperature is the key to prevent the decomposition of diazonium salts. And 4-fluoroaniline also needs to be properly obtained and used, because it has certain toxicity.
Third, the coupling reaction catalyzed by transition metals is used. For example, the coupling of palladium-catalyzed aromatic 4-Fluorohalobenzene (chlorobenzene or bromobenzene, etc.) is reacted with iodine source in the presence of palladium catalyst, ligand and base. The reaction conditions are mild and the selectivity is good, which can effectively synthesize 4-fluoroiodobenzene. However, the price of palladium catalyst is higher, or the cost may increase, and the reaction system is more complicated, so the proportion of each reactant and the reaction conditions need to be precisely adjusted.
The above synthesis methods have their own advantages and disadvantages. In practical application, when considering the availability of raw materials, cost, yield and product purity, an appropriate method is selected to prepare 4-fluoroiodobenzene.
Where is 4-Fluoroiodobenzene used?
4 - Fluoroiodobenzene is an organic compound and has applications in many fields.
In the field of medicinal chemistry, its use is quite critical. Because its structure contains fluorine and iodine atoms, it is endowed with unique chemical properties and biological activities. It can be used as a synthetic drug intermediate, which can be converted into complex compounds with specific pharmacological activities through chemical reactions. For example, when developing antibacterial drugs, 4 - Fluoroiodobenzene can be connected to the target molecular structure through a series of reactions, changing the lipophilicity of the drug, electron cloud distribution, etc., to improve the affinity and effect on bacterial cell walls or specific targets, and to help develop high-efficiency antibacterial drugs.
The field of materials science also has its own impact. In the preparation of organic optoelectronic materials, 4-Fluoroiodobenzene can participate in the construction of conjugated systems, because fluorine and iodine atoms have a significant impact on electron transport and optical properties. The introduction of this compound can regulate the luminous efficiency and charge mobility of the material. Such as the preparation of organic Light Emitting Diode (OLED) materials, optimize the material properties, make the OLED screen display clearer and brighter colors.
In organic synthetic chemistry, 4-Fluoroiodobenzene is an important synthetic block. Due to the different activities of fluorine and iodine atoms, different reactions can be selectively occurred. Fluorine atoms are relatively stable, while iodine atoms are active, prone to nucleophilic substitution, metal catalytic coupling reactions, etc. With this, chemists can flexibly construct various complex organic molecular structures, providing powerful means for the synthesis of new functional materials and total synthesis of natural products. During the total synthesis process of natural products, using their characteristics, the complex structure of the target natural product can be accurately constructed through multi-step reactions, which helps to research and develop the activity of natural products.
What is the market price of 4-Fluoroiodobenzene?
4 - Fluoroiodobenzene, there are also compounds. Its market price varies due to general factors, and the value is determined.
The market is affected by the cost of raw materials. The cost of its raw materials is like that of 4 - Fluoroiodobenzene. If raw materials are scarce or increased, the cost will increase, and the market price will be high.
The complexity of production is also due to. If the production is not good, high-end production and fine operation are required, and the cost of production will increase greatly, and the price will also increase. On the contrary, the cost of easy production is controllable, or slightly lower.
Supply and demand are particularly affected. If the market demand is strong and the supply is insufficient, the price will increase. If some industries have a sudden increase in demand, and the quantity has not kept up, the price will be high. If the supply is in demand, the supplier will sell it, or reduce the price.
In addition, the brand and the quality of the product all play a role. Well-known and high-quality products often have high prices.
Generally speaking, the price is low. For small quantities in the warehouse, due to the small quantity and the cost of packaging, etc., the price per gram may range from 10 to 100 yuan. If the work is large and the mold is low, depending on the batch size, the price per kilogram may be between 1,000 and 10 yuan. However, this is generally different, and the price must depend on the transaction situation.
What are the storage conditions for 4-Fluoroiodobenzene?
4 - Fluoroiodobenzene is an organic compound, and its storage conditions are very critical, which is related to the stability and safety of this compound.
This substance needs to be stored in a cool and ventilated warehouse. Because a cool environment can slow down its chemical reaction rate and avoid decomposition or other adverse reactions due to excessive temperature. Well ventilated can disperse harmful gases that may evaporate in time, reducing the risk of explosion or poisoning.
Store away from fire and heat sources. Fire and heat sources can easily cause combustion or even explosion. 4 - Fluoroiodobenzene may cause combustion and explosion when exposed to open flames, hot topics or contact with oxidants.
At the same time, it should be stored separately from oxidants and edible chemicals, and should not be mixed. Oxidants have strong oxidizing properties, and contact with 4-Fluoroiodobenzene may cause severe redox reactions, causing danger. Separated from edible chemicals, it is designed to prevent pollution and avoid serious health problems caused by accidental ingestion.
Storage containers must be sealed. 4-Fluoroiodobenzene may be volatile. Sealed containers can prevent it from evaporating and escaping, and can also avoid reactions with oxygen, moisture and other components in the air, affecting its quality.
In addition, the warehouse should be equipped with suitable materials to contain leaks. If a leak occurs accidentally, it can be collected and treated in time to reduce the harm to the environment and personnel. During storage, the container should also be checked regularly for signs of leakage to ensure safe storage. In short, following the above storage conditions can effectively ensure the storage safety and quality stability of 4-Fluoroiodobenzene.