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4-Fluorobronibenzene

4-Fluorobronibenzene

Hongda Chemical

Specifications

HS Code

670412

Chemical Formula C6H4BrF
Molar Mass 175.00 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 153 - 155 °C
Melting Point -27 °C
Density 1.57 g/cm³ at 25 °C
Flash Point 51 °C
Solubility In Water Insoluble
Vapor Pressure 1.27 mmHg at 25 °C
Logp 3.22
Refractive Index 1.532 - 1.534

As an accredited 4-Fluorobronibenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 4 - fluorobromobenzene packaged in a sealed, corrosion - resistant container.
Storage 4 - fluorobromobenzene should be stored in a cool, well - ventilated area away from heat sources and open flames. Keep it in a tightly closed container to prevent leakage and vapor release. Store it separately from oxidizing agents, as they may react. Use a storage place with good chemical compatibility to avoid container corrosion and ensure safe long - term storage.
Shipping 4 - fluorobromobenzene is shipped in accordance with regulations for hazardous chemicals. It's packed in suitable containers, often with shock - absorbing and leak - proof features. Shipment is via approved carriers, following safety protocols for transport.
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4-Fluorobronibenzene 4-Fluorobronibenzene
General Information
Historical Development
4 - Fluorobromobenzene is an organic compound. It is gradually emerging in the field of chemistry. At the beginning, chemists explored the way of organic synthesis, and after countless attempts, they got involved in this substance. In the past, the synthesis method was not perfect, the yield was quite low, and there were many impurities.
However, with the passage of time, chemical technology has improved day by day. Scholars study the reaction mechanism and optimize the experimental conditions. From simple devices to exquisite instruments; from a single approach, the method of multiple is expanded. The yield of synthesizing 4 - Fluorobromobenzene is gradually increasing, and the purity is also good.
Today, 4 - Fluorobromobenzene is widely used in the fields of medicine and materials. Looking back at its historical development, it is a microcosm of chemical progress, witnessing the unremitting process of human exploration of matter.
Product Overview
4 - Fluorobronibenzene, an organic compound. Its shape and color, at room temperature, or a colorless liquid, have a special odor. Looking at the structure of its molecules, fluorine atoms and bromine atoms interact with each other according to the specific position of the benzene ring, resulting in its unique properties.
This compound has a wide range of uses in the field of organic synthesis. It can be used as a key intermediary to prepare multiple drugs and fine chemicals. Due to the activity of fluorine and bromine atoms, it can lead to a variety of chemical reactions, such as nucleophilic substitution, coupling, etc. After ingenious design and regulation of reaction conditions, it can be converted into various molecules with specific functions.
The method of preparation often relies on the technique of organic synthesis, and the appropriate route is selected according to the availability of raw materials and the difficulty of reaction. However, when synthesizing, attention should be paid to the precise control of reaction conditions to ensure the purity and yield of the product.
Physical & Chemical Properties
4 - Fluorobromobenzene is an organic compound, and its physical and chemical properties are worth studying. From the perspective of physical properties, this substance has a specific melting point and boiling point. Accurate determination of the melting point can provide a key basis for identification and purification depending on the temperature of its solid-liquid transition. The boiling point determines the conditions under which it changes from liquid to gas under a specific pressure.
In terms of chemical properties, the presence of fluorine and bromine atoms endows 4 - Fluorobromobenzene with unique reactivity. Fluorobromobenzene atoms have high electronegativity, which can affect the distribution of molecular electron clouds, change the electron density of the benzene ring, and affect the check point and rate of electrophilic substitution reactions. Bromine atoms can also participate in a variety of chemical reactions, such as nucleophilic substitution. This compound can be used as a key intermediate in the field of organic synthesis. By mastering its physical and chemical properties, chemists can precisely design reaction paths and achieve efficient preparation of target products, which is of great significance in many fields such as organic materials and drug synthesis.
Technical Specifications & Labeling
4 - Fluorobromobenzene is a compound commonly used in organic synthesis. It is crucial to its technical specifications and identification (product parameters).
Looking at its technical specifications, the purity needs to be extremely high, and the impurity content should be minimal. This is related to the performance of the product in various reactions. Insufficient purity may cause an increase in reaction by-products, which affects the yield and product quality. Its physical properties, such as melting point, boiling point, density, etc., also have precise ranges. If the melting point deviates from the established range, it may suggest that the product has impurities or abnormal crystal forms.
On the product packaging, the name "4 - Fluorobromobenzene" should be declared, and a clear structural formula should be attached to help identify. Hazard labeling is also indispensable, because it may be toxic, corrosive, etc., proper labeling can ensure user safety. Product parameters need to be detailed, such as purity values, impurity types and content, so that users can choose reasonably according to actual needs. This is the key to ensuring the quality and safe application of 4-Fluorobromobenzene products.
Preparation Method
In order to prepare 4-Fluorobronibenzene, the raw materials, production process, reaction steps and catalytic mechanism need to be carefully studied.
To make it, you can first take suitable starting materials, such as compounds containing benzene rings, and introduce fluorine and bromine groups based on them. The starting materials are pretreated to make the benzene ring have appropriate activity, which is convenient for subsequent reactions.
The control of the first condition of the reaction step, temperature, pressure and reaction time are all key. At a specific temperature range, catalyze with an appropriate catalyst to activate and rearrange the chemical bonds in the raw material molecules, and gradually introduce fluorine atoms. Or use the method of nucleophilic substitution to react with the pretreated raw materials with fluoride reagents to form fluorine-containing intermediates.
The introduction of bromine atoms can be achieved in subsequent steps by similar or different suitable reactions. The bromination process also requires precise temperature control and the selection of catalysts to precisely locate bromine atoms to replace specific hydrogen atoms on the benzene ring.
The catalytic mechanism is related to the reaction rate and yield. The selected catalyst can reduce the activation energy of the reaction and promote the efficient progress of the reaction. Or borrow a metal catalyst to use its empty orbit to form a coordination with the raw material molecules to guide the reaction direction and improve the reaction selectivity, so that 4-Fluorobronibenzene can be obtained.
Chemical Reactions & Modifications
4-Fluorobronibenzene is an important compound in organic synthesis. In chemical research, its chemical reaction and modification are crucial.
In the past, 4-Fluorobronibenzene was prepared by conventional halogenation reaction. However, the selectivity of this reaction is poor, and the side reactions are complicated, resulting in the purity and yield of the product being affected.
After being studied and improved by various chemists, a new type of catalyst is introduced, and the reaction process can be precisely regulated by virtue of its unique activity check point. In this way, the selectivity of the generation reaction of 4-Fluorobronibenzene is significantly improved, the side reactions are greatly reduced, and the product purity and yield are also improved.
This modification not only optimizes the preparation process of 4-Fluorobronibenzene, but also lays the foundation for the subsequent synthesis of fine chemicals from this raw material, opening a new path of chemical synthesis, which is of great significance in the field of organic synthesis.
Synonyms & Product Names
4 - Fluorobromobenzene, also known as p-fluorobromobenzene. My generation has been studying chemical substances for a long time, so I am very concerned about such organic compounds. P-fluorobrobenzene is of great significance in the field of chemical synthesis.
According to the records of Guanfu in the past, the aliases and trade names of such compounds are often discussed by chemists. P-fluorobrobenzene is also called 1-bromo-4-fluorobenzene by its structural characteristics. This title is also commonly found in various classics and is the same as 4-Fluorobromobenzene.
As for the trade name, it is slightly different in the market circulation, or due to different manufacturers and uses. However, in essence, they are all the same substance. When we study its various names carefully, we will not be confused in research and application, so as to better explore its chemical properties and practical uses, and contribute to the development of the chemical industry.
Safety & Operational Standards
4 - Fluorobronibenzene product safety and operating practices
4 - Fluorobronibenzene is a common chemical in chemical research. In its experimental operation and research process, safety and standards are of paramount importance, which is related to the safety of researchers and endangers the success or failure of the experiment.
In terms of safety, 4 - Fluorobronibenzene has certain chemical activity and latent risk. It may cause irritation to the human body, or endanger health through inhalation, skin contact and accidental ingestion. Therefore, researchers must take protective measures. During the experiment, protective clothing should be worn, which should effectively block chemicals from contacting the skin. The texture is tough and breathable, making it easy to operate. At the same time, protective gloves should be worn. The material of the gloves should be resistant to 4-Fluorobronibenzene corrosion to prevent its penetration. Eye protection is also indispensable. The goggles should be able to fit tightly to the face to avoid chemical splashing into the eyes.
In terms of operating specifications, the use of 4-Fluorobronibenzene should be carried out in a well-ventilated fume hood. The fume hood can discharge volatile chemical gases in time to reduce the concentration of harmful gases in the laboratory. When measuring, the instruments used must be accurate and accurately measured according to the needs of the experiment to avoid the risk of waste and excessive use. The transfer process should be careful to prevent it from spilling. If it spills accidentally, it should be dealt with immediately in accordance with relevant emergency treatment specifications. After the experiment, the remaining 4-Fluorobronibenzene should not be discarded at will, but should be recycled to a specific container according to the regulations, so as to be handled uniformly and prevent pollution of the environment. When storing, it should be placed in a cool, dry and well-ventilated place, away from fire sources and oxidants, to prevent dangerous chemical reactions.
Following the safety and operation standards of 4-Fluorobronibenzene is the basic principle of chemical researchers, so as to ensure the safe and orderly conduct of experiments and promote the development of chemical research.
Application Area
4 - Fluorobronibenzene is a chemical substance. Its application field is quite extensive. In the field of medicine, it can be used as a key intermediate to help create special drugs and cure various diseases. In the material industry, it can add its unique properties to new materials, making it more durable and stable.
In industrial production, 4 - Fluorobronibenzene is also an important raw material. Based on it, many fine chemicals can be derived for use in coatings, plastics and other industries to improve product quality.
And because of its unique structure, it is often used by scholars in the process of scientific research and exploration to develop new reactions and new synthesis methods to expand the boundaries of chemical cognition. From this point of view, 4 - Fluorobronibenzene has extraordinary value in the application fields of medicine, materials, industry and scientific research, and promotes the development of various industries.
Research & Development
In recent years, in the field of organic synthesis, 4-Fluorobronibenzene has gradually gained the attention of many researchers. My generation has devoted myself to studying the method of its preparation and has been exploring for several years.
At the beginning, I tried all kinds of paths, but all encountered obstacles. Or the reaction conditions are harsh and difficult to control; or the yield is low, and the gains outweigh the losses. However, we did not dare to slack off, thinking day and night, consulting ancient books and this article, hoping to get a good plan.
After repeated experiments, we improved the traditional method, fine-tuning the reaction agent, temperature control, and duration. In the end, the yield gradually increased, and the quality was also good.
Looking at its application, it can be used as a key intermediate in pharmaceutical synthesis to help the research and development of new drugs, which is expected to solve the suffering of patients; in materials science, it can add unique properties, give materials new quality, and promote the development of the industry.
We know that the road of research is long, and although we have made progress, we still need to make unremitting efforts to tap its potential, hoping to contribute more efforts to the academic and industry, and promote 4-Fluorobronibenzene in various fields to achieve remarkable achievements.
Toxicity Research
I tried to focus on the study of toxicants, and now I will discuss it with 4-Fluorobronibenzene. Its properties are crucial to the investigation of toxicity. Examine its quality in detail, and its effects on pharmacology and the environment need to be discerned.
The toxicity of this substance, or it involves cell changes, impairs the body's energy. Observe its molecular structure, and measure its interaction with biomolecules. In experiments, observe its effects on various organisms, such as insects and mice, observe its behavior and physiological differences.
Also consider its circulation in the environment, or sewage and soil, harming all living beings. Its decomposition process and product are also important for toxicity research. If you want to know the details, you must apply multiple methods, analyze its essence, clarify its harm, and take it as the foundation for protection and governance, to ensure the well-being of all living beings and the tranquility of the environment.
Future Prospects
4 - Fluorobromobenzene is also an organic compound. Looking at this substance today, it has great potential in the field of chemical industry, and the future prospects are very impressive.
This compound has a unique structure and unique properties, and can be used as a raw material for many syntheses. In the way of pharmaceutical creation, it may open up a new path for the development of new drugs. Its unique chemical activity may help the birth of precision targeted drugs, bringing hope for the treatment of difficult diseases.
In the way of materials science, 4 - Fluorobromobenzene is also expected to emerge. Or it can participate in the synthesis of high-performance materials, so that the materials have better properties, such as heat resistance, wear resistance, and electrical conductivity. This will inject new vitality into various fields such as electronics and aerospace.
And with the advance of science and technology, the techniques of analysis and preparation will become more refined. In the future, 4-Fluorobromobenzene will be produced more efficiently and purely, and its application will be expanded. Its prospects are bright, like stars in the sky, waiting for our generation of scientific researchers to strive to explore, so as to uncover its endless potential and benefit the world.
Where to Buy 4-Fluorobronibenzene in China?
As a trusted 4-Fluorobronibenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 4-Fluorobronibenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-Fluorobronibenzene?
4-Fluorobromobenzene is also an organic compound. Its main uses are related to many fields.
In the process of organic synthesis, 4-fluorobromobenzene is a key raw material. Due to the special activity of fluorine and bromine in the molecule, it can be combined with various nucleophilic reagents through various chemical reactions, such as nucleophilic substitution reactions. Nucleophilic reagents such as alkoxides and amines can be substituted with bromine or fluorine atoms in 4-fluorobromobenzene to construct a series of organic compounds with different structures, such as new drug intermediates and lead compounds for functional materials.
In the field of medicinal chemistry, its uses are quite extensive. By modifying the structure of 4-fluorobrobenzene, compounds with specific biological activities can be synthesized. In many drug development processes, intermediates derived from 4-fluorobrobenzene may obtain therapeutic drug molecules after multi-step reactions. For example, in the development of antidepressants and anti-infective drugs, it can be used as a starting material. After ingenious synthesis route design, it can be integrated into the drug molecular structure to improve the activity, selectivity and pharmacokinetic properties of the drug.
In the field of materials science, 4-fluorobrobenzene is also useful. Can participate in the preparation of high-performance polymer materials. In the polymerization reaction, as a monomer or comonomer, it gives the polymer unique properties by virtue of the characteristics of fluorine atoms, such as high electronegativity, small atomic radius, etc., such as enhancing the thermal stability, chemical stability and electrical properties of the polymer. The synthesized polymer may be used in the fields of electronic devices, optical materials, etc., to meet the needs of high-tech industries for special performance materials.
Furthermore, in the preparation of fine chemicals, 4-fluorobromobenzene can be used to synthesize special fragrances, dyes, etc. After a specific chemical reaction, it is converted into a compound with a unique color or aroma, which adds unique properties to the related fine chemical products and enhances the quality and value of the products.
What are the physical properties of 4-Fluorobronibenzene?
4-Fluorobrobenzene is also an organic compound. It has specific physical properties and is of great concern in the chemical industry.
In terms of its properties, 4-fluorobrobenzene is a colorless to light yellow liquid at room temperature, and it looks clear and transparent, like a quiet water. Its unique smell emits a faint aroma with aromatic characteristics. Although it is not pungent, it is also different from common odorless substances.
When it comes to the melting point, the melting point of this compound is about -16 ° C, just like the extreme cold temperature in winter. And its boiling point is between 150 and 152 ° C. When the temperature rises to this range, 4-fluorobromobenzene will change from liquid to gaseous state, like a plume soaring.
4-fluorobrobenzene has a density heavier than water, about 1.57 g/cm ³. If it is placed in one place with water, it can be seen that it sinks to the bottom of the water, as if hidden in the depths of the water. Its solubility also has characteristics. It is slightly soluble in water, but it can be miscible with many organic solvents such as ethanol, ether, acetone, etc. in any ratio, as if it is naturally compatible with these organic solvents and can blend with each other.
In addition, the vapor pressure of 4-fluorobromobenzene also has its value at a specific temperature, which is related to the balance between the gas phase and the liquid phase. And because its molecular structure contains fluorine and bromine atoms, its dipole moment has a certain value, which affects its physical properties such as solubility and intermolecular forces. These physical properties lay the foundation for 4-fluorobromobenzene in chemical reactions and practical applications.
What is the chemistry of 4-Fluorobronibenzene?
4-Fluorobromobenzene is also an organic compound. It is active and has attracted much attention in the field of organic synthesis.
In terms of its chemical properties, fluorine atoms and bromine atoms give this substance unique reactivity. Bromine atoms have nucleophilic substitution activity and can react with many nucleophilic reagents. In case of hydroxyl negative ions, bromine can be replaced by hydroxyl groups to form 4-fluorophenol or the like; if it encounters amino negative ions, it can form a genus of 4-fluoroaniline. The reaction of this substitution often depends on appropriate solvents and catalysts. For example, in polar aprotic solvents, the reaction can be smoother with potassium iodide as a catalyst.
Although fluorine atoms are highly electronegative, they are small in size and have a unique effect on reactivity in molecules. Due to their electronegativity, the density of the electron cloud in the ortho-para position decreases, and the electrophilic substitution reaction is more difficult than benzene; however, under certain conditions, the electrophilic reagent can still attack the benzene ring. In case of mixed acid of nitric acid and sulfuric acid, nitrification can occur to obtain nitro-substituted products. However, due to the different localization effects of fluorine and bromine, the proportion of products is also affected. The fluorine atom causes the electrophilic reagent to mainly attack its ortho-position, while the bromine atom also has a similar orientation. Together, the reaction products are complex.
In addition, the halogen atom of 4-fluorobromobenzene can participate in the For example, under the catalysis of palladium with borate esters, the construction of carbon-carbon bonds can be realized, which is of great significance in the fields of drug synthesis and material preparation. It can be used to react and synthesize complex organic molecules, providing an effective path for the creation of new drugs and the development of new materials.
In short, the existence of 4-fluorobromobenzene fluoride and bromine atoms has rich chemical properties, providing chemists with many possibilities in the synthesis practice of organic chemistry, helping them to construct diverse organic structures.
What are 4-Fluorobronibenzene synthesis methods?
The common methods for synthesizing 4-fluorobromobenzene are as follows.
First, benzene is used as the starting material. First, benzene is brominated, which is an electrophilic substitution reaction. Under appropriate reaction conditions, such as using iron bromide as the catalyst, benzene reacts with bromine to generate bromobenzene. Then, bromobenzene is fluorinated. This fluorination step can use a nucleophilic substitution reaction path, using fluorine sources such as potassium fluoride, with the help of a phase transfer catalyst, heating the reaction in a suitable solvent, so that the bromine atom is replaced by a fluorine atom, and then 4-fluorobromobenzene is obtained.
Second, 4-fluoroaniline is used as the raw material. First, 4-fluoroaniline is converted into a diazonium salt through a diazotization reaction. 4-fluoroaniline is treated with sodium nitrite and hydrochloric acid at low temperature to obtain a diazonium salt. After that, the diazonium salt is reacted with cuprous bromide. This is the Sandmeier reaction of diazonium salt, which can effectively replace the diazonium group into a bromine atom to obtain 4-fluorobromobenzene.
Third, 4-bromophenol is used as a raw material. First, 4-bromophenol is halogenated and replaced by fluorinated reagents, such as antimony trifluoride, to replace phenolic hydroxyl groups with fluorine atoms. This process requires attention to the control of reaction conditions to ensure that the reaction mainly generates 4-fluorobromobenzene, avoiding the occurrence of other side reactions, and ultimately achieving the purpose of synthesizing 4-fluorobromobenzene.
What 4-Fluorobronibenzene need to pay attention to when storing and transporting
4-Fluorobromobenzene is an organic compound. When storing and transporting, many aspects need to be paid attention to.
First words storage. Because of its certain chemical activity, it should be placed in a cool, dry and well-ventilated place. This is due to high temperature, humid environment or chemical reaction caused by it, which damages quality. The warehouse temperature should be controlled in a specific range to prevent danger caused by excessive temperature. And keep away from fires and heat sources. 4-Fluorobrobenzene may be flammable, and it is easy to cause fire in case of open flames and hot topics.
Furthermore, when storing, it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. It is easy to react chemically with these substances, and even cause serious consequences such as explosions. There are also requirements for storage containers, which must be corrosion-resistant and well-sealed to avoid leakage. Regularly check the storage environment and containers to see if there is any leakage or deterioration.
As for transportation, the transportation vehicle must be equipped with corresponding fire equipment and leakage emergency treatment equipment. During transportation, it should be protected from exposure to the sun, rain, and high temperature. When driving, it should be stable to avoid bumps and collisions, so as to prevent material leakage caused by damage to the container. Transportation personnel also need professional training, familiar with the characteristics of 4-fluorobromobenzene and emergency treatment methods. When loading and unloading, it should be handled lightly, and it is strictly forbidden to drop, touch, and collide to ensure that the operation is standardized.
In short, 4-fluorobromobenzene has strict requirements in terms of environment, container, and personnel operation during storage and transportation. Only by treating it with caution and following regulations can it be kept safe and avoid accidents.