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4-Fluorobenzenesulphonyl Chloride

4-Fluorobenzenesulphonyl Chloride

Hongda Chemical

Specifications

HS Code

712607

Name 4-Fluorobenzenesulphonyl Chloride
Chemical Formula C6H4ClFO2S
Molar Mass 194.61 g/mol
Appearance Colorless to light yellow liquid
Density 1.486 g/cm³ (approximate)
Boiling Point 245 - 247 °C
Melting Point 21 - 23 °C
Solubility Reacts with water, soluble in organic solvents like dichloromethane
Flash Point 102 °C
Pungency Has a pungent odor
Reactivity Reactive towards nucleophiles

As an accredited 4-Fluorobenzenesulphonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 4 - fluorobenzenesulphonyl chloride packaged in a sealed, corrosion - resistant bottle.
Storage 4 - fluorobenzenesulphonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and moisture. Store in a tightly - sealed container to prevent contact with air and water, which can cause decomposition. It should be segregated from incompatible substances like bases, reducing agents, and reactive metals to avoid potential chemical reactions.
Shipping 4 - fluorobenzenesulphonyl chloride, a hazardous chemical, is shipped in specialized, tightly - sealed containers. These are designed to prevent leakage and are carefully labeled. Shipments follow strict safety regulations for chemical transportation.
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4-Fluorobenzenesulphonyl Chloride 4-Fluorobenzenesulphonyl Chloride
General Information
Historical Development
4 - Fluorobenzenesulphonyl Chloride, it is also the result of chemical chemistry. Its beginning is the result of diligent research by chemical industry. For the first time, it is still known about the nature and use of human beings, and it is still explored in the field of research.
Its performance, the development of chemical technology, researchers understand its characteristics, and can be used to multiply and reverse, so as to create new materials. Since the work has been completed, the use of this product has been limited, and it has its own function in the field of chemical synthesis and material research.
Since then, 4 - Fluorobenzenesulphonyl Chloride has been polymorphized. Chemical industry does not improve its method, improve its degree, and increase its quantity. The rare products of the past are now indispensable to the chemical industry, and the development of the chemical industry has a deep impact.
Product Overview
4-Fluorobenzenesulfonyl chloride is an important reagent for organic synthesis. Its color is colorless to light yellow, with a pungent smell, and its properties are liquid. This compound has a wide range of uses in the field of organic chemistry. It is often used as a sulfonylation reagent to prepare various sulfonamides, sulfonates and other derivatives.
The preparation method is often obtained by the reaction of 4-fluorobenzenesulfonic acid with chlorinating agents such as phosphorus pentachloride and sulfinyl chloride. When reacting, attention should be paid to the control of reaction conditions, such as temperature and reaction time, to ensure the purity and yield of the product.
4-fluorobenzenesulfonyl chloride is chemically active and should be used with caution. Due to its corrosive nature, it is irritating to the skin, eyes and respiratory tract. When operating, appropriate protective measures must be taken, such as protective clothing, protective glasses and gloves.
For storage, it should be placed in a cool, dry and well-ventilated place, away from fire and heat sources, to prevent danger. This compound is indispensable in the development of organic synthetic chemistry.
Physical & Chemical Properties
4 - Fluorobenzenesulphonyl Chloride is a chemical substance. Its physical and chemical properties are related to our research. This substance has special properties. Its state is either liquid or light in color. Its melting point, solubility, etc. are all key. The melting point is related to the temperature and pressure of its phase transition. Solubility depends on different solvents. And its chemical activity cannot be ignored. Under specific conditions, it can react with other substances and exhibit unique chemical properties. These physical and chemical properties may affect its application in industry and scientific research. Only by exploring in detail can we fully understand its properties and make it useful in various fields to help our generation's progress in chemical research.
Technical Specifications & Labeling
Today there are 4 - Fluorobenzenesulphonyl Chloride, which is widely used in industry. Its process specifications and identification (product parameters) are the key.
The process specifications are related to the preparation process and conditions. The purity of raw materials, the temperature of reaction, and the control of time are all fixed. It must be made with precision, good methods, and in accordance with regulations to get a good product.
The logo (product parameters) should not be ignored. Its color, state, taste, purity, and amount of impurities should all be detailed. The color should be normal, the state should be uniform, the purity must be high, and the impurities must be slight. In this way, its quality can be clearly distinguished from others.
The process specifications and identification (product parameters) of 4-Fluorobenzenesulphonyl Chloride should be carefully observed and carefully researched to ensure the excellence of the product and meet the needs of the market.
Preparation Method
The preparation method of 4-fluorobenzenesulfonyl chloride is related to the raw materials and production process, reaction steps and catalytic mechanism. The selection of raw materials is very critical, and benzene, fluorine gas and chlorosulfonic acid are used as starting materials.
In the first step, benzene and fluorine gas undergoes a substitution reaction at a specific temperature and under the action of a catalyst to generate fluorobenzene. This process requires precise temperature control to prevent side reactions from breeding.
In the second step, the prepared fluorobenzene reacts with chlorosulfonic acid under appropriate reaction conditions. In the meantime, chlorosulfonic acid provides sulfonyl groups and chlorine atoms, and after a complex reaction process, 4-fluorobenzenesulfonyl chloride is finally In the
reaction step, reaction time, temperature and material ratio are all key factors affecting the yield and purity. In addition, in terms of catalytic mechanism, suitable catalysts can greatly improve the reaction rate and selectivity. Some metal halide catalysts, such as some metal halide catalysts, can effectively reduce the activation energy of the reaction and make the reaction easier to proceed. In this way, the efficient preparation of 4-fluorobenzenesulfonyl chloride can be achieved through subtle regulation of raw materials, strict control of reaction steps and rational use of catalytic mechanisms.
Chemical Reactions & Modifications
4 - Fluorobenzenesulphonyl Chloride, it is also a chemical substance. Its anti-modification is the most important research in our research.
The anti-modification of this compound, or involving nuclear substitution, chlorine atom activity, is easy to replace by other groups. When encountering groups and amino groups, new compounds are often generated. If alcohol is reversed, sulfonates can be obtained; when amine is reversed, sulfonamides are formed.
As for modification, it can be integrated, and its properties and activities can be increased. With the properties of fluorine atoms, or its properties and lipids can be reduced. In this way, it can be extended to be used in materials and materials.
Study its anti-modification, and seek refinement. Its parts, both degree and solubility are required. We hope to make good use of this compound to benefit the world.
Synonyms & Product Names
4 - Fluorobenzenesulphonyl Chloride, it is also a chemical product. It is widely used, sold in the market, and also has a general trade name. This compound, with its own characteristics, is used in the field of chemical research and application. Or used in the synthesis of general products, or special materials. Its name is well known to all people, and different classics and merchants may have the same name. And the name of the product is determined, or according to its characteristics and uses, or the name of the family. Those who study and use it must check the name of the same product, so that they can obtain its correct product, so as to facilitate the research and behavior, and do not let it be caused by the name.
Safety & Operational Standards
4-Fluorobenzenesulfonyl chloride safety and operating specifications
4-Fluorobenzenesulfonyl chloride is a reagent commonly used in chemical research. During its experimental operation, safety regulations are very important, and if you are not careful, you will cause disasters.
Handling this object is the first protection. The operator must wear complete protective equipment, such as protective clothing, gloves, goggles, etc. Protective clothing must be resistant to chemical corrosion, and the material of gloves must be able to resist the erosion of 4-fluorobenzenesulfonyl chloride to prevent contact with the skin, causing skin burns, allergies, etc. Goggles can protect the eyes from the splashing of reagents, covering them with strong corrosive properties. If they enter the eyes, they will cause serious eye diseases.
Furthermore, the operating environment also has strict requirements. It is suitable for operation in a well-ventilated fume hood. The fume hood can remove volatile harmful gases in time, reduce the concentration of 4-fluorobenzenesulfonyl chloride in the air, and reduce the risk of inhalation by the operator. And the operating table should be clean, dry, and free of debris accumulation, so as not to affect the operation or cause the agent to spill.
When taking 4-fluorobenzenesulfonyl chloride, the action should be stable and accurate. Use a suitable pipette or dropper and measure it accurately according to the experimental requirements. Do not use mouth suction during the measurement process to prevent accidental aspiration poisoning. If it is accidentally spilled, emergency measures should be taken immediately. A small amount of sprinkling can be covered with inert adsorption materials, and then properly collected and disposed of; if a large amount of sprinkling, it is necessary to quickly evacuate people, start emergency exhaust devices, and clean up with protective equipment by professionals.
Storage should also not be ignored. 4-Fluorobenzenesulfonyl chloride should be stored in a cool, dry and ventilated place, away from fire and heat sources. Store separately from oxidants and alkalis, etc., and avoid mixed storage to prevent violent chemical reactions and cause danger.
After the experiment, the remaining 4-Fluorobenzenesulfonyl chloride and related wastes should be properly disposed of in accordance with regulations. It should not be dumped at will, but should be collected centrally and handed over to a professional treatment agency for recycling and safe disposal.
In short, the handling of 4-fluorobenzenesulfonyl chloride requires strict adherence to safety and operating standards at all times, so as to ensure the safe and orderly conduct of experiments, avoid accidents, and protect others.
Application Area
4 - Fluorobenzenesulphonyl Chloride, it is also a chemical product. Its application is not limited. In the field of synthesis, it can use important raw materials to help create a variety of special effects. With its unique properties, it can be the inverse of subtlety, the core framework of the object. In the research and development, it also occupies an important position. It can improve its performance, increase its effectiveness, and reduce the harm of diseases. And in the context of material science, it can be modified to make the material have extraordinary properties, such as increasing its performance and improving its performance. In short, 4 - Fluorobenzenesulphonyl Chloride is of great use in many fields, promoting the progress of science and technology, and benefiting the world.
Research & Development
In modern times, chemical refinement has deepened, and the research on various compounds has deepened. Today, 4 - Fluorobenzenesulphonyl Chloride is a key to its research and development.
Begin to study its properties, analyze its structure, and clarify its physical and chemical characteristics. Explore the rules of its reaction with other substances, hoping to obtain a new synthesis path. After years of research, in the synthesis method, gradually refined. At first, the synthesis was difficult, the yield was quite low, and there were many impurities. However, the researchers made unremitting efforts to think about changes and improve the process. Or adjust the temperature and pressure of the reaction, or change the reagents and solvents used, and eventually the yield and purity increased.
The field of its application is also expanding. In medical chemistry, it can be a key intermediate to help create new drugs; in material science, it can participate in material modification and give new energy to materials. Looking forward to the future, with research and exploration, 4-Fluorobenzenesulphonyl Chloride will develop its talents in more fields and contribute to scientific development and social progress.
Toxicity Research
Taste the chemical industry, related to people's livelihood, but the study of poisons among them, can not be careless. In today's words 4 - Fluorobenzenesulphonyl Chloride, the study of its toxicity is quite important.
Viewing its properties, it is highly irritating, and it harms the viscera when it enters the body. Touch the skin, it can cause redness, swelling and ulceration; enter the way of breathing, injure the lungs and damage qi. If you eat it carelessly, the stomach will suffer from it, and you will have colic and diarrhea.
Study its toxicology, act on the metabolism of cells, and disrupt the order of its biochemistry. Denature the protein, lose the ability of enzymes, and cause physiological work.
Therefore, those who study this thing should not ignore the way of protection. Wear special clothes and protective gear, and work in a well-ventilated place. And the way to deal with the aftermath must also be detailed to prevent the damage of poisons. Make sure that the prosperity of this business will not be burdened by poison, and everyone will be well-being, and the business will be prosperous and harmless.
Future Prospects
Today there is a thing called 4 - Fluorobenzenesulphonyl Chloride, which is a chemical product. Looking at it at the moment, although it has been formed here, we still look at it with unfinished prospects.
The future development of this product can be used to improve chemical technology. Or it can help the pharmaceutical industry, make the drug more accurate and efficient, cure various diseases, and save patients from pain. It is also expected to be used in materials science, giving materials novelty, strengthening their quality and increasing their use, and adding benefits to buildings and equipment.
Our chemical researchers should have lofty ambitions and study unremitting. It is hoped that with wisdom and diligence, it will expand its potential and develop its unfinished path, so that 4-Fluorobenzenesulphonyl Chloride will shine in the future, seek well-being for the world, and live up to its scientific mission.
Where to Buy 4-Fluorobenzenesulphonyl Chloride in China?
As a trusted 4-Fluorobenzenesulphonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 4-Fluorobenzenesulphonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-Fluorobenzenesulphonyl Chloride?
4-Fluorobenzenesulfonyl chloride is a crucial reagent in organic synthesis. Its main uses cover a wide range of fields.
In the synthesis of drugs, 4-fluorobenzenesulfonyl chloride is often a key intermediate. Because fluorinated compounds can significantly change the physical, chemical and biological properties of compounds in drug molecules. For example, by reacting with compounds containing amino groups, hydroxyl groups and other groups, structural units with specific pharmacological activities can be constructed. This reaction can be precisely regulated to obtain drug precursors with diverse structures, laying the foundation for the creation of new drugs.
It is also useful in the field of materials science. For example, when reacted with specific polymer monomers, fluorobenzenesulfonyl groups can be introduced into the main chain or side chain of the polymer. In this way, the properties of the polymer such as thermal stability, chemical stability and surface properties can be optimized. The obtained materials may be used in high-end coatings, special plastics, etc., to meet the specific properties of materials in different industrial scenarios.
Furthermore, 4-fluorobenzenesulfonyl chloride also plays an important role in the synthesis of pesticides. By combining with the parent of various pesticide active ingredients, pesticides can be given better biological activity, durability and environmental compatibility. The pesticides synthesized by it may have stronger killing or inhibitory ability to target organisms, and have suitable degradation characteristics in the environment, reducing the potential harm to the ecological environment.
In summary, 4-fluorobenzenesulfonyl chloride, with its unique chemical activity, plays an irreplaceable role in the synthesis of drugs, materials, pesticides and many other fields, promoting the technological progress and innovative development of related industries.
What are the physical properties of 4-Fluorobenzenesulphonyl Chloride?
4-Fluorobenzenesulfonyl chloride is an important compound in organic chemistry. Its physical properties are quite specific and are described in detail today.
Looking at its properties, under room temperature, 4-fluorobenzenesulfonyl chloride is mostly colorless to yellowish liquid, with a clear texture, similar to clear water, but its chemical properties are active and abnormal, and cannot be compared with ordinary liquids.
When it comes to the boiling point, about 250 degrees Celsius, this temperature is not low, which shows the characteristics of its intermolecular forces. The boiling point is related to the attractive force between molecules. 4-fluorobenzenesulfonyl chloride has a moderate attractive force between molecules due to its own structure, so it has this boiling point.
Furthermore, the melting point is about - 20 ° C, which is lower than room temperature and is a liquid at room temperature. The determination of the melting point is crucial in distinguishing the purity and characteristics of substances.
Its density is greater than that of water, about 1.49g/cm ³. When mixed with water, it will sink to the bottom of the water, such as a stone falling into the abyss. Due to the molecular composition and structure, its unit volume mass is greater than that of water.
As for solubility, 4-fluorobenzenesulfonyl chloride is quite soluble in organic solvents, such as ether and chloroform, just like water for fish. However, in water, it is extremely insoluble, which is caused by the difference between its molecular polarity and the polarity of water molecules. The structure of organic molecules has many non-polar regions, which are inconsistent with the polar structure of water, so it is difficult to dissolve.
The vapor of 4-fluorobenzenesulfonyl chloride has a pungent smell, is uncomfortable to smell, and has a certain toxicity. Its vapor density is greater than that of air. If it escapes in the air, it will more sink in the near ground. This requires special attention in terms of safety protection.
In summary, the physical properties of 4-fluorobenzenesulfonyl chloride are closely related to its molecular structure. Understanding these properties is of great significance in many fields such as organic synthesis, chemical production, and experimental operation. It can help practitioners use it properly, avoid risks, and maximize its effectiveness.
4-Fluorobenzenesulphonyl the chemistry of Chloride
4-Fluorobenzenesulfonyl chloride is a very important class of organic compounds. It has unique chemical properties and has a wide range of uses in the field of organic synthesis.
Looking at its chemical activity, the sulfonyl chloride in 4-fluorobenzenesulfonyl chloride is very reactive. Chlorine atoms can be used as good leaving groups for nucleophilic substitution reactions. When encountering nucleophilic reagents, such as alcohols and amines, chlorine atoms are easily replaced by nucleophilic reagents, and then the corresponding sulfonate esters or sulfonamides are formed. This reaction is often a key step in the construction of sulfonyl-containing structures in organic synthesis. For example, when reacting with alcohols, 4-fluorobenzenesulfonate can be prepared after nucleophilic substitution. Such compounds are often used as intermediates in some drug synthesis and materials science fields.
Furthermore, the fluorine atom also affects the properties of the compound. Fluorine atoms have the characteristics of large electronegativity and small atomic radius. Due to the existence of fluorine atoms, the electron cloud distribution of the molecule can be changed, which in turn affects the physical and chemical properties of the compound. In terms of reactivity, the electron cloud density of the benzene ring can be reduced, and the electrophilic substitution reactivity on the benzene ring can be changed. At the same time, the introduction of fluorine atoms can often enhance the lipid solubility of compounds, which is of great significance in drug development and can affect the pharmacokinetic properties of drug absorption and distribution. In terms of stability of 4-fluorobenzenesulfonyl chloride, due to its active sulfonyl chloride group, it is necessary to pay attention to the conditions during storage and use. It is easy to hydrolyze in water to form 4-fluorobenzenesulfonic acid and hydrogen chloride. Therefore, it should be stored in a dry environment to avoid contact with water. Under alkaline conditions, the hydrolysis reaction is more rapid and can cause structural damage of compounds.
In short, 4-fluorobenzenesulfonyl chloride shows important value in many fields of organic synthesis due to its active sulfonyl chloride group and fluorine atom. However, when used, it needs to be properly handled and handled according to its chemical properties to obtain ideal reaction results.
What are the synthesis methods of 4-Fluorobenzenesulphonyl Chloride?
There are various ways to synthesize 4-fluorobenzenesulfonyl chloride. One is to use 4-fluorobenzenesulfonic acid to react with a chlorinating agent. Phosphorus pentachloride, phosphorus trichloride or sulfinyl chloride are often used as chlorination agents. For example, when taking phosphorus pentachloride as an example, the hydroxyl group in 4-fluorobenzenesulfonic acid is replaced by chlorine atoms due to its strong chlorination ability. This reaction is usually carried out in suitable organic solvents, such as dichloromethane and chloroform, to facilitate the smooth occurrence of the reaction and facilitate the separation of the product.
Furthermore, 4-fluorobenzenesulfonic acid can be prepared initially. 4-Fluorobenzenesulfonyl chloride is obtained by diazotization of shilling 4-fluoroaniline. Then it interacts with sodium bisulfite to introduce a sulfonic acid group, and then through a chlorination step, 4-fluorobenzenesulfonyl chloride can be obtained. The diazotization reaction needs to be carefully operated in a low temperature and acidic environment to prevent the decomposition of diazonium salts.
Another way is to use 4-fluorobenzene as raw material to obtain 4-fluorobenzenesulfonic acid through sulfonation reaction. In this step, concentrated sulfuric acid or fuming sulfuric acid are used as sulfonation reagents. The resulting 4-fluorobenzenesulfonic acid is subsequently converted into 4-fluoroben In the chlorination process, the choice and dosage of chlorinating agent, as well as the reaction temperature, time and other factors have a great influence on the yield and purity of the product. It is necessary to fine-tune the reaction conditions to achieve the best synthesis effect, so that the formation of 4-fluorobenzenesulfonyl chloride is both efficient and pure.
What to look out for when storing and transporting 4-Fluorobenzenesulphonyl Chloride
4-Fluorobenzenesulfonyl chloride is a chemical substance. When storing and transporting, many matters must be paid attention to.
Store first. This substance is corrosive and reactive, and should be stored in a cool, dry and well-ventilated place. If the temperature is too high, it may cause it to decompose, which may cause danger. Therefore, the temperature should be controlled within a specific range, not too high. Humidity is also particular. If the humidity is too high, it may react with water, causing deterioration or accidents, so the environment should be kept dry.
Furthermore, it should be stored separately from substances such as alkalis, alcohols, and amines. This is because 4-fluorobenzenesulfonyl chloride is chemically active, encounters with the above substances, or reacts violently, or even explodes. And the storage place must be kept away from fire and heat sources. Open flames and high temperatures can cause danger.
Storage containers are also required. Corrosion-resistant materials such as glass or specific plastics should be selected, and the containers must be well sealed to prevent leakage. At the same time, the storage place should be equipped with suitable leak-containing materials for emergencies.
As for transportation, it is necessary to ensure that the packaging is complete and sealed before transportation. Packaging materials should be able to withstand certain external impact and chemical corrosion to prevent leakage caused by package damage during transportation. During transportation, vehicles should be equipped with corresponding fire-fighting equipment and leakage emergency treatment equipment. When driving, keep away from densely populated areas to avoid endangering people in the event of an accident. Transport personnel must also undergo professional training and be familiar with the characteristics of 4-fluorobenzenesulfonyl chloride and emergency treatment methods. Transportation route planning is also important, try to avoid high temperature, high humidity and dangerous areas. In this way, the safety of storage and transportation can be guaranteed.