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4 Fluorobenzenesulfonyl Chloride Cas:349-88-2

4 Fluorobenzenesulfonyl Chloride Cas:349-88-2

Hongda Chemical

    Specifications

    HS Code

    654206

    Chemical Name 4-Fluorobenzenesulfonyl chloride
    Cas Number 349-88-2
    Molecular Formula C6H4ClFO2S
    Molecular Weight 194.61
    Appearance Colorless to light yellow liquid
    Boiling Point 110 - 112 °C at 15 mmHg
    Melting Point N/A
    Density 1.492 g/mL at 25 °C
    Solubility Reacts with water, soluble in organic solvents like dichloromethane
    Flash Point 113 °C
    Purity Typically high - purity products are around 97%+
    Stability Stable under normal conditions, but moisture - sensitive

    As an accredited 4 Fluorobenzenesulfonyl Chloride Cas:349-88-2 factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 4 - Fluorobenzenesulfonyl Chloride (Cas:349 - 88 - 2) packaged in a sealed bottle.
    Storage 4 - Fluorobenzenesulfonyl chloride (CAS: 349 - 88 - 2) should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly sealed container, preferably in a corrosion - resistant material. Avoid storing near incompatible substances like strong bases, reducing agents, and moisture - sensitive materials.
    Shipping 4 - Fluorobenzenesulfonyl Chloride (Cas: 349 - 88 - 2) is shipped in well - sealed, corrosion - resistant containers. It must comply with hazardous chemical shipping regulations, ensuring safe transportation due to its reactive nature.
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    4 Fluorobenzenesulfonyl Chloride Cas:349-88-2 4 Fluorobenzenesulfonyl Chloride Cas:349-88-2
    General Information
    Historical Development
    About the history of 4-fluorobenzenesulfonyl chloride
    Fu 4-fluorobenzenesulfonyl chloride (Cas: 349-88-2), an important chemical substance. Its first appearance in the world depends on the research of many sages. In the past, chemists studied the physical properties and explored the method of its synthesis to obtain this substance.
    At the beginning, the synthesis was difficult, and the choice of raw materials and the control of conditions were all difficult matters. However, the public was not discouraged, and after countless attempts, it was finally successful. With the passage of time, the method of synthesis has become more and more refined, and the yield has gradually increased.
    In the way of application, it was only used in niche fields at first, but later expanded to be used in medicine, materials and other industries. Looking at its historical evolution, it is actually a microcosm of the development of chemistry, witnessing the wisdom and unremitting of various sages, and paving the foundation for future development.
    Product Overview
    4-Fluorobenzenesulfonyl chloride (Cas: 349-88-2), a genus of chemical substances. Its color or nearly colorless, like a liquid, has special properties.
    This compound is widely used in the field of organic synthesis. It can be used as a key intermediate and is involved in many organic reactions. Through its participation in the reaction, a variety of products with specific properties can be obtained. It is of great value in the fields of medicine, pesticides and materials science.
    However, it also has certain hazards. When operating, it is necessary to strictly follow the procedures and take good protection to prevent harm to people and the environment. Knowing the properties and uses of this substance is essential for chemical research and industrial production.
    Physical & Chemical Properties
    4-Fluorobenzenesulfonyl chloride (Cas: 349-88-2), its physical and chemical properties are of great importance to our chemical researchers. The appearance of this agent is often colorless to yellowish liquid, with an irritating odor. Its boiling point is suitable for a certain number, which is related to its state change in the thermal environment. The melting point is also one of the characteristics, reflecting the conditions of its phase transition.
    Its solubility varies in a variety of solvents, and it may have a good solubility in organic solvents such as ethanol and ether, which is related to the adaptation of the medium involved in the reaction. And its chemical activity, due to the fluorine and sulfonyl chloride groups, it can react with many reagents, or nucleophilic substitution, or participate in the construction of new chemical structures, making it an important raw material for organic synthesis.
    Technical Specifications & Labeling
    There is a product today, named 4 - Fluorobenzenesulfonyl Chloride, Cas number is 349 - 88 - 2. Its process specifications and identification (commodity parameters) are the key.
    On the process specifications, it is necessary to clarify the method of preparation, the geometry of the materials used, the steps, the heat and duration. If any raw materials are used, how to react, and how to remove impurities during the process, the purity and quality can be guaranteed.
    As for the identification, its characteristics should be detailed, color, taste, and state must be clear; and its key parameters, such as molecular weight, melting point, boiling point, etc., should be marked to clarify its physical characteristics. And the warning label is also indispensable, related to its toxic, corrosive and other dangerous properties, to ensure that the user is clear, to prevent accidents. This is the process specifications and identification (product parameters) are also essential.
    Preparation Method
    This product is made of 4 - Fluorobenzenesulfonyl Chloride (Cas: 349 - 88 - 2). The raw materials used and the preparation method are quite critical. The selection of raw materials needs to be carefully selected, and the high-quality material is the starting point. The preparation process, the first reaction step. First, [specific raw material 1] and [specific raw material 2] are mixed in a special vessel in a certain proportion, and the temperature and duration are controlled to make it slowly react. This process needs to be carefully regulated. If the temperature is too high, the product will be impure, and if it is too low, the reaction will be delayed. When the reaction is initially completed, impurities will be removed through a specific purification mechanism to obtain a pure product. When purifying, either by filtration or distillation, depending on the actual situation. In this way, after several processes and careful operation, this product can be produced to achieve the required quality.
    Chemical Reactions & Modifications
    Regarding the chemical reaction and modification of 4-fluorobenzenesulfonyl chloride (Cas: 349-88-2), the chemical properties of 4-fluorobenzenesulfonyl chloride are very active. In many reactions, it is often a key agent. Looking at the reaction, it can interact with nucleophiles and undergo nucleophilic substitution. In case of alcohols, the oxygen of the hydroxyl group is nucleophilic and can attack the carbon of the sulfonyl chloride, and the chlorine leaves to form sulfonates. In this reaction, although the fluorine of 4-fluorobenzenesulfonyl chloride is not directly involved, its electron-absorbing effect makes the sulfonyl chloride group more active and promotes the reaction to proceed quickly.
    As for modification, in order to find new substances, different groups are often introduced. Fluorine can be replaced by a specific group through substitution reaction. Due to the unique properties of fluorine, after it is replaced, the electron cloud distribution and spatial structure of the product change, so the chemical activity and physical properties of the product are changed. This is of great benefit to the creation of new compounds and the expansion of application fields.
    Synonyms & Product Names
    4-Fluorobenzenesulfonyl Chloride (Cas: 349-88-2) is also known as p-fluorobenzenesulfonyl chloride in the field of chemical industry. It is also known as p-fluorobenzenesulfonyl chloride, which is named according to the position of the fluorine atom in its molecular structure. In Shangjia trade, or it is called by a trade name, but it all refers to the same thing.
    This product is one of the chemical raw materials and has specific chemical properties and uses. In the field of organic synthesis, it is often used as a key reagent and participates in the preparation of many organic compounds. In the reaction, with the activity of sulfonyl chloride, it can react with a variety of compounds such as substitution and condensation, thereby constructing various complex organic structures, which can assist the process of chemical research and industrial production.
    Safety & Operational Standards
    4-Fluorobenzenesulfonyl chloride, its Cas number is 349-88-2. In the field of chemical industry, it is crucial to safety and operating standards.
    This compound has unique properties, but it also poses risks. It is active and easy to react violently in contact with water or moisture, releasing irritating gases. Therefore, when storing, it is necessary to choose a dry, cool and well-ventilated place, away from water sources and fires, to prevent accidents.
    When taking it, the procedures must be strictly followed. The operator protects himself in front of complete protective equipment, such as gas masks, protective gloves and protective clothing. And the operation is appropriate in the fume hood, so that the escaping gas can be dispersed in time to avoid indoor accumulation and endanger the human body.
    When weighing and transferring, the action should be stable and accurate to avoid its spilling. If it is accidentally spilled, do not panic, and deal with it quickly according to the established emergency method. Evacuate the surrounding people first, then cover it with appropriate adsorbed objects, collect it carefully, and dispose of it properly according to the regulations.
    Furthermore, during use, the utensils involved must be clean and dry to prevent adverse reactions caused by impurities. After use, the utensils should also be cleaned and stored in time for later use.
    In conclusion, the safe and standardized operation of 4-fluorobenzenesulfonyl chloride is the cornerstone of the smooth progress of chemical industry experiments and production, which is related to personnel safety and the environment.
    Application Area
    4-Fluorobenzenesulfonyl chloride (Cas: 349-88-2), this compound has wonderful uses in various fields. In the process of pharmaceutical research and development, it can contribute to the creation of special drugs, help the construction of pharmacological active ingredients, and solve the problem of diseases. In the field of materials science, polymer structures can be integrated into specific reactions to improve the properties of materials, such as enhancing their stability and durability. In the process of chemical synthesis, as a key intermediate, it leads the synthesis of many fine chemicals and expands the variety of chemical products. This compound is like a key, opening the door to multiple application fields, injecting vitality into scientific research and industrial development, with its unique chemical properties, blooming in various fields, and promoting the progress of science and technology and production.
    Research & Development
    In recent years, those who have studied chemical substances have been very attentive to this object in 4-Fluorobenzenesulfonyl Chloride (Cas: 349-88-2). It is available in all kinds of chemical fields, and the prospect is promising.
    At the beginning, the method of researching its system is refined and pure, and the cost is also reduced. Scholars explore various paths, and after many attempts, they either change the conditions of the reaction or change the reagents used, hoping to obtain a good method.
    Then, study the quality of its nature, and observe its transformation under different circumstances. It is clear that its state when it is combined with other things is the foundation for its wide use.
    As for its use, it gradually expands the new environment. In the manufacture of medicine, it may be a key agent; in the manufacture of materials, it also adds unique ability. Everyone is united, hoping to use this material to help the cause of chemistry, reach a higher level, and promote the development of all things, for the benefit of the world. The road ahead is long, and the ambition is unremitting.
    Toxicity Research
    Toxicity study of 4-fluorobenzenesulfonyl chloride
    There is a substance 4-fluorobenzenesulfonyl chloride, its Cas number is 349-88-2, which is among our chemical studies. Toxicity research is of great significance.
    After repeated investigation, 4-fluorobenzenesulfonyl chloride has certain toxicity. It touches the skin and can cause burns, make the skin red, swollen, painful, and even ulcerated. If inhaled carelessly, the toxin enters the lungs, which can cause cough, asthma, and even damage lung function, causing breathing difficulties.
    In the experiment, small animals were used as samples to observe the influence of 4-fluorobenzenesulfonyl chloride. It is seen that the small animals have abnormal behavior, lost vitality, and some organs are also diseased. From this perspective, the toxicity of this substance cannot be underestimated. When we study, we must be cautious and take comprehensive protection measures to avoid being injured by its poison, so as to ensure the smooth research and the well-being of personnel.
    Future Prospects
    In today's world, science and technology are changing day by day, and all kinds of compounds are of great importance to researchers. 4 - Fluorobenzenesulfonyl Chloride (Cas: 349 - 88 - 2) This compound is expected to be developed in the future.
    Its unique nature may be used in various new technologies. In terms of chemical synthesis, it can add its help to the production of new materials. In the future, scientific research may be able to use this material to create new territory. In the field of medicine, it may become the foundation for the development of new drugs and solve the suffering of people's diseases.
    And industrial manufacturing, if used well, may improve the quality of products. Although the current knowledge is still limited, the researchers are unremitting, looking forward to exploring its more potential in the future, using it for the world, so as to achieve great good, develop its infinite possibilities, and benefit all people in the world.
    Where to Buy 4 Fluorobenzenesulfonyl Chloride Cas:349-88-2 in China?
    As a trusted 4 Fluorobenzenesulfonyl Chloride Cas:349-88-2 manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4 Fluorobenzenesulfonyl Chloride Cas:349-88-2 supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of 4-fluorobenzenesulfonyl chloride (Cas: 349-88-2)?
    3-%E6%B0%9F%E8%8B%AF%E7%A3%BA%E9%85%B0%E6%B0%AF (Cas: 349-88-2), this is a special chemical substance, and its physical properties are quite impressive.
    Looking at its properties, under normal conditions, it is mostly colorless to light yellow transparent liquid, just like clear water, but it contains unique properties. Its smell is unique, often with a weak and characteristic smell, although not strong and pungent, it can be detected by those with a keen sense of smell.
    When it comes to boiling point, it is about a specific temperature range. The value of this boiling point is one of its important physical characteristics, which is related to its physical state transformation under different temperature environments. The melting point is also fixed. Under a specific low temperature condition, this substance will gradually solidify from liquid state to solid state. This melting point characteristic is of great significance in related processes and research.
    Its density is also a key property. The specific value indicates its mass per unit volume. Compared with other substances, this density property determines its distribution and behavior in the mixed system. Furthermore, solubility is also a property that cannot be ignored. In a specific organic solvent, it can exhibit good solubility and can be evenly dispersed. However, its solubility in water may vary, or slightly soluble, or insoluble, which affects its application in different media.
    In addition, the volatility of this substance also has characteristics. Under suitable temperatures and environments, it will gradually evaporate from liquid to gaseous state. The rate and degree of volatilization are also part of its physical properties, and specific requirements are placed on storage and use environments.
    Such various physical properties are intertwined to form the unique physical properties of 3-%E6%B0%9F%E8%8B%AF%E7%A3%BA%E9%85%B0%E6%B0%AF (Cas: 349-88-2), which are important bases for research and application in many fields such as chemical industry and scientific research.
    What are the chemical properties of 4-fluorobenzenesulfonyl chloride (Cas: 349-88-2)
    4-Bromoanisole (Cas: 349-88-2), an organic compound, has unique chemical properties and is worth studying.
    Looking at its physical properties, 4-bromoanisole is a colorless to light yellow liquid with a special odor and is difficult to dissolve in water, but it can be miscible with organic solvents such as ethanol and ether. This solubility is an important property in many organic synthesis reactions and industrial applications.
    In terms of chemical properties, the bromine atom on its aromatic ring is quite active. Bromine atoms have an electron-absorbing effect, which reduces the electron cloud density of aromatic rings, so they are more prone to nucleophilic substitution reactions. For example, under alkaline conditions, it can be substituted with nucleophiles, such as sodium alcohols and amines, to form new organic compounds. This reaction is widely used in the field of drug synthesis and material chemistry.
    At the same time, 4-bromoanisole aromatic ring can also undergo electrophilic substitution reaction. Although the bromine atom is an ortho-para-site, the subsequent electrophilic substitution reaction can mainly occur in its ortho-site and para-site, but because the methoxy group is a stronger ortho-site and the power supply capacity is stronger than that of the bromine atom, the electrophilic substitution reaction preferentially occurs in the ortho-site of the methoxy group. Electrophilic substitution reactions such as halogenation, nitrification, and sulfonation can be realized by this principle, which lays the foundation for the preparation of various anisole derivatives.
    In addition, 4-bromoanisole can participate in metal-catalyzed coupling reactions. Under the action of transition metal catalysts such as palladium and nickel, it is coupled with carbon-containing nucleophiles to form carbon-carbon bonds. This is an important means to construct complex molecular structures in organic synthesis, and is of great significance in the research and development of new materials and the total synthesis of natural products.
    In summary, 4-bromoanisole has rich and diverse chemical properties and occupies an important position in the field of organic synthesis chemistry, providing an effective way for the preparation of many organic compounds.
    What are the main uses of 4-fluorobenzenesulfonyl chloride (Cas: 349-88-2)?
    3-Fluorobrobenzyl (Cas: 349-88-2) is an important raw material for organic synthesis and is widely used in medicine, pesticides, materials and other fields.
    In the field of medicine, it can be used as a key intermediate for the synthesis of many bioactive compounds. With its active chemical properties, it can react with a variety of reagents to construct complex drug molecular structures. For example, in the preparation of some antibacterial and antiviral drugs, 3-fluorobrobenzyl participates in the reaction, which has a significant impact on drug activity and efficacy. Due to its fluorine atom and benzyl structure, the synthesized drugs have unique pharmacological activities and pharmacokinetic properties.
    In the field of pesticides, 3-fluorobrobenzyl can be used to synthesize new pesticides. Its structure can bring specific mode of action and biological activity to pesticide molecules, or enhance the toxic effect of pesticides on target organisms, or improve the environmental compatibility and sustainability of pesticides. For example, synthesizing pesticide products with high insecticidal, bactericidal or weeding properties can help the prevention and control of agricultural pests and diseases, and improve crop yield and quality.
    In the field of materials science, 3-fluorobrobenzyl also has important applications. It can participate in the synthesis of polymer materials. By introducing fluorine atoms and benzyl groups, it can improve the properties of materials, such as improving the thermal stability, chemical stability, and mechanical properties of materials. It provides key raw materials for the development of high-performance new materials in electronic materials, polymer materials, etc.
    In addition, 3-fluorobrobenzyl is often used as a model compound in the study of organic synthetic chemistry, assisting scientists in exploring new reaction paths and synthesis methods, and promoting the development and progress of organic synthetic chemistry.
    What are the preparation methods of 4-fluorobenzenesulfonyl chloride (Cas: 349-88-2)
    4-Bromothiophene-2-formaldehyde (Cas: 349-88-2) is an important intermediate in organic synthesis. There are several common methods for its preparation.
    First, the method of using thiophene as the starting material. Bromothiophene can be obtained by bromination of shilling thiophene. When brominating, liquid bromine, N-bromosuccinimide (NBS) and other brominating reagents can be selected. Taking NBS as an example, in an appropriate solvent, such as carbon tetrachloride, under the action of an initiator such as benzoyl peroxide, under light or heating, thiophene can be smoothly converted into bromothiophene. Then, through the Vilsmeier-Haack reaction, N, N-dimethylformamide (DMF) and phosphorus oxychloride (POCl) are used as reagents, and at a suitable temperature, bromothiophene can be converted into 4-bromothiophene-2-formaldehyde. In this process, pay attention to the reaction temperature and reagent dosage to prevent side reactions from occurring.
    Second, use 2-methyl-4-bromothiophene as raw material. 2-methyl-4-bromothiophene is oxidized first, and suitable oxidizing agents such as potassium permanganate, potassium dichromate, etc. However, such oxidants have strong oxidizing ability, and the reaction conditions need to be strictly controlled to prevent excessive oxidation. Mild oxidants, such as manganese dioxide, can also be used to oxidize methyl to aldehyde groups under specific solvents and conditions to obtain 4-bromothiophene-2-formaldehyde.
    Third, with the help of metal-organic reagents. First prepare metal-organic reagents containing thiophene structure, such as 4-bromothiophene lithium reagent. 4-bromothiophene and butyl lithium can be obtained by reacting at low temperature and anhydrous conditions. After hydrolysis, the target product 4-bromothiophene-2-formaldehyde can be obtained by reacting the lithium reagent with suitable aldehyde-based reagents, such as N, N-dimethylformamide. This process has strict requirements on the reaction environment, and it is necessary to ensure anhydrous and oxygen-free to prevent the inactivation of metal-organic reagents.
    4-Fluorobenzenesulfonyl chloride (Cas: 349-88-2) What to pay attention to when storing and transporting
    4-Bromofluorobenzene (Cas: 349-88-2) is a chemical substance, and many matters need to be paid attention to during storage and transportation.
    When storing, the first environment. It should be placed in a cool and ventilated warehouse, away from fires and heat sources. This is because it has certain chemical activity, high temperature or open flame is easy to cause danger. The temperature of the warehouse should be controlled within an appropriate range to prevent changes in material properties. In addition, it should be stored separately from oxidants, acids, bases, etc., and should not be mixed. Due to its chemical properties, it can be mixed with various chemicals, or react violently, causing safety concerns. And the storage area should be equipped with suitable materials to contain leaks in case of leakage, which can be treated in time to avoid pollution expansion.
    During transportation, caution is also required. Before transportation, make sure that the packaging is complete and the loading is secure. The packaging should be able to prevent leakage, rain, vibration, etc. During transportation, make sure that the container does not leak, collapse, fall, or damage. The trough (tank) car used during transportation should have a grounding chain, and holes can be set in the trough to reduce static electricity generated by shock. It is strictly forbidden to mix with oxidants, acids, alkalis, etc. During transportation, it should be protected from exposure to sunlight, rain, and high temperature. During stopovers, it should also be kept away from fire, heat sources, and high temperature areas. Transport vehicles should follow the prescribed route and do not stop in residential areas and densely populated areas.
    In this way, when storing and transporting 4-bromofluorobenzene (Cas: 349-88-2), carefully follow all requirements to ensure safety and avoid disasters.