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What are the main uses of 4-Fluorobenzenesulfonamide?
4-Fluorobenzenesulfonamide has a wide range of uses. In the field of medicine, it is often used as a key intermediate to help synthesize a variety of specific drugs. Due to its unique structure, it can participate in many chemical reactions to construct compounds with specific pharmacological activities. For example, when developing antibacterial drugs, 4-fluorobenzenesulfonamide can contribute key groups, making new drugs have stronger antibacterial ability, effectively fight various bacteria, and relieve patients' pain.
In the field of materials science, 4-fluorobenzenesulfonamide also plays an important role. It can be used to prepare polymer materials with special properties. After proper treatment and polymerization, it can improve the thermal stability and mechanical properties of the materials. For example, when manufacturing high-performance engineering plastics, adding an appropriate amount of 4-fluorobenzenesulfonamide can improve the strength and heat resistance of the plastic, so that it can be used stably in harsher environments, and is widely used in industries with extremely high material requirements such as automobiles and aerospace.
In agriculture, 4-fluorobenzenesulfonamide can be used as a raw material to participate in the synthesis of pesticides. Its structural characteristics help to enhance the activity and pertinence of pesticides, precisely attack pests and pathogens, and reduce the adverse impact on the environment, help agriculture achieve efficient and green production, and ensure the yield and quality of crops. In short, 4-fluorobenzenesulfonamide plays an indispensable role in many important fields, promoting the development and progress of various industries.
What are the physical properties of 4-Fluorobenzenesulfonamide?
4 - Fluorobenzenesulfonamide is an organic compound, and its physical properties are worth exploring.
This compound is often solid at room temperature and pressure. Its appearance is mostly white to white crystalline powder, like finely crushed ice crystals, delicate and uniform, under light or visible subtle luster, just like frost covering it.
When it comes to melting point, 4 - Fluorobenzenesulfonamide is usually within a certain range, this property is very critical when identifying and purifying the substance. Like the fit of a lock and a key, accurate melting point determination can help to identify its authenticity and purity.
Its solubility also has characteristics. In organic solvents such as ethanol and acetone, it can show a certain solubility, just like fish entering water, and some molecules can be evenly dispersed in the solvent system. However, in water, its solubility is relatively limited, and only a few molecules can interact with water molecules and dissolve. It is like watching fire from the shore, and most of them remain solid.
The density of 4 - Fluorobenzenesulfonamide gives it a specific weight and volume relationship. This physical parameter is indispensable in many fields such as chemical production and preparation. It is essential for the precise measurement of materials and the smooth progress of reactions.
Its stability is also an important physical property. Under normal environmental conditions, if you avoid direct light and hot topic, and stay away from active substances such as strong oxidants, 4-Fluorobenzenesulfonamide can maintain a relatively stable state, just like ancient trees hidden in the deep forest, keeping time changing.
These physical properties, like a set of codes, reveal the essence and characteristics of 4-Fluorobenzenesulfonamide, lay the foundation for its application in chemical, pharmaceutical and other fields, and help researchers and producers to control its performance and maximize its function.
Is 4-Fluorobenzenesulfonamide chemically stable?
4 - Fluorobenzenesulfonamide is one of the organic compounds. The stability of its chemical properties is related to many chemical properties and reaction environments.
The stability of this substance has its own internal reasons. As far as its molecular structure is concerned, the benzene ring structure gives it a certain degree of stability. The benzene ring has a conjugated system, and the electron cloud is evenly distributed, which reduces the energy of the whole molecule and tends to be stable. Fluorine atoms are connected to the benzene ring, and the electronegativity of fluorine is extremely strong. Although it will affect the electron cloud density distribution of the benzene ring, it also helps to stabilize the molecular structure to a certain extent. And in the sulfonamide group (-SO _ 2 NH _ 2), the chemical bond formed by sulfur with oxygen and nitrogen is also relatively strong, which contributes a lot to the overall stability.
However, its stability is not absolute. If placed in a specific reaction environment, the stability may change. For example, in a strong acid or strong base environment, the sulfonamide group may undergo hydrolysis reaction. In a strong acid, the amino group (-NH ²) is easily protonated, which prompts hydrolysis reactions to occur, destroying the original structure of the molecule and reducing the stability. In a strong base environment, the hydroxyl group (-OH) attacks the sulfonyl carbon atom, which can also initiate hydrolysis and break the stable state of the molecule. High temperature environment will also pose a challenge to its stability. High temperature provides enough energy to intensify the vibration of chemical bonds in the molecule. When the bond energy threshold is reached, the chemical bond breaks and the stability is lost.
In summary, 4-Fluorobenzenesulfonamide has certain chemical stability under normal conditions, but when specific chemical and physical conditions change, its stability may be affected, resulting in changes in molecular structure and chemical reactions.
What is the preparation method of 4-Fluorobenzenesulfonamide?
The preparation method of 4-fluorobenzenesulfonamide is as follows:
First take an appropriate amount of 4-fluorobenzenesulfonic acid as the starting material, which is quite common in the chemical industry. 4-fluorobenzenesulfonic acid and phosphorus pentachloride are co-placed in the reactor, and the ratio of the two needs to be precisely prepared. Usually, the molar ratio of 4-fluorobenzenesulfonic acid to phosphorus pentachloride is about 1:1.2 to 1:1.5. The reaction is carried out under heating conditions, and the temperature is preferably controlled at 100 ° C to 120 ° C. This temperature range allows the reaction to proceed fully and smoothly. In the reaction process, phosphorus pentachloride is used as a chlorination agent to react with 4-fluorobenzenesulfonic acid to generate 4-fluorobenzenesulfonyl chloride. The chemical reaction formula is roughly: 4-fluorobenzenesulfonic acid + phosphorus pentachloride → 4-fluorobenzenesulfonyl chloride + phosphorus oxychloride + hydrogen chloride. The generated 4-fluorobenzenesulfonyl chloride needs to be separated and purified, and the method of vacuum distillation can be used. Through this operation, impurities in the reaction mixture can be removed, and fractions within a specific temperature range can be collected to obtain higher purity 4-fluorobenzenesulfonyl chloride.
Then, the obtained 4-fluorobenzenesulfonyl chloride is reacted with excess concentrated ammonia water. The molar ratio of 4-fluorobenzenesulfonyl chloride to concentrated ammonia water is generally 1:3 to 1:4. The reaction can be carried out at room temperature without additional heating, and this reaction is relatively mild. 4-fluorobenzenesulfonyl chloride reacts with ammonia in ammonia water to form 4-fluorobenzenesulfonamide. The reaction formula can be expressed as: 4-fluorobenzenesulfonyl chloride + ammonia → 4-fluorobenzenesulfonamide + ammonium chloride. After the reaction is completed, the resulting mixture contains 4-fluorobenzenesulfonamide and ammonium chloride. At this time, it can be dissolved by adding water, because ammonium chloride is easily soluble in water, while 4-fluorobenzenesulfonamide has less solubility in water. After filtration, the filter residue is crude 4-fluorobenzenesulfonamide. Then the crude product is recrystallized, and a suitable organic solvent is selected, such as a mixed solvent of ethanol and water. After recrystallization, the purity of 4-fluorobenzenesulfonamide can be further improved, and finally a high-quality 4-fluorobenzenesulfonamide product is obtained.
What is the price range of 4-Fluorobenzenesulfonamide in the market?
The price range of 4-fluorobenzenesulfonamide in the market is difficult to determine. The price of 4-fluorobenzenesulfonamide is influenced by many factors, such as the cost of raw materials, the preparation process, the supply and demand of the market, and even changes in the current situation.
First of all, the cost of raw materials, the production of 4-fluorobenzenesulfonamide requires specific starting materials. If such raw materials are scarce, or their mining and production are difficult, the price will rise. And the preparation process is also critical. The complex and exquisite method, although it can obtain high-quality products, the cost is also high, resulting in a high price; the simple method, the cost may be reduced, but the quality or loss will also affect the pricing.
The supply and demand of the market, the price is If the demand for 4-fluorobenzenesulfonamide increases sharply at a certain time, and the supply is limited, the price will rise; on the contrary, if the supply exceeds the demand, the price will tend to fall. And the situation changes, such as policy changes, trade disputes, can cause price fluctuations.
In the past, the price of 4-fluorobenzenesulfonamide was between tens and hundreds of yuan per kilogram. However, this is only a rough idea. Today, due to the intertwining of the above factors, it is difficult to determine the exact price range. To know the details, it is advisable to consult chemical raw material suppliers, industry experts, or check the latest market reports to get the current price.
