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What are the chemical properties of 4-Fluorobenzenemethanamine?
4-Fluorobenzenemethanamine, Chinese name 4-fluorobenzyl amine, is an organic compound with unique chemical properties.
It is alkaline. Due to the amino group, the nitrogen atom in the amino group has a lone pair of electrons, which can bind protons and react with acids to form salts. If it reacts with hydrochloric acid, a corresponding ammonium salt is formed. This property makes it useful as a nucleophilic reagent in organic synthesis and participates in many reactions.
The benzyl ring of 4-fluorobenzyl amine has fluorine atom substitution, and the fluorine atom has strong electronegativity, which has an impact on the electron cloud density distribution of the benzene ring, so that the electron cloud density of the benzene ring is relatively reduced, and the density of the meta-electron cloud is slightly increased. The electrophilic substitution reaction activity is different from that of Electrophilic reagents are more likely to attack intersites.
From the perspective of spatial structure, the benzene ring is a planar structure, and the benzyl group is connected to the amino group. The molecule has a certain polarity, which affects its physical properties, such as solubility. It has a certain solubility in organic solvents, but its solubility in water is limited due to the structure of polar groups and non-polar benzene rings.
The amino group of 4-fluorobenzyl amine has active hydrogen atoms, which can participate in condensation reactions, such as reacting with aldose and ketone to form imines. This is an important reaction path for organic synthesis to prepare nitrogen-containing heterocycles or other nitrogen-containing compounds.
Because of its active chemical properties, it should be paid attention to when storing and using. Keep in a cool and ventilated place away from ignition and oxidants to prevent dangerous reactions. Follow safety procedures and take protective measures to avoid contact with skin and inhalation.
What are the common uses of 4-Fluorobenzenemethanamine?
4-Fluorobenzenemethanamine is 4-fluorobenzamide. The common preparation routes of this substance are as follows:
One is to use 4-fluorobenzaldehyde as the starting material. 4-fluorobenzaldehyde is placed in a suitable reaction vessel, and an appropriate amount of ammonia alcohol solution is added. The two first undergo a condensation reaction to form an imine intermediate. Subsequently, a suitable reducing agent, such as sodium borohydride, is added to the system. Sodium borohydride can efficiently reduce imines to amines to produce 4-fluorobenzamide. In this path, 4-fluorobenzaldehyde is easy to obtain, the reaction conditions are relatively mild, and the operation is not complicated. It is commonly used in laboratory preparation.
The second is to use 4-fluorobenzyl halide as raw material. Select 4-fluorobenzyl chloride or 4-fluorobenzyl bromide and mix it with excess ammonia in a suitable solvent, such as ethanol or dichloromethane. The halogenated hydrocarbons undergo a nucleophilic substitution reaction with ammonia, and the halogen atoms are replaced by amino groups to generate 4-fluorobenzamine. After the reaction is completed, pure products can be obtained by conventional separation methods such as distillation and extraction. This method has low raw material cost and considerable reaction yield, which is suitable for large-scale production.
The third is to use 4-fluorobenzoic acid as the starting material. 4-Fluorobenzoic acid and methanol are first esterified under the catalysis of concentrated sulfuric acid to form methyl 4-fluorobenzoate. After that, the reduction of methyl 4-fluorobenzoate with strong reducing agents such as lithium aluminum hydride can reduce the ester group to methyl and generate 4-fluorobenzoamine at the same time. However, lithium aluminum hydride is active, and special attention should be paid to safety during operation, and the reaction conditions are relatively harsh.
All these production methods have their own advantages and disadvantages. In actual operation, the appropriate method should be carefully selected according to many factors such as the availability of raw materials, reaction conditions, production costs, and requirements for product purity.
What are 4-Fluorobenzenemethanamine synthesis methods?
The synthesis method of 4-fluorobenzamide has been described in many books in the past, and the following methods are more common.
First, 4-fluorobenzaldehyde is used as the starting material and is reduced to amination. In this case, 4-fluorobenzaldehyde and ammonia or amine compounds are first condensed in a suitable reaction medium with the help of a catalyst to form an imine intermediate. Then a reducing agent, such as sodium borohydride and sodium cyanoborohydride, is used to reduce the imine to 4-fluorobenzamide. The beauty of this method is that the raw materials are easily available and the reaction conditions are relatively mild. It is necessary to pay attention to the selectivity of the reaction to avoid side reactions.
Second, 4-fluorobenzyl halide is reacted with ammonia. 4-fluorobenzyl halide, such as 4-fluorobenzyl chloride or 4-fluorobenzyl bromide, with excess ammonia, is heated and refluxed in alcohol solvents or water. The halogen atom is attacked by the nucleophilic attack of ammonia and is replaced by the amino group, so 4-fluorobenzamine is obtained. This approach is easy to operate, but it is necessary to pay attention to the activity of the halide and the amount of ammonia to prevent the formation of secondary amines, tertiary amines and other by-products.
Third, through the nucleophilic substitution reaction on the aromatic ring. First introduce a suitable leaving group on the benzene ring, and then attack with an amino-containing nucle For example, 4-fluoronitrobenzene is reduced to obtain 4-fluoroaniline, which is then treated with formaldehyde, formic acid and other reagents. After the Mannich reaction, methylene and amino groups are introduced to obtain 4-fluorobenzamine. Although this method is slightly complicated, the synthesis path can be flexibly adjusted according to different raw materials and reaction conditions.
Or, using 4-fluorobenzoic acid as the starting material, it is first converted into the corresponding acid chloride, and then reacted with ammonia to form an amide. Finally, after reduction, if the amide is reduced with lithium aluminum hydride, 4-fluorobenzamine can also be obtained. However, lithium aluminum hydride is active in nature, and extra caution is required during operation. Pay attention to the control of reaction conditions.
All these synthetic methods have their own advantages and disadvantages, and the appropriate method should be carefully selected according to the actual situation, such as the availability of raw materials, cost considerations, and the purity requirements of the target product.
4-Fluorobenzenemethanamine What are the precautions in storage and transportation?
4-Fluorobenzenemethanamine, Chinese name 4-fluorobenzyl amine, is an organic compound. When storing and transporting it, many important things need to be paid attention to.
Let's talk about storage first. Because it has certain chemical activity, the first storage environment is dry. Moisture is easy to cause reactions such as hydrolysis, which damages its purity and quality. Therefore, it should be stored in a dry and well-ventilated place, away from water sources and places with high humidity. Secondly, it needs to be protected from heat. This compound is easily decomposed by heat or triggers other chemical reactions, causing it to deteriorate. Therefore, it should be placed in a cool place, and the temperature should be controlled at a lower level, generally not exceeding 25 ° C. In addition, 4-fluorobenzyl amine may be toxic and corrosive to a certain extent. When storing, it must be separated from oxidants, acids, alkalis, etc., to prevent mutual reaction and cause danger. Storage containers are also particular. Corrosion-resistant materials must be used, such as glass or specific plastic containers, and ensure that they are well sealed to prevent leakage.
As for transportation, the same cannot be ignored. Before transportation, the packaging of the container must be tight and stable to prevent damage and leakage due to vibration and collision. During transportation, temperature should be strictly controlled to avoid exposure to the sun and high temperature environment. Because it may be a hazardous chemical category, transportation personnel should be professionally trained and familiar with its characteristics and emergency treatment methods. In the event of a leak, they can respond quickly and correctly. And transport vehicles need to be equipped with corresponding emergency treatment equipment and protective equipment, such as fire extinguishers, leakage emergency treatment tools, protective gloves and protective clothing. At the same time, transportation should follow relevant regulations and standards, and handle necessary transportation licenses and procedures to ensure transportation compliance and safety.
What is the market price range for 4-Fluorobenzenemethanamine?
4-Fluorobenzenemethanamine, that is, 4-fluorobenzamine, the price of this product in the market is difficult to determine, and its price often varies due to various factors.
First, the amount of quantity has a huge impact on the price. If the buyer wants a lot, the merchant may give a discount for customers, and the price may be relatively easy; if only a small amount is needed for research and testing, the price may be slightly higher.
Second, the quality is also the key. Those with high quality and high purity have more complicated preparation, high cost, and the price will rise accordingly; if the quality is slightly inferior, although it can meet some ordinary needs, the price may be low.
Third, the supply and demand of the city determines the fluctuation of the price. If there are many people seeking, but the supply is limited, according to the rules of the city, the price will tend to rise; on the contrary, if the supply exceeds the demand, the merchant will sell the goods, or reduce the price.
Fourth, the manufacturer and the source place are also related to the price. Different manufacturers have different pricing due to differences in technology and origin; and the source place is different, and the transportation and other fees are added, which also makes the price different.
Roughly speaking, the price per gram may range from a few yuan to tens of yuan. However, this is only an approximate amount, and the actual price must be determined by consulting the supplier in detail according to the current market conditions, purchase quantity, quality, etc.
