4-Fluorophenylboronic acid is widely used. In the field of organic synthesis, it is often a key reagent. Organic synthesis is like building a delicate chemical building, and 4-fluorophenylboronic acid is an indispensable masonry. In carbon-carbon bond formation reactions, such as the Suzuki coupling reaction, it plays a crucial role. Suzuki coupling reaction is a common and efficient method for building carbon-carbon bonds in organic synthesis. 4-fluorophenylboronic acid can be coupled with halogenated aromatics or alkenyl halides in the presence of palladium catalysts and bases to form biaryl or alkenyl aromatics with specific structures. Such compounds are of great significance in many fields such as materials science and medicinal chemistry.
In the field of materials science, materials synthesized by the reaction of 4-fluorophenylboronic acid can exhibit unique photoelectric properties. For example, some of the synthesized organic semiconductor materials may be applied to organic Light Emitting Diodes (OLEDs), organic solar cells and other devices. OLEDs have the advantages of self-luminescence, wide viewing angle, and fast response speed, and have broad prospects in the display field. Suitable organic semiconductor materials are the key to achieving their good properties. 4-fluorophenylboronic acid may play a role in promoting here.
In the field of medicinal chemistry, it can assist in the synthesis of compounds with specific biological activities. The structure of many drug molecules contains aryl or alkenyl structural units. The reaction of 4-fluorophenylboronic acid can precisely construct such structures, providing an effective way for the development of new drugs. Researchers can design and synthesize a series of compounds based on 4-fluorophenylboronic acid, and screen for potential lead compounds after biological activity, and then develop new drugs.
In addition, 4-fluorophenylboronic acid is also used in the preparation of some fine chemicals. For example, in the synthesis process of some special dyes, fragrances and other fine chemicals, it can participate in the reaction as an intermediate, and after specific reaction steps, it can be converted into target products, which adds to the fine chemical industry.

4-Fluorophenylboronic acid has unique physical properties. Viewed, it is in the state of white to light yellow crystalline powder, which makes it easy to disperse and participate in reactions in various reaction systems.
The melting point is about 284-288 ° C. A higher melting point indicates that the intermolecular force is strong and the structure is relatively stable. At this temperature, the substance remains solid for easy storage and transportation.
In terms of solubility, it is slightly soluble in water, but soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. This solubility property provides convenience for its application in organic synthesis reactions. In organic phase reaction systems, it can be well dissolved, thus promoting the smooth progress of the reaction.
Furthermore, 4-fluorophenylboronic acid has a certain degree of hygroscopicity. When exposed to air, it is easy to absorb moisture, so it needs to be properly stored, often sealed and stored in a dry place to prevent it from affecting the quality and reactivity due to moisture absorption.
Although its density does not have an exact fixed value, the overall density is different from that of common organic compounds due to the presence of fluorine atoms, benzene rings, and boric acid groups in the molecular structure. In related separation and extraction operations, the density properties will also affect its state and separation effect.
These physical properties are interrelated and jointly determine the application characteristics and usage of 4-fluorophenylboronic acid in organic synthesis, medical chemistry, and other fields.

The method of synthesizing 4-Fluorobenzeneboronic acid is of great interest in the field of organic synthesis. One of the common methods is to use halogenated aromatics as starting materials. Take 4-fluorobromobenzene and react it with magnesium chips in an anhydrous ether or tetrahydrofuran solvent at a low temperature and protected by an inert gas to make a Grignard reagent. This reaction must be carefully maintained at a low temperature to prevent side reactions. The resulting Grignard reagent is then reacted with borate esters, such as trimethyl borate, at an appropriate temperature. After the reaction is completed, it can be hydrolyzed and treated with dilute acid to obtain 4-fluorophenylboronic acid.
The second method can be started from 4-fluoroaniline. First, 4-fluoroaniline is reacted by diazotization, with sodium nitrite and inorganic acid at low temperature to form a diazonium salt. The diazonium salt is unstable and needs to be reacted immediately with reducing agents such as sodium borohydride and boric acid derivatives, and in the presence of a specific catalyst, the conversion to 4-fluorophenylboronic acid is realized. In this process, the temperature and reaction time of the diazotization reaction need to be precisely controlled to avoid the decomposition of diazonium salts.
Furthermore, the cross-coupling reaction catalyzed by palladium can also be used as a synthesis route. The reaction of 4-fluorobenzene with boron-containing reagents was carried out in a suitable organic solvent under the combined action of palladium catalyst, ligand and base. This method requires high reaction conditions. The choice of catalyst, the structure of ligand, and the type and amount of base all have significant effects on the yield and selectivity of the reaction. After the reaction, pure 4-fluorophenylboronic acid can be obtained through separation and purification steps, such as column chromatography, recrystallization, etc.

4-Fluorophenylboronic acid is a key reagent in organic synthesis. When storing this reagent, many aspects need to be paid attention to.
The first to bear the brunt, temperature control is extremely important. 4-Fluorophenylboronic acid should be stored in a cool place. Generally speaking, the temperature should be maintained at 2-8 ° C. This is because excessive temperature is likely to cause the reagent to deteriorate, such as accelerating its decomposition process. If the temperature exceeds the appropriate range, the chemical structure inside the reagent may be damaged, which may affect its chemical activity and purity.
Furthermore, humidity is also a factor that cannot be ignored. Be sure to keep it in a dry place to prevent moisture. Due to its certain hygroscopicity, once damp, it will cause many adverse consequences, such as agglomeration, and even react with water in severe cases, making the reagent ineffective. Therefore, desiccants can be used to maintain the dryness of the storage environment.
Storage away from light is also not negligible. 4-Fluorophenylboronic acid is more sensitive to light, and long-term exposure to light can easily cause photochemical reactions, resulting in changes in its structure and chemical properties. Therefore, it should be stored in brown bottles or dark containers.
In addition, the storage area should be well ventilated to prevent the accumulation of harmful gases. At the same time, it should be stored separately from oxidants, acids, bases, etc., to avoid mutual contact and reaction. Because these substances may react chemically with 4-fluorophenylboronic acid, causing it to deteriorate or cause safety accidents.
When storing 4-fluorophenylboronic acid, full attention should be paid to temperature, humidity, light and isolation from other substances, so as to ensure the stability and quality of the reagent, and play its due role in subsequent organic synthesis experiments or production.

The price of 4-fluorophenylboronic acid in the market varies for many reasons. Its price is often affected by various factors such as supply and demand, difficulty in production, quality and competition in the market.
In the past, in the chemical industry, if the supply exceeded the demand, the price may decrease. Because merchants compete to sell, they want to compete for the market and reduce the price. On the contrary, if the demand exceeds the supply, especially at a specific time, if the demand for a certain industry increases sharply, but the production does not respond, the price will rise.
In addition, its production method is also the key. If the production method is complex and expensive, and requires more resources, manpower and material consumption, the price will be higher. The simple and low-cost method may make the price drop.
Furthermore, the quality is related to the price. Those with high quality have less impurities and high purity, and are suitable for high-end fields, such as fine chemicals such as medicine and electronics, and their price is also high. Those with lower quality are mostly suitable for general chemical industries, and the price is lower.
Competition in the market also affects its price. There are many and fierce merchants, who are competing to expand the market share, or push discounts, or sell them at a reduced price. If the market is almost controlled by widows, the price may be stable and high.
Looking at the market conditions, the price of 4-fluorophenylboronic acid is about tens to hundreds of yuan per gram. However, this is only a rough estimate, and the actual price should be explored in detail according to the real-time market conditions, purchase volume and purchase time. When purchasing this item, the buyer must compare it in many ways, and compare the price and quality of each family to obtain a suitable one.