4-Fluorobenzeneacetic Acid

Hongda Chemical

Specifications

HS Code	708156
Chemical Formula	C8H7FO2
Molar Mass	154.14 g/mol
Appearance	White to off - white solid
Melting Point	97 - 101 °C
Boiling Point	271 - 273 °C
Solubility In Water	Slightly soluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, acetone
Pka	3.98
Density	1.264 g/cm³
Flash Point	126 °C
Odor	Faint, characteristic odor

As an accredited 4-Fluorobenzeneacetic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	500g of 4 - fluorobenzeneacetic acid packaged in a sealed plastic - lined carton.
Storage	4 - Fluorobenzeneacetic acid should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent moisture absorption and evaporation. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions. This ensures its stability and safety during storage.
Shipping	4 - Fluorobenzeneacetic Acid is shipped in sealed, corrosion - resistant containers. It's transported following strict hazardous chemical regulations, ensuring proper handling to prevent spills and exposure during transit.

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General Information

Historical Development

The development of 4-fluorophenylacetic acid, although the name was not heard in ancient times, the research of chemistry has gradually come to today. At the beginning, the knowledge of chemistry was not wide, and the research was only on ordinary things. After the advance of science and technology, the exploration became more and more profound.
In the past, the beginning of organic chemistry, various sages tried their best to analyze the properties of matter and find a way. The study of 4-fluorophenylacetic acid also originated from this. At that time, researchers thought hard about it and went through various experiments to find a good way. At the beginning of the attempt, there were many failures, but they were not discouraged.
As the years passed, the researcher's skills became more and more refined, analyzing its structure, exploring its sexual characteristics, and gradually understanding its reason. With the improvement of experiments and the optimization of conditions, the yield and quality of 4-fluorophenylacetic acid have gradually increased. Therefore, its use in various fields of medicine and chemical industry has gradually appeared, helping the industry and promoting the progress of the world.

Product Overview

4 - Fluorobenzeneacetic Acid is an organic compound with unique properties. Looking at its color, it often appears as a white to white crystalline powder. Smell it, there is little odor. Its melting point is about [specific melting point value], which is crucial in the identification and purification of this substance.
When talking about the use of this compound, it is of great significance in the field of medicinal chemistry. It is often used as a key intermediate to assist in the synthesis of a variety of drugs. For example, when developing specific anti-cancer drugs, 4 - Fluorobenzeneacetic Acid participates in it. After a series of chemical reactions, it can promote the precise construction of drug molecular structures and improve the targeting and efficacy of drugs on cancer cells.
Furthermore, in the field of organic synthetic chemistry, it is also an extremely important raw material. Due to the special structure of fluorobenzene ring and carboxyl group, many organic compounds with unique properties can be derived through various reactions such as esterification and amidation, which contribute to the development of materials science, fine chemistry and other fields.

Physical & Chemical Properties

4-Fluorophenylacetic acid is also an organic compound. Its physical and chemical properties are particularly important. Looking at its properties, at room temperature, or in the shape of white crystals, this is due to the orderly arrangement of its molecules. Its melting point is also fixed, about within a certain range, which is limited by the intermolecular force. As for solubility, it may have better solubility in organic solvents such as ethanol and ether. Due to the similar principle of compatibility, its molecular structure has a certain affinity with organic solvent molecules. Chemically, carboxyl groups can participate in many reactions, such as neutralization with bases to form corresponding salts, which is the embodiment of the acidity of carboxyl groups. The existence of fluorine atoms also endows it with unique reactivity and can participate in specific substitution reactions. It is quite useful in the field of organic synthesis, and it is indeed an interesting and practical compound.

Technical Specifications & Labeling

Today there are 4 - Fluorobenzeneacetic Acid products, and its technical specifications and identification (product parameters) are crucial. This product is related to many characteristics. In terms of chemical structure, it is necessary to accurately determine the position and binding state of its fluorine atom in the phenylacetic acid structure. Its purity label should reach a very high standard, and the impurity content must be strictly controlled at an extremely small level.
Discuss physical parameters, such as melting point, boiling point, etc., when measured in detail and clearly marked to ensure uniform product quality. Solubility parameters cannot be ignored, and the solubility characteristics in different solvents are the basis for application. And the appearance label is also important, and the color and shape must be clearly defined. If the technical specifications and identification are accurate, this product can be properly applied in various fields of chemical industry, laying a solid foundation for subsequent research and production.

Preparation Method

4 - Fluorobenzeneacetic Acid is an important compound in the field of organic synthesis. Its preparation method is related to raw materials, production process, reaction steps and catalytic mechanism.
The selection of raw materials is often based on fluorobenzenzeneacetic benzene and carboxyl-containing related substances. For example, fluorobenzenzeneacetic benzene is used as the starting material, and halogenated atoms are introduced through halogenation to generate halogenated fluorobenzene. The halogenated fluorobenzenzeneacetic benzene and carboxyl-containing reagents can realize the construction of carbon-carbon bonds according to specific reaction conditions.
In terms of production process, the reaction environment needs to be precisely regulated. Temperature, pressure and reaction time all affect the purity and yield of the product. Appropriate
The reaction steps are rigorous. After the halogenation reaction, a suitable nucleophilic reagent is required, nucleophilic substitution occurs, and a carboxyl precursor is introduced. After hydrolysis or other conversion steps, the target product 4-Fluorobenzeneacetic Acid is generated.
Catalytic mechanism, or a metal catalyst is selected to reduce the activation energy of the reaction and increase the reaction rate. Metals and reactants form specific intermediates to guide the reaction in a favorable direction. The precise design and application of this catalyst is the key to the preparation.

Chemical Reactions & Modifications

4-Fluorophenylacetic acid, the chemical reaction and modification of this compound are related to many wonderful changes. In past studies, the reaction path has been observed, and many discoveries have been made.
Its reaction often involves a substitution change. The fluorine atom on the aromatic ring has a unique activity, which can lead to other groups into the structure and cause structural changes. This change affects its physicochemical properties, such as solubility and stability.
Modification method, or by chemical modification, adjust its functional group to suit different needs. Or add a group to change its reactivity, which is important in the field of medicine and materials.
We continue to study to clarify its reaction laws, make good use of modification methods, create more possibilities for various fields, and explore the endless potential of this compound, making it brilliant in scientific research and application.

Synonyms & Product Names

4-Fluorophenylacetic acid is also a chemical substance. Its name and trade name can be investigated. The husband's name, so its nature and clarity, so that those who know it can be identified. The business name is involved in the market transaction, and the circulation of this substance in the world.
Consider 4-fluorophenylacetic acid, its name or according to its characteristics and characteristics. With the principle of chemistry, analyze the structure of its molecules, or have its name because of its atomic arrangement and functional characteristics. And the determination of the business name, or the need of the market, the need for publicity. Merchants want their products to be known, so they take the name of easy and easy to sell in order to facilitate sales.
A name is a business name, which is important for research and business. The research name can help those who are original, not confused by the appearance. The business name can attract customers and promote the circulation of goods. Therefore, the business name of 4-fluorophenylacetic acid should not be ignored for those who are chemical and business.

Safety & Operational Standards

4-Fluorophenylacetic acid is an important chemical that is widely used in many fields. However, during its preparation and use, safety and operating practices are of paramount importance, which is related to the safety of people and the environment.
When preparing 4-fluorophenylacetic acid, the experimental site should be well ventilated to expel harmful gases. Operators must wear protective clothing, goggles and gloves to prevent the drug from coming into contact with the skin and eyes. In case of accidental contact, rinse with plenty of water as soon as possible and seek medical attention.
The experimental instrument should be clean and dry to ensure that the reaction is carried out normally. The drug must be weighed accurately and added according to the specified ratio, so as not to affect the reaction result or even cause danger. The reaction temperature and time must also be strictly controlled and set according to the reaction characteristics to achieve the best reaction effect.
When using 4-fluorophenylacetic acid, the storage conditions should not be ignored. It should be placed in a cool, dry place, away from fire sources and oxidants to prevent fire or explosion. After taking it, the container must be sealed to prevent the drug from being damp or volatilized.
Waste treatment should also not be ignored. Waste containing 4-fluorophenylacetic acid should be collected in accordance with relevant regulations and handed over to professional institutions for treatment. It should not be discarded at will to avoid polluting the environment.
In short, the safety and operation standards of 4-fluorophenylacetic acid are the key to chemical research and production. Only by strictly adhering to the regulations can we ensure the smooth operation of the experiment, the safety of personnel, and the cleanliness of the environment.

Application Area

4-Fluorophenylacetic acid is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be a key intermediate for the synthesis of many drugs with special curative effects, or for the healing of nervous system diseases, or for the creation of anti-inflammatory drugs to solve the suffering of patients.
In materials science, it also has its uses. It can be integrated into polymer materials through specific reactions to give materials different properties, such as improving the stability of materials, enhancing their compatibility with other substances, and making materials suitable for more special scenarios.
And in the field of fine chemicals, 4-fluorophenylacetic acid can be used as a special additive to add unique properties to the product, playing a key role in the preparation of fine chemicals such as coatings and fragrances, improving product quality and performance, and meeting the needs of different industries.

Research & Development

4-Fluorophenylacetic acid is also a chemical substance. I have been studying things for a long time. At first, I observed the structure of its molecules, examined the arrangement and combination of its atoms in detail, and revealed its chemical characteristics.
Then explore the method of synthesis, and try to adjust the temperature of the reaction or change the ratio of reagents to obtain an efficient and pure preparation way. In the reaction mechanism, I have also repeatedly inferred, hoping to be able to accurately control.
And look at its application potential in different fields, the genus of medicine, and think about whether it can be used as a cure; in the field of materials, measure whether it has unique properties. In the process of research, I often encounter difficulties, but I uphold the heart of research and unremitting exploration. It is hoped that through continuous research, 4-fluorophenylacetic acid will have better properties and wider applications, contributing to the development of the chemical field and promoting its progress and expansion.

Toxicity Research

Husband 4 - Fluorobenzeneacetic Acid, a chemical substance is also a chemical substance. I am a researcher of chemical substances, and I have always investigated its toxicity.
This compound has chemical functions, but the investigation of toxicity cannot be ignored. I will use the method of science to observe its properties. It is like this, and it is the shadow of living things.
In the environment of this compound, it can be investigated. It may have organs, or it may have energy.
And in the environment, the dispersion of this compound also has implications. Whether it enters the water and soil, or is stained with air, the biological experience is different.
The study of toxicity is to seek harm. Only by knowing its harm can it be prevented from being dangerous, and by using it, it can be avoided. It can be used to make things that are used by people and harm the world.

Future Prospects

4-Fluorophenylacetic acid, although it is a corner of chemical research in this world, its future prospects are really promising.
Looking at the current state of chemistry, 4-fluorophenylacetic acid, with its unique structure, is gradually showing its ability in the synthesis of medicine. It may be used as a key intermediate to help the birth of new drugs, cure various diseases, and treat diseases and diseases for the world. This is also a hope.
Furthermore, in the field of materials science, with the deepening of exploration, 4-fluorophenylacetic acid may be able to participate in the creation of new materials. It is a second hope to give materials specific properties, or increase their toughness, or add their stability, so that materials can develop their talents in various industries.
Although there may be thorns ahead, we chemical researchers should explore the secrets with enthusiasm. With unremitting research, 4-fluorophenylacetic acid will shine in the future and open up new days for human well-being.

Where to Buy 4-Fluorobenzeneacetic Acid in China?

As a trusted 4-Fluorobenzeneacetic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 4-Fluorobenzeneacetic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-Fluorobenzeneacetic Acid?

4-Fluorophenylacetic acid is widely used. In the field of medicinal chemistry, it is a key raw material for the preparation of a variety of drugs. The introduction of fluorine atoms on the benzene ring can significantly change the physical, chemical and biological activities of compounds. Taking anticancer drugs as an example, with 4-fluorophenylacetic acid as the starting material, through a series of chemical transformations, anti-cancer molecules with specific targeting and high activity can be synthesized. Because fluorine atoms can enhance the interaction between drugs and targets, improve efficacy and reduce side effects.
In materials science, 4-fluorophenylacetic acid also plays an important role. It can be used to synthesize polymer materials with special functions. After polymerization with suitable monomers, fluoropolymers are obtained. Due to the characteristics of fluorine atoms, such polymers have excellent chemical resistance, low surface energy and good thermal stability. For example, they are used in the preparation of anti-fouling coating materials, which can make the surface of objects have anti-adhesion and easy cleaning properties, and are widely used in construction, automotive and other fields.
In organic synthetic chemistry, 4-fluorophenylacetic acid is an important building block for the construction of complex organic molecules. Due to the chemical activity of carboxyl groups and benzene rings, it can react with many organic reagents through esterification, amidation and other reactions to build various complex organic structures, providing the possibility for the synthesis of new organic functional materials and fine chemicals, helping organic chemists to expand the diversity of molecular structures and develop new compounds with unique properties.

What are the physical properties of 4-Fluorobenzeneacetic Acid?

4-Fluorophenylacetic acid, its physical properties are as follows:
This substance is a white to off-white crystalline powder under normal conditions. Looking at its morphology, when pure, it is white like snow, delicate and uniform, just like natural powder.
When talking about the melting point, it is about 104-106 ° C. When the temperature gradually rises to the melting point, this substance is like ice in warm sun, and it gradually melts from the solid state to the liquid state. The change of morphology follows the laws of nature.
Its solubility is also an important physical property. In organic solvents, such as ethanol, ether, etc., it is like fish entering river water, soluble and evenly dispersed. Because the molecular structures of ethanol and ether are compatible with 4-fluorophenylacetic acid, they attract each other, so they can dissolve. In water, its solubility is slightly inferior, only slightly soluble. The polarity of water interacts weakly with the partial structure of 4-fluorophenylacetic acid, resulting in limited solubility.
The density of 4-fluorophenylacetic acid is about 1.328 g/cm ³. This value shows that under the same volume, it is heavier than water. If placed in water, it will sink automatically, following the principle of density. Its smell is slightly special, not pungent, but it is also unique, and it can be recognized as unique. And the chemical properties of this substance are relatively stable at room temperature and pressure, and it will also react chemically under specific conditions, such as high temperature, strong acid and alkali, etc. This is what follows. In terms of physical properties alone, the above is its main characterization.

4-Fluorobenzeneacetic the chemical properties of Acid

4-Fluorophenylacetic acid has mild properties and is very important in the field of organic synthesis. Looking at its structure, the fluorine atom on the benzene ring occupies a stable position, and the side chain acetic acid group is connected to it. This unique structure endows it with different chemical properties.
Fluorine atoms have strong electronegativity, which can change the electron cloud density of the benzene ring and change the electrophilic substitution activity of the benzene ring. When encountering electrophilic reagents, the reaction check point and rate are different from those of fluorine-free phenylacetic acid. And due to the presence of fluorine atoms, the polarity of the molecule increases, and the solubility in polar solvents may also be different.
Its acetic acid side chain has carboxylic acid commonality. It can be neutralized with bases In case of alcohols, under the catalysis of acids, esters can be formed. This ester product is widely used in many aspects such as fragrance and pharmaceutical synthesis. It can also be carboxylated into alcohol hydroxyl groups by reduction reaction to derive other compounds.
In organic synthesis, 4-fluorophenylacetic acid is often used as a key intermediate. Starting with it, various reactions such as nucleophilic substitution and condensation can be used to produce a variety of fluorine-containing organic compounds. When creating new drugs and agricultural chemicals, the introduction of fluorine atoms can often improve biological activity and metabolic stability.
4-Fluorophenylacetic acid, due to its special structure and chemical properties of both benzene ring and carboxylic acid, is of great significance in organic synthesis and related industries, and is a powerful "masonry" for chemical craftsmen to create new substances.

What are the synthetic methods of 4-Fluorobenzeneacetic Acid?

The synthesis method of 4-fluorophenylacetic acid is not detailed in the ancient book "Tiangong Kaiwu", but there are many ways to be found in today's chemical synthesis methods.
First, 4-fluorotoluene is used as the starting material. First, 4-fluorotoluene is interacted with halogens (such as bromine) under the conditions of halogenation reaction, under the condition of light or initiator, to obtain 4-fluorobenzyl halide. This step of reaction is like introducing an active halogen atom into the side chain of toluene, which lays the foundation for subsequent conversion. Then, sodium cyanide is replaced by sodium cyanide, and the halogen atom is replaced by a cyanide group through a nucleophilic substitution reaction to generate 4-fluorophenylacetonitrile. This cyanyl compound is then hydrolyzed under the condition of acid or base catalysis to obtain 4-fluorophenylacetic acid. The hydrolysis process is similar to the gradual conversion of cyanyl groups to carboxyl groups, and the final target product is obtained.
Second, 4-fluorobenzoic acid is used as the starting material. First reduce it to 4-fluorobenzyl alcohol, and a suitable reducing agent can be used, such as sodium borohydride or lithium aluminum hydride. This reduction reaction converts the carboxyl group into an alcohol hydroxyl group to obtain 4-fluorobenzyl alcohol. After that, 4-fluorobenzyl alcohol is converted into 4-fluorobenzyl halide with a halogenating agent, and then 4-fluorophenylacetic acid can be obtained through steps similar to the above cyanidation and hydrolysis.
Or, using phenylacetonitrile as a raw material, first through a halogenation reaction, a halogen atom is introduced at a specific position in the benzene ring, and then through a nucleophilic substitution reaction, the halogen is replaced with fluoride ions, and then through a hydrolysis reaction, 4-fluorophenylacetic acid can also be obtained. Although these methods have their own differences, they all achieve the synthesis of 4-fluorophenylacetic acid with reasonable chemical conversion.

What is the price range of 4-Fluorobenzeneacetic Acid in the market?

It is difficult to determine the price range of 4-fluorophenylacetic acid in the market. The price of 4-fluorophenylacetic acid often varies due to various factors.
First, the price of raw materials has a great impact. If the supply of raw materials required for the synthesis of 4-fluorophenylacetic acid is tight, or the price rises due to disasters in the place of origin or market monopoly, the cost of 4-fluorophenylacetic acid will increase, and its price in the market will also rise. On the contrary, if the supply of raw materials is sufficient and the price is stable, the price of 4-fluorophenylacetic acid may also stabilize and decline.
Second, the preparation process and scale are related to the price. Sophisticated and efficient preparation processes can reduce production costs. Large-scale production can also share fixed costs based on scale effects, so that unit product costs can be reduced at market prices or more affordable. However, if the process is complicated, the scale is small, and the cost is high, the price will be high.
Third, the market supply and demand situation is the key. The demand is strong, such as the pharmaceutical, chemical and other industries have a large increase in demand for 4-fluorophenylacetic acid, but the supply is difficult to respond for a while, and the price will rise. If the market demand is weak and the supply is excessive, the merchant will destock or reduce the price for promotion.
Fourth, regional factors also have an impact. Different places have different prices due to different transportation costs, tax policies, and the degree of market competition.
Generally speaking, the price of 4-fluorophenylacetic acid fluctuates between tens of yuan and hundreds of yuan per kilogram. However, this is only an approximate number, and the actual price depends on the specific time, place and the above factors. Buyers who want to know the exact price should consult chemical raw material suppliers, traders, or refer to the real-time quotation of the chemical product trading platform.