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What are the main uses of 4-Fluorobenzene-1-Thiol?
4-Fluorobenzene-1-mercaptan is an organic compound with a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to the high activity of thiol groups, it can participate in a variety of chemical reactions, such as nucleophilic substitution, oxidation and condensation reactions. With such reactions, many sulfur-containing organic compounds can be prepared, which are of great significance in many industries such as medicine, pesticides, and materials.
In the field of medicine, sulfur-containing organic compounds synthesized from 4-fluorobenzene-1-mercaptan may have unique biological activities. Some compounds may exhibit pharmacological activities such as antibacterial, antiviral or antitumor, providing key directions for the development of new drugs.
In terms of pesticides, pesticides synthesized by this compound may have an efficient control effect on specific pests or pathogens. Its unique chemical structure can cause the physiological process of pests or pathogens to be disturbed, and then achieve the purpose of control.
In the field of materials science, 4-fluorobenzene-1-thiol is also used. It can participate in the surface modification of materials and change the surface properties of materials, such as wettability and adhesion. Materials modified by it may have better properties in coatings, inks, electronic materials and other fields.
In addition, in the preparation of some fine chemical products, 4-fluorobenzene-1-thiol also plays an important role in the production of high-quality, high-performance fine chemicals to meet the needs of different industries.
What are the physical properties of 4-Fluorobenzene-1-Thiol?
4-Fluorobenzene-1-mercaptan, its physical properties are as follows:
This substance is mostly liquid at room temperature, and it has a special appearance. Its color is nearly colorless, or slightly yellowish, clear and has a certain fluidity.
Smell it, emit a strong and pungent smell, this smell is unique, easy to identify, if you accidentally smell it, it can cause olfactory discomfort.
As for its melting point, the melting point is in a relatively low range, and it can be easily converted from solid to liquid under certain conditions. The boiling point is relatively moderate, and it can be converted from liquid to gas within a specific temperature range.
The density of 4-fluorobenzene-1-mercaptan is higher than that of water. If it is placed in one place with water, it can sink underwater.
In terms of solubility, in organic solvents such as ethanol and ether, it shows good solubility and can be miscible with them to form a uniform system. However, the solubility in water is poor. Due to its molecular structure characteristics, it is difficult to form effective interactions with water molecules, so it is multi-layered in water.
In addition, 4-fluorobenzene-1-mercaptan has a certain volatility. In an open environment, it will gradually evaporate into the air, causing its concentration to change in the surrounding environment. These many physical properties are important to pay attention to when understanding and using 4-fluorobenzene-1-mercaptan.
What is the chemistry of 4-Fluorobenzene-1-Thiol?
4-Fluorobenzene-1-mercaptan is also an organic compound. It has unique chemical properties and is very important in the field of organic synthesis.
In terms of its physical properties, under normal conditions, 4-fluorobenzene-1-mercaptan is mostly a colorless to light yellow liquid, with a pungent and unpleasant smell. This smell originates from the characteristics of thiol groups. Its boiling point, melting point and other properties are closely related to the intermolecular force and structure. Due to the introduction of fluorine atoms, the polarity of the molecule is changed, which in turn affects its melting boiling point. Generally speaking, compared with benzene mercaptan, due to the large electronegativity of fluorine atoms, the intermolecular force is changed, and the boiling point may change to a certain extent. However, the specific value needs to be determined by precise experiments.
In terms of chemical properties, thiol groups (-SH) are extremely active. First, oxidation reactions can occur. Under the action of appropriate oxidants, -SH can be oxidized to sulfonic acid groups (-SOH) or disulfide bonds (-S-S-). For example, in case of mild oxidants such as iodine elemental, disulfides can be formed. This reaction is often used in organic synthesis to construct compounds containing sulfur-sulfur bonds, which is of great significance for adjusting molecular structure and properties. Second, 4-fluorobenzene-1-mercaptan can react with metal ions. Sulfur atoms in mercaptan have lone pairs of electrons and can form coordination compounds with metal ions as ligands. If they meet mercury ions (Hg ² 🥰), they will form stable complexes. This property is often used to detect and remove mercury ion pollutants in the environment, demonstrating its application value in the field of environmental chemistry. Third, this compound can participate in nucleophilic substitution reactions. Although fluorine atoms on the benzene ring have certain stability, under specific conditions, such as strong nucleophiles and suitable temperature and solvent environments, fluorine atoms can be replaced by other nucleophilic groups. This reaction provides an effective way to synthesize organosulfur compounds with diverse structures and enriches the strategies and methods of organic synthesis.
In addition, due to the presence of benzene ring, 4-fluorobenzene-1-mercaptan also has some properties of aromatic compounds. The conjugate system of benzene ring endows it with certain electron delocalization characteristics, enabling it to participate in some reactions related to benzene ring, such as Friedel-Crafts reaction, which lays the foundation for its further derivatization in organic synthesis. Through such reactions, more different functional groups can be introduced, expanding the application range of compounds, and has potential applications in many fields such as medicinal chemistry and materials science.
What are 4-Fluorobenzene-1-Thiol synthesis methods?
There are many paths to follow in the synthesis of 4-fluorobenzene-1-mercaptan. Ancient chemical experts often used subtle methods to produce this compound.
One method can also be started with 4-fluorobromobenzene. Take an appropriate amount of 4-fluorobromobenzene, put it in a special reactor, and combine it with metal magnesium to form a Grignard reagent. This Grignard reagent is active, and reacts when it encounters sulfur powder. Control its temperature and pressure to make the two blend, and then obtain the precursor of 4-fluorobenzene-1-mercaptan. After hydrolysis, its impurities are removed and its pure product is analyzed.
Another method starts with 4-fluoroaniline. First, 4-fluoroaniline is blended with sodium nitrite and acid to form diazonium salts. Diazonium salts are extremely unstable and prone to changes. At this time, thiocyanate is added, so that the diazonium group is replaced by thiocyanide. Subsequent to the reduction method, part of the bond in the thiocyanyl group is broken, and the final product is 4-fluorobenzene-1-thiol.
In addition, 4-fluorobenzoic acid can also be used as a raw material. First, 4-fluorobenzoic acid is reduced to an acid chloride, and then a sulfur-containing reagent, such as sodium hydrosulfide, is used to react with it. This reaction requires the selection of a suitable solvent to control the reaction process. After multi-step conversion, the carboxyl group is removed while the fluorine and sulfur are retained, and 4-fluorobenzene-1-mercaptan can also be obtained.
Synthesis methods have their own advantages and disadvantages. With 4-fluorobromobenzene as the starting material, the raw material is easy to obtain, but the preparation of Grignard's reagent needs to be cautious and the reaction conditions are harsh. The method of 4-fluoroaniline requires a little more complicated steps, and the treatment of diazonium salts requires fine operation. The method of 4-fluorobenzoic acid, although the raw materials are different, also faces the problem of regulating the reaction conditions. Fang's choice method should be weighed according to the availability of raw materials, the level of cost, and the difficulty
What 4-Fluorobenzene-1-Thiol need to pay attention to when storing and transporting
4 - Fluorobenzene - 1 - Thiol, a substance with special chemical properties. When storing and transporting, many matters must be paid attention to.
First words storage. This substance should be stored in a cool, dry and well-ventilated place. Because it is quite sensitive to temperature and humidity, high temperature and humid environment can easily cause it to deteriorate. If the temperature is too high, or cause a chemical reaction, damage its chemical structure; if the humidity is too high, or make it absorb moisture, affect the purity. Therefore, choose a suitable warehouse, control the temperature in a reasonable range, and set up dehumidification equipment to keep dry, which is the key.
Furthermore, the storage place must be kept away from fire sources and oxidants. 4 - Fluorobenzene - 1 - Thiol has a certain flammability. In case of open flames and hot topics, there is a risk of combustion and explosion; and the contact of oxidants with it is easy to induce violent reactions and endanger safety. In the warehouse, when fireworks are strictly prohibited, and this substance and oxidant are placed separately, with obvious signs to prevent accidental touch.
When transporting, the packaging must be tight. Use suitable packaging materials to ensure that it is not damaged in bumps and vibrations. Generally speaking, use sturdy containers with cushioning materials, such as foam, cotton, etc., to prevent collision and rupture. At the same time, the transportation vehicle should also be carefully selected, and it is advisable to choose those with good ventilation and fire protection devices to ensure safety during transportation.
In addition, transportation personnel must be professionally trained and familiar with the characteristics and emergency treatment methods of 4 - Fluorobenzene - 1 - Thiol. In case of emergencies such as leaks on the way, effective measures can be taken quickly to reduce hazards. And transportation routes should be properly planned to avoid densely populated areas and environmentally sensitive areas to reduce latent risks. In this way, 4 - Fluorobenzene - 1 - Thiol must be safely stored and transported.
