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What is the chemistry of 4-Fluorobenzene-1-Sulfonyl Chloride?
4-Fluorobenzene-1-sulfonyl chloride is an organic compound with specific properties in the field of chemistry. Looking at its structure, the fluorine atom is connected to the benzene ring, and the sulfonyl chloride group is also connected to the benzene ring.
This compound has active chemical activity. Sulfonyl chloride (-SO ² Cl) is very active and easily participates in many chemical reactions. First, it can undergo nucleophilic substitution with nucleophiles. When water is used as a nucleophilic reagent, the chlorine atom in the sulfonyl chloride group can be replaced by a hydroxyl group to form 4-fluorobenzene sulfonic acid. This reaction is a hydrolysis reaction. The chemical equation is as follows: 4-fluorobenzene-1-sulfonyl chloride + H2O O → 4-fluorobenzene sulfonate + HCl.
Furthermore, alcohol nucleophiles can also react with 4-fluorobenzene-1-sulfonyl chloride to form sulfonate compounds. Taking ethanol as an example, during the reaction, the hydroxyl oxygen atoms in ethanol attack the sulfur atoms of the sulfonyl chloride group, and the chlorine atoms leave to obtain the corresponding sulfonate. This reaction is often used in organic synthesis to construct sulfonate structures.
Amine compounds can also react with 4-fluorobenzene-1-sulfonyl chloride to form sulfonamides. Nitrogen atoms in amines nucleophilically attack sulfonyl chloride sulfur atoms, and chlorine atoms leave to obtain sulfonamides. Sulfonamides are widely used in pharmaceutical chemistry and materials science.
In addition, the benzene ring in 4-fluorobenzene-1-sulfonyl chloride has different electron cloud density distributions due to the presence of fluorine atoms, and the electrophilic substitution reaction activity on the benzene ring is also affected. The fluorine atom has an electron-sucking induction effect, which reduces the electron cloud density of the benzene ring. However, because the lone pair electron can be conjugated with the benzene ring and has a certain role in the positioning of the electrophilic substitution reaction, there are relatively more ortho and para-substitution products.
4-fluorobenzene-1-sulfonyl chloride is an important intermediate in the field of organic synthesis. With its active sulfonyl chloride group and benzene ring properties, it can construct a variety of organic compounds with specific functions and structures, and is widely used in many industries such as medicine, pesticides, and materials.
What are the main applications of 4-Fluorobenzene-1-Sulfonyl Chloride?
4-Fluorobenzene-1-sulfonyl chloride, an important organic synthesis reagent, is widely used in many fields.
In the field of medicinal chemistry, its application is quite critical. The synthesis of many drugs often relies on this compound. For example, in the development of new antibacterial drugs, 4-fluorobenzene-1-sulfonyl chloride can be used as a key intermediate. Through its reaction with specific nitrogen-containing heterocyclic compounds, sulfonamide derivatives with unique structures can be constructed. Such derivatives often have good antibacterial activity and can effectively inhibit the growth and reproduction of bacteria, providing a powerful drug choice for the treatment of bacterial infectious diseases.
In the field of materials science, 4-fluorobenzene-1-sulfonyl chloride also plays an important role. During the preparation of high-performance polymer materials, it can be introduced into the main or side chains of the polymer. In this way, the resulting polymer materials can have special properties, such as enhanced thermal stability, chemical stability, and unique electrical properties. For example, when preparing insulating materials for microelectronic devices, polymers derived from 4-fluorobenzene-1-sulfonyl chloride can meet the strict material requirements of devices with their excellent dielectric properties and chemical stability.
In the field of pesticide chemistry, 4-fluorobenzene-1-sulfonyl chloride is also an important raw material. It can be used to synthesize pesticides with high insecticidal and herbicidal activities. By rationally designing the reaction path, it can be combined with various active groups to generate new pesticide compounds. Such compounds can precisely act on specific physiological targets of pests or weeds, so as to achieve high-efficiency and low-toxicity pesticide effects, which is of great significance for pest control and weed control in agricultural production. In conclusion, 4-fluorobenzene-1-sulfonyl chloride plays an indispensable role in many important fields such as medicine, materials, and pesticides due to its unique chemical properties, which greatly promotes technological progress and product innovation in various fields.
What are the preparation methods of 4-Fluorobenzene-1-Sulfonyl Chloride?
4-Fluorobenzene-1-sulfonyl chloride, there are many ways to make it. One common method is to use 4-fluorobenzene sulfonic acid as the starting material and heat it with sulfoxide chloride. The two are mixed, heated to a specific temperature in a suitable container, and the chlorine atom of the sulfonic acid group replaces the hydroxyl group of the sulfonic acid group, escapes sulfur dioxide and hydrogen chloride gas, and finally obtains 4-fluorobenzene-1-sulfonyl chloride. It should be done in a well-ventilated place, because it escapes harmful gas.
Another method starts with 4-fluoroaniline. First, it is made into a diazonium salt, and the sulfonic acid group is introduced through the Sandmeier reaction, and then chlorinated. 4-Fluorobenzenesulfonic acid derivatives are obtained by the reaction of 4-fluoroaniline with sodium nitrite and hydrochloric acid at low temperature, and then with sodium bisulfite, etc., and then react with chlorination reagents such as phosphorus pentachloride. After chlorination, the target product can be obtained.
There are also those who use 4-fluorotoluene as raw material. First, methyl is oxidized to a sulfonic acid group with an appropriate oxidizing agent, and 4-fluorobenzene-1-sulfonyl chloride is obtained by using potassium permanganate as the starting material.
All methods to prepare 4-fluorobenzene-1-sulfonyl chloride have their own advantages and disadvantages. With 4-fluorobenzene sulfonic acid as the starting material, the steps are simple; with 4-fluorobenzene as the starting material, although the steps are complicated, the raw materials are easy to obtain. Starting with 4-fluorotoluene, the raw materials are also common, and the oxidation step needs to be controlled. In actual preparation, the method is selected according to the availability of raw materials, cost, yield and many other factors.
What to pay attention to when storing and transporting 4-Fluorobenzene-1-Sulfonyl Chloride
4-Fluorobenzene-1-sulfonyl chloride, which is a chemical substance, should be stored and transported with caution.
First word storage. Because of its active nature, it is easy to react in contact with water, so it must be stored in a dry place. The humidity of the warehouse should be strictly controlled at a low level to prevent moisture intrusion. And the material is corrosive and should be separated from alkalis, alcohols and other substances that are easy to react with. Do not mix, otherwise it may react violently and cause danger. Storage temperature should also be paid attention to, and it should be stored in a cool place, generally not exceeding 30 ° C. Excessive temperature may affect the stability of the substance and even cause adverse consequences such as decomposition.
As for transportation, packaging is extremely critical. Appropriate packaging materials must be used to ensure good sealing and effectively prevent leakage. Warning labels should be clearly marked on the outside of the package, such as "corrosive items" and "wet danger", so that the transporter can see at a glance and treat it with caution. During transportation, try to avoid vibration and impact to prevent package damage. And the transportation vehicle should also be kept dry and ventilated, and should not be transported with contraindicated items.
All storage and transportation of 4-fluorobenzene-1-sulfonyl chloride must strictly follow the relevant safety procedures and operating guidelines to ensure the safety of personnel and the environment is not endangered, and there must be no slack.
What is the market price range for 4-Fluorobenzene-1-Sulfonyl Chloride?
4-Fluorobenzene-1-sulfonyl chloride, an important organic synthesis intermediate in the field of fine chemicals, is widely used in medicine, pesticides, dyes and many other industries. However, its market price range is difficult to generalize, because many factors have a significant impact on its price.
First, the fluctuation of raw material prices has a great impact on the price of 4-fluorobenzene-1-sulfonyl chloride. The synthesis of this compound often requires specific fluoride, sulfonating agent and other raw materials. If the price of these raw materials fluctuates due to production, market supply and demand, etc., the cost of 4-fluorobenzene-1-sulfonyl chloride will be affected, which will lead to price changes.
Second, the market supply and demand relationship is the key factor. If downstream industries such as pharmaceuticals and pesticides have strong demand for them but limited supply, according to market laws, their prices will rise; on the contrary, if market demand is low and supply is excessive, prices may decline.
Third, the production process and technical level also affect prices. Advanced and efficient production processes can improve production efficiency and reduce production costs, so they have more advantages in market pricing; if the production process is backward and the cost remains high, the price will be relatively high.
Fourth, the price of 4-fluorobenzene-1-sulfonyl chloride will also vary in different regions due to differences in economic development level, transportation costs, policies and regulations. Generally speaking, in economically developed areas, due to high labor costs and operating costs, the price may be relatively high; while near the origin of raw materials, due to factors such as low transportation costs, the price may be relatively low.
Considering many factors, the current market price of 4-fluorobenzene-1-sulfonyl chloride ranges from a few hundred to several thousand yuan per kilogram. However, this is only a rough range, and the actual price needs to be determined according to factors such as the specific transaction time, transaction quantity, product purity and supplier. If the buyer wants to know the exact price, he should discuss with the relevant suppliers in detail to obtain an accurate quotation.
