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What is the chemical structure of 4-Fluoro-N- [4- (Morpholin-4-Yl) Phenyl] Benzenesulfonamide?
4 - Fluoro - N - [4 - (Morpholin - 4 - Yl) Phenyl] Benzenesulfonamide, which is the name of an organic compound. To clarify its chemical structure, the information contained in its name should be analyzed in detail.
"4 - Fluoro", it is said that there is a fluorine atom substituted at the 4 positions above the benzene ring. The fluorine atom, one of the halogen elements, has unique chemical properties and can affect the polarity, stability and biological activity of molecules.
"Benzenesulfonamide" shows that its core structure is benzenesulfonamide. Benzenesulfonamide structure, the benzene ring is connected to the sulfonamide group (-SO _ 2 NH _ 2). The benzene ring is a conjugated system with certain stability and electron delocalization characteristics. In the sulfonamide group, the sulfur atom is connected to two oxygen atoms and nitrogen atoms, and the nitrogen atom can form bonds with other groups, giving the molecule diverse reactivity.
"N - [4- (Morpholin - 4 - Yl) Phenyl]" indicates that the nitrogen atom is connected to a specific phenyl group. The fourth position of this phenyl group is connected with a morpholino (Morpholin - 4 - Yl). Morpholinyl is a five-membered heterocycle containing nitrogen and oxygen, which has certain alkalinity and nucleophilicity, and has a great impact on the physical and chemical properties and biological activities of the molecule as a whole.
In summary, the chemical structure of this compound is based on benzenesulfonamide. There is a fluorine atom at the 4th position of the benzene ring, and the nitrogen atom of the sulfonamide is connected to a 4-morpholinyl phenyl group. The interaction of various parts in its structure makes the molecule exhibit unique chemical, physical and biological properties, and may have important uses in organic synthesis, medicinal chemistry and other fields.
What are the main uses of 4-Fluoro-N- [4- (Morpholin-4-Yl) Phenyl] Benzenesulfonamide?
4 - Fluoro - N - [4 - (Morpholin - 4 - Yl) Phenyl] Benzenesulfonamide, the Chinese name is often 4 - fluoro - N - [4 - (morpholine - 4 - yl) phenyl] benzenesulfonamide. This compound has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry to create a variety of specific drugs.
Guanfu's way of pharmaceutical research and development, which can participate in the construction of novel chemical structures and help to develop molecules with specific biological activities. It can be seen in the synthesis of many antihypertensive, antitumor and antiviral drugs. Due to the fluorine atom, benzene ring and morpholine group in its structure, the compound is endowed with unique physicochemical and bioactive properties, which can optimize the binding ability of drugs to targets and improve drug efficacy and selectivity.
In the field of materials science, it also has extraordinary functions. Because of its benzenesulfonamide structure, it can interact with the surface of specific materials or act as a surfactant to improve the surface properties of materials, such as wettability and adhesion. When preparing high-performance coatings, plastics and fiber materials, adding this substance can improve the surface properties of materials, enhance their weather resistance, wear resistance and anti-pollution ability.
In addition, in the field of organic synthetic chemistry, as an important synthetic block, it can undergo various chemical reactions to derive organic compounds with complex structures and unique functions. Through nucleophilic substitution, coupling reactions, etc., it is cleverly connected with other organic molecules to expand the library of organic molecules, providing rich materials and possibilities for organic synthesis chemists to explore new reaction paths and compound structures.
What are the physical properties of 4-Fluoro-N- [4- (Morpholin-4-Yl) Phenyl] Benzenesulfonamide?
4 - Fluoro - N - [4 - (Morpholin - 4 - Yl) Phenyl] Benzenesulfonamide, this is an organic compound. Its physical properties are unique, and it is essential for its in-depth understanding in many fields such as chemical industry and pharmaceutical research and development.
This compound is mostly in the state of white to quasi-white crystalline powder under normal conditions, which is easy to store and transport, and can exist stably in most reaction systems. Looking at its color, pure white implies its high purity and few impurities. In chemical reactions, high-purity substances can greatly reduce the occurrence of side reactions and ensure accurate and efficient reactions.
When it comes to melting point, it is between 180 and 185 ° C. Melting point is one of the key physical properties of substances, which is of great significance for the identification and purification of this compound. In the R & D and production process, melting point measurement can help determine the purity of the product. If the actual melting point deviates greatly from the theoretical value, it indicates that the product may contain impurities and needs to be further purified.
Its solubility also has characteristics. It is slightly soluble in water, but soluble in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). This difference in solubility is based on its molecular structure characteristics. There are both lipophilic and hydrophilic groups in the molecule, but the lipophilic part is dominant, resulting in good solubility in organic solvents. In organic synthesis and drug development, the selection of suitable solvents is crucial. The good solubility of this compound in dichloromethane and DMF provides convenience for the optimization of reaction conditions, product separation and purification.
In addition, this compound has certain stability and can be stored for a long time without significant decomposition under conventional conditions. However, in case of strong acid, strong base or high temperature environment, the structure may change. When storing and using, pay attention to environmental factors to prevent its deterioration.
The physical properties of 4 - Fluoro - N - [4 - (Morpholin - 4 - Yl) Phenyl] Benzenesulfonamide are of great significance in the fields of chemical industry and medicine. Deep understanding and rational application of these properties can promote technological development and innovation in related fields.
What are the synthesis methods of 4-Fluoro-N- [4- (Morpholin-4-Yl) Phenyl] Benzenesulfonamide?
The synthesis method of 4-fluoro-N- [4- (morpholine-4-yl) phenyl] benzenesulfonamide is not directly described in ancient books, but it can follow the principles of chemical industry and the wisdom of predecessors to promote its possible method.
First, 4-fluorobenzenesulfonyl chloride can be taken as the starting material. This compound has good activity and is easy to react with nucleophiles. Meet it with 4-aminophenylmorpholine in a suitable solvent, such as dichloromethane or N, N-dimethylformamide, and then add an appropriate amount of acid binding agent, such as triethylamine. The acid binding agent can capture the acid generated by the reaction and move the reaction equilibrium towards the product. In this environment, the two interact like dancers, and through the step of nucleophilic substitution, the chlorine atom of 4-fluorobenzenesulfonyl chloride is replaced by the amino group of 4-aminophenylmorpholine, and the target product is obtained.
Second, start with 4-fluorobenzenesulfonic acid, and first convert it into a more active derivative, such as by co-heating with thionyl chloride, the sulfonic acid can be converted into sulfonyl chloride. Then, as in the previous method, the 4-fluorobenzenesulfonyl chloride is reacted with 4-aminophenyl morpholine in the presence of a suitable solvent and acid binding agent, and 4-fluoro-N - [4 - (morpholine-4-yl) phenyl] benzenesulfonamide can also be synthesized.
Furthermore, if 4 - (morpholine-4-yl) aniline is used as the starting material, it can be reacted with 4-fluorobenzenesulfonyl isocyanate. The isocyanate group is highly reactive and can react rapidly when it meets the amine group. After the process of addition and rearrangement, the structure of the target molecule is ingeniously constructed to obtain 4-fluoro-N- [4- (morpholine-4-yl) phenyl] benzenesulfonamide.
Although this synthesis method is not stated in ancient books, it can also be synthesized according to the general principles of chemical synthesis, referring to the preparation of similar compounds. When operating, it is necessary to pay attention to the precise control of reaction conditions, such as temperature, reactant ratio, reaction time, etc., in order to make the synthesis smooth and obtain a pure product.
What are the precautions for using 4-Fluoro-N- [4- (Morpholin-4-Yl) Phenyl] Benzenesulfonamide?
4 - Fluoro - N - [4 - (Morpholin - 4 - Yl) Phenyl] Benzenesulfonamide is a chemical substance. When using, there are many things to pay attention to.
First, safety is paramount. This substance may be toxic and may be dangerous to health if it touches the skin, inhaled or taken by mistake. Therefore, when using, be sure to wear appropriate protective equipment, such as gloves, goggles and protective clothing, to prevent direct contact with the body. Operate in a well-ventilated place to avoid inhaling its dust or volatile aerosols. If conditions permit, it is advisable to carry out relevant operations in a fume hood.
Second time, use it accurately. Due to its special nature, the dosage needs to be precisely controlled. Before taking it, carefully read the relevant literature and instructions, and measure it with an accurate measuring tool according to the specific requirements of the experiment or production. Do not increase or decrease the dosage at will, so as not to affect the experimental results or product quality.
Furthermore, store it properly. It should be placed in a dry, cool and ventilated place, away from fire sources, heat sources and oxidants. Due to its chemical properties or changes due to environmental factors, improper storage or deterioration will affect its performance. Different batches of the substance may have slightly different properties. Before use, it needs to be tested in detail to understand its characteristics and adjust the use method and conditions accordingly.
Repeat, waste treatment cannot be ignored. Waste generated during use must not be discarded at will. When in accordance with relevant environmental regulations and laboratory regulations, it should be collected and properly handled to prevent pollution to the environment.
In short, when using 4 - Fluoro - N - [4 - (Morpholin - 4 - Yl) Phenyl] Benzenesulfonamide, attention must be paid to safety protection, accurate access, proper storage and reasonable waste disposal to ensure smooth and safe operation.