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4-Fluoro(Chloromethyl)Benzene

4-Fluoro(Chloromethyl)Benzene

Hongda Chemical

Specifications

HS Code

390236

Chemical Formula C7H6ClF
Molar Mass 146.574 g/mol
Appearance Colorless liquid
Boiling Point 173 - 174 °C
Density 1.194 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents
Flash Point 61 °C
Odor Characteristic aromatic odor

As an accredited 4-Fluoro(Chloromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 4 - fluoro(chloromethyl)benzene packaged in a sealed, chemical - resistant bottle.
Storage 4 - fluoro(chloromethyl)benzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, acids, and bases. Given its potential toxicity and flammability, proper safety measures like signage and restricted access are essential to ensure storage safety.
Shipping 4 - fluoro(chloromethyl)benzene is shipped in specialized containers, compliant with chemical transport regulations. Shipment requires proper labeling, temperature - controlled if needed, and handling by trained personnel to ensure safety during transit.
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4-Fluoro(Chloromethyl)Benzene 4-Fluoro(Chloromethyl)Benzene
General Information
Historical Development
4 - Fluoro (Chloromethyl) Benzene is an important raw material for organic synthesis. Its historical development has led to the continuous research of early chemists in the field of organic synthesis. At that time, the preparation of various halogenated aromatics was explored. After years of trial and error, chemists paid attention to the special structural compounds containing fluorine and chloromethyl.
The initial synthesis method was simple and the yield was low. Later, with the refinement of chemical theory, new catalytic systems emerged. Based on the metal-catalyzed halogenation reaction, the reaction conditions were optimized to gradually improve the synthesis efficiency of 4 - Fluoro (Chloromethyl) Benzene. Over the years, its preparation technology has become increasingly mature, paving the way for broad applications in many fields such as organic synthesis and materials science, and occupying an indispensable position in the development of chemistry.
Product Overview
4 - Fluoro (Chloromethyl) Benzene is also an organic compound. Its color is pure and light, and it is liquid. It is quite useful in the field of organic synthesis.
Looking at its structure, above the benzene ring, fluorine atoms are attached to chloromethyl groups. The activity of fluorine atoms makes this compound have specific chemical activity. Chloromethyl can be used as a check point for the reaction, introducing various functional groups into the molecule to form a variety of organic products.
In industrial preparation, it is often obtained by a specific reaction path. The process is fine, and temperature control, pressure control, and appropriate catalysts are required to increase its yield and maintain its purity.
Due to its activity and structural characteristics, 4-Fluoro (Chloromethyl) Benzene is an important raw material for the creation of pharmaceuticals, pesticides, and materials science, which can initiate the synthesis of many new compounds and lead to scientific and technological progress.
Physical & Chemical Properties
The chemical properties of 4-fluoro (chloromethyl) benzene are related to the chemical research of our generation. Looking at its shape, under room temperature, or as a colorless liquid, it is clear and has a special taste, and its fluidity is good.
In terms of its degree of melting and boiling, the melting point is quite low, so it is liquid at room temperature; the boiling point varies according to the external air pressure, roughly between a specific temperature. Its density is lighter than that of water, floating on water, and the two are insoluble.
As for solubility, it is well miscible in organic solvents such as ethanol and ether, but difficult to dissolve in water. This is due to the molecular structure, the characteristics of phenyl ring and fluorine and chlorine atoms make it an organic solvent and hydrophobic. Its chemical activity is active due to the presence of fluorine and chlorine atoms, and can involve a variety of reactions, such as nucleophilic substitution, which is a material for organic synthesis. It plays an important role in the field of chemical and pharmaceutical research and development.
Technical Specifications & Labeling
Today there is a product called 4 - Fluoro (Chloromethyl) Benzene. Its process specifications and identification (product parameters) are related to the quality and application of this product, which cannot be ignored.
To make this product, you should first clarify the essence of its raw materials, the accuracy of the ratio, and the order of operation. All steps need to follow strict regulations, and a slight difference will affect the finished product. And the temperature, time, pressure, etc. of the reaction are all key and need to be regulated in detail.
As for the label, when the characteristic parameters of this product are included, such as molecular weight, purity geometry, and physical properties, it is clear to the user at a glance to meet different needs. In this way, it can ensure that 4-Fluoro (Chloromethyl) Benzene does its best in various applications without losing its effectiveness.
Preparation Method
The preparation method of 4-fluoro (chloromethyl) benzene is related to the raw materials and production process, reaction steps and catalytic mechanism. The selection of raw materials is very critical, and fluorobenzene and chloromethylation reagents are the main ones. In the production process, suitable reaction conditions must be selected. The first step is to put fluorobenzene into the reactor, add an appropriate amount of catalyst, and heat up to a specific temperature. The chloromethylation reagent is added dropwise at a specific rate. This process requires strict control of the reaction temperature and dropwise speed to ensure the steady progress of the reaction. The reaction steps also need to be carefully operated, the reaction process should be closely monitored, and the degree of reaction should be controlled by means of detection methods, such as gas chromatography. As for the catalytic mechanism, the catalyst used can effectively reduce the activation energy of the reaction, In this way, 4-fluoro (chloromethyl) benzene can be prepared in an ideal manner.
Chemical Reactions & Modifications
4 - Fluoro (Chloromethyl) Benzene is an important compound in organic synthesis. In the field of chemical research, the exploration of its chemical reaction and modification is related to the expansion of many synthesis paths.
Looking at past studies, we observe its reaction mechanism. The substitution reaction of halogenated hydrocarbons allows this compound to participate in the formation of new carbon-carbon bonds, which is of great significance in the synthesis of complex organic molecules. However, the reaction conditions are quite critical, such as temperature and the choice of solvent, which can affect the efficiency of the reaction and the purity of the product.
As for the modification, the electron cloud distribution can be changed by introducing different functional groups to achieve the purpose of modification. This move can optimize its physicochemical properties, such as solubility and stability. The chemical reaction and modification of this compound is similar to the art of alchemy. Only by studying its method can the substance play a greater role, adding to the hall of organic synthesis and paving the way for subsequent research.
Synonyms & Product Names
4 - Fluoro (Chloromethyl) Benzene is also a chemical substance. Among various chemicals, it has many synonymous names and commodity names.
This substance is a synonymous name, or named after the characteristics of its chemical structure. From its structural analysis, fluoro (fluoro) and chloromethyl (chloromethyl) are above the benzene ring, so there are also people who call it according to this structural characteristic.
As for the trade name, the merchant enters the market for it, or takes the name of easy to remember and highlight the characteristics. However, whether it is a synonymous name or a commodity name, it is convenient to recognize and use it. In the field of chemistry, it is necessary to understand its various names, so that you can enjoy all things in research and production. Although the names are different, they actually refer to the same thing, just as the ancients said: "Those who are famous are not the same and different, and they know right from wrong." The same is true of the synonymous name and trade name of 4-Fluoro (Chloromethyl) Benzene.
Safety & Operational Standards
4-Fluoro (chloromethyl) benzene is a common chemical in chemical research. In its experiment and production process, safety and operating standards are of paramount importance, which is related to the safety of the researcher and the success or failure of the experiment.
All operations involving 4-fluoro (chloromethyl) benzene must be carried out in a well-ventilated environment. This is because the substance may evaporate harmful gases. If the ventilation is poor, the gas will accumulate, which will easily cause the researcher to inhale and damage health. And the operating site should strictly prohibit fireworks, because it is flammable to a certain extent. In case of open flames or hot topics, it may cause fires or even explosions.
When operating, the researcher must wear professional protective equipment. Protective clothing should be able to resist the erosion of the chemical and prevent it from contacting the skin. At the same time, protective gloves should be worn to ensure the safety of the hands. Eye protection is also indispensable, and goggles can effectively block the liquid that may splash and avoid eye damage.
When taking 4-fluoro (chloromethyl) benzene, the specified operating procedures should be strictly followed. The measurement process should be accurate to avoid errors in measurement affecting the experimental results or causing chemical waste. When transferring this substance, the action should be cautious to prevent it from spilling. If it is accidentally spilled, it should be cleaned up immediately in accordance with emergency handling regulations to prevent it from spreading and causing pollution to the environment.
Storage of 4-fluoro (chloromethyl) benzene also needs to follow specific guidelines. It should be stored in a cool, dry place, away from heat sources and oxidants. Due to its active chemical properties, it is prone to chemical reactions in contact with oxidants or in a high temperature environment, resulting in danger. And the storage container must be well sealed to prevent leakage.
In short, in the research and use of 4-fluoro (chloromethyl) benzene, strict safety and operating standards must be adhered to at all times to ensure the smooth development of research work and ensure the safety of personnel and the environment.
Application Area
Today, there is a product named 4 - Fluoro (Chloromethyl) Benzene, which is quite useful in various application fields. In the field of medicine, it can be used as a key intermediate to help medicine research and development, and become a good medicine for treating diseases and saving people. In material research and development, it can change the characteristics of materials, increase durability and stability, and make materials more widely used. And in organic synthesis, it is also an important raw material. After ingenious synthesis, a variety of organic products are produced. This substance has an invaluable effect in various application fields, contributing to scientific research and industrial development, helping to make extraordinary progress, and promoting the continuous development of various fields.
Research & Development
In recent years, Yu dedicated himself to the research of 4 - Fluoro (Chloromethyl) Benzene. This material has unique properties and wide uses, and has potential in various fields.
At the beginning, I studied its physicochemical properties in detail, analyzed its molecular structure, and sought to clarify its essence. Then I studied the method of making art, tried various paths, and wanted to obtain efficient techniques. Although the process is difficult and there are many obstacles, I have not given up.
After months of study, I have made some progress in making art, the yield has gradually increased, and the quality has also become better. However, I know that in order to achieve wide application, it still needs to be refined. It is hoped that in the future, it can break through the remaining barriers, expand its uses, and make it shine in the fields of industry, medicine, etc., contributing to the research and development, so as to feed the academic community and various industries.
Toxicity Research
Taste chemical things, the study of its properties is related to people's livelihood and safety. Today there is 4 - Fluoro (Chloromethyl) Benzene, and our generation should carefully observe its toxicity.
Looking at this substance, its structure is unique, fluorine and chloromethyl are combined with benzene ring. Fuhalogenated aromatic hydrocarbons, many are toxic, or damage the human organs, or disturb the physiological order. 4 - Fluoro (Chloromethyl) Benzene may be no exception. It enters the human body, or interacts with the molecules of the cell, causing a perverse biochemical reaction.
However, the study of toxicity is not achieved overnight. Rigorous experiments are required, using animals as models to observe its intake, absorption, distribution and metabolism. It is also necessary to consider its residue, migration and transformation in the environment to prevent it from escaping from heaven and earth and causing disasters. Only by studying its toxicity can we make good use of this substance, avoid harm and profit, protect the safety of people's livelihood, and protect the peace of nature.
Future Prospects
Today there is a thing called 4 - Fluoro (Chloromethyl) Benzene. In my chemical research, this substance is crucial. Its future prospects are really what we care about.
This thing has unique characteristics, has a field of application, and has endless potential. On the road of organic synthesis, it may be a new path, leading to the wonders of the unknown. On top of industrial preparation, if the process is advanced, the cost can be reduced and the yield can be increased, it will be widely distributed in the world and benefit all people.
Furthermore, in scientific research and exploration, it is like a key, opening the door to new theories and discoveries. Or help us to penetrate the secrets of the microscopic and understand the true meaning of chemical changes. With time, advanced technology, and seamless collaboration, 4-Fluoro (Chloromethyl) Benzene will surely bloom, shining with unique brilliance in the scientific firmament of the future, contributing to the progress of mankind and creating a new chapter.
Where to Buy 4-Fluoro(Chloromethyl)Benzene in China?
As a trusted 4-Fluoro(Chloromethyl)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 4-Fluoro(Chloromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-fluoro (chloromethyl) benzene?
4-Hydroxy (methoxy) benzaldehyde, although it did not have this exact chemical name in the era covered by "Tiangong Kaiwu", it also had many important uses at that time in terms of similar substances.
In the dyeing and weaving industry, it can be used as a dye aid. At that time, dyers wanted a bright and long-lasting color, and often looked for natural or synthetic additives to assist. 4-Hydroxy (methoxy) benzaldehyde has a certain chemical activity, or can be combined with fabric fibers to enhance dye adsorption and fixation, making dyeing more uniform and firm, helping craftsmen dye a brilliant color like Suhang satin.
In the field of fragrance production, this substance is of great significance. The ancients pursued a high degree of aroma, and its unique smell can add a unique flavor to the fragrance.
Furthermore, in terms of medicine, traditional medicine attaches great importance to the medicinal use of natural substances. 4-Hydroxy (methoxy) benzaldehyde may have certain pharmacological activity. After traditional processing and compatibility, it can regulate human qi and blood and relieve discomfort. For example, in ancient Langzhong or in the exploration, it was found that drugs containing such ingredients were effective for some diseases. Although there was no modern precise pharmacological cognition, they played their medicinal value by accumulating experience.
In addition, in the preservative process of some traditional handmade products, it may play a role. For example, the production of high-grade paper, calligraphy and painting mounting, etc., in order to prevent moths and preservatives, the use of preparations containing this ingredient can prolong the storage time of products, so that precious calligraphy, painting and ancient books can be passed down for a long time.
What are the physical properties of 4-fluoro (chloromethyl) benzene?
4-Cyanogen (cyanomethyl) quinoline, this physical property is strange and worth exploring.
Its color state is often white or yellowish powder, the texture is delicate, and it looks shiny, like a fine pearl. Under normal temperature and pressure, it exists stably, like a lying stone, and does not change easily.
When it comes to the melting point, the melting point is about a specific range. When the temperature rises to this point, it is like ice melting in spring, gradually turning from solid to liquid. The boiling point also has its own number, and when it reaches this high temperature, it will turn into gas and rise.
In terms of solubility, in some organic solvents, such as alcohols and ethers, it can quietly disperse, just like salt melts in water and fuses with the solvent, but in water, it is difficult to find its trace, just like oil falls in water and floats alone.
Furthermore, its density is different from common substances. When held in the hand, it feels light or heavy, depending on its purity and the environment.
In terms of stability, under normal circumstances, it can maintain its original state and does not easily combine with surrounding substances. In case of strong acids and alkalis, or extreme conditions of high temperature and high pressure, it will react instantaneously when it encounters dry wood from a hot fire, generating something different, and its properties will completely change.
As for toxicity, it must not be underestimated. If you accidentally touch or inhale its dust, it may be harmful to human health, like a hidden arrow, quietly hurting people. Therefore, when using it, you must be cautious and strictly follow the procedures to prevent accidents.
Is 4-fluoro (chloromethyl) benzene chemically stable?
The chemical properties of 4-% hydrazine (cyanomethyl) ether are quite stable. In its structure, nitrogen atoms are connected to carbon atoms to form a relatively stable structure.
Looking at its chemical properties, this substance is not prone to violent reactions in many common chemical environments. Under normal temperature and pressure, it can maintain its own structure intact for a long time without obvious decomposition or deterioration.
In organic solvents, 4-% hydrazine (cyanomethyl) ether exhibits a certain solubility, but its solubility is also restricted by solvent properties. In polar organic solvents, such as alcohols and ketones, it can be moderately dissolved; in non-polar solvents, the solubility is relatively limited.
When it comes to reactivity, although its structure is relatively stable, it can still participate in some chemical reactions under certain conditions. For example, in the presence of a catalyst, suitable temperature and pressure environment, it can react with some nucleophiles, and the cyanomethyl part or the hydrogen atom on the nitrogen atom can be replaced to form new compounds. However, such reactions require precise control of the reaction conditions in order to proceed smoothly, which shows that it has certain chemical stability.
In addition, 4-% hydrazine (cyanomethyl) ether also has a certain tolerance to acid-base environments. In weakly acidic or weakly alkaline media, the chemical properties do not change significantly for a short time. Only under the action of strong acid and alkali for a long time, its structure may be damaged and hydrolysis and other reactions occur, but this also indicates that the chemical properties of the substance are stable under common acid and alkali conditions.
What are the preparation methods of 4-fluoro (chloromethyl) benzene?
To prepare tetrahydroxy (hydroxymethyl) furfural, the methods are as follows:
First, choose the appropriate raw materials. Usually start with carbohydrate-rich substances, such as sugars, monosaccharides such as glucose and fructose, and polysaccharides such as sucrose and starch. Because sugars can be converted into this substance through a series of reactions. If fructose is used, its structure makes the conversion easier and can improve the yield.
Second, choose a suitable catalyst. Acid catalysts are quite commonly used, such as inorganic acids (sulfuric acid, hydrochloric acid, etc.), which can promote the reaction, reduce the activation energy of the reaction, and increase the reaction rate. However, it has strong corrosion to equipment. There are also solid acid catalysts, such as sulfonic acid ion exchange resins, which are easy to separate and reusable, and can reduce damage to equipment. In addition, metal salt catalysts can also be used, such as chromium salts, zinc salts, etc., which can efficiently catalyze this reaction under specific conditions.
Third, control the appropriate reaction conditions. The temperature is very critical, generally between 100 and 200 ° C. Low temperature, slow reaction, low yield; high temperature, increased side reactions, and reduced product selectivity. The reaction time also needs to be accurately controlled, depending on the raw materials and catalysts, usually hours to ten hours. In addition, the choice of reaction solvents is also heavy. Polar organic solvents, such as dimethyl sulfoxide, N, N-dimethylformamide, etc., are used as soluble raw materials and catalysts to facilitate mass and heat transfer in the reaction.
Fourth, adopt a suitable separation and purification method. After the reaction, the product contains impurities and needs to be separated and purified. Distillation can be used first to steam out some low-boiling impurities according to the difference in boiling point of each component. After that, an extraction method is used to select a suitable extractant to improve the purity of the target product. Column chromatography can also be used to separate the product from impurities by means of a fixed phase and a mobile phase to obtain high-purity tetrahydroxy (hydroxymethyl) furfural.
What are the precautions for the storage and transportation of 4-fluoro (chloromethyl) benzene?
In the storage and transportation of 4-hydroxymethyl furfural, the following matters should be paid attention to:
First, temperature control is essential. This substance is quite sensitive to temperature, and high temperature is easy to cause it to decompose or deteriorate. Therefore, when storing, it should be placed in a cool place, and the warehouse temperature should be strictly controlled below 25 ° C. During transportation, it is also necessary to avoid direct sunlight and close to heat sources. If it is transported during the high temperature season in summer, refrigerated transportation tools should be used to maintain its stability.
Second, moisture resistance should not be ignored. 4-hydroxymethyl furfural has certain hygroscopicity, and the quality is easily affected after being damp. The storage environment must be kept dry, and the humidity should be controlled below 60%. The packaging should be tight, often sealed barrels or sealed bags to prevent the intrusion of external water vapor. During transportation, the carriage should also be kept dry, and a desiccant can be placed if necessary.
Third, anti-oxidation needs to be treated with caution. The substance is easily oxidized in the air, thereby changing its chemical properties. When storing, it can be filled with inert gases such as nitrogen to isolate the air and inhibit the oxidation process. The transportation package should also minimize contact with air, and the transportation time should not be too long, and it should be delivered to the destination as soon as possible.
Fourth, avoid contact with incompatible substances. 4-Hydroxy (hydroxymethyl) furfural cannot be stored or transported together with strong oxidants, strong alkalis and other substances. Because of its encounter with strong oxidizing agents, it is easy to cause violent chemical reactions, and even the risk of explosion; contact with strong alkalis will also cause chemical reactions, resulting in its failure. Before storage and transportation, be sure to clarify the chemical properties of other substances in contact with it to prevent danger.
Fifth, storage and transportation equipment should be dedicated. In order to prevent cross-contamination, storage and transportation of 4-hydroxymethyl (hydroxymethyl) furfural equipment should be dedicated, and it should be thoroughly cleaned and dried before and after use to avoid residual other substances affecting its quality.