4-Fluoro-Benzeneethanamine, Chinese name 4-fluorophenethylamine, is widely used. In the field of medicinal chemistry, it is an important intermediate in organic synthesis. In many drug development processes, specific molecular structures are built on this basis, which in turn imparts the desired biological activity and pharmacological properties of the drug. For example, in the preparation of some neurological drugs, 4-fluorophenethylamine is involved in key steps, helping to create active ingredients that interact with neurotransmitters or regulate neurotransmission processes to deal with neurological diseases.
In the field of materials science, 4-fluorophenethylamine is also useful. Materials with special properties can be prepared by reacting with other compounds through its special chemical structure. Such as the synthesis of some functional polymers, with its fluorine-containing group and amine group characteristics, the polymer has unique electrical, optical or mechanical properties, and plays a role in electronic devices and optical materials.
Furthermore, in the field of organic synthesis chemistry, 4-fluorophenethylamine, as a highly active amine compound, can participate in a variety of organic reactions. Such as condensation reactions with carboxylic acids and their derivatives to form amide bonds, or participate in nucleophilic substitution reactions, introducing phenethylamine structural fragments, thereby enriching the variety of organic compounds and laying the foundation for the synthesis of more complex organic molecules with specific functions. In short, 4-fluorophenethylamine plays a key role in many fields and is of great significance to promote the development of related fields.

4-Fluoro-Benzeneethanamine, that is, 4-fluorophenethylamine, is a genus of organic compounds. Its physical properties are quite worthy of detailed investigation.
Looking at its properties, under normal temperature and pressure, it is mostly colorless to light yellow oily liquid, which is similar to many organic amine compounds. And because of the action of specific atoms and groups in the molecular structure, it has such appearance characteristics.
When it comes to the melting point, due to the interaction between atoms and molecules in the structure, its melting point is relatively low, about - 20 ° C to - 10 ° C. This melting point range makes it difficult for the substance to solidify at room temperature and often exists in a liquid state.
In terms of boiling point, under normal pressure conditions, the boiling point is about between 210 ° C and 220 ° C. This boiling point indicates the degree of intermolecular forces, and a higher temperature is required to overcome the attractive forces between molecules, so that it can change from liquid to gaseous state.
As for solubility, 4-fluorophenethylamine can be partially soluble in water. Its molecular structure contains both the hydrophobic part of the benzene ring and the hydrophilic part of the amino group. Therefore, in water, the hydrophilic amino group is associated with the water molecule by the force of hydrogen bonds, but the hydrophobic benzene ring hinders its dissolution, causing it to be only partially soluble in water. However, in common organic solvents such as ethanol, ether, chloroform, etc., the substance exhibits good solubility. This is because the organic solvent is compatible with the intermolecular force of 4-fluorophenethylamine and can be miscible with each other.
4-fluorophenethylamine has a slightly higher density than water, about 1.10-1.15 g/cm ³. This density characteristic is due to its molecular composition and atomic weight distribution, which makes it settle at the bottom when coexisting with liquids such as water.
In addition, the substance has a certain volatility, which emits a special odor in the air, slightly ammonia and accompanied by aromatic hydrocarbons. This odor is caused by the stimulation of olfactory receptors after the evaporation of its molecules, and its volatility is also related to the intermolecular force and boiling point.

4-Fluoro-Benzeneethanamine, or 4-fluorophenethylamine, is a family of organic compounds. Its chemical properties are unique, with the characteristics of amines and aromatic hydrocarbons, and it has made great contributions to the fields of organic synthesis and medicinal chemistry.
In terms of alkalinity, 4-fluorophenethylamine contains amino groups and is basic. Nitrogen atoms in amino groups have lone pairs of electrons, which can grab protons from acids or water to form positively charged ammonium ions. This alkalinity can react with acids in acidic media to form salts. In organic synthesis, it can be used to adjust the pH of reaction systems or as a base catalyst to promote specific reactions.
Nucleophilicity is also its significant property. The amino group is a nucleophilic group, and 4-fluorophenethylamine has strong nucleophilicity. In the nucleophilic substitution reaction, the lone pair electrons of the amino group can attack electron-deficient atoms, such as the carbon atoms of halogenated hydrocarbons. During the reaction, the halogen atoms leave, form new carbon-nitrogen bonds, and synthesize nitrogen-containing organic compounds, which are widely used in the construction of complex organic molecular structures.
In addition, its phenyl ring properties cannot be ignored. The phenyl ring is rich in electrons and prone to electrophilic substitution reactions. On the benzene ring of 4-fluorophenethylamine, although the fluorine atom has an electron-withdrawing induction effect, the conjugation effect is relatively weak. Overall, the electron cloud density of the benzene ring is still high, and the electrophilic reagents are prone to attack the benzene ring, and electrophilic substitution reactions such as nitrification, halogenation, and sulfonation occur. The products vary according to the reaction conditions and the type of electrophilic reagents.
At the same time, 4-fluorophenethylamine has a certain reduction activity. Some chemical bonds in the molecule can be reduced under specific reduction conditions. For example, if there are suitable reducing agents, the benzene ring may be partially hydrogenated and reduced, or the carbon-nitrogen bonds attached to the amino group may be broken and reduced under extreme conditions, but such reactions require precise control of the reaction conditions.
Furthermore, 4-fluorophenethylamine has certain solubility. Because it contains polar amino groups and non-polar benzene rings, it has unique solubility in organic solvents and water. Generally, it has good solubility in polar organic solvents such as ethanol and methanol, and its solubility in water is relatively limited, but its solubility may change with the change of pH of the solution. Under acidic conditions, it forms salt and increases its solubility in water.

The synthesis method of 4-fluorophenethylamine has been recorded in many books in the past, and the methods are different.
First, 4-fluorophenylacetic acid is used as the starting material. First, 4-fluorophenylacetic acid is co-heated with dichlorosulfoxide, which is the process of acylation, which can convert the carboxyl group into an acyl chloride to obtain 4-fluorophenylacetyl chloride. Then, 4-fluorophenylacetyl chloride is reacted with ammonia, and the nucleophilicity of ammonia can attack the carbonyl carbon of the acid chloride. After nucleophilic substitution, 4-fluorophenylacetamide is generated. Finally, using lithium aluminum hydride as a reducing agent, under suitable reaction conditions, the carbonyl group of 4-fluorophenylacetamide is reduced to methylene to obtain 4-fluoro-phenethylamine. This process needs to pay attention to the control of reaction conditions, such as temperature, reaction time, reagent dosage, etc., to ensure the smooth progress of the reaction and the purity of the product.
Second, start from 4-fluorobenzaldehyde. First, 4-fluorobenzaldehyde and nitromethane undergo condensation reaction under alkaline conditions to generate 4-fluoro - β - nitrostyrene. In this condensation reaction, the alkaline environment can promote the departure of α-hydrogen from nitromethane to form carbon negative ions, and then attack the carbonyl carbon of 4-fluorobenzaldehyde to complete the condensation. Subsequently, metal zinc powder and hydrochloric acid are used as the reduction system to reduce the nitro group of 4-fluoro - β - nitrophenylvinyl to an amino group, and the double bond is also reduced to obtain 4-fluoro-phenethylamine. In this method, the reduction step needs to pay attention to control the reaction rate to avoid excessive reduction or other side reactions.
Third, 4-fluorobromobenzene is used as the raw material. Schilling 4-fluorobromobenzene reacts with magnesium chips in anhydrous ether to form Grignard's reagent 4-fluorophenyl magnesium bromide. This Grignard reagent has high activity and can react with ethylene oxide to form corresponding alcohols after ring opening. Then, the alcohol is halogenated and treated with halogenating reagents such as phosphorus tribromide to convert hydroxyl groups into halogen atoms. Finally, through aminolysis, the halogen atom is replaced with ammonia to obtain 4-fluoro-phenethylamine. This synthesis route needs to be carried out under anhydrous and oxygen-free conditions to prevent the failure of Grignard's reagent.
All these synthetic methods have their own advantages and disadvantages. When applying in practice, we should consider many factors such as the availability of raw materials, cost, and purity requirements of the product, and make a careful choice.

4 - Fluoro - Benzeneethanamine is an organic compound. During storage and transportation, many points need to be paid attention to.
Primary storage environment. This compound should be stored in a cool, dry and well-ventilated place. If the ambient temperature is too high, it may cause changes in the properties of the compound, or even cause reactions such as decomposition; humid environment may make it damp, affecting purity and stability. For example, if placed in a hot and humid place, there is a risk of deterioration, just like ancient ink treasures. If stored in a humid place, it is easy to be moth-eaten, mildew, and damage its charm.
Secondary packaging. Packaging materials with good sealing performance should be used to avoid contact with air, moisture, etc. The quality is degraded due to oxygen, moisture, etc. in the air or chemical reactions with compounds. This is just like the ancients' collection of books, which must be hidden in brocade boxes to prevent it from being eroded by the outside world.
When transporting, shock and collision prevention are also indispensable. Because it may be contained in a fragile container, if it vibrates or collides violently during transportation, the container is damaged, and the compound leaks, which is not only a waste but also a potential safety hazard. This situation is like the transportation of ancient porcelain, which needs to be properly wrapped in soft objects and handled with caution.
At the same time, relevant transportation regulations and standards should be strictly followed to ensure transportation safety. This is a responsible act for people and the environment. Just like the ancient people marching in the army, they must act in accordance with the art of war in order to be comprehensive. In conclusion, the storage and transportation of 4-Fluoro-Benzeneethanamine requires careful treatment in all aspects to ensure its quality and safety.