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What are the main uses of 4-Fluoro-A-Oxo-Benzeneacetic Acid?
4-Fluoro - α - -phenylacetic acid has a wide range of uses. In the field of medicinal chemistry, it is a key intermediate for the synthesis of a variety of specific drugs. Due to its specific chemical structure, it can participate in the construction of many drug molecules, which has a great impact on drug activity and efficacy. For example, when developing new therapeutic drugs for specific diseases, it is often used as a starting material, and through a series of chemical reactions, complex molecular structures with specific pharmacological activities are precisely constructed, which is expected to bring new breakthroughs in disease treatment.
In the field of materials science, 4-fluoro - α - -phenylacetic acid also has important uses. It can be used as a key component in the synthesis of functional materials, giving materials unique properties. When preparing some organic materials with special optical and electrical properties, the introduction of this compound can adjust the molecular arrangement and electron cloud distribution of the material, so as to obtain materials that meet specific needs, such as materials used in new display technologies or electronic devices.
In organic synthetic chemistry, it is an important building block for organic synthesis. With its unique functional groups, it can skillfully combine with other organic compounds through various organic reactions, such as esterification reactions, condensation reactions, etc., to build organic molecules with diverse and complex structures, providing an important foundation for the development of organic synthetic chemistry and helping scientists create more novel and practical organic compounds.
What are the physical properties of 4-Fluoro-A-Oxo-Benzeneacetic Acid?
4-Fluoro - α - phenylacetic acid, this substance has many physical properties. Looking at its shape, at room temperature, it is mostly white to light yellow crystalline powder, with fine texture, like finely crushed jade chips, which is its external and intuitive state.
When the melting point is discussed, it is about 145-149 ° C. When the temperature rises gradually, the substance melts like ice in the spring sun and slowly converts from the solid state to the liquid state. This clear transition boundary is its important thermal property.
Its solubility also has characteristics. In organic solvents, such as common ethanol and acetone, it can dissolve better, just like salt dissolves in water, and fuses with these organic solvents to form a uniform and stable system; however, in water, its solubility is relatively small, just like oil floats in water, only a small amount can be dispersed, which is due to the difference in the interaction between molecular structure and water.
Furthermore, its density is also fixed. Although the exact value varies slightly due to measurement conditions, it is roughly within a certain range. This density determines its sedimentation, floating and other behavioral characteristics in various media.
has an odor. The substance has a slightly special smell, which is not pungent but unique. It is like a different smell hidden in the bookish fragrance, and it needs to be detected by smelling it carefully. This odor originates from the emission of volatile substances determined by its molecular structure, which is also one of its physical properties.
What are the chemical properties of 4-Fluoro-A-Oxo-Benzeneacetic Acid?
4-Fluorine - α - phenylacetic acid, this is an organic compound with unique chemical properties. Its molecules contain fluorine atoms, carbonyl groups and carboxyl groups, which give it a variety of chemical activities.
Let's talk about fluorine atoms first. Its high electronegativity can enhance molecular polarity and affect the physical and chemical properties of compounds. For example, it can improve the lipid solubility of compounds and affect their solubility in different solvents. It can be used as a positioning group in organic synthesis to guide the reaction direction. In nucleophilic substitution reactions, fluorine atoms in the ortho or para-position can change the electron cloud density of the benzene ring, making the reaction easier to proceed.
Furthermore, carbonyl groups, as strong electron-absorbing groups, can enhance the acidity of carboxyl groups. Due to its existence, the compound can undergo typical carbonyl reactions, such as condensation reactions with alcohols to form esters; reactions with ammonia or amines to form amides. Moreover, carbonyl groups can also participate in nucleophilic addition reactions, and many nucleophilic reagents, such as Grignard reagents and organolithium reagents, can react with them to form new carbon-carbon bonds, which is of great significance in the synthesis of complex organic molecules.
Finally, the carboxyl group is acidic and can be neutralized with bases to form corresponding carboxylic salts. In the esterification reaction, the carboxyl group and the alcohol are dehydrated under acid catalysis to form esters, which is a common method for preparing ester compounds. In addition, the carboxyl group can also participate in the polycondensation reaction, react with hydroxy or amino compounds to form polyester or polyamide and other polymer compounds.
4-fluoro - α - phenylacetic acid is widely used in organic synthesis, pharmaceutical chemistry and other fields due to these chemical properties. It can be used as a key intermediate for the synthesis of biologically active compounds and drugs.
What is the production method of 4-Fluoro-A-Oxo-Benzeneacetic Acid?
4-Fluorophenylacetic acid - α - has also been studied in the past. One of these methods is to use 4-fluorophenylacetonitrile as the initial material. First, 4-fluorophenylacetonitrile is placed in a strong base, such as sodium hydroxide solution, and hydrolyzed at a suitable temperature. This hydrolysis process requires careful temperature control, not too high or too low, to prevent side reactions from breeding. After hydrolysis, 4-fluorophenylacetate is obtained.
Then, the obtained 4-fluorophenylacetate is acidified with an appropriate amount of strong acid, such as hydrochloric acid. When acidifying, also pay attention to the amount of acid and the reaction temperature, so that the reaction is smooth. After acidification, 4-fluorophenylacetic acid is obtained.
However, 4-fluoro - α - oxyphenylacetic acid needs to be further oxidized. A suitable oxidizing agent can be selected, such as Jones reagent (a mixture of chromium trioxide, sulfuric acid and water). At low temperature and stirring state, slowly add the oxidizing agent to the reaction system of 4-fluorophenylacetic acid. This oxidation reaction is quite sensitive to the reaction conditions, and the temperature, the amount of oxidizing agent, and the reaction time need to be accurately controlled. If the conditions are not appropriate, it is easy to cause adverse consequences such as excessive oxidation.
After the reaction is completed, pure 4-fluoro - α - phenylacetic acid can be obtained through extraction, distillation, recrystallization and other purification techniques. Although there are many steps in this preparation method, each step is interconnected, and fine operation is required to achieve the ideal yield and purity.
What is the price range of 4-Fluoro-A-Oxo-Benzeneacetic Acid in the market?
The price of 4-fluoro - α - phenylacetic acid in the market often varies depending on the quality, quantity and source. Looking at the past, if this chemical is of high quality and abundant in the chemical raw material market, the price per gram is about tens to hundreds of yuan.
If purchased from ordinary chemical reagents, retail in small quantities (such as gram grade), the price may be slightly higher, or more than one hundred and fifty yuan per gram. However, if the bulk purchase, the quantity to kilograms, the price may be reduced to less than ten thousand yuan per kilogram, about ten yuan per gram.
In addition, its price is also affected by the source of production and the trend of supply and demand. If the source is close and the supply is sufficient, the price will be stable and low; if the supply is thin and prosperous, the price will rise. And those with different purity have different prices, and the price of high-purity products may be several times higher than that of ordinary products. Therefore, if you want to know the exact price, you need to consult the suppliers in detail to check their quality, quantity, purchase quantity, etc., before you can get the actual price.
