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4-Fluoro-3-(Trifluoromethyl)Benzenesulfonyl Chloride

4-Fluoro-3-(Trifluoromethyl)Benzenesulfonyl Chloride

Hongda Chemical

    Specifications

    HS Code

    971811

    Chemical Formula C7H3ClF4O2S
    Molecular Weight 276.61
    Appearance Typically a colorless to light - yellow liquid
    Physical State At Room Temperature Liquid
    Boiling Point Approximately 220 - 225 °C
    Density Around 1.6 g/cm³
    Solubility Soluble in common organic solvents like dichloromethane, chloroform
    Pungency Has a pungent odor
    Reactivity Highly reactive towards nucleophiles, especially amines and alcohols

    As an accredited 4-Fluoro-3-(Trifluoromethyl)Benzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 4 - fluoro - 3 - (trifluoromethyl)benzenesulfonyl chloride in sealed chemical - grade vial.
    Storage 4 - fluoro - 3 - (trifluoromethyl)benzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat, ignition sources, and moisture as it is reactive. Store in a tightly - sealed container, preferably made of corrosion - resistant materials, to prevent leakage and contact with air or water which could cause decomposition or dangerous reactions.
    Shipping 4 - fluoro - 3 - (trifluoromethyl)benzenesulfonyl chloride is a chemical. Ship it in well - sealed, corrosion - resistant containers. Follow hazardous chemical shipping regulations, ensuring proper labeling and documentation for safe transportation.
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    4-Fluoro-3-(Trifluoromethyl)Benzenesulfonyl Chloride 4-Fluoro-3-(Trifluoromethyl)Benzenesulfonyl Chloride
    General Information
    Historical Development
    The industry of chemical industry is changing with each passing day, and all kinds of products have their own origins. In today's words, 4 - Fluoro - 3 - (Trifluoromethyl) Benzenesulfonyl Chloride was first explored by researchers in the past.
    In the past, all the sages were in the field of chemistry, and they worked hard to explore new frontiers. Those who began to pay attention to compounds containing fluoride and sulfonyl chloride, after years of study, complicated tests, and adjustment of various factors, such as temperature, dose, and reaction timing.
    After all kinds of hardships, they finally obtained this 4 - Fluoro - 3 - (Trifluoromethyl) Benzenesulfonyl Chloride. At first, the yield was still small, only for niche research. Later, with the advancement of skills and the improvement of methods, its production increased gradually, and its application also became more and more extensive. It has emerged in the fields of medicine and materials, contributing to the development of chemical industry and achieving today's scale.
    Product Overview
    Today there is a substance called 4 - Fluoro - 3 - (Trifluoromethyl) Benzenesulfonyl Chloride. This is an important reagent for organic synthesis, and its properties are active. Looking at its structure, fluorine atoms and trifluoromethyl are connected to benzene rings, and have sulfonyl chloride groups. The introduction of fluorine atoms gives it a unique electronic effect, which changes the polarity of the molecule, and the reactivity is also different from that of normal substances. The presence of trifluoromethyl groups increases its lipid solubility, which has unique advantages in specific reactions and applications. Sulfonyl chloride groups are the activity check points of many reactions, and can be derived from a variety of compounds through reactions such as nucleophilic substitution. In the field of organic synthesis, it is often used to construct compounds containing fluorosulfonamides and sulfonates, and has great potential in medicine, materials science, etc. It is expected to open up new avenues for related research and help the creation and application of new compounds.
    Physical & Chemical Properties
    4-Fluoro-3- (Trifluoromethyl) Benzenesulfonyl Chloride is an important chemical substance. Its physical properties are unique, and it is often colorless to slightly yellow in appearance. It has a certain density and has a specific boiling point and melting point at room temperature. Its chemical properties are active, and the sulfonyl chloride group has strong reactivity, which is easy to replace with a variety of nucleophiles. The presence of fluorine atoms and trifluoromethyl groups significantly affects the electron cloud distribution of molecules, giving the substance unique chemical stability and reaction selectivity. Due to its special physical and chemical properties, it has a wide range of uses in the field of organic synthesis. It can be used as a key intermediate for the preparation of a variety of fluorinated organic compounds, and plays an important role in many fields such as medicine, pesticides and materials science.
    Technical Specifications & Labeling
    4-Fluoro-3- (trifluoromethyl) benzenesulfonyl chloride is a chemical we are dedicated to researching. Its technical specifications and identification (product parameters) are extremely critical.
    Looking at the technical specifications of this product, the purity must reach a very high level, and the impurity content must be strictly controlled. The chemical structure is stable, and all physical and chemical indicators are accurate. In the production process, strict procedures are followed at every step to ensure the same quality.
    When it comes to the logo, its name is clear and clear, with detailed origin, batch and other information. On the packaging, the warning logo is eye-catching to inform everyone of the characteristics and precautions of this product. In this way, users can clearly understand product parameters, ensure safe and accurate use, and play their due role in the field of scientific research and production.
    Preparation Method
    To prepare 4 - Fluoro - 3 - (Trifluoromethyl) Benzenesulfonyl Chloride, the raw materials and production process, reaction steps and catalytic mechanism are the key.
    First take an appropriate amount of fluoroaromatic hydrocarbons, mix with the reagent containing trifluoromethyl in a specific ratio, in a special reactor, control the temperature to a certain range, and add a catalyst. The catalytic mechanism is to activate the reaction check point, promote the combination of the two, and generate a preliminary intermediate.
    Then, the intermediate and the sulfonating reagent are mixed in precise proportions, and the reaction environment is adjusted to a specific pH and temperature range. After a series of reaction steps, the sulfonyl group is connected to a specific location.
    Finally, chlorination reagents are introduced, the reaction time and temperature are strictly controlled, and the chlorination process is realized by clever catalytic means to obtain 4-Fluoro-3- (Trifluoromethyl) Benzenesulfonyl Chloride. Every step requires careful attention to ensure the purity and yield of the product.
    Chemical Reactions & Modifications
    Guanfu 4 - Fluoro - 3 - (Trifluoromethyl) Benzenesulfonyl Chloride, its chemical reaction and modification are worth exploring.
    Past studies have observed its reaction, either limited by conditions, or trapped in unclear mechanisms. The reactions in which it participates are not ideal, and the side reactions are disturbed.
    Now I want to modify it, hoping for a new way. Or choose a special catalyst, or adjust the environment of the reaction to make the reaction go as expected.
    When considering mild conditions, control the reaction rate and increase the purity of the product. The key to modification is to accurately grasp its chemical properties, simplify complexity, and achieve high efficiency. In this way, it is expected to open up new horizons in the field of chemical synthesis, add new power to related industries, and enable this compound to play a greater role.
    Synonyms & Product Names
    4-Fluoro-3- (trifluoromethyl) benzenesulfonyl chloride, which is of great importance in the field of chemical research. Its aliases are many, such as fluorotrifluoromethyl benzenesulfonyl chloride. Trade names also have a variety of titles, and different manufacturers may have their own unique names.
    In ancient chemical research books, although there is no exact record of it, from today's perspective, its chemical properties are unique and it is widely used in organic synthesis. It can participate in many chemical reactions and is a key raw material for the preparation of specific structural compounds. For example, in the preparation of some fine chemicals, it plays an indispensable role. As a starting material, through clever reaction steps, products with special properties can be prepared. It is a weapon in the hands of chemical researchers and plays an important role in promoting the development of the chemical industry.
    Safety & Operational Standards
    4 - Fluoro - 3 - (Trifluoromethyl) Benzenesulfonyl Chloride, this is a special chemical substance. During its experimental preparation and application, safety and operating standards are of paramount importance.
    In terms of safety, this substance is dangerous. Its chemical properties are active and may react violently with many substances. Operators must wear professional protective equipment, such as protective clothing, gloves and goggles, to prevent the substance from coming into contact with the skin and eyes, as it may cause serious irritation and injury to the skin and eyes. At the same time, the operation should be carried out in a well-ventilated environment, preferably in a fume hood, to avoid inhaling the volatile aerosol of the substance to prevent damage to the respiratory tract.
    As far as the operating specifications are concerned, when taking the substance, it is necessary to use a precise measuring tool, and measure it accurately according to the experimental requirements to avoid waste and danger caused by excessive use. During mixing and reaction, the established reaction conditions and operating procedures should be strictly followed. When heating, the temperature and time should be controlled to prevent the reaction from getting out of control due to excessive temperature. After the reaction is completed, the remaining substance and reaction products should be properly disposed of in accordance with relevant regulations, and should not be discarded at will to avoid pollution to the environment.
    Furthermore, there are strict requirements for storage. It should be stored in a dry, cool and ventilated place, away from fire, heat and other easily reactive substances, and marked for identification and management. Only in this way can we ensure the safety of personnel, maintain the smooth progress of experiments, and protect the environment from pollution during the research and application of 4-Fluoro-3- (Trifluoromethyl) Benzenesulfonyl Chloride.
    Application Area
    4-Fluoro-3- (trifluoromethyl) benzenesulfonyl chloride has a wide range of application fields. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help the birth of many specific drugs. Taking some antibacterial drugs as an example, their introduction can significantly enhance the antibacterial activity and stability of drugs.
    In the field of materials science, it can improve the surface properties of materials. For example, it makes the material more corrosion-resistant and wear-resistant, suitable for high-end equipment protective coatings. In the fine chemical industry, a variety of additives with unique functions can be prepared to improve the quality and performance of chemical products. In short, it has important applications in many fields and is of great significance for promoting technological progress in various industries.
    Research & Development
    Today there is a product named 4 - Fluoro - 3 - (Trifluoromethyl) Benzenesulfonyl Chloride. I am a chemical researcher, and I have been studying it for a long time. This compound has unique characteristics and has a wide range of uses.
    I began to explore its properties, observe the changes in its reaction, and find the best preparation method. At the beginning, the process was difficult and there were many setbacks. However, I did not give up. I carefully observed various factors, temperature, amount of reagents, and reaction time, and considered them one by one.
    After months of work, I gradually gained something. The preparation method has stabilized, and the quality of the product has also improved. And it was found that it can be used as a key reagent in organic synthesis to help form a variety of delicate molecules. I believe that with time and in-depth research, this compound will surely shine in the fields of chemical industry and medicine, and contribute to the development of the industry.
    Toxicity Research
    The toxicity of 4 - Fluoro - 3 - (Trifluoromethyl) Benzenesulfonyl Chloride was studied. Detailed observation of its properties, placed in various media, observe its reaction, and test its effect on various substances. After repeated trials, it can be seen that in a solvent, when it encounters a certain substance, it changes rapidly, generates new substances, and has a certain degree of corrosiveness. Tested with living organisms, its physiological changes were observed, and it was seen that it disturbed the function of living organisms, or damaged its organs, or disrupted its metabolism. From this, it can be seen that the toxicity of this substance cannot be underestimated. When using and storing, strict regulations should be followed to prevent disasters, ensure the safety of people and things, and do not leave behind.
    Future Prospects
    Fu 4 - Fluoro - 3 - (Trifluoromethyl) Benzenesulfonyl Chloride is an important raw material in today's chemical research. It is active in nature, and in the field of organic synthesis, it is often the basis for building different knots and creating new substances.
    Looking at the future development, its use will become more and more extensive. In the way of medical research, I hope to use its properties to make special drugs to treat difficult diseases and solve the suffering of patients. In the way of material science, or to help make strange materials, we should meet the needs of high-tech and promote the progress of industry.
    My generation of researchers should do their best to explore its deep secrets and explore its new uses. It is hoped that with diligence and wisdom, this material will shine brightly on the undeveloped path, contributing to the progress of the world and the well-being of the people.
    Where to Buy 4-Fluoro-3-(Trifluoromethyl)Benzenesulfonyl Chloride in China?
    As a trusted 4-Fluoro-3-(Trifluoromethyl)Benzenesulfonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Fluoro-3-(Trifluoromethyl)Benzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-fluoro-3- (trifluoromethyl) benzenesulfonyl chloride?
    4-Hydroxy-3- (trihydroxymethyl) phenylserine lanthanum salt is a unique compound with a wide range of uses and extraordinary uses in various fields.
    First in the field of medicine. In the preparation of pharmaceuticals, this compound exhibits unique activity. It may regulate human physiology and help prevent and treat diseases. Cover because of its special structure, it can interact with human biomolecules in a specific way, or it can be used as an active ingredient to participate in the development of drugs for specific diseases, such as the alleviation of chronic diseases, the regulation of the immune system, etc., adding new tools for doctors to treat diseases.
    Furthermore, in the field of materials science, it can also be used. Because of its special chemical properties, it can be used to prepare materials with special properties. For example, in the synthesis of some functional coating materials, the addition of this compound can endow the material with excellent properties such as antibacterial and antioxidant, expand the application scenarios of the material, play a role in food packaging, medical apparatus protection, etc., and improve the quality and function of the material.
    In the process of scientific research and exploration, 4-hydroxyl-3- (trihydroxymethyl) phenylserine lanthanum salt is also an important research object. Scientists can use in-depth research on it to gain insight into the relationship between molecular structure and properties, provide theoretical cornerstones for the design and synthesis of new compounds, lead the chemical discipline to continue to advance, open up new knowledge frontiers, and promote the progress of science and technology.
    In addition, in the field of catalysis, it may have potential catalytic activity. It can act as a catalyst or participate in the catalytic process in specific chemical reactions, change the rate and selectivity of chemical reactions, and help efficient chemical synthesis. It may play a positive role in promoting the development of the chemical industry, improving production efficiency, reducing production costs, and bringing new opportunities for industrial production.
    What are the synthesis methods of 4-fluoro-3- (trifluoromethyl) benzenesulfonyl chloride?
    To prepare 4-alkynyl-3- (triethylmethyl) naphthalene phenolic, the following ancient methods can be used.
    First, naphthalene is used as the starting material. First, the naphthalene is alkylated by Fu-gram, and in the presence of an appropriate catalyst such as anhydrous aluminum trichloride, it is co-heated with triethylmethyl halogenated hydrocarbons to obtain 3- (triethylmethyl) naphthalene. In this step, attention should be paid to the ratio of the reaction temperature to the reactant. If the temperature is too high or the ratio is improper, it is easy to produce side reactions.
    Then, the 3 - (triethylmethyl) naphthalene is brominated with bromine and a suitable catalyst, such as iron powder, at a mild temperature, and bromine atoms can be introduced at the 4 - position of the naphthalene ring to obtain 4 - bromo - 3 - (triethylmethyl) naphthalene. In this reaction, the trickle acceleration of bromine and the reaction time need to be precisely controlled to prevent over-bromination.
    Then 4-bromo-3- (triethylmethyl) naphthalene is reacted with alkynyl-based reagents such as sodium acetylation. This step can form a carbon-carbon triple bond to obtain 4-alkynyl-3- (triethylmethyl) naphthalene. The reaction environment needs to be anhydrous and oxygen-free to avoid the decomposition of alkynyl-based reagents.
    Finally, 4-alkyne-3- (triethylmethyl) naphthalene is heated with a suitable aldehyde-based reagent, such as N, N-dimethylformamide and phosphorus oxychloride under the catalysis of aluminum trichloride, and 4-alkyne-3- (triethylmethyl) naphthalene phenolic is obtained by introducing an aldehyde group into the phenolic hydroxyl ortho-position of naphthol through the Wellsmeier-Hack reaction.
    Second, a suitable organic compound containing alkyne group and triethylmethyl group can also be used as the starting material to construct the naphthalene ring through a series of cyclization reactions. First, the alkynyl compound containing alkynyl and triethylmethyl groups is cyclized with benzene derivatives containing aldehyde and phenolic hydroxyl groups under the action of suitable transition metal catalysts such as palladium catalysts to directly construct the naphthalene ring skeleton, while retaining the appropriate positional relationships of alkynyl, triethylmethyl, phenolic hydroxyl and aldehyde groups. This route requires fine design of the structure of the starting material and strict reaction conditions. The type of transition metal catalyst, the choice of ligand and the reaction solvent all have a significant impact on the yield and selectivity of the reaction.
    What are the physical properties of 4-fluoro-3- (trifluoromethyl) benzenesulfonyl chloride?
    The physical properties of 4-3-trimethylquinoxaline nitrogen oxides are as follows:
    This compound is mostly solid at room temperature, with a white or nearly yellowish color and a fine texture. It looks like a powder. Its melting point is about a specific range. In this temperature range, it gradually melts from a solid state to a liquid state. This temperature characteristic is crucial when identifying and purifying the substance.
    In addition, its solubility also has characteristics. In common organic solvents, such as ethanol and acetone, there may be a certain degree of solubility. In ethanol, after moderate stirring, heating, etc., it can be partially dissolved into it to form a uniform dispersion system; in acetone, the degree of dissolution may vary, depending on the specific conditions. However, in water, its solubility is not good, and it is mostly suspended or sunk in the state of solid particles, making it difficult to dissolve with water.
    Its density is slightly lighter than that of common inorganic substances. Placed in a specific measuring instrument, its density value can be accurately measured. This value is of great significance in considering the behavior of the substance in different environments, such as the distribution in the mixed system. And the color and shape of its appearance are also one of the important characteristics to identify the substance, which can provide an intuitive basis for subsequent chemical operations and research. The various physical properties are interrelated, and the application exploration in many fields such as chemical industry and medicine is an indispensable basic cognition.
    What are the precautions for 4-fluoro-3- (trifluoromethyl) benzenesulfonyl chloride during storage and transportation?
    4-Ming-3- (trimethylmethyl) benzaldehyde oxime has several precautions to be taken during storage and transportation.
    One is related to storage. This compound should be placed in a cool, dry and well-ventilated place. Because the cool environment can reduce the risk of its chemical properties changing due to excessive temperature, drying can avoid its hydrolysis and other accidents, and good ventilation can avoid the accumulation of harmful gases. And it should be kept away from fires and heat sources to prevent ignition or promote violent chemical reactions. Furthermore, it should be stored separately from oxidizing agents, acids, alkalis, etc., and must not be mixed. Because of these substances or chemical reactions with 4-Ming-3- (trimethylmethyl) benzaldehyde oxime, it is dangerous. At the same time, the storage place should be equipped with suitable materials to contain leaks. Once there is a leak, it can be dealt with in time.
    Second, as for transportation. Make sure that the packaging is complete and sealed before transportation. The integrity of the packaging can prevent it from leaking, and the sealing can block the influence of external factors. During transportation, make sure that the container does not leak, collapse, fall or damage. When driving, you should drive slowly to avoid severe bumps, vibrations and collisions, otherwise the packaging may be damaged and the material leaks. The transportation vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. If there is an accident such as leakage on the way, you can respond in time. And the exhaust pipe of the vehicle transporting the goods must be equipped with a fire retardant device, and it is strictly forbidden to use wooden boats and cement ships for bulk transportation, so as to avoid the occurrence of fire and other dangerous conditions during transportation.
    What are the safety risks during the use of 4-fluoro-3- (trifluoromethyl) benzenesulfonyl chloride?
    The safety risks during the use of 4-ether-3- (triether methyl) naproxen sodium solution are mainly in the following categories:
    First, it is related to toxic reactions. If this agent accidentally enters the human body, it may cause many toxic symptoms. For example, it causes damage to internal organs, especially the liver and kidneys. The liver is responsible for detoxification, and the kidneys are responsible for excretion. Once the ingredients of the drug interfere with its normal function, or cause abnormal liver and kidney function, it can be life-threatening in severe cases. And if it comes into contact with sensitive parts such as the eyes, it will cause strong irritation, resulting in redness, swelling, pain, and even damage to vision.
    Second, there is a fire hazard. The solution may be flammable, and it is easy to be ignited in a high temperature environment or in the event of an open fire, which will cause a fire. In the storage and use site, if the fire prevention regulations are not followed, if there is a fire source nearby or poor ventilation, a slight carelessness will cause a fire, and the spread of the fire will pose a huge threat to people and property.
    Third, it involves environmental hazards. If the solution is not properly treated and flows into the environment, it will cause pollution to soil, water sources, etc. The microbial community in the soil may be unbalanced as a result, affecting plant growth; after the water source is polluted, not only will it harm aquatic life, but human drinking contaminated water will also damage health and destroy ecological balance.
    Fourth, the operational risk cannot be ignored. During handling and use, if the container is not well sealed or the operator is negligent, causing the solution to leak, it will not only pollute the surrounding environment, but also may cause injury due to personnel contact. And if the operation is not in accordance with the standard procedures, if the protective equipment is not worn, it will also increase the risk of personnel exposure.
    Therefore, in the entire use process of 4-ether-3- (triether methyl) naproxen sodium solution, the above safety risks must be highly regarded, and safety procedures must be strictly followed, and protective and emergency measures must be taken to ensure safety.