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4-Fluoro-3-Methylnitrobenzene

4-Fluoro-3-Methylnitrobenzene

Hongda Chemical

Specifications

HS Code

133629

Chemical Formula C7H6FNO2
Molar Mass 155.126 g/mol
Appearance Yellow - brown liquid
Boiling Point 214 - 216 °C
Melting Point 12 - 14 °C
Density 1.279 g/cm³
Solubility In Water Insoluble
Vapor Pressure Low
Flash Point 90 °C
Refractive Index 1.526 (20 °C)

As an accredited 4-Fluoro-3-Methylnitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 4 - fluoro - 3 - methylnitrobenzene packaged in a sealed, chemical - resistant bottle.
Storage 4 - fluoro - 3 - methylnitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and bases to prevent chemical reactions. Regularly check storage conditions to ensure safety.
Shipping 4 - fluoro - 3 - methylnitrobenzene is shipped in well - sealed, corrosion - resistant containers. It must comply with strict regulations for hazardous chemicals during transport, ensuring safety from potential spills and environmental hazards.
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4-Fluoro-3-Methylnitrobenzene 4-Fluoro-3-Methylnitrobenzene
General Information
Historical Development
"The History of 4-Fluoro-3-Methyl Nitrobenzene"
Taste the field of chemical industry, there are many substances, 4-fluoro-3-methyl nitrobenzene, although not famous, but in the process of organic synthesis, also has a unique position. Its origin can be traced back to the beginning of chemistry and the rise of organic synthesis. At that time, scholars studied the physical properties and explored new ways.
At the beginning, synthesizing this substance was complicated and the yield was quite low. Chemists worked hard to improve their techniques. After years, the process gradually changed, from simple methods to exquisite techniques. The reaction conditions gradually became milder, and the yield also had to be improved.
Looking at its development, the contributions of all sages are indispensable. Every breakthrough is the crystallization of wisdom. From the initial exploration of ignorance to the deep understanding of its Tao, the role of this substance in the chemical industry has become increasingly important, paving the foundation for many subsequent synthesis reactions and becoming one of the shining stars in the long river of organic chemistry development.
Product Overview
4-Fluoro-3-methyl nitrobenzene is also an important compound in organic chemistry. Its color is light yellow, like a liquid, with a special smell. This compound is widely used in the field of organic synthesis.
Its preparation method is often obtained by a specific reaction path. Through precise chemical reaction manipulation, the reactants act in sequence to generate 4-fluoro-3-methyl nitrobenzene.
In industrial production and academic research, it has received much attention. Due to its unique structure, it can be used as a key intermediate in many organic synthesis, assisting in the construction of a variety of complex organic molecules, and has made great contributions to the development of the field of chemistry.
Physical & Chemical Properties
4-Fluoro-3-methyl nitrobenzene is also an organic compound. It has specific physical and chemical properties. Looking at its physical properties, it is mostly liquid at room temperature, has a special odor, and is difficult to dissolve in water, but can be soluble in some organic solvents, such as ethanol, ether and the like.
In terms of its chemical properties, it is active because it contains functional groups such as fluorine, methyl and nitro. Nitro has strong oxidizing properties, which makes this compound can participate in many chemical reactions under specific conditions, such as nucleophilic substitution reactions. The presence of methyl groups affects the distribution of electron clouds in molecules, which in turn affects their reactivity. The introduction of fluorine atoms enhances the stability of compounds and guides the direction of reactions in some reactions. These physical and chemical properties have important application value in fields such as organic synthesis.
Technical Specifications & Labeling
4-Fluoro-3-methyl nitrobenzene, its process specifications and identification (product parameters) are related to the preparation and identification of this substance. The synthesis method should follow rigorous steps. Material dosage, reaction temperature and time length are all key. Raw materials need to be selected to ensure purity. The reaction vessel also needs to be clean to prevent impurities from disturbing it.
During the reaction, the temperature should be controlled in an appropriate range. If it is too low, the reaction will be slow, and if it is too high, it may cause side reactions. The duration also needs to be accurate. If it is not reached, the product will be impure, and if it is too long, it may cause the product to decompose. On the
label, its chemical properties and hazard warnings should be detailed. This product may be toxic and corrosive, and it needs to be marked prominently to warn everyone. Only in this way can we ensure safety and quality during preparation and use.
Preparation Method
The method of making 4 - Fluoro - 3 - Methylnitrobenzene is the key to the raw materials and production process. Take an appropriate amount of fluorobenzene and methylating reagent and put it in the reactor according to a certain ratio. First, at a mild temperature, the two slowly blend to promote the orderly methylation reaction. After the methylation is completed, a nitrifying reagent is introduced, and the temperature is properly controlled to make the nitrification step smooth. Among them, the rhythm of the reaction, the temperature, and the ratio of reagents need to be accurately grasped to ensure the purity and yield of the product. In order to make the reaction efficient and the product high-quality, the catalytic mechanism is also indispensable. Choose the appropriate catalyst and add it at the appropriate time to accelerate the reaction process and reduce the generation of side reactions. In this way, with the help of the selection of raw materials, the control of reaction steps and the catalytic mechanism, the better 4-Fluoro-3-Methylnitrobenzene product can be obtained.
Chemical Reactions & Modifications
In modern times, chemistry has flourished, and the reactions and properties of various substances have been explored more and more deeply. Today, there are many chemists who have studied 4-Fluoro-3-Methylnitrobenzene. The wonders of its reaction and the changes in its properties are all important to the academic community.
The chemical changes of the husband may vary depending on the temperature, pressure, or catalyst. 4-Fluoro-3-Methylnitrobenzene reacts when it encounters a certain agent, or the temperature is moderate, and its molecular structure is easy, resulting in new substances. Looking at its properties, stability, activity, etc., also change with the reaction.
In the past, this thing was unknown, but now it can be made and used by chemical methods. If you want to do your best, you must carefully observe the rules of its reaction and understand the changes in its nature. Only in this way can you make good use of it in the chemical and pharmaceutical industries and benefit the world.
Synonyms & Product Names
4 - Fluoro - 3 - Methylnitrobenzene, this substance is also very important in the field of my chemical research. Its aliases are also common, such as fluorinated methyl nitrobenzene, all refer to this. Sold in the market, the names are different, but they are all the same substance.
Looking at its chemical properties, its structure is unique. Fluorine, methyl and nitro coexist on a benzene ring, so it has different chemical activities. Because of its characteristics, it is often a key raw material in various chemical synthesis.
In commercial stores, it is either sold under the name of 4-fluoro-3-methyl nitrobenzene, or it is expressed under its alias. Although the names are different, the references are the same. Our chemical researchers need to understand the situation of their synonyms in order to be correct and correct in their research and application.
Safety & Operational Standards
4 - Fluoro - 3 - Methylnitrobenzene is an important chemical for its laboratory and industrial applications. Safety and operating practices are of paramount importance.
When handling this chemical, the first thing to do is to ensure that the experimental site is well ventilated. Because it may be volatile, good ventilation can avoid the accumulation of harmful gases and reduce the potential threat to the health of the experimenter. And it must be equipped with effective ventilation equipment, such as a fume hood, in which the operation process should be carried out to ensure that the gas is discharged in a timely manner.
Furthermore, the experimenter must strictly follow the protective practices. Appropriate protective equipment should be worn, including but not limited to protective gloves, goggles and lab clothes. Protective gloves should be able to resist the erosion of 4 - Fluoro - 3 - Methylnitrobenzene and prevent it from contacting the skin; goggles can effectively protect the eyes from the chemical splashing and causing damage.
Storage should also not be ignored. 4 - Fluoro - 3 - Methylnitrobenzene should be stored in a cool, dry and ventilated place, away from sources of ignition and oxidants. Storage containers should be well sealed to prevent leakage. They should also be clearly marked with the name of the chemical, hazard characteristics and emergency treatment methods.
If a leak unfortunately occurs, emergency measures should be taken immediately. First evacuate unrelated people to avoid contact with the leak. In the case of small leaks, inert materials such as sand and vermiculite can be absorbed and collected in airtight containers; in the case of large leaks, embankments or pits need to be built for containment, and transferred to a tanker or special collector by pump for recycling or transportation to a waste treatment site for disposal.
When operating 4 - Fluoro - 3 - Methylnitrobenzene, strict follow of safety and operating standards can ensure personnel safety and the smooth progress of experiments and production.
Application Area
4 - Fluoro - 3 - Methylnitrobenzene is also a chemical material. Its application field involves a wide range of. In the field of pharmaceutical synthesis, it can be a key intermediate, helping to create special drugs and cure various diseases. In the development of pesticides, it can also play a role, helping to develop high-efficiency and low-toxicity agricultural agents, protecting crops. And in the field of materials science, it may participate in the preparation of special materials and increase the properties of materials. Its application potential cannot be underestimated, just like a shining pearl, shining in various fields, promoting the progress of science and technology and the prosperity of people's livelihood.
Research & Development
Yu has been dedicated to the research of chemical products for a long time, and recently focused on 4-Fluoro-3-Methylnitrobenzene. This substance has unique properties and has potential uses in many fields.
Initially study its synthesis method, try all kinds of things, or improve the old system, or explore new ways. We hope to increase its yield and reduce its cost with efficient and green methods.
Then observe its physicochemical properties, test its melting point and solubility in detail, etc., to show that its properties change under different conditions.
It also examines its application field. In pharmaceutical synthesis, it can be used as a key intermediate to assist in the development of new drugs; in material preparation, or to give materials special properties.
Although some achievements have been made today, there is still a long way to go. In the future, we should continue to study and expand its application, hoping to promote the development of this chemical, add new colors to the industry, and benefit the world.
Toxicity Research
Since modern times, chemical refinement, new substances have emerged. The toxicity of 4 - Fluoro - 3 - Methylnitrobenzene is quite important.
Detailed examination of its properties, 4 - Fluoro - 3 - Methylnitrobenzene has a special structure, fluorine and methyl, nitro and benzene ring. The signs of its toxicity, or involved in biochemical mechanisms. Entering the organism, it may disturb the metabolism of cells and disrupt the activity of enzymes.
After various experiments, observe its effect on the tested organisms. Small animals touch it, or present physiological abnormalities, such as behavioral disorders, organ damage. And this substance may have accumulated harm, accumulated in the body for a long time, gradually damaging health.
Therefore, when it comes to its production and consumption, strict regulations should be set up, and caution should be taken to prevent it from escaping, to ensure the safety of all beings, and not to make toxicity a disaster to the world.
Future Prospects
4 - Fluoro - 3 - Methylnitrobenzene is also a chemical substance. I have been researching it, and I hope it has not yet been developed. This compound is unique, or can be used in many domains.
Today's technology is new and new. As expected, we can find out more of its characteristics, and use it in the field, or it can help research special effects, saving life and pain; it can be used in materials, or it can be used to make novel things, which is like a need.
Our chemical researchers must exhaust their efforts to study the secrets of this compound. Hope that it can be used in the world, and it can be used in our research. This is the great thing we have not yet done.
Where to Buy 4-Fluoro-3-Methylnitrobenzene in China?
As a trusted 4-Fluoro-3-Methylnitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 4-Fluoro-3-Methylnitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-fluoro-3-methylnitrobenzene?
4-N-3-methylbenzylphenylalanine is an important chemical compound. Its main uses involve multiple domains.
In the process of research and development, this compound can be used as a kind of medicine. With its original properties, it is hoped that new kinds of chemical compounds will be developed. For example, some specific biological activities can act on specific receptors or enzymes in humans, which can affect physiological functions and treat diseases, such as inhibiting the proliferation of specific cancer cells, or assisting in the treatment of spiritual diseases.
In the field of materials, 4-N-3-methylbenzylphenylalanine is also useful. It can be introduced into the polymer material, so as to improve the physical properties of the material. If it has better biocompatibility, it can be used in biological materials, such as artificial organs, materials, etc. These materials can be used in the biological environment and phase, and can be released slowly to improve the treatment effect.
Furthermore, in the field of chemical research, due to its special chemical properties, it may have certain antioxidant, whitening and other effects. It can be used as an active ingredient to add to chemical formulations to help muscles resist oxidation, reduce the formation of pigmentation, and achieve the purpose of beauty.
Therefore, 4-3-methylbenzylphenylalanine has important uses in many aspects such as medicine, materials, chemicals, etc. Due to the depth of research, more applications may be discovered.
What are the physical properties of 4-fluoro-3-methylnitrobenzene?
4-Alkynyl-3-methylpentyl carbonyl naphthalene is one of the organic compounds. Its physical properties are quite characteristic.
Looking at its morphology, under normal temperature and pressure, it is mostly in a solid state. Due to the relatively strong intermolecular forces, it aggregates tightly. Its melting point also has a considerable value, and usually requires a higher temperature to make it from solid to liquid. Due to the existence of polar groups such as alkynyl and carbonyl in the molecular structure, there is a dipole-dipole interaction between molecules in addition to van der Waals force, which enhances the attractive force between molecules, so the melting point is higher.
As for the boiling point, it is also in a higher range. Due to the stable chemical bonds between atoms in the molecule and the complex interactions between molecules, a large amount of energy needs to be supplied to overcome the intermolecular forces in order to change it from a liquid state to a gaseous state.
In terms of solubility, because it has a certain polarity, it has a certain solubility in polar organic solvents such as ethanol and acetone. However, in non-polar solvents such as n-hexane, the solubility is very small. This follows the principle of "similar compatibility". Polar molecules are easily soluble in polar solvents, and non-polar molecules are easily soluble in non-polar solvents.
Its density is slightly larger than that of common organic solvents, which is determined by the type and quantity of atoms in its molecules. The molecular structure is relatively compact, and the relative mass of atoms is large, which increases the mass of matter per unit volume, and then increases the density. In addition, 4-alkyne-3-methylpentyl carbonyl naphthalene exhibits certain stability under light and heat conditions. However, under certain conditions, such as high temperature, strong light or the presence of catalysts, active parts such as alkynyl and carbonyl in its structure may initiate chemical reactions, resulting in changes in physical properties.
What are the chemical properties of 4-fluoro-3-methylnitrobenzene?
4-Alkynyl-3-methylpentynyl benzene is a strange organic compound with unique and complex chemical properties, which is worthy of further investigation.
In this compound, the presence of the alkynyl group gives it active chemical activity. The alkynyl group has electron-rich properties and is prone to participate in many chemical reactions, such as nucleophilic addition reactions. Because the carbon-carbon triple bond in the alkynyl group is rich in electron clouds, it is quite attractive to nucleophiles. When encountering nucleophiles, the nucleophilic reagents can attack the carbon atom of the alkynyl group, causing one of the three bonds to break, thereby forming a new chemical bond and deriving a variety of products.
The introduction of methyl groups also has a significant impact on the electron cloud distribution and spatial structure of the compound. Methyl groups are the power supply groups, which can increase the electron cloud density of the carbon atoms connected to them by inducing effects. This not only changes the polarity of the molecule, but also affects the activity of the reaction check point in some reactions. In some reactions involving electron transfer, the electron supply action of methyl groups or the adjacent alkynyl groups are more likely to give electrons, thus affecting the rate and direction of the reaction.
Furthermore, the presence of benzene rings also adds other chemical properties to the compound. The benzene ring has a conjugated system and has high stability. It can form a conjugation effect with alkynyl groups, further changing the electron cloud distribution of the molecule. In some reactions, the benzene ring can be used as a storage and transfer center for electrons, making it easier for the whole molecule to participate in the electron transfer process. For example, in photochemical reactions, the conjugated system of the benzene ring can absorb light energy of a specific wavelength, excite electron transitions in the molecule, and initiate a series of subsequent chemical reactions.
In addition, from the perspective of spatial structure, each group of 4-alkyne-3-methylpentynylbenzene interacts to form a specific spatial configuration. This spatial configuration also affects its chemical properties. In some reactions that require specific spatial adaptation, such as enzyme-catalyzed simulated reactions, the appropriate spatial configuration is the key to the smooth progress of the reaction. The steric hindrance between groups may affect the interaction between molecules, which in turn affects whether the reaction can occur and the selectivity of the reaction.
What are the synthesis methods of 4-fluoro-3-methylnitrobenzene?
To prepare 4-hydrocarbon-3-methylcarbonyl benzonitrile, the following ancient methods can be followed:
First, the aromatic halogen and the alkenyl borate are used as the beginning, and the corresponding olefin is obtained by the coupling reaction of Suzuki catalyzed by palladium. After that, the olefin and the cyanogen halide are reacted in an appropriate solvent under the catalysis of a base, the cyanophilic attack, the cyanyl group is introduced, and the carbonyl group is introduced under suitable reaction conditions, and the methyl group is introduced at a specific position. This step requires fine regulation of the reaction conditions to ensure that the methyl group and the carbonyl group are precisely generated based on the target position.
Second, starting from the compound containing the benzyl structure, the benzyl group is first halogenated, and the hydrogen on the benzyl group is replaced by halogen Then, it interacts with a cyanide reagent to form a benzyl nitrile structure. After a series of carbonylation reactions, a carbonyl group is introduced. In this process, the introduction of methyl groups can be achieved by reacting with suitable methylating reagents under specific reaction conditions. For example, when Grignard reagents such as methylhalide are reacted with corresponding carbonyl precursors, methyl groups and carbonyl groups can be introduced at specific positions.
Third, a compound containing benzene ring is used as the starting material, and a suitable substituent is introduced through the Friedel-Crafts reaction to construct a basic carbon skeleton. After that, through multi-step reactions such as oxidation, halogenation, and cyanidation, carbonyl groups, halogen atoms, and cyanyl groups are gradually introduced. By ingeniously designing the reaction sequence and conditions, methyl groups are introduced at suitable positions to achieve the synthesis of 4-hydrocarbon-3-methylcarbonyl benzonitrile. This route requires strict control of the selectivity and conditions of each step of the reaction to ensure the purity and yield of the target product.
What are the precautions for the storage and transportation of 4-fluoro-3-methylnitrobenzene?
4-Methyl-butyl-thionaphthalene, hiding and losing, there are all things to pay attention to.
When hiding, the first place is the ground. It is advisable to choose a dry and cool place, away from direct sunlight and moisture. Cover this material may change due to moisture and heat, and sunlight may promote its transformation and damage its quality. Ventilation of the ground is also necessary to avoid danger caused by the accumulation of gas.
Furthermore, it must be solid. Hold it in a strong and closed device to prevent it from leaking out. Because of its special gas nature, it may be leaked outside, or disturb the surrounding air, and it may be unfavorable to people. The packaging material should also be reviewed. Do not react with the substance, causing the package to break and the substance to leak.
When transporting, the transportation equipment must be clean and suitable. There should be no miscellaneous stains to prevent it from mixing with the substance and causing qualitative change. The temperature control is also tight. Set a suitable temperature according to its nature to avoid high temperature and causing it to evaporate and decompose. The temperature is low and condensate, which hinders its flow.
Stability on the way is also critical. Driving and sailing should be stable to avoid shocks and bumps. If the shock is over the drama, or the package is damaged, all kinds of dangerous situations will occur.
Also, the loser should be aware of its nature. If you know what you encounter, you can respond to it, and avoid it on the way. And carry the corresponding rescue gear, if there is a leak, you can quickly rescue and reduce the harm.
In the storage and transportation of 4-3-methyl-butylthionaphthalene, all the things you pay attention to are related to its safety and safety, and should not be ignored.