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What are the main uses of 4-Fluoro-3-Methylbenzeneboronic Acid?
4-Fluoro-3-methylphenylboronic acid has a wide range of uses. In the field of organic synthesis, it is a key intermediate. It can participate in the Suzuki coupling reaction, which can efficiently form carbon-carbon bonds. Through this reaction, chemists can connect it with halogenated aromatics or olefins to generate many organic compounds with special structures and properties, which are of great significance in drug development, materials science and many other fields.
In drug development, compounds synthesized from 4-fluoro-3-methylphenylboronic acid through the Suzuki coupling reaction may have unique physiological activities or may become active ingredients of new drugs. For example, anticancer drugs with specific targeting properties can be synthesized to target specific cancer cells, improving therapeutic effects and reducing side effects.
It also plays an important role in the field of materials science. By participating in organic synthesis reactions, materials with special photoelectric properties can be prepared. For example, materials that can be applied to organic Light Emitting Diodes (OLEDs) can be synthesized to improve their luminous efficiency and stability, making display screens clearer and more energy efficient.
In addition, 4-fluoro-3-methylphenylboronic acid is also indispensable in the preparation of fine chemical products. It can provide key structural units for the synthesis of special fragrances, pigments, etc., endowing products with unique properties and functions to meet market demand for high-quality fine chemical products.
What are the physical properties of 4-Fluoro-3-Methylbenzeneboronic Acid?
4-Fluoro-3-methylphenylboronic acid, its physical properties are as follows:
This substance is usually white to light yellow solid powder. Looking at its shape, the powder texture is relatively fine and uniform, which is conducive to increasing the contact area with other reactants in many chemical reactions, thereby promoting the reaction.
When it comes to the melting point, it is within a certain range. The melting point value is crucial for determining its purity and the feasibility of participating in the reaction under specific temperature conditions. The melting point is relatively stable. If the impurities contained increase, the melting point will tend to decrease and the melting range will become wider.
In terms of solubility, 4-fluoro-3-methylphenylboronic acid exhibits different solubility characteristics in some common organic solvents. In polar organic solvents such as methanol and ethanol, it can have a certain solubility, which is attributed to the interaction between the polarity of the boric acid groups in the molecular structure and the molecules of these solvents. However, in non-polar solvents such as n-hexane, its solubility is very small, because the molecule as a whole is not completely non-polar, and the interaction with non-polar solvent molecules is weak.
In addition, its density is also a specific value, and this density parameter is of great significance when it comes to solution preparation and substance separation operations. Knowing its density can accurately determine the distribution in the mixed system and perform relevant metrological calculations.
In terms of stability, it can maintain a relatively stable chemical structure in a dry environment at room temperature and pressure. However, it is necessary to avoid contact with strong oxidants, strong bases and other substances to prevent chemical reactions from causing structural changes. If it is in a humid environment, boric acid groups may have a certain impact on their physical properties and subsequent chemical properties due to factors such as moisture absorption.
What are the synthetic methods of 4-Fluoro-3-Methylbenzeneboronic Acid?
There are several methods for the synthesis of 4-fluoro-3-methylphenylboronic acid as follows.
First, 4-fluoro-3-methylbromobenzene is used as the starting material. First, it is combined with magnesium chips in anhydrous ether or tetrahydrofuran in a low temperature and nitrogen-protected atmosphere to initiate a Grignard reaction to generate 4-fluoro-3-methylphenylmagnesium bromide. This reaction needs to be handled with caution. Due to the high activity of Grignard reagents, the reaction conditions are strict. Subsequently, the obtained Grignard reagent is reacted with borate esters, such as trimethyl borate or triethyl borate, at low temperature. After the reaction is completed, 4-fluoro-3-methylphenylboronic acid can be obtained by hydrolysis. The steps of this method are relatively clear, but the Grignard reaction conditions are difficult to control, and a strict anhydrous and anaerobic environment is required.
Second, the palladium-catalyzed Suzuki coupling reaction strategy can be used. 4-fluoro-3-methylhalobenzene (such as chlorobenzene, bromobenzene, etc.) and boric acid pinacol ester are used as reactants. In the reaction system, palladium catalysts, such as tetra (triphenylphosphine) palladium (0), etc., and bases, such as potassium carbonate, sodium carbonate, etc., are added to react in organic solvents, such as dioxane, toluene and water. This reaction condition is relatively mild, with good selectivity, and can effectively avoid the occurrence of many side reactions, but the price of palladium catalysts is expensive, which will increase the cost.
Third, 4-fluoro-3-methylaniline is used as the starting material. First, the amino group is converted into a diazonium salt by diazotization. Then it reacts with sodium borohydride and an appropriate amount of additives to replace the diazo group with boron group, and then generates 4-fluoro-3-methylphenylboronic acid. Although this route has a little more steps, the raw material 4-fluoro-3-methylaniline is relatively easy to obtain, and the diazotization reaction technology is mature and easy to operate and control.
4-Fluoro-3-Methylbenzeneboronic Acid during storage and transportation
4-Fluoro-3-methylphenylboronic acid is an important reagent for organic synthesis. During storage and transportation, many matters need careful attention.
First of all, this compound needs to be stored in a dry and cool place. Because it has a certain chemical activity, it is easy to react in case of moisture and cause deterioration, so moisture prevention is extremely important. The humidity in the warehouse should be controlled in a moderate range, and the humidity should not be too high. And a cool environment can slow down its chemical reaction rate and maintain its chemical stability. If placed in a high temperature place, or cause adverse changes such as decomposition.
Furthermore, it should be kept away from fire sources and oxidants. 4-Fluoro-3-methylphenylboronic acid may react violently when exposed to open flames or strong oxidizing agents, and may cause fire or explosion. When storing, it must be placed separately from such dangerous substances, with obvious signs and intervals.
When transporting, the packaging must be sturdy and tight. Choose suitable packaging materials to effectively protect it from vibration and collision damage. And the outside of the package should also be clearly marked with warning labels, indicating its chemical properties and key points to pay attention to, so that the transporter can understand.
In addition, the control of temperature during transportation cannot be ignored. According to its characteristics, maintain a suitable temperature range to avoid quality problems caused by drastic temperature changes. At the same time, transportation personnel should be familiar with emergency handling methods, and in case of emergencies such as leaks, they can respond quickly and properly to minimize harm.
What is the market price range for 4-Fluoro-3-Methylbenzeneboronic Acid?
The market price range of 4-fluoro-3-methylphenylboronic acid is difficult to determine with certainty. The price of the cover varies due to various reasons, and the following is a detailed analysis for you.
The first to bear the brunt are the manufacturers and brands. Different manufacturers, due to different production processes, raw material quality, and brand reputation, produce 4-fluoro-3-methylphenylboronic acid at very different prices. Large factories with outstanding reputation and excellent craftsmanship have high product quality and high prices; while emerging or unknown manufacturers, in order to compete for the market, have slightly lower prices.
Furthermore, product purity has a great impact. If it is used in high-end scientific research or pharmaceutical synthesis, high-purity products are required, and the preparation process is complicated, the cost is high, and the price is naturally high; while the purity requirements are slightly lower, for general industrial purposes, the price should be relatively low.
The market supply and demand situation also affects its price. If the demand for 4-fluoro-3-methylphenylboronic acid increases sharply at a certain time, but the supply is limited, according to market rules, the price will rise; on the contrary, if the supply is abundant and the demand is weak, the price may drop.
The number of purchases is also related to the price. Generally speaking, when purchasing in bulk, the manufacturer may give a certain discount for small profits but quick turnover, and the unit price will be reduced; if you buy sporadically, the price may be relatively high.
Looking at past market conditions, its price fluctuations are not small. For those with high purity and excellent quality, the price per gram may reach tens or even hundreds of yuan; while for products with slightly lower purity and for ordinary industrial applications, the price per gram may be between a few yuan and a dozen yuan.
To sum up, in order to know the exact price range of 4-fluoro-3-methylphenylboronic acid, it is necessary to comprehensively consider various factors such as manufacturers, purity, supply and demand, and purchase volume, and to clarify the specific transaction scenario.