Hongda Chemical
Products
Home  /  Products  / 

4-Fluoro-3-Methylbenzeneboronic Acid

4-Fluoro-3-Methylbenzeneboronic Acid

Hongda Chemical

Specifications

HS Code

157749

Name 4-Fluoro-3-Methylbenzeneboronic Acid
Chemical Formula C7H8BFO2
Molar Mass 153.95 g/mol
Appearance White to off - white solid
Solubility In Water Slightly soluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, dichloromethane
Melting Point 127 - 131 °C
Boiling Point Decomposes before boiling
Pka Around 8 - 9
Stability Stable under normal conditions, but moisture - sensitive
Reactivity Reacts with electrophiles, used in cross - coupling reactions

As an accredited 4-Fluoro-3-Methylbenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 4 - fluoro - 3 - methylbenzeneboronic Acid in sealed, labeled chemical - grade vial.
Storage 4 - fluoro - 3 - methylbenzeneboronic acid should be stored in a cool, dry place, away from heat sources and ignition sources. Keep it in a tightly - sealed container to prevent moisture absorption and contact with air, as boronic acids can react with water and oxygen over time. Store it separately from incompatible substances like strong oxidizing agents and bases to avoid potential chemical reactions.
Shipping 4 - fluoro - 3 - methylbenzeneboronic acid is shipped in sealed, corrosion - resistant containers. It's carefully packaged to prevent leakage. Shipment follows strict chemical transport regulations, ensuring safe transit.
Free Quote

Competitive 4-Fluoro-3-Methylbenzeneboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.

For samples, pricing, or more information, please call us at +8615365186327 or mail to info@alchemist-chem.com.

We will respond to you as soon as possible.

Tel: +8615365186327

Email: info@alchemist-chem.com

4-Fluoro-3-Methylbenzeneboronic Acid 4-Fluoro-3-Methylbenzeneboronic Acid
General Information
Historical Development
4 - Fluoro - 3 - Methylbenzeneboronic Acid, it is also a chemical thing. Its origin, the beginning of the year, the research of chemical people seeking new things, and the effort of the mind. In the end, the general method and material phase are used. After many times, this compound can be obtained. The first obtained, its properties are not yet known, and people have further explored it. Its characteristics and inverse properties have been clarified again and again. In the future, this compound will be used in the chemical field. Or used in the synthesis of other substances, with its special properties, to help the reaction. Or in the research of chemical substances, etc., there are also. From the initial unknown, to the present day, the development process of chemical products that are commonly used in the daily industry is one of the first steps in the research of chemical products.
Product Overview
Today, there is a compound called 4 - Fluoro - 3 - Methylbenzeneboronic Acid. It is an organic compound with a unique structure. Looking at its appearance, it is often in the form of a white to off-white solid powder.
This substance is very useful in the field of organic synthesis. It can be used as a key intermediate to help build a multi-component organic molecular structure. Its boron and fluorine-containing groups give special chemical activity and selectivity. In many reactions, it can accurately guide the direction of the reaction and improve the purity and yield of the product.
And because of its stable structure, it can withstand various chemical transformations under specific conditions. Chemists use their characteristics to design and implement the synthesis of various complex organic compounds, providing indispensable basic raw materials for drug research and development, materials science, and many other fields, with promising prospects.
Physical & Chemical Properties
4 - Fluoro - 3 - Methylbenzeneboronic Acid is also an organic compound. Its physical and chemical properties are of great importance to those who study chemistry.
Looking at its physical properties, under room temperature, or in a solid state, it has a specific color and shape. Its melting point and boiling point are fixed, which is related to the transformation of its physical state. Under different temperature conditions, it shows different phases. Solubility is also an important physical characteristic. In various solvents, the dissolution situation varies, either easily soluble in polar agents or poorly soluble in non-polar substances.
On its chemical properties, boron-containing groups give it unique activity. It can participate in many organic reactions, such as coupling with halogenated hydrocarbons to form carbon-carbon bonds, and has a wide range of uses in the field of organic synthesis. Its acidic properties can interact with alkali phases and cause neutralization reactions, which is a manifestation of its chemical activity. And because it contains fluorine and methyl, it has an impact on its chemical stability and reaction selectivity, making it important in the research and application of organic chemistry.
Technical Specifications & Labeling
4-Fluoro-3-methylphenylboronic acid is a crucial reagent in the field of organic synthesis. Its preparation process requires strict adherence to specific technical specifications and standards.
During the synthesis process, the selection of raw materials is extremely critical, and high purity must be ensured to ensure the quality of the product. The reaction conditions cannot be ignored, and parameters such as temperature, pressure, and reaction time must be precisely controlled.
Technical specifications require that the reaction device is well sealed to prevent impurities from mixing. The monitoring of the reaction process should be accurate, and the progress of the reaction should be discerned in real time with the help of advanced analytical methods.
Product identification (commodity parameters) is also very important, and information such as chemical name, molecular formula, purity, and storage conditions should be clearly marked. This is not only convenient for users to accurately recognize the product, but also conducive to safe storage and use. Strictly abide by technical specifications and labeling requirements to produce high-quality 4-fluoro-3-methylphenylboronic acid products.
Preparation Method
4 - Fluoro - 3 - Methylbenzeneboronic Acid is 4 - fluoro - 3 - methylphenylboronic acid. The following is the preparation method in ancient form:
To prepare 4 - fluoro - 3 - methylphenylboronic acid, prepare raw materials. Take the corresponding halogenated aromatic hydrocarbons, such as 4 - fluoro - 3 - methyl bromobenzene, this is the starting material. Using anhydrous ether as a solvent, put magnesium chips into it, stir and heat up to initiate a reaction to obtain Grignard's reagent.
Then, slowly add borate esters, such as trimethoxy borate, at low temperature. Add it, heat up and reflux to make the reaction sufficient. After the reaction is completed, it is cooled to room temperature, hydrolyzed with dilute acid, and the product is precipitated. The product is purified by extraction, washing, drying, recrystallization and other processes. The preparation method, raw materials and production process need to be strictly controlled, the reaction steps are gradual, and the catalytic mechanism is appropriate to obtain high-purity 4-fluoro-3-methylphenylboronic acid.
Chemical Reactions & Modifications
The study of modern chemistry has been very diligent in the change of the nature of things. Today there is 4-Fluoro-3-Methylbenzeneboronic Acid, and scholars have studied its chemical reaction and denaturation.
Looking at its reaction, in a specific environment, it can combine with various things to form a new quality. The disconnection of its bonds can be traced according to the laws of chemistry, or nucleophilic, or electrophilic.
As for denaturation, the temperature, pressure, catalyst, etc. of the outside world can change it. The rise and fall of temperature can either promote its response or slow it down; the increase or decrease of pressure also affects its state. The catalyst can change the rate of adaptation, but not itself.
The study of the chemical reaction and denaturation of this substance is of great use in the fields of medicine and materials. It can help us make new drugs and make good materials, which is of great benefit. We should study the reason deeply and use it for the world.
Synonyms & Product Names
4 - Fluoro - 3 - Methylbenzeneboronic Acid, this substance is also a chemical product. Its synonyms are also various. Or fluoromethylphenylboronic acid and the like, although the names are different, they actually refer to this substance.
In the market, the names of its products are also called. However, they are all identified as this chemical material. It is sold by merchants and used by scholars because of its name. This chemical substance is widely used in the field of scientific research. It can be used as a raw material for synthesis and has its unique ability in the process of organic synthesis. Because of its specific structure, it can react with other substances in many ways to form the desired product. Therefore, chemists often use it as a research resource, explore its nature, study its use, and hope to make progress in the path of chemistry, so as to promote the prosperity of science and technology and be used by the world.
Safety & Operational Standards
4 - Fluoro - 3 - Methylbenzeneboronic Acid Safety and Operation Specifications
4 - Fluoro - 3 - Methylbenzeneboronic Acid, a substance commonly used in chemical research. During its access, storage and operation, the safety and operation specifications should be strictly observed to prevent hazards and ensure smooth experiments.
#1. Storage Regulations
This substance should be stored in a cool, dry and well-ventilated place. It must be kept away from fire and heat sources to prevent it from being decomposed by heat or triggering dangerous reactions. And it should be stored separately from oxidants, acids, bases, etc., and should not be mixed. Because of contact with it, it may cause severe chemical reactions and endanger safety. The storage area should be equipped with suitable materials to contain leaks for emergency response.
#2. How to use
When using 4-Fluoro-3-Methylbenzeneboronic Acid, the experimenter must wear suitable protective equipment, such as protective glasses, gloves and lab clothes, to avoid contact with the skin and eyes. Use clean, dry utensils to use, and the action should be stable and accurate to avoid spillage. If it is a solid form, use a spoon or forceps to take it carefully; if it is a liquid, use a pipette or dropper to measure it accurately, and take it according to the amount required for the experiment. Do not waste or exceed it.
#Third, the operation
It is better to operate in the fume hood, so that the harmful gases that may be generated can be discharged in time to ensure the safety of the experimental environment. During the experiment, it is necessary to strictly control the reaction conditions, such as temperature, pressure, reaction time, etc. When heating, when using a suitable heating device, heat evenly to avoid local overheating causing material decomposition or accidents. When stirring, the speed is moderate to ensure that the reaction is sufficient and the solution does not splash out. If the operation accidentally causes leakage, stop the experiment immediately and clean it up quickly. A small amount of leakage can be absorbed by inert materials such as sand and vermiculite; a large amount of leakage needs to be contained and properly handled.
Following these safety and operational guidelines, the study of 4 - Fluoro - 3 - Methylbenzeneboronic Acid can ensure safety and promote the process of scientific exploration.
Application Area
Today there is a thing called 4 - Fluoro - 3 - Methylbenzeneboronic Acid. It is widely used in the field of medicine and can be used as a key intermediate to assist in the research of special effects and treat various diseases in the world. In the field of materials, it can participate in the synthesis of materials, impart unique properties, or increase their toughness, or increase their conductivity. In the process of organic synthesis, it is a powerful tool to assist in the construction of complex molecules and expand the frontier of organic chemistry. This compound, with its unique properties, has extraordinary power in various fields. It is like a sharp blade, breaking the problems of scientific research and opening up innovative methods. It is valued by the academic community and is also a practical treasure. It can be expected to make greater achievements in the future.
Research & Development
Today, there is a thing named "4 - Fluoro - 3 - Methylbenzeneboronic Acid", which is very important for my chemical research.
We study this substance, observe its properties, explore its quality, and hope to gain something. At first, we study its structure in detail, and we know that its molecular structure is delicate, and the atoms are connected in an orderly manner. Then we test its chemistry, observe its performance in various reactions, or combine with other substances, or decompose itself, and record it in detail.
Study this substance, and also seek its development path. To find new ways, make it high yield, low cost, and widely used. Looking forward to the future, this substance will be able to shine in the fields of medicine and materials, for the well-being of the world, and in the field of chemistry, it will become a bright pearl, promoting the continuous progress of our research and opening up new frontiers.
Toxicity Research
4 - Fluoro - 3 - Methylbenzeneboronic Acid Toxicity Study
4 - Fluoro - 3 - Methylbenzeneboronic Acid, it is also a chemical substance. In today's world, it is used in the field of engineering and scientific research. However, its toxicity cannot be ignored.
Our research, we want to understand the shadow of its biological. With the general biological, its physiological and biochemical properties. Observe the role of its cells, or its replacement, or the harm of the cells. And in the material, there are also similar images. Or cause the weight of the material, or make the device have a problem.
If it is used, the toxicity cannot be ignored. It must be further studied to know its harm, and if it can be used, it will be beneficial to avoid harm and protect the safety of the product.
Future Prospects
Wuguan 4 - Fluoro - 3 - Methylbenzeneboronic Acid This substance has unique properties and a wide range of uses. In today's chemical research, it has been seen emerging. Future development can be expected.
It is expected that in the future, with the advancement of science and technology, the deeper the investigation of its properties, more potential will be discovered. Or in the field of medicine, to help the research and development of new drugs to cure more diseases; or in materials science, to provide key elements for the creation of new materials, so that the material properties are better.
Furthermore, the synthesis method will also be optimized, the efficiency will be improved, the cost will be reduced, and its production will be more convenient. This is the future can look forward to the scene, we should look forward to the heart, looking forward to the brilliant future of 4 - Fluoro - 3 - Methylbenzeneboronic Acid.
Where to Buy 4-Fluoro-3-Methylbenzeneboronic Acid in China?
As a trusted 4-Fluoro-3-Methylbenzeneboronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 4-Fluoro-3-Methylbenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-Fluoro-3-Methylbenzeneboronic Acid?
4-Fluoro-3-methylphenylboronic acid has a wide range of uses. In the field of organic synthesis, it is a key intermediate. It can participate in the Suzuki coupling reaction, which can efficiently form carbon-carbon bonds. Through this reaction, chemists can connect it with halogenated aromatics or olefins to generate many organic compounds with special structures and properties, which are of great significance in drug development, materials science and many other fields.
In drug development, compounds synthesized from 4-fluoro-3-methylphenylboronic acid through the Suzuki coupling reaction may have unique physiological activities or may become active ingredients of new drugs. For example, anticancer drugs with specific targeting properties can be synthesized to target specific cancer cells, improving therapeutic effects and reducing side effects.
It also plays an important role in the field of materials science. By participating in organic synthesis reactions, materials with special photoelectric properties can be prepared. For example, materials that can be applied to organic Light Emitting Diodes (OLEDs) can be synthesized to improve their luminous efficiency and stability, making display screens clearer and more energy efficient.
In addition, 4-fluoro-3-methylphenylboronic acid is also indispensable in the preparation of fine chemical products. It can provide key structural units for the synthesis of special fragrances, pigments, etc., endowing products with unique properties and functions to meet market demand for high-quality fine chemical products.
What are the physical properties of 4-Fluoro-3-Methylbenzeneboronic Acid?
4-Fluoro-3-methylphenylboronic acid, its physical properties are as follows:
This substance is usually white to light yellow solid powder. Looking at its shape, the powder texture is relatively fine and uniform, which is conducive to increasing the contact area with other reactants in many chemical reactions, thereby promoting the reaction.
When it comes to the melting point, it is within a certain range. The melting point value is crucial for determining its purity and the feasibility of participating in the reaction under specific temperature conditions. The melting point is relatively stable. If the impurities contained increase, the melting point will tend to decrease and the melting range will become wider.
In terms of solubility, 4-fluoro-3-methylphenylboronic acid exhibits different solubility characteristics in some common organic solvents. In polar organic solvents such as methanol and ethanol, it can have a certain solubility, which is attributed to the interaction between the polarity of the boric acid groups in the molecular structure and the molecules of these solvents. However, in non-polar solvents such as n-hexane, its solubility is very small, because the molecule as a whole is not completely non-polar, and the interaction with non-polar solvent molecules is weak.
In addition, its density is also a specific value, and this density parameter is of great significance when it comes to solution preparation and substance separation operations. Knowing its density can accurately determine the distribution in the mixed system and perform relevant metrological calculations.
In terms of stability, it can maintain a relatively stable chemical structure in a dry environment at room temperature and pressure. However, it is necessary to avoid contact with strong oxidants, strong bases and other substances to prevent chemical reactions from causing structural changes. If it is in a humid environment, boric acid groups may have a certain impact on their physical properties and subsequent chemical properties due to factors such as moisture absorption.
What are the synthetic methods of 4-Fluoro-3-Methylbenzeneboronic Acid?
There are several methods for the synthesis of 4-fluoro-3-methylphenylboronic acid as follows.
First, 4-fluoro-3-methylbromobenzene is used as the starting material. First, it is combined with magnesium chips in anhydrous ether or tetrahydrofuran in a low temperature and nitrogen-protected atmosphere to initiate a Grignard reaction to generate 4-fluoro-3-methylphenylmagnesium bromide. This reaction needs to be handled with caution. Due to the high activity of Grignard reagents, the reaction conditions are strict. Subsequently, the obtained Grignard reagent is reacted with borate esters, such as trimethyl borate or triethyl borate, at low temperature. After the reaction is completed, 4-fluoro-3-methylphenylboronic acid can be obtained by hydrolysis. The steps of this method are relatively clear, but the Grignard reaction conditions are difficult to control, and a strict anhydrous and anaerobic environment is required.
Second, the palladium-catalyzed Suzuki coupling reaction strategy can be used. 4-fluoro-3-methylhalobenzene (such as chlorobenzene, bromobenzene, etc.) and boric acid pinacol ester are used as reactants. In the reaction system, palladium catalysts, such as tetra (triphenylphosphine) palladium (0), etc., and bases, such as potassium carbonate, sodium carbonate, etc., are added to react in organic solvents, such as dioxane, toluene and water. This reaction condition is relatively mild, with good selectivity, and can effectively avoid the occurrence of many side reactions, but the price of palladium catalysts is expensive, which will increase the cost.
Third, 4-fluoro-3-methylaniline is used as the starting material. First, the amino group is converted into a diazonium salt by diazotization. Then it reacts with sodium borohydride and an appropriate amount of additives to replace the diazo group with boron group, and then generates 4-fluoro-3-methylphenylboronic acid. Although this route has a little more steps, the raw material 4-fluoro-3-methylaniline is relatively easy to obtain, and the diazotization reaction technology is mature and easy to operate and control.
4-Fluoro-3-Methylbenzeneboronic Acid during storage and transportation
4-Fluoro-3-methylphenylboronic acid is an important reagent for organic synthesis. During storage and transportation, many matters need careful attention.
First of all, this compound needs to be stored in a dry and cool place. Because it has a certain chemical activity, it is easy to react in case of moisture and cause deterioration, so moisture prevention is extremely important. The humidity in the warehouse should be controlled in a moderate range, and the humidity should not be too high. And a cool environment can slow down its chemical reaction rate and maintain its chemical stability. If placed in a high temperature place, or cause adverse changes such as decomposition.
Furthermore, it should be kept away from fire sources and oxidants. 4-Fluoro-3-methylphenylboronic acid may react violently when exposed to open flames or strong oxidizing agents, and may cause fire or explosion. When storing, it must be placed separately from such dangerous substances, with obvious signs and intervals.
When transporting, the packaging must be sturdy and tight. Choose suitable packaging materials to effectively protect it from vibration and collision damage. And the outside of the package should also be clearly marked with warning labels, indicating its chemical properties and key points to pay attention to, so that the transporter can understand.
In addition, the control of temperature during transportation cannot be ignored. According to its characteristics, maintain a suitable temperature range to avoid quality problems caused by drastic temperature changes. At the same time, transportation personnel should be familiar with emergency handling methods, and in case of emergencies such as leaks, they can respond quickly and properly to minimize harm.
What is the market price range for 4-Fluoro-3-Methylbenzeneboronic Acid?
The market price range of 4-fluoro-3-methylphenylboronic acid is difficult to determine with certainty. The price of the cover varies due to various reasons, and the following is a detailed analysis for you.
The first to bear the brunt are the manufacturers and brands. Different manufacturers, due to different production processes, raw material quality, and brand reputation, produce 4-fluoro-3-methylphenylboronic acid at very different prices. Large factories with outstanding reputation and excellent craftsmanship have high product quality and high prices; while emerging or unknown manufacturers, in order to compete for the market, have slightly lower prices.
Furthermore, product purity has a great impact. If it is used in high-end scientific research or pharmaceutical synthesis, high-purity products are required, and the preparation process is complicated, the cost is high, and the price is naturally high; while the purity requirements are slightly lower, for general industrial purposes, the price should be relatively low.
The market supply and demand situation also affects its price. If the demand for 4-fluoro-3-methylphenylboronic acid increases sharply at a certain time, but the supply is limited, according to market rules, the price will rise; on the contrary, if the supply is abundant and the demand is weak, the price may drop.
The number of purchases is also related to the price. Generally speaking, when purchasing in bulk, the manufacturer may give a certain discount for small profits but quick turnover, and the unit price will be reduced; if you buy sporadically, the price may be relatively high.
Looking at past market conditions, its price fluctuations are not small. For those with high purity and excellent quality, the price per gram may reach tens or even hundreds of yuan; while for products with slightly lower purity and for ordinary industrial applications, the price per gram may be between a few yuan and a dozen yuan.
To sum up, in order to know the exact price range of 4-fluoro-3-methylphenylboronic acid, it is necessary to comprehensively consider various factors such as manufacturers, purity, supply and demand, and purchase volume, and to clarify the specific transaction scenario.