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What are the chemical properties of 4-Fluoro-3- (Methoxycarbonyl) Benzeneboronic Acid
4-Fluoro-3- (methoxycarbonyl) phenylboronic acid, this is an organic chemical with unique chemical properties. In its structure, the benzene ring is the basic structure, and the boron atom is connected to the benzene ring, together with two hydroxyl groups to form a boric acid group, showing weak acidity. It can release protons in aqueous solution, and can form stable cyclic borate esters with compounds with o-diol structures. This property is widely used in the fields of glycoprotein, carbohydrate detection and separation.
Methoxycarbonyl group is connected to the benzene ring as an electron-withdrawing group, which affects the electron cloud density of the benzene ring by induction effect and conjugation effect, so that the electron cloud density of the benzene ring is reduced, and the meta-position is relatively high. This results in the change of the electrophilic substitution activity of the benzene ring, and the electrophilic substitution activity is lower than that of benzene due to the electron-withdrawing effect, and the reaction tends to interposition. Fluorine atoms are also connected to the benzene ring. Due to their large electronegativity, they have a significant impact on the electron cloud distribution of the benzene ring, changing the reactivity and selectivity of the benzene ring.
In the field of organic synthesis, this compound is a key intermediate. Boric acid groups can be coupled with halogenated aromatics or olefins under the catalysis of palladium through Suzuki-Miyaura coupling reactions, etc., to form carbon-carbon bonds with halogenated aromatics or olefins to realize the construction of complex organic molecules, which are used in pharmaceutical chemistry, materials science, etc., to synthe Due to the presence of methoxycarbonyl and fluorine atoms, specific functional groups can be introduced into the target product, which endows the product with unique physical and chemical properties and biological activities.
What are the common synthesis methods of 4-Fluoro-3- (Methoxycarbonyl) Benzeneboronic Acid
4-Fluoro-3- (methoxycarbonyl) phenylboronic acid is a commonly used reagent in organic synthesis. The common synthesis methods are as follows:
First, 4-fluoro-3- (methoxycarbonyl) bromobenzene is used as the starting material. First, 4-fluoro-3- (methoxycarbonyl) bromobenzene is reacted with magnesium chips in anhydrous ether or tetrahydrofuran to make Grignard's reagent. During this process, the reaction system needs to be kept anhydrous and oxygen-free to ensure the stability of Grignard's reagent. Then, the prepared Grignard reagent is reacted with trimethyl borate at low temperature, and the reaction is completed. After hydrolysis treatment, 4-fluoro-3- (methoxycarbonyl) phenylboronic acid can be obtained. The operation steps of this method are relatively clear, but the preparation conditions of Grignard reagent are harsh, and a strict anhydrous and anaerobic environment is required.
Second, 4-fluoro-3- (methoxycarbonyl) iodobenzene is used as the raw material, and the borination reaction is catalyzed by palladium. In the presence of palladium catalysts (such as tetra (triphenylphosphine) palladium, etc.) and ligands (such as tri-tert-butylphosphine, etc.), 4-fluoro-3- (methoxycarbonyl) iodobenzene reacts with diphenacol borate. This reaction is usually carried out in an organic solvent (such as toluene, dioxane, etc.), and the reaction process needs to be protected by inert gas. After the reaction is completed, the target product can be obtained after appropriate post-treatment. This method has the advantages of relatively mild reaction conditions and good selectivity, but palladium catalysts are expensive and costly.
Third, 4-fluoro-3- (methoxycarbonyl) benzoic acid is used as the starting material. First convert it into the corresponding acyl chloride, and chlorination reagents such as dichlorosulfoxide can be selected. The obtained acyl chloride is then reacted with reagents such as sodium borohydride and boric acid under appropriate conditions to obtain 4-fluoro-3- (methoxycarbonyl) phenylboronic acid. The raw materials of this method are relatively common, but there are many reaction steps, and the treatment of intermediate products also needs to be handled with caution.
In short, different synthesis methods have their own advantages and disadvantages. In practical applications, it is necessary to comprehensively consider many factors such as raw material availability, cost, reaction conditions and product purity requirements to choose the most suitable synthesis path.
In which fields is 4-Fluoro-3- (Methoxycarbonyl) Benzeneboronic Acid used?
4-Fluoro-3- (methoxycarbonyl) phenylboronic acid is widely used in the field of organic synthesis. It can be used to construct complex organic molecular structures, just like the delicate tools in the hands of skilled craftsmen, which facilitate the formation of carbon-carbon bonds and carbon-heteroatomic bonds.
In the field of medicinal chemistry, this compound has also made its mark. By precisely interacting with specific targets, it can help to develop drugs with novel structures and excellent activities. It may be a key intermediate for the synthesis of new drugs for the treatment of intractable diseases, and is of great significance for the improvement of human health and well-being.
In the field of materials science, 4-fluoro-3- (methoxycarbonyl) phenylboronic acid also has its uses. It can participate in the preparation of materials with special properties, such as optoelectronic materials. Its unique chemical structure can endow materials with different optical and electrical properties, opening up new paths for the development of materials science.
In addition, in chemical biology, this compound can be used as a probe molecule to explore chemical reactions and biological processes in living organisms. Like a keen "scout", it helps scientists gain insight into the mysteries of life and deeply understand the interaction mechanism between biomolecules, contributing to solving the mysteries of life science.
What are the storage conditions for 4-Fluoro-3- (Methoxycarbonyl) Benzeneboronic Acid?
4-Fluoro-3- (methoxycarbonyl) phenylboronic acid, which is an important reagent in organic synthesis. Its storage conditions need to be treated carefully to ensure its quality and activity.
This reagent should be stored in a cool and dry place. In a cool place, the temperature is stable, which can avoid the decomposition or deterioration of the reagent due to excessive temperature. There is no water vapor intrusion in the dry place, because water can react with many boric acid compounds, causing it to deactivate. The storage place should be well ventilated to avoid the accumulation of harmful gases and adverse reactions with the reagent.
Furthermore, 4-fluoro-3- (methoxycarbonyl) phenylboronic acid is sensitive to air, so it should be sealed and stored. A sealed container can be used, such as a glass or plastic bottle. The cap must be tightened to prevent air from entering. To ensure the sealing effect, a rubber gasket or sealing film can be placed on the mouth of the bottle.
If stored for a long time, it should be placed in a low temperature environment, such as the refrigerator's refrigerator compartment (about 2-8 ° C). Low temperature can reduce its chemical reaction rate and prolong the shelf life. However, when taking it, it should be restored to room temperature, and then used unsealed to avoid damage to the reagent due to sudden changes in temperature.
In addition, the storage place should be kept away from fire sources and oxidants. Although the reagent is not flammable, it may be dangerous to encounter open flames or strong oxidants. Oxidants can cause oxidation reactions and cause deterioration.
In conclusion, 4-fluoro-3- (methoxycarbonyl) phenylboronic acid should be stored in a cool, dry, ventilated and sealed environment, or supplemented by low temperature, away from ignition and oxidants, so as to maintain its quality and activity, and play its due role in organic synthesis experiments.
What is the market price of 4-Fluoro-3- (Methoxycarbonyl) Benzeneboronic Acid
I think what you are asking is the market price of 4-fluoro-3- (methoxycarbonyl) phenylboronic acid. However, this price is variable and varies with many factors.
First, the state of supply and demand affects its price. If there are many people who want it, but the supply is small, the price will rise; on the contrary, if the supply exceeds the demand, the price will drop.
Second, the price of raw materials also affects. The synthesis of this product requires all kinds of raw materials. If the price of raw materials increases and the cost increases, the price will also increase; if the price of raw materials decreases, the price may decrease.
Third, the preparation method and the complexity of the process are related to the cost, which in turn affects the price.
Fourth, the market competition situation is important. There are many manufacturers, and the competition is fierce. In order to compete for market share, or reduce its price; there are few manufacturers, the competition is slow, and the price may be stable and high.
Fifth, the price varies from region to region. In a place with smooth traffic and economic prosperity, and convenient logistics, the cost may be low, and the price may be different from remote places.
To sum up, if you want to know the exact price, you should consult chemical raw material suppliers, traders, or check the recent transaction price on the chemical product trading platform to get a more accurate number.