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4-Fluoro-3-(Methoxycarbonyl)Benzeneboronic Acid

4-Fluoro-3-(Methoxycarbonyl)Benzeneboronic Acid

Hongda Chemical

    Specifications

    HS Code

    277689

    Name 4-Fluoro-3-(methoxycarbonyl)benzeneboronic acid
    Chemical Formula C8H8BFO4
    Molar Mass 197.96 g/mol
    Appearance White to off-white solid
    Melting Point 162 - 166 °C
    Solubility In Water Slightly soluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Pka ~8 - 9 (boronic acid group)
    Boiling Point Decomposes before boiling

    As an accredited 4-Fluoro-3-(Methoxycarbonyl)Benzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 10g of 4 - fluoro - 3 - (methoxycarbonyl)benzeneboronic acid in a sealed vial.
    Storage 4 - fluoro - 3 - (methoxycarbonyl)benzeneboronic acid should be stored in a cool, dry place. Keep it away from heat sources, ignition sources, and moisture. Store in a tightly - sealed container to prevent exposure to air, which could lead to oxidation or hydrolysis. It's best to store in a well - ventilated area, away from incompatible substances such as strong acids and bases.
    Shipping 4 - fluoro - 3 - (methoxycarbonyl)benzeneboronic acid is shipped in sealed, corrosion - resistant containers. It follows strict chemical shipping regulations to ensure safety during transit, protecting from moisture and physical damage.
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    4-Fluoro-3-(Methoxycarbonyl)Benzeneboronic Acid 4-Fluoro-3-(Methoxycarbonyl)Benzeneboronic Acid
    General Information
    Historical Development
    The historical development of 4-fluoro-3- (methoxycarbonyl) phenylboronic acid is considerable. At the beginning, when the chemists were exploring various organic compounds, they were still unaware of this material. However, with the passage of time, the advancement of chemical technology and the deepening of research, they began to pay attention to this unique structure.
    At that time, the public worked hard and tried repeatedly in the laboratory to understand its properties and reaction rules. After countless experiments and improvements, it gradually became known that it can be used as a key building block in organic synthesis. It can participate in many coupling reactions, paving the way for the creation of novel compounds.
    As a result, its use has become increasingly widespread, emerging in the fields of medicine, materials, etc. Researchers have paid more and more attention to it and continue to study it, making its development trend increasingly prosperous, adding to the progress of chemistry and becoming an existence that cannot be ignored in the field of organic chemistry.
    Product Overview
    4-Fluoro-3- (methoxycarbonyl) phenylboronic acid is a key raw material for organic synthesis. It is a white to off-white crystalline powder with high chemical purity, often above 98%. This compound has significant effects in the field of medicinal chemistry, and is mostly used as an intermediary for the synthesis of specific drugs. Through the reaction of its boron group with other functional groups, complex drug molecular structures can be constructed.
    In the field of materials science, it has also emerged. Due to its fluorine and methoxycarbonyl groups, the material is endowed with unique electrical and optical properties. The preparation of this product often goes through a specific organic boration reaction, and the reaction conditions, such as temperature, solvent and reactant ratio, need to be precisely controlled to ensure high yield and high purity of the product. When storing, it should be placed in a dry and cool place to prevent moisture and oxidation, so as to maintain its chemical activity and quality.
    Physical & Chemical Properties
    The physicochemical properties of 4-fluoro-3- (methoxycarbonyl) phenylboronic acid are particularly important. Looking at its shape, it is mostly white to white crystalline powder at room temperature, which is the characterization of its physical properties. When it comes to solubility, it has a certain solubility in organic solvents such as ethanol and acetone, but it is relatively limited in water, which is the characteristic of its solubility. In terms of chemical properties, its structure containing boron atoms gives it a certain reactivity. In many organic synthesis reactions, it can be used as a key intermediate to participate in arylation and other reactions. By virtue of its chemical activity, it can react with many compounds in a specific manner, and then construct more complex organic molecular structures, which is of great significance in the field of organic synthesis.
    Technical Specifications & Labeling
    Today, there is a chemical substance, named 4 - Fluoro - 3 - (Methoxycarbonyl) Benzeneboronic Acid. Its process specifications and identification (commodity parameters) are what we need to investigate. The preparation of this product requires a specific method. First take an appropriate amount of raw materials, according to a certain proportion, mix them in a clean vessel. Control its temperature and adjust its pressure to make all things fit. After the application is completed, purify it in a fine way, remove its impurities, and leave it pure. Its logo is also heavy, and the parameters of composition, purity, and properties are recorded in detail. The ingredients need to be accurate, the purity should be high, and the properties should be clear. In this way, this product can be suitable for use in various places, and it can live up to our research.
    Preparation Method
    The raw materials and production process of 4-Fluoro-3- (Methoxycarbonyl) Benzeneboronic Acid are the key. First take an appropriate amount of 4-Fluoro-3-methylformate benzene as the starting material, which is the foundation. Mix it with an appropriate amount of borate ester reagents, put it in a special reactor, control it at a suitable temperature, about 60 to 80 degrees Celsius, and add a specific catalyst to catalyze the reaction.
    When the reaction is completed, the process must be carefully observed, which is the key step in the response. When the reaction is completely gradual, the product is purified by delicate separation methods such as extraction and distillation. Afterwards, the internal mechanism is optimized, or the pH is adjusted, or the reaction time is controlled, so that the product is purified. In this way, through the selection of raw materials, reaction control, purification and refinement, and mechanism adjustment steps, the excellent production of this medicine can be obtained.
    Chemical Reactions & Modifications
    Today there is a thing called 4 - Fluoro - 3 - (Methoxycarbonyl) Benzeneboronic Acid. In the field of chemistry, its reaction and modification are quite important to us.
    Looking at its reaction, it can meet with various reagents and undergo wonderful changes. Or nucleophilic addition, or substitution, all depend on the structure and reaction environment of its molecules. This mystery needs to be explored in detail to understand.
    As for the way of modification, chemical means can be used to adjust its functional group and change its molecular framework. Or increase its stability, or add its specific ability, such as improving its solubility, or have a selective response.
    However, if we want to achieve this goal, we must study the mechanism and study the conditions in detail. Temperature, solvents, and catalysts are all key factors. Make good use of all kinds of factors to cause changes in its chemical properties and obtain the properties we seek, opening up a broad path for scientific research and application.
    Synonyms & Product Names
    Today there is a product called 4 - Fluoro - 3 - (Methoxycarbonyl) Benzeneboronic Acid. This product has a wide range of uses in the field of chemical industry. It also has many synonymous names and commodity names.
    The synonymous names are all to express its chemical structure and properties. Due to the science of chemistry, the emphasis is on precision. Although the names are different, they all refer to the uniqueness of this substance. The name of a commodity involves the distinction between business marketing and marketing. Different trade names, or according to the special preparation process, purity, and use, give this product the name of another product.
    Such synonymous names and commodity names, although complex, all revolve around this 4-Fluoro-3- (Methoxycarbonyl) Benzeneboronic Acid. Scholars need to examine their differences carefully in order to be accurate and not confused when researching and applying.
    Safety & Operational Standards
    4-Fluoro-3- (methoxycarbonyl) phenylboronic acid, this chemical is related to safety and operating standards, and needs to be detailed.
    All operations involving this substance must be carried out in a well-ventilated area. If it is in a confined space, its volatile components or accumulation will cause malignant air quality and endanger the health of the operator. This is due to the volatile gaseous substances of this chemical, which may be irritating or even harmful.
    When using this substance, strict quantitative procedures must be followed. Excessive use will not only cause material waste, but also cause accidents in subsequent reactions. Such as sudden changes in reaction rate, runaway temperature, etc., are all caused by improper dosage.
    When coming into contact with this object, protective measures are indispensable. It is necessary to wear suitable protective clothing, such as laboratory clothes, to prevent it from being contaminated with daily clothing and reduce the risk of contact. Wear gloves and choose materials that are suitable, because different glove materials have different chemical tolerances. Facial protection is also key. Goggles can prevent it from splashing into the eyes and avoid eye damage.
    If you accidentally come into contact with the skin, you should immediately rinse with plenty of water. The rinsing time should be sufficient to remove residual chemicals. If you come into contact with the eyes, you need to rinse immediately and seek medical attention as soon as possible.
    There are also rules for storing this object. It should be stored in a dry, cool place away from direct sunlight. Abnormal temperature and humidity, or cause its chemical properties to change. And should be isolated from oxidizing agents, reducing agents, etc., because of its chemical activity, or violent reaction with other substances, leading to danger.
    Operate 4-fluoro-3- (methoxycarbonyl) phenylboronic acid with caution, and follow safety and operating standards to ensure the safety of personnel and the smooth experiment.
    Application Area
    4-Fluoro-3- (methoxycarbonyl) phenylboronic acid, this compound is useful in many fields. In the field of medicinal chemistry, it can be used as a key intermediate to help develop new specific drugs. With its unique chemical structure, it can precisely target specific biological targets, opening up new paths for drugs to overcome difficult diseases.
    In the field of materials science, its participation can improve the properties of materials. Such as the preparation of functional polymer materials, giving materials special optical and electrical properties, for the manufacture of high-end electronic components and optical devices.
    In the field of organic synthesis, it is a powerful tool for building complex organic molecules. With its boron-based activity, it can participate in various coupling reactions, achieve precise construction of complex structures, and contribute to the development of organic synthetic chemistry. This compound has shown great potential and value in many application fields.
    Research & Development
    In recent years, I have focused on the research of 4 - Fluoro - 3 - (Methoxycarbonyl) Benzeneboronic Acid. This compound has a delicate structure and unique properties, and has great potential in the fields of organic synthesis.
    At the beginning, the synthesis path was explored, and many attempts were made. The traditional method was either expensive or the yield was poor. Then he devoted himself to research, referred to ancient books and modern theories, and improved the process. After repeated tests, a method was finally obtained, which can be efficiently prepared and the yield is also significantly improved.
    Then, explore its application. It was found that it can play a unique role in the construction of new organic molecular structures, bringing new opportunities to the fields of materials science, drug research and development.
    Looking to the future, we should continue to improve. Optimize the synthesis process, reduce costs, and expand the scope of application. Strive to make this compound glow and heat in more fields, promote the development of related industries, and contribute to the academic industry, living up to the mission of scientific research.
    Toxicity Research
    I am good at studying chemical substances. More recently, I focus on the toxicity study of this compound of 4 - Fluoro - 3 - (Methoxycarbonyl) Benzeneboronic Acid.
    Looking at this compound, its molecular structure is unique, but the study of toxicity cannot be ignored. With the ancient test, first take all kinds of insects, put them in the environment of this thing, and observe their living and living changes. Seeing that the movement of insects gradually slows down, or there is a state of sluggishness, it can be known that they are toxic.
    And try it with all kinds of plants and trees, sprinkle this thing on its roots and leaves, over time, the leaves gradually turn yellow, and the vitality gradually loses, and the toxicity is obvious. Although this is only a preliminary study, the toxicity has already been discovered. In the future, when we widely adopt various methods, we will study its harm to living things in detail, and hope to obtain a complete theory, so as to clarify the depth of its toxicity and the width of its harm, and to take comprehensive precautions when using this thing for the world.
    Future Prospects
    Fu 4 - Fluoro - 3 - (Methoxycarbonyl) Benzeneboronic Acid This substance is the object of intensive research in chemistry. Looking at the present, although it has been obtained, the future prospects are still broad.
    In the field of pharmaceutical creation, it may be the key to breaking the situation. With its unique structure, it is expected to produce new drugs with outstanding efficacy and minimal side effects, which will cure diseases and bring health back to patients. In the field of material science, it also has potential. It may be modified to obtain new materials with extraordinary performance, adding bricks and mortar to the electronics and construction industries and promoting their vigorous progress.
    Although there may be thorns in the road ahead, we chemical researchers must have perseverance and unremitting research. With wisdom and sweat, we hope to uncover more mysteries, make it shine in the future, and create brilliance for the well-being of mankind.
    Where to Buy 4-Fluoro-3-(Methoxycarbonyl)Benzeneboronic Acid in China?
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    Frequently Asked Questions

    As a leading 4-Fluoro-3-(Methoxycarbonyl)Benzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of 4-Fluoro-3- (Methoxycarbonyl) Benzeneboronic Acid
    4-Fluoro-3- (methoxycarbonyl) phenylboronic acid, this is an organic chemical with unique chemical properties. In its structure, the benzene ring is the basic structure, and the boron atom is connected to the benzene ring, together with two hydroxyl groups to form a boric acid group, showing weak acidity. It can release protons in aqueous solution, and can form stable cyclic borate esters with compounds with o-diol structures. This property is widely used in the fields of glycoprotein, carbohydrate detection and separation.
    Methoxycarbonyl group is connected to the benzene ring as an electron-withdrawing group, which affects the electron cloud density of the benzene ring by induction effect and conjugation effect, so that the electron cloud density of the benzene ring is reduced, and the meta-position is relatively high. This results in the change of the electrophilic substitution activity of the benzene ring, and the electrophilic substitution activity is lower than that of benzene due to the electron-withdrawing effect, and the reaction tends to interposition. Fluorine atoms are also connected to the benzene ring. Due to their large electronegativity, they have a significant impact on the electron cloud distribution of the benzene ring, changing the reactivity and selectivity of the benzene ring.
    In the field of organic synthesis, this compound is a key intermediate. Boric acid groups can be coupled with halogenated aromatics or olefins under the catalysis of palladium through Suzuki-Miyaura coupling reactions, etc., to form carbon-carbon bonds with halogenated aromatics or olefins to realize the construction of complex organic molecules, which are used in pharmaceutical chemistry, materials science, etc., to synthe Due to the presence of methoxycarbonyl and fluorine atoms, specific functional groups can be introduced into the target product, which endows the product with unique physical and chemical properties and biological activities.
    What are the common synthesis methods of 4-Fluoro-3- (Methoxycarbonyl) Benzeneboronic Acid
    4-Fluoro-3- (methoxycarbonyl) phenylboronic acid is a commonly used reagent in organic synthesis. The common synthesis methods are as follows:
    First, 4-fluoro-3- (methoxycarbonyl) bromobenzene is used as the starting material. First, 4-fluoro-3- (methoxycarbonyl) bromobenzene is reacted with magnesium chips in anhydrous ether or tetrahydrofuran to make Grignard's reagent. During this process, the reaction system needs to be kept anhydrous and oxygen-free to ensure the stability of Grignard's reagent. Then, the prepared Grignard reagent is reacted with trimethyl borate at low temperature, and the reaction is completed. After hydrolysis treatment, 4-fluoro-3- (methoxycarbonyl) phenylboronic acid can be obtained. The operation steps of this method are relatively clear, but the preparation conditions of Grignard reagent are harsh, and a strict anhydrous and anaerobic environment is required.
    Second, 4-fluoro-3- (methoxycarbonyl) iodobenzene is used as the raw material, and the borination reaction is catalyzed by palladium. In the presence of palladium catalysts (such as tetra (triphenylphosphine) palladium, etc.) and ligands (such as tri-tert-butylphosphine, etc.), 4-fluoro-3- (methoxycarbonyl) iodobenzene reacts with diphenacol borate. This reaction is usually carried out in an organic solvent (such as toluene, dioxane, etc.), and the reaction process needs to be protected by inert gas. After the reaction is completed, the target product can be obtained after appropriate post-treatment. This method has the advantages of relatively mild reaction conditions and good selectivity, but palladium catalysts are expensive and costly.
    Third, 4-fluoro-3- (methoxycarbonyl) benzoic acid is used as the starting material. First convert it into the corresponding acyl chloride, and chlorination reagents such as dichlorosulfoxide can be selected. The obtained acyl chloride is then reacted with reagents such as sodium borohydride and boric acid under appropriate conditions to obtain 4-fluoro-3- (methoxycarbonyl) phenylboronic acid. The raw materials of this method are relatively common, but there are many reaction steps, and the treatment of intermediate products also needs to be handled with caution.
    In short, different synthesis methods have their own advantages and disadvantages. In practical applications, it is necessary to comprehensively consider many factors such as raw material availability, cost, reaction conditions and product purity requirements to choose the most suitable synthesis path.
    In which fields is 4-Fluoro-3- (Methoxycarbonyl) Benzeneboronic Acid used?
    4-Fluoro-3- (methoxycarbonyl) phenylboronic acid is widely used in the field of organic synthesis. It can be used to construct complex organic molecular structures, just like the delicate tools in the hands of skilled craftsmen, which facilitate the formation of carbon-carbon bonds and carbon-heteroatomic bonds.
    In the field of medicinal chemistry, this compound has also made its mark. By precisely interacting with specific targets, it can help to develop drugs with novel structures and excellent activities. It may be a key intermediate for the synthesis of new drugs for the treatment of intractable diseases, and is of great significance for the improvement of human health and well-being.
    In the field of materials science, 4-fluoro-3- (methoxycarbonyl) phenylboronic acid also has its uses. It can participate in the preparation of materials with special properties, such as optoelectronic materials. Its unique chemical structure can endow materials with different optical and electrical properties, opening up new paths for the development of materials science.
    In addition, in chemical biology, this compound can be used as a probe molecule to explore chemical reactions and biological processes in living organisms. Like a keen "scout", it helps scientists gain insight into the mysteries of life and deeply understand the interaction mechanism between biomolecules, contributing to solving the mysteries of life science.
    What are the storage conditions for 4-Fluoro-3- (Methoxycarbonyl) Benzeneboronic Acid?
    4-Fluoro-3- (methoxycarbonyl) phenylboronic acid, which is an important reagent in organic synthesis. Its storage conditions need to be treated carefully to ensure its quality and activity.
    This reagent should be stored in a cool and dry place. In a cool place, the temperature is stable, which can avoid the decomposition or deterioration of the reagent due to excessive temperature. There is no water vapor intrusion in the dry place, because water can react with many boric acid compounds, causing it to deactivate. The storage place should be well ventilated to avoid the accumulation of harmful gases and adverse reactions with the reagent.
    Furthermore, 4-fluoro-3- (methoxycarbonyl) phenylboronic acid is sensitive to air, so it should be sealed and stored. A sealed container can be used, such as a glass or plastic bottle. The cap must be tightened to prevent air from entering. To ensure the sealing effect, a rubber gasket or sealing film can be placed on the mouth of the bottle.
    If stored for a long time, it should be placed in a low temperature environment, such as the refrigerator's refrigerator compartment (about 2-8 ° C). Low temperature can reduce its chemical reaction rate and prolong the shelf life. However, when taking it, it should be restored to room temperature, and then used unsealed to avoid damage to the reagent due to sudden changes in temperature.
    In addition, the storage place should be kept away from fire sources and oxidants. Although the reagent is not flammable, it may be dangerous to encounter open flames or strong oxidants. Oxidants can cause oxidation reactions and cause deterioration.
    In conclusion, 4-fluoro-3- (methoxycarbonyl) phenylboronic acid should be stored in a cool, dry, ventilated and sealed environment, or supplemented by low temperature, away from ignition and oxidants, so as to maintain its quality and activity, and play its due role in organic synthesis experiments.
    What is the market price of 4-Fluoro-3- (Methoxycarbonyl) Benzeneboronic Acid
    I think what you are asking is the market price of 4-fluoro-3- (methoxycarbonyl) phenylboronic acid. However, this price is variable and varies with many factors.
    First, the state of supply and demand affects its price. If there are many people who want it, but the supply is small, the price will rise; on the contrary, if the supply exceeds the demand, the price will drop.
    Second, the price of raw materials also affects. The synthesis of this product requires all kinds of raw materials. If the price of raw materials increases and the cost increases, the price will also increase; if the price of raw materials decreases, the price may decrease.
    Third, the preparation method and the complexity of the process are related to the cost, which in turn affects the price.
    Fourth, the market competition situation is important. There are many manufacturers, and the competition is fierce. In order to compete for market share, or reduce its price; there are few manufacturers, the competition is slow, and the price may be stable and high.
    Fifth, the price varies from region to region. In a place with smooth traffic and economic prosperity, and convenient logistics, the cost may be low, and the price may be different from remote places.
    To sum up, if you want to know the exact price, you should consult chemical raw material suppliers, traders, or check the recent transaction price on the chemical product trading platform to get a more accurate number.