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4-Fluoro-2-(Trifluoromethyl)Bromobenzene

4-Fluoro-2-(Trifluoromethyl)Bromobenzene

Hongda Chemical

    Specifications

    HS Code

    349935

    Chemical Formula C7H3BrF4
    Molecular Weight 257.00
    Appearance Liquid (usually)
    Color Colorless to light yellow
    Odor Characteristic organic odor
    Boiling Point 145 - 147 °C
    Density 1.72 g/cm³ (approximate)
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
    Flash Point 45 °C (approximate)
    Vapor Pressure Low (volatile organic compound)

    As an accredited 4-Fluoro-2-(Trifluoromethyl)Bromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 4 - fluoro - 2 - (trifluoromethyl)bromobenzene packaged in a sealed glass bottle.
    Storage 4 - fluoro - 2 - (trifluoromethyl)bromobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container made of suitable materials like glass or corrosion - resistant metal to prevent leakage and exposure to air or moisture, which could potentially cause decomposition or unwanted reactions.
    Shipping 4 - fluoro - 2 - (trifluoromethyl)bromobenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring safe transportation to prevent any leakage or risks.
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    4-Fluoro-2-(Trifluoromethyl)Bromobenzene 4-Fluoro-2-(Trifluoromethyl)Bromobenzene
    General Information
    Historical Development
    Those who have learned about chemistry in ancient times have studied substances and explored their mysteries. As for 4 - Fluoro - 2 - (Trifluoromethyl) Bromobenzene, there are also traces to be found. At the beginning, many scholars studied at the microscopic level to observe its physical properties and analyze its structure. Although it has been difficult, it has not changed.
    Years pass, technology improves day by day. Many people have improved their experimental methods, from crude to exquisite, from ignorance to clarity. The understanding of 4 - Fluoro - 2 - (Trifluoromethyl) Bromobenzene has also been tasted from the beginning, reaching deep into the bone marrow. The method of synthesis is constantly refined, the yield is gradually higher, and the quality is better.
    Looking at its historical development, it is like walking on a hidden path, exploring step by step, and finally seeing the light. This is not the work of one person, but the efforts of scholars of all dynasties have brought together, making this object from obscure to well-known to everyone, and it has been used in many fields, adding to the prosperity of chemistry.
    Product Overview
    4-Fluoro-2- (trifluoromethyl) bromobenzene is also a good product for organic synthesis. It is a colorless to light yellow liquid with a unique odor. This compound is widely used in the field of organic synthesis. In its molecular structure, fluorine, trifluoromethyl are cleverly connected to bromine atoms, giving it specific chemical properties.
    In organic reactions, it is often a key intermediate. With its active reactivity, it can be converted into other valuable compounds through many chemical reactions. For example, nucleophilic substitution reactions can be combined with a variety of nucleophiles to expand the structure of molecules. And because of its fluorine-containing group characteristics, it can improve the stability and lipophilicity of the product, etc., and it is very useful in the fields of medicine and pesticide creation. Preparation of this product requires fine craftsmanship and precise operation to obtain high-purity products to meet the needs of scientific research and industry.
    Physical & Chemical Properties
    4-Fluoro-2- (trifluoromethyl) bromobenzene is also an organic compound. Its properties are both physical and chemical. In terms of its physics, at room temperature, it is a colorless liquid with a specific odor. Its boiling point and melting point have fixed numbers, which are related to the force between its molecules. Density is also a characteristic, which is related to the density of the substance.
    As for chemical properties, it contains fluorine, bromine, trifluoromethyl and other groups, which are very active. Fluorine atoms have strong electronegativity, which changes the distribution of molecular electron clouds and affects their reactivity. Bromine atoms are often the check point for nucleophilic substitution reactions. Trifluoromethyl has strong electron absorption, which reduces the electron cloud density of the benzene ring, making it difficult for the electrophilic substitution reaction on the benzene ring to occur, and the ortho-para-localization effect is also changed by it. This compound is often a key raw material in the field of organic synthesis due to its unique physical and chemical properties. It helps to form a variety of organic molecules and is useful in the fields of medicine and materials.
    Technical Specifications & Labeling
    Today, there is a chemical substance 4 - Fluoro - 2 - (Trifluoromethyl) Bromobenzene, and its process specifications and identification (product parameters) are the key. To view this substance, it is necessary to clarify its preparation method, the raw materials used must comply with precise regulations, and the reaction conditions must also be controlled in detail. Such as temperature, pressure, duration, etc., are all factors that affect quality.
    On the label, there should be a clear name indicating its chemical composition and a precise molecular formula to clarify its structure. In the product parameters, the purity must reach a specific standard, and the impurity content must be limited to a strict degree, so as to ensure its stable performance. And its physical properties, such as melting point, boiling point, density, etc., should also be detailed for users to observe. In this way, it is possible to make good use of this material in the chemical industry and achieve the desired effect.
    Preparation Method
    To prepare 4 - Fluoro - 2 - (Trifluoromethyl) Bromobenzene, the raw materials and production process are the key. The selection of raw materials needs to be carefully selected, and the quality is better. In the production process, the reaction steps are particularly important.
    Take something as the base material first, and mix it with others according to a specific ratio. Control it at a suitable temperature, adjust the temperature, and make the two phase slowly. In the meantime, the reaction rate needs to be carefully observed, not too fast or too slow. When the reaction is initially formed, transfer it to a special device, and apply a separation method to remove its impurities and purify the product.
    Furthermore, the catalytic mechanism is also indispensable. Selecting the appropriate catalyst can promote the process of the reaction and improve the purity of the product. The amount of catalyst, when accurately measured, is less effective, and more or different. In this way, through layers of processes and rigorous operation, 4-Fluoro-2 - (Trifluoromethyl) Bromobenzene can be obtained, and the quality can also be guaranteed.
    Chemical Reactions & Modifications
    Modern chemical refinement, in the synthesis of organic, a wonderful way to layer out. 4 - Fluoro - 2 - (Trifluoromethyl) Bromobenzene This substance has been studied by chemists every time. At the beginning of its chemical reaction, it was prepared according to the usual method, and the yield was not good, and there were many impurities, which hindered its use.
    Later, the researchers worked hard to improve the conditions of the reaction, and studied the temperature, solvent, and catalyst carefully. After repeated tests, the temperature was changed to find the right one, the easy solvent was used to find the right one, and the catalyst was selected to promote the speed. Finally, the new method was obtained, and the reaction rate was greatly increased, the yield was also significantly increased, and the impurities were greatly reduced.
    From this point of view, chemical reactions are not static, good is changed, and performance can be optimized. Scholars should take delving into the business of seeking the beauty of reactions and the goodness of performance, so as to benefit the industry of chemistry and the use of the world.
    Synonyms & Product Names
    Today there is a thing called 4 - Fluoro - 2 - (Trifluoromethyl) Bromobenzene. This thing is especially important in the field of my chemical research.
    Its synonyms also refer to each other. The cover refers to this quality, and the names are different, all of which are used to facilitate academic communication. As for the name of the commodity, it also depends on the rules and uses. Although the names are different, they are actually the same thing.
    The science of chemistry is good at distinguishing physical properties and studying their changes. The name of this substance, whether it is a synonym or a commodity name, is to identify its uniqueness and facilitate researchers to distinguish it. Synonyms are either based on their structural characteristics or their reaction characteristics; trade names are often involved in market and use considerations. Although the two have different names, they both refer to this 4-Fluoro-2 - (Trifluoromethyl) Bromobenzene, which cannot be ignored.
    Safety & Operational Standards
    4 - Fluoro - 2 - (Trifluoromethyl) Bromobenzene is an important chemical compound in the field of chemistry. It is necessary to be cautious about the safety and operation of this compound.
    When taking and handling this compound, the first priority is to ventilate the environment. It should be done in a well-ventilated experimental site, preferably in a fume hood to prevent the accumulation of harmful gases and threaten the health of the experimenter. This compound has certain chemical activity, improper contact or danger. Therefore, the experimenter must be equipped with suitable protective equipment, such as protective gloves, and chemical-resistant materials must be selected to prevent it from penetrating into the skin of the hands; protective glasses are also indispensable, which can effectively resist the damage of the eyes that may be splashed. Wearing laboratory clothes can protect the body from accidental contamination.
    Furthermore, storage also has its own rules. It should be placed in a cool, dry place away from fire sources and oxidants. Because it may react violently with certain substances, it should be stored separately, marked, and key information such as name, nature and hazard should be indicated to prevent misuse.
    In terms of operation procedures, strictly follow established procedures. Measure the required amount accurately to avoid waste and danger caused by excessive use. If there is a spill during operation, take emergency measures immediately. If a small amount is spilled, cover it with highly adsorbent materials such as sand, activated carbon, etc., and handle it properly; if a large amount is spilled, in addition to the above operations, quickly evacuate personnel, seal the scene, and wait for professional personnel to deal with it.
    Disposal should not be ignored. It should not be dumped at will, and should be handed over to a professional organization in accordance with the regulations on chemical waste disposal. It should be disposed of in an environmentally friendly and safe manner to prevent pollution to the environment.
    In short, the safety and operation specifications of 4-Fluoro-2 - (Trifluoromethyl) Bromobenzene are interlinked, which is related to the safety of the experimenter and the environmental safety, and must not be ignored.
    Application Area
    4-Fluoro-2- (trifluoromethyl) bromobenzene is also an organic compound. Its application field is quite wide, in the field of medicinal chemistry, it can be a key intermediate, help to create new special drugs, and fight against various diseases, such as being a sharp blade for curing diseases and breaking the shackles of diseases. In material science, it is also indispensable, or it can prepare materials with special properties, such as corrosion resistance and wear resistance, optical specificity, just like masonry, which makes the material performance unique. In the field of pesticide chemistry, it can be used as the basis for efficient pesticide synthesis to help crops resist diseases and pests. If it is a field guard, it will ensure a harvest of grains. From this perspective, 4-fluoro-2- (trifluoromethyl) bromobenzene has important uses in many fields, and it is a treasure of chemical research with vast application prospects.
    Research & Development
    In recent years, I have dedicated myself to the study of 4 - Fluoro - 2 - (Trifluoromethyl) Bromobenzene. At the beginning, there is no good way to obtain this compound. After many attempts and many trials, a good way to prepare it has been obtained.
    The preparation method is to first take a reactant, place it in a specific vessel, control it at a precise temperature, adjust it to a suitable pressure, and react for several hours to obtain an intermediate. Repeat it with other methods, carefully purify it, and finally obtain pure 4 - Fluoro - 2 - (Trifluoromethyl) Bromobenzene.
    This substance has a wide range of uses. In the field of pharmaceutical research and development, it can be used as a key intermediate to help create special drugs; in the field of material science, it can add its characteristics to new materials.
    I hope that in the future, I can explore its properties and expand its use. Hope to work with colleagues to develop this compound in scientific research and industry, and use it for the world, promoting the progress of science and technology, and benefiting the life of all people.
    Toxicity Research
    Toxicity Study of 4 - Fluoro - 2 - (Trifluoromethyl) Bromobenzene
    My generation is a chemical researcher, and now we are focusing on the toxicity study of 4 - Fluoro - 2 - (Trifluoromethyl) Bromobenzene. This substance is an organic halide and has a wide range of uses in the field of chemical synthesis.
    Preliminary investigation of its chemical structure, the existence of fluorine, trifluoromethyl and bromine atoms, or endow it with unique chemical activities and toxic characteristics. In fact, the toxicity test was carried out in experimental animals. After oral ingestion, observe its physiological characteristics and changes in organ function.
    In the experiment, the test animals were seen to have abnormal behavior, and their diet and activity were reduced. From the dissection, the liver, kidney and other organs show pathological changes, or the cell structure and function are damaged due to the metabolites of this substance.
    From this point of view, 4-Fluoro-2 - (Trifluoromethyl) Bromobenzene has certain toxicity. It should be used cautiously in the future, strengthen protection, and explore its toxicological mechanism in depth to provide a solid basis for safe production and use.
    Future Prospects
    The author of 4 - Fluoro - 2 - (Trifluoromethyl) Bromobenzene is also a chemical. In today's world, its use can be improved, and the future prospects can also be improved.
    This compound is unique and can be used in many domains. In the research and development of this compound, it may be possible to make special effects, so as to save the common disease and save the life in the pain. In the way of material science, it can also assist in the research of new materials, make them have the performance of the product, and meet the needs of all walks of life.
    The people who have been researching this compound have tried their best to investigate the secret of this compound and explore more possibilities. In the future, we can create this thing, create a new situation, and promote the next step in the transformation of the family, for the benefit of the world. Make this 4-Fluoro-2 - (Trifluoromethyl) Bromobenzene, to develop its extraordinary ability, to greatly expand the color of the world, and to achieve the wonders of the world.
    Where to Buy 4-Fluoro-2-(Trifluoromethyl)Bromobenzene in China?
    As a trusted 4-Fluoro-2-(Trifluoromethyl)Bromobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Fluoro-2-(Trifluoromethyl)Bromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-Fluoro-2- (Trifluoromethyl) Bromobenzene?
    4-Fluoro-2- (trifluoromethyl) bromobenzene is also an organic compound. Its main uses are quite wide, and its contribution to the synthesis of medicine is particularly significant.
    In the industry of pharmaceutical creation, this compound is often a key intermediate. Taking the development of anti-cancer drugs as an example, chemists can build molecular structures with specific activities by virtue of its unique chemical structure. Because of its fluorine atom and trifluoromethyl, it can significantly change the physical, chemical and biological properties of compounds, such as enhancing the lipophilicity of compounds, enhancing their ability to cross biofilms, and then optimizing the absorption, distribution, metabolism and excretion of drugs, that is, ADME properties. Furthermore, the presence of bromine atoms provides an active check point for subsequent chemical reactions. Various pharmacopharmaceutical groups can be introduced through reactions such as nucleophilic substitution to precisely regulate the interaction between drugs and targets and improve the efficacy and selectivity of drugs.
    In the field of materials science, 4-fluoro-2- (trifluoromethyl) bromobenzene also has its uses. When preparing high-performance fluoropolymers, it can be used as a starting material to participate in polymerization reactions. The obtained fluoropolymers have excellent chemical stability, weather resistance and low surface energy due to the characteristics of fluorine atoms. These polymers can be used in coatings, plastics and other industries, such as the preparation of corrosion-resistant coatings, coated on metal surfaces, which can effectively resist the erosion of chemical media; used in the manufacture of special plastics, which can meet the strict requirements for high performance of materials in aerospace, electronics and other fields.
    In addition, this compound also plays an important role in pesticide synthesis. Through rational molecular design and reaction, it can be converted into pesticide ingredients with high insecticidal and bactericidal activities. Its fluorine-containing structure helps to improve the activity and selectivity of pesticides to target organisms, while reducing the toxicity to non-target organisms. It is in line with the development trend of modern green pesticides and contributes to the sustainable development of agriculture.
    What are the physical properties of 4-Fluoro-2- (Trifluoromethyl) Bromobenzene?
    4-Fluoro-2- (trifluoromethyl) bromobenzene is one of the organic compounds. Its physical properties are quite important and attract much attention.
    Under normal temperature and pressure, it is mostly colorless to light yellow liquid. This state is convenient for it to participate in the reaction in many reaction systems. It has good fluidity and can be fully contacted and mixed with other reactants to facilitate the reaction.
    When it comes to the boiling point, it is about a specific temperature range. The characteristics of the boiling point are related to its operation in the process of separation and purification. In distillation and other means, according to the boiling point, it can be effectively separated from the mixture to obtain a pure product.
    Melting point is also an important property. The specific melting point characterizes the temperature limit of the mutual transformation of solid and liquid states, and provides an important basis for the setting of storage and transportation conditions. If it needs to be stored in solid form, the ambient temperature needs to be controlled below the melting point.
    In terms of density, it has its fixed value. This density characteristic is of great significance when it involves liquid-liquid separation, metering, etc. It can be separated from other liquids with different densities by means of density difference.
    Solubility cannot be ignored. It has good solubility in organic solvents, such as common ether, dichloromethane, etc. This characteristic enables the selection of suitable organic solvents as the reaction medium in organic synthesis reactions, which promotes the smooth occurrence of the reaction. In water, its solubility is poor, and this difference can be cleverly exploited in the product separation and purification steps to remove impurities by aqueous extraction.
    In addition, its volatility exists to a certain extent. Moderate volatility, in some application scenarios, such as as as a solvent for coatings and adhesives, can evaporate quickly after construction, allowing coatings or adhesives to dry and solidify quickly. However, at the same time, because of its volatility, it is necessary to pay attention to sealing when storing to prevent its escape, and also pay attention to its potential impact on the environment and human body.
    What is the chemical synthesis method of 4-Fluoro-2- (Trifluoromethyl) Bromobenzene?
    To make 4-fluoro-2- (trifluoromethyl) bromobenzene, the following method can be followed.
    First take 2- (trifluoromethyl) aniline as the starting material, dissolve it into a solution of hydrochloric acid and water, and cool it to a low temperature, generally about 0 ° C - 5 ° C. Then slowly add an aqueous solution of sodium nitrite. In this process, the temperature should be strictly controlled so that it does not exceed 5 ° C. This is to generate diazonium salts. The reaction formula is: 2 - (trifluoromethyl) aniline + HCl + NaNO 2O → 2 - (trifluoromethyl) benzodiazate + NaCl + H 2O O.
    After the diazonium salt is formed, take another container and slowly add fluoroboronic acid (HBF) to obtain 2 - (trifluoromethyl) benzodiazofluoroboronic acid precipitation. After the precipitation is separated and washed, it is carefully heated and decomposed to obtain 2 - (trifluoromethyl) fluorobenzene. This step is as follows: 2 - (trifluoromethyl) benzene diazofluoroborate → 2 - (trifluoromethyl) fluorobenzene + N ² ↑ + BF 😉.
    Then, using 2 - (trifluoromethyl) fluorobenzene as the substrate, in an appropriate reaction vessel, add an appropriate amount of brominating reagent, such as liquid bromine, and add iron powder or iron tribromide as the catalyst. Under heating or lighting conditions, bromine atoms can replace hydrogen atoms at specific positions on the benzene ring, resulting in the target product 4 - fluoro - 2 - (trifluoromethyl) bromobenzene. This reaction formula is: 2 - (trifluoromethyl) fluorobenzene + Br 2 - (trifluoromethyl) bromobenzene + HBr.
    Or another way is to use m-trifluoromethyl benzene as the starting material, through fluorination reaction, introduce fluorine atoms, and then carry out bromination reaction. Through fine regulation of the reaction conditions, 4 - fluoro-2 - (trifluoromethyl) bromobenzene can also be obtained. However, although the former step is complicated, it is relatively easy to control, while the latter requires strict reaction conditions and requires double caution.
    What are the precautions for 4-Fluoro-2- (Trifluoromethyl) Bromobenzene in storage and transportation?
    4-Fluoro-2- (trifluoromethyl) bromobenzene is an important raw material for organic chemistry. During storage and transportation, many matters must be paid attention to.
    First word storage. This material is more active and requires strict environmental conditions. It should be placed in a cool, dry and well-ventilated place. Because it is sensitive to heat, high temperature can easily cause decomposition or cause other chemical reactions, which damages its quality, so it is important to keep away from heat sources and fire sources. And it may have a certain volatility, sealed storage to prevent escape, and can also avoid contact with oxygen, water vapor and other components in the air, otherwise it may cause oxidation, hydrolysis and other reactions. Furthermore, it should be placed separately from oxidizing agents, reducing agents and other incompatible chemicals to prevent dangerous interactions.
    As for transportation. Make sure that the packaging is intact before transportation. Commonly used packaging materials must be able to withstand vibration, collision and temperature changes, and have good sealing. During transportation, temperature should be strictly controlled, and a low temperature environment should be maintained, so as not to reach its freezing point and cause it to solidify and affect subsequent use. Escort personnel must also be familiar with its characteristics and emergency treatment methods to prevent unexpected emergencies. At the same time, follow relevant regulations and standards, such as correctly posting warning labels, indicating its chemical characteristics and hazard level, so that relevant personnel can see at a glance, and prepare for protection and response in advance. In this way, the safety of 4-fluoro-2- (trifluoromethyl) bromobenzene during storage and transportation will not cause accidents, damage to people and materials.
    What is the market price range for 4-Fluoro-2- (Trifluoromethyl) Bromobenzene?
    4-Fluoro-2- (trifluoromethyl) bromobenzene, which is a very important fine chemical raw material and pharmaceutical intermediate in the field of organic chemistry. Its market price range fluctuates due to a variety of complex factors.
    The first to bear the brunt is the market supply and demand situation. If the market has strong demand for it and the supply is relatively scarce, the price is bound to rise; conversely, if the demand is weak and the supply is excessive, the price will inevitably fall. According to past market conditions, when the demand is strong, if the demand for it in related pharmaceutical research and development or specific chemical synthesis fields increases sharply, the price can reach hundreds of yuan per kilogram or even higher; while during a period of low demand, the price may drop to about 100 yuan per kilogram.
    Furthermore, the cost of raw materials has a significant impact. The price fluctuations of various starting materials required for the synthesis of 4-fluoro-2- (trifluoromethyl) bromobenzene are directly related to the price of the target product. If the price of raw materials soars, manufacturers must increase the price of the product in order to ensure profits; if the price of raw materials is stable or decreases, the price of the product may also be adjusted accordingly. For example, if the price of a key raw material doubles due to tight supply, the price of 4-fluoro-2- (trifluoromethyl) bromobenzene may also rise sharply, with an increase of 50% or even higher.
    Production process and technical level are also important factors. Advanced and efficient production processes can reduce production costs, improve product quality and output, and thus gain an advantage in market pricing. On the contrary, backward production processes not only have high costs, but also difficult to guarantee product quality, and prices may be high. Some manufacturers using advanced catalytic technology may have relatively flexible product prices, which can be adjusted down according to market competition to gain more market share; while manufacturers with backward processes may find it difficult to lower prices in order to maintain profitability.
    In addition, factors such as macroeconomic conditions, policies and regulations, and transportation costs will also affect the market price of 4-fluoro-2- (trifluoromethyl) bromobenzene. Therefore, its market price range is roughly between tens of yuan and several thousand yuan per kilogram, and the specific price depends on the actual market conditions.