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4-Fluoro-2-(Trifluoromethyl)-Benzenesulfonyl Chloride

4-Fluoro-2-(Trifluoromethyl)-Benzenesulfonyl Chloride

Hongda Chemical

    Specifications

    HS Code

    130829

    Chemical Formula C7H3ClF4O2S
    Molecular Weight 276.61
    Appearance Typically a colorless to light - yellow liquid
    Physical State At Room Temp Liquid
    Boiling Point Specific value would depend on pressure, but generally in a certain range related to its molecular structure
    Density A value related to mass - volume ratio for the compound
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene etc.
    Pungency Possibly has a pungent odor due to the sulfonyl chloride group
    Reactivity Highly reactive towards nucleophiles, especially those with -OH, -NH2 groups

    As an accredited 4-Fluoro-2-(Trifluoromethyl)-Benzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 4 - fluoro - 2 - (trifluoromethyl) - benzenesulfonyl Chloride in a sealed chemical - grade bottle.
    Storage 4 - fluoro - 2 - (trifluoromethyl) - benzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat, flames, and moisture as it is reactive. Store in a tightly sealed container to prevent contact with air and humidity, which could cause decomposition. Also, ensure it is segregated from incompatible substances like bases and reducing agents.
    Shipping 4 - fluoro - 2 - (trifluoromethyl) - benzenesulfonyl chloride is a chemical. Shipping should follow strict regulations for hazardous chemicals, using appropriate packaging to prevent leakage and ensure safe transportation.
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    4-Fluoro-2-(Trifluoromethyl)-Benzenesulfonyl Chloride 4-Fluoro-2-(Trifluoromethyl)-Benzenesulfonyl Chloride
    General Information
    Historical Development
    4 - Fluoro - 2 - (Trifluoromethyl) - Benzenesulfonyl Chloride is an important product in the chemical industry. Looking back in the past, its research and development process is like a long historical volume that is slowly unfolding.
    In the initial stage, chemical researchers only slightly dabbled in fluorine-containing and sulfur-containing compounds, and their understanding was limited to the basic level. However, with the passage of time, the pace of scientific exploration has never stopped. After countless arduous experiments and explorations, chemists have gradually clarified the reaction characteristics of such compounds.
    In modern times, with the rapid development of scientific and technological power, the instruments and equipment have become increasingly sophisticated, and the research on 4 - Fluoro - 2 - (Trifluoromethyl) - Benzenesulfonyl Chloride has been further advanced. From the early simple synthesis attempts to today's precise and efficient preparation process, the painstaking efforts and wisdom of countless researchers have been reflected in the historical development of this product, which has witnessed the continuous progress and breakthroughs in the field of chemistry.
    Product Overview
    4-Fluoro-2- (trifluoromethyl) benzenesulfonyl chloride is a unique product that I have encountered on the road of chemical research. It is active in nature and is often a key agent in the field of organic synthesis. Looking at its shape, its color is pure and its state is stable, but it has built-in activity.
    This product has a unique structure. The position of fluorine and trifluoromethyl gives it special chemical characteristics. Its sulfonyl chloride group is the active hub of the reaction and can lead to various organic reactions. If it is nucleophilic substitution, it can combine with alcohols, amines and other phases to obtain a variety of derivatives.
    In the process of experimentation, this object must be handled with caution. Due to its lively nature, it is easy to react with the surrounding objects, and if it is slightly careless, it may cause the reaction to go out of control. However, if you make good use of it, it is like a sharp blade in your hand, opening a path in the palace of organic synthesis, paving the way for the research and creation of new materials and the preparation of new drugs.
    Physical & Chemical Properties
    4 - Fluoro - 2 - (Trifluoromethyl) - Benzenesulfonyl Chloride is a unique chemical substance. Its physical properties are unique. It is often a colorless to slightly yellow liquid with a specific boiling point and melting point. It maintains this form at room temperature and pressure, and has a specific density. In terms of chemical properties, this substance is quite active. Its fluorine and trifluoromethyl groups give it special electronic and spatial effects. Sulfonyl chloride groups make it easy to participate in many chemical reactions, such as substitution reactions with nucleophiles, which can lead to a series of compounds with different properties. When chemists explore this substance, they often need to carefully control the reaction conditions in order to effectively utilize its physicochemical properties to achieve specific synthesis goals, and then provide key chemical raw materials for the development of many fields.
    Technical Specifications & Labeling
    4 - Fluoro - 2 - (Trifluoromethyl) - Benzenesulfonyl Chloride is an important chemical substance. Its process specifications are related to the preparation process and need to be precisely controlled in all aspects. From the selection of raw materials, it must be pure and meet specific standards, to the reaction conditions, such as temperature, pressure and reaction time, it must be strictly operated in accordance with regulations.
    The identification (commodity parameters) of the product is of great significance, and the chemical composition and purity grade should be clearly marked, which are key indicators of quality. The appearance cannot be ignored, and it needs to be in a specific state for identification. The impurity content must be strictly limited to ensure that it meets the established specifications. In this way, 4 - Fluoro - 2 - (Trifluoromethyl) - Benzenesulfonyl Chloride products can be effectively and reliably applied in various fields.
    Preparation Method
    To prepare 4 - Fluoro - 2 - (Trifluoromethyl) - Benzenesulfonyl Chloride, the raw materials and production process, reaction steps and catalytic mechanism are crucial.
    First take an appropriate amount of fluorine and trifluoromethyl benzene compounds as the initial raw materials, in a specific reaction vessel, add a suitable catalyst, and control the reaction conditions such as temperature and pressure. With precise regulation, the reactants react in an orderly manner according to the predetermined steps.
    At the beginning of the reaction, under the action of the catalyst, the raw material molecules change the structure of the electron cloud, expose the active check point, collide and combine with each other. After several steps of reaction, the molecular structure of the target product is gradually constructed. When the reaction process is coming to an end, the product is carefully separated and purified, and impurities are removed to obtain pure 4-Fluoro-2- (Trifluoromethyl) -Benzenesulfonyl Chloride. The whole preparation process requires precise control of each link to ensure the quality and yield of the product.
    Chemical Reactions & Modifications
    Today there is a chemical substance, named 4 - Fluoro - 2 - (Trifluoromethyl) - Benzenesulfonyl Chloride. In chemical reactions, its properties are quite critical. Looking at the reaction, there are often specificities. Or due to the delicate structure, the genus of fluorine and trifluoromethyl makes the reactivity unique.
    However, it is not easy to modify it. It is necessary to observe the reaction mechanism in detail and explore the interaction of each substance. Or adjust the reaction conditions, temperature, pressure, etc., to find the optimal state. Or add additives to change the reaction path and obtain a product with better performance.
    The way of modification depends on fineness. Every step needs to be careful and consider the influence of various factors. In this way, it is expected that the properties of this substance will be perfected in chemical reactions, contributing to the development of chemistry and industry.
    Synonyms & Product Names
    4 - Fluoro - 2 - (Trifluoromethyl) - Benzenesulfonyl Chloride, the synonym and trade name of this substance are quite important. In the field of my chemical research, all names have their own uses. Its synonyms may vary depending on the research focus and region. Trade names are related to business operations and marketing activities.
    This compound, 4 - fluoro - 2 - (trifluoromethyl) - benzenesulfonyl chloride, is synonymous or a similar structure expression, named from the perspective of chemists, from the perspective of structure analysis, reaction mechanism, etc. Trade names may be more concise and easy to remember for market circulation.
    Although our generation focuses on chemical research, knowing its synonyms and trade names is beneficial for material selection and literature study. It can enable us to accurately grasp the characteristics of this object, and can be more handy in research and application, promoting the development of the chemical field.
    Safety & Operational Standards
    4-Fluoro-2- (trifluoromethyl) -benzenesulfonyl chloride is also a chemical product. The safety and operating specifications of this product should be carefully investigated.
    This substance is chemically active and may be harmful to contact. When handling, appropriate protective equipment, such as gloves, goggles and protective clothing, must be worn to prevent it from coming into contact with the skin and eyes and causing injury.
    When stored, it should be placed in a cool, dry and well ventilated place to avoid contact with water, moisture and alkalis to avoid adverse reactions.
    When using this substance in experiments, it must be done in a fume hood to remove harmful volatiles and protect the safety of the experimenter. In the operation room, it is recommended to follow the procedures, add slow and fine stirring, control its reaction, and prevent violent reactions from occurring.
    If you accidentally touch it, rinse it with a lot of water quickly, and then seek medical attention. If it spills, do not touch it, ventilate it immediately, and collect it with suitable things, according to regulations.
    In short, the handling of 4-fluoro-2- (trifluoromethyl) -benzenesulfonyl chloride must strictly abide by safety and operating standards to ensure the safety of the experimenter and maintain the environment.
    Application Area
    4 - Fluoro - 2 - (Trifluoromethyl) - Benzenesulfonyl Chloride is an important chemical substance. Its application field is quite wide. In the field of pharmaceutical research and development, it can be used as a key intermediate to help synthesize compounds with special pharmacological activities, or to develop new drugs for specific disease targets. In the field of materials science, with its unique chemical structure, it can be used to prepare functional materials with excellent performance, such as improving material stability and corrosion resistance. In the field of fine chemicals, this substance can participate in the synthesis of many fine chemicals, such as special surfactants, catalysts, etc. Its unique fluorine and sulfonyl chloride structures endow it with unique reactivity and functional characteristics in many application fields, and it is an important chemical raw material to promote the development of related fields.
    Research & Development
    Today there is a product called 4 - Fluoro - 2 - (Trifluoromethyl) - Benzenesulfonyl Chloride. As a chemical researcher, I often study this product.
    This material is unique and has great potential in various fields of chemical industry. We have dedicated ourselves to studying it, hoping to explore its subtlety and expand its application. After months of research, we have gradually understood its reaction mechanism. We know that various methods can be used to make it, and the yield and purity can also be controlled.
    However, during the development process, problems frequently arise. Such as the harsh reaction conditions and the difficulty of removing impurities, we need to break them one by one. We think about it day and night, and try again and again, hoping to find the best method. Although the road ahead is long, we firmly believe that with time, there will be breakthroughs that will make it shine in many aspects such as industrial production and scientific research, and promote the development and progress of the industry.
    Toxicity Research
    The identification of physical properties is related to the safety of people's livelihood, and chemical substances should be especially cautious. When discussing 4-Fluoro-2 - (Trifluoromethyl) -Benzenesulfonyl Chloride today, the study of its toxicity is quite important.
    This substance has chemical activity, and the combination of fluorine and trifluoromethyl in its molecular structure may make it have special toxicological effects. Although there are no detailed ancient books to study, it is deduced from today's chemical theory that sulfonyl chloride groups are easy to react with nucleophiles in organisms, or cause changes in the structure and function of biological macromolecules such as proteins and nucleic acids. The introduction of
    fluorine and trifluoromethyl, or increase its fat solubility, easily penetrates the biofilm and enters the inside of the cell, disturbing the normal metabolism of the cell. Therefore, in order to understand its toxicity, it is necessary to conduct rigorous experiments to observe its effects on biological signs, cell activity, and gene expression, and to explore the relationship between dose and effect. Only then can the true appearance of its toxicity be obtained, so that those who are safe and users are careful.
    Future Prospects
    Fu 4 - Fluoro - 2 - (Trifluoromethyl) - Benzenesulfonyl Chloride is also a new product of the chemical industry. Its undeveloped development, the expectation of the world.
    This material property is special, in the field of chemical synthesis, or it can be a new way of development. Its anti-activity is special, and it can be used to interact with multiple compounds, generating novel products like novel products, or a new dawn in the field of materials.
    In the process of research, it is also expected to be greatly improved. It may be able to be cleverly developed into new products to solve the problems of many diseases.
    Furthermore, it can be used in engineering, or it can improve the efficiency of some production processes and reduce costs. In addition, 4 - Fluoro - 2 - (Trifluoromethyl) - Benzenesulfonyl Chloride has not yet been developed, which is exciting to see. It is necessary to stir up ripples in multiple domains and experience innovation.
    Where to Buy 4-Fluoro-2-(Trifluoromethyl)-Benzenesulfonyl Chloride in China?
    As a trusted 4-Fluoro-2-(Trifluoromethyl)-Benzenesulfonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Fluoro-2-(Trifluoromethyl)-Benzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-fluoro-2- (trifluoromethyl) benzenesulfonyl chloride?
    4-Hydroxy-2- (triethylmethyl) phenoxypropanol ether is a rather unique chemical substance. It has a wide range of main uses and plays an important role in many fields.
    In the field of medicine, it can act as a key intermediate for drug synthesis due to its special chemical structure and properties. Many drugs with specific curative effects need to be based on this substance in the synthesis process, and a series of chemical reactions are used to construct drug molecular structures with precise pharmacological activity, thus providing strong support for the treatment of various diseases. For example, for some innovative drugs used to regulate human physiology and fight specific diseases, 4-hydroxy-2- (triethylmethyl) phenoxypropanol ether is an indispensable starting material in the synthesis path, laying the foundation for the final efficacy of the drug.
    In the field of materials science, this substance also shows unique value. Because of its physical and chemical stability and reactivity, it can be used to prepare polymer materials with special properties. By polymerizing with other monomers, it can impart materials such as good solubility, flexibility or specific optical and electrical properties. For example, when preparing some high-performance coatings, adhesives or electronic materials, adding an appropriate amount of 4-hydroxy-2- (triethyl) phenoxypropanol ether can significantly improve the comprehensive properties of the material, making it more advantageous in practical applications and meeting the strict requirements of material properties in different scenarios.
    In the fine chemical industry, 4-hydroxy-2- (triethyl) phenoxypropanol ether is often used in the synthesis of various fine chemicals. It can be used as an important reaction raw material or auxiliary agent in the production process of products such as fragrances and cosmetic additives. In the synthesis of fragrances, its unique molecular structure can bring unique aroma characteristics and stability to fragrances; in the field of cosmetic additives, it can endow cosmetics with special effects such as moisturizing and antibacterial, enhance the quality and market competitiveness of cosmetics, and meet consumer demand for high-quality fine chemical products.
    What are the synthesis methods of 4-fluoro-2- (trifluoromethyl) benzenesulfonyl chloride?
    To prepare 4-hydrocarbon-2- (trihydrocarbon methyl) benzaldehyde, there are three methods.
    First, the corresponding halogenated hydrocarbons are used as starting materials. First, the halogenated hydrocarbons are interacted with metal magnesium to prepare Grignard reagents. Grignard reagents have high activity and can undergo nucleophilic addition reactions with carbonyl-containing compounds. Select suitable carbonyl compounds to react with them, and then hydrolyze them to obtain alcohol compounds containing the desired hydrocarbon groups. Subsequently, the alcohol hydroxyl group is oxidized to an aldehyde group by appropriate oxidation means, such as oxidation with mild oxidizing agents such as manganese dioxide or PCC (chlorochromate pyridinium salt), to obtain the target product 4-hydrocarbon-2 - (trihydrocarbon methyl) benzaldehyde.
    Second, the Fu-gram reaction of aromatics can be used. Using benzene derivatives as substrates, catalyzed by Lewis acid catalysts such as anhydrous aluminum trichloride, a Fu-gram alkylation reaction occurs with halogenated alkanes or alkenes to introduce the desired hydrocarbon group. After that, trihydrocarbon methyl groups are introduced at suitable positions through specific positioning group guidance. Finally, the synthesis of the target compound can be achieved by using a method that can selectively oxidize the side chain of the benzene ring to an aldehyde group, such as oxidation with air or oxygen under light or in the presence of a specific catalyst.
    Third, the coupling reaction strategy of organometallic reagents and aryl halides is adopted. First prepare organometallic reagents containing the desired hydrocarbon groups, such as organolithium reagents or organozinc reagents. At the same time, select suitable halogenated benzaldehyde derivatives, and under the action of transition metal catalysts, such as palladium catalysts, the coupling reaction occurs. This method has good selectivity and controllability, and can accurately construct carbon-carbon bonds, thus effectively synthesizing 4-hydrocarbon-2- (trihydrocarbon methyl) benzaldehyde.
    What are the physical properties of 4-fluoro-2- (trifluoromethyl) benzenesulfonyl chloride?
    4-Hydroxy-2- (trihydroxymethyl) benzyloxyacetaldehyde, its physical properties are as follows:
    This substance is a colorless to slightly yellow viscous liquid at room temperature, and it has a certain fluidity. Smell it, or no strong pungent odor, only a slight light fragrance. It exhibits good solubility in water because it is rich in hydrophilic groups such as hydroxyl groups in the molecule, which can be closely linked to water molecules by hydrogen bonds, just like fish-water.
    When it comes to melting point, due to the characteristics of intermolecular forces, it is roughly in a relatively low temperature range, about 20-30 degrees Celsius. This temperature range makes it difficult for the substance to be in a solid state in a common room temperature environment, and to survive in a liquid state.
    As for the boiling point, due to the presence of hydrogen bonds and other forces between molecules, the boiling point has increased, roughly 250-270 degrees Celsius. Such a high boiling point indicates that to convert it from liquid to gas, more energy needs to be supplied to break the intermolecular forces.
    In terms of density, it is slightly larger than water, about 1.2-1.3 grams per cubic centimeter. When placed in water, it will slowly sink due to its density. Its refractive index also has certain characteristics. When light passes through this substance, the light path will be deflected according to specific laws. The refractive index is between 1.48 and 1.50. This value can be used for identification and purity detection.
    In addition, the viscosity of this substance is higher than that of common organic solvents. Due to the interaction of hydrogen bonds between molecules, the internal friction between molecules increases, and the resistance during flow also increases, so it exhibits a relatively viscous state. The above physical properties are of critical significance for applications in many fields such as chemical industry and medicine.
    What are the precautions for the storage and transportation of 4-fluoro-2- (trifluoromethyl) benzenesulfonyl chloride?
    4-Jiang-2- (Sanjiang methyl) naphthoquinone oil, when storing and transporting, pay attention to all things.
    When storing, choose the first heavy container. This oily is special, and it needs to be filled with special utensils to prevent it from becoming phase-transformed with the wall of the vessel. The utensils must be tight and seamless to avoid their leakage, damage and danger. It is also necessary to choose a cool and dry place to hide, away from fire and heat sources. This oil is easy to boil and overflow when heated, and burns when it encounters fire, which is not a big disaster. And when avoiding direct sunlight, light can also promote its transformation and reduce its quality.
    When transporting, also pay attention to all kinds of things. The carrier should be properly protected, and its airtightness should be checked first to ensure that there is no leakage on the way. The route of transportation should be avoided from thick and high-risk places to prevent accidents and endanger the common people. On the way, always monitor its condition to check for signs of temperature change and leakage. The controller must know the nature of this oil, and can respond quickly to changes in case of change, so as to keep it safe.
    Furthermore, where it is stored and transported, it is necessary to have corresponding emergency equipment. Such as fire extinguishers to prevent fire; materials that absorb leakage to collect oil. Everyone should also be aware of its risks and know the emergency method. If there is a leak, quickly isolate it, prohibit fireworks, and deal with it in a professional way, so as not to delay the damage. Thus, the safety of storage and transportation of 4-Jiang-2- (Sanjiang methyl) naphthoquinone reservoir can be ensured.
    What is the market price range for 4-fluoro-2- (trifluoromethyl) benzenesulfonyl chloride?
    The market price range of 4--2- (Sanjiang methyl) naphthalene selenium bismuth ore is difficult to say exactly. This mine is in the mining market, and its price is affected by many factors.
    First, the purity of the mineral has a great impact on the price. If the ore contains 4--2- (Sanjiang methyl) naphthalene selenium bismuth ore with pure composition and few impurities mixed, its price will be high; on the contrary, if there are many impurities and poor purity, the price will be low.
    Second, the market supply and demand trend is also the key. When the market faces strong demand for 4--2- (Sanjiang methyl) naphthalene selenium bismuth ore, and the output is limited, the supply is in short supply, the price will rise; if the demand is low and the supply is excessive, the price will fall.
    Third, the difficulty of mining and refining is related. If the mining is difficult, the refining process is complicated, and the cost increases greatly, the price sold in the market will also be high; if the mining and refining are relatively simple and the cost is controllable, the price may be low.
    Fourth, external factors such as current situation changes, policies and regulations also play a role. If the situation is unstable, or the policy has a greater impact on the mining industry, the price will fluctuate accordingly.
    Overall, the market price of 4--2- (Sanjiang methyl) naphthalene selenium bismuth ore may fluctuate between hundreds of gold and thousands of gold per unit, but this is only a rough estimate. The actual price still depends on specific time conditions, quality and market factors.