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4-Fluoro-2-(Trifluoromethyl)Benzeneboronic Acid

4-Fluoro-2-(Trifluoromethyl)Benzeneboronic Acid

Hongda Chemical

    Specifications

    HS Code

    267342

    Chemical Formula C7H5BF4O2
    Molar Mass 210.92 g/mol
    Appearance white to off-white solid
    Solubility In Water slightly soluble
    Solubility In Organic Solvents soluble in common organic solvents like dichloromethane, toluene
    Melting Point 120 - 125 °C
    Purity usually high - can be 97%+
    Reactivity reacts with aryl halides in Suzuki - Miyaura coupling reactions
    Stability stable under normal conditions, but sensitive to moisture and air over time

    As an accredited 4-Fluoro-2-(Trifluoromethyl)Benzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 4 - fluoro - 2 - (trifluoromethyl)benzeneboronic acid in sealed chemical - grade packaging.
    Storage 4 - fluoro - 2 - (trifluoromethyl)benzeneboronic acid should be stored in a cool, dry place away from heat and ignition sources. Keep it in a tightly sealed container to prevent moisture absorption, as boronic acids can react with water. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions that could compromise its integrity.
    Shipping 4 - fluoro - 2 - (trifluoromethyl)benzeneboronic acid is shipped in well - sealed, corrosion - resistant containers. Packaging adheres to chemical transport regulations, ensuring safe transit to prevent any leakage or damage during handling.
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    4-Fluoro-2-(Trifluoromethyl)Benzeneboronic Acid 4-Fluoro-2-(Trifluoromethyl)Benzeneboronic Acid
    General Information
    Historical Development
    4-Fluoro-2- (trifluoromethyl) phenylboronic acid is an important agent in organic synthesis. At the beginning, chemists paid attention to this unique structure in the journey of exploring new compounds. At the beginning, the synthesis method was difficult and the yield was quite low, and it was only occasionally made in the laboratory.
    With the passage of time, technology has advanced, and the synthesis technology has gradually become exquisite. All kinds of reaction conditions have been optimized, and new catalysts have emerged, so that the synthesis efficiency of this compound has skyrocketed. What used to exist only in theoretical concepts has gradually become available.
    Today, 4-fluoro-2- (trifluoromethyl) phenylboronic acid is found in many fields such as pharmaceutical research and development, materials science, and so on. The course of its development is like a pearl gradually blooming, from the darkness to the light, adding luster to the field of chemistry, and the prospect is vast and boundless.
    Product Overview
    Today there is a substance called 4 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid. It is a derivative of phenylboronic acid, which is very useful in the field of organic synthesis. Looking at its structure, fluorine atoms and trifluoromethyl groups are placed on the benzene ring, giving this substance unique physicochemical properties.
    This substance is often used as an arylation reagent and plays an important role in the formation of carbon-carbon and carbon-heteroatom bonds. The reactions it participates in have mild conditions and good yields, and can be a key intermediate for the synthesis of various complex organic compounds.
    And because of the characteristics of fluorine-containing groups, the products made from this substance exhibit specific properties in many fields such as materials science and medicinal chemistry. Either it has good biological activity or excellent stability, it is a treasure of organic synthetic chemistry, with broad prospects. We need to explore it in depth to make the best use of it.
    Physical & Chemical Properties
    4-Fluoro-2- (Trifluoromethyl) Benzeneboronic Acid is a chemical substance. Its properties are related to the characteristics of physicalization. Looking at its color, it often appears in the shape of white crystals, or in the shape of the ground. As it melts, it has a specific value, which is one of the characteristics of its physical rationality. In terms of solubility, in some soluble substances, it can be dissolved in the image, showing the characteristics of its solubility interaction.
    The solubility of boron atoms, the basis of the boron atom, can be transformed into a general way. In case of problems, there may be neutralization; in the field of synthesis, it can be reacted together with many substances, and the power of new transformation can be achieved. The physical properties of this compound make it suitable for exploration and application in many fields such as chemical research and material synthesis.
    Technical Specifications & Labeling
    4 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid is an important chemical product. Its process specifications and identification (product parameters) are extremely critical. When preparing this product, the ratio of raw materials must be accurate, and the reaction temperature, duration and other conditions must also be strictly controlled. If a specific reactor is used, the raw materials should be put into the exact proportion and fully reacted at a suitable temperature to ensure product quality.
    Its identification (product parameters) should clearly indicate key information such as composition, purity, molecular weight, etc. The determination of purity requires rigorous analytical methods, such as the use of high performance liquid chromatography and other means. Only by strictly adhering to process specifications and accurate identification (product parameters) can this 4 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid meet the needs of various applications and play its due role in the chemical industry and other fields.
    Preparation Method
    The method of making 4 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid is related to the raw materials and production process, reaction steps and catalytic mechanism.
    The raw materials are first taken and carefully proportioned. The selection of raw materials needs to be carefully selected to ensure quality. In the reaction step, the raw materials are initially added in a specific order, and the temperature is controlled at a suitable degree, step by step. If a two substances are mixed first, slowly heat up to XX degrees, and wait for them to fully blend before introducing other materials.
    As for the production process, the environment should be kept clean and impurities should be avoided. The stirring rate is also critical, and it must be uniform and stable to promote the reaction.
    In terms of catalytic mechanism, the suitable catalyst is selected, which can reduce the reaction barrier and speed up the process. And the amount of catalyst is adjusted in a timely manner, and the reaction rate and product purity are checked to achieve both. In this way, this product can be prepared, which is the key to the process.
    Chemical Reactions & Modifications
    Taste the wonders of chemistry, the changes are all-encompassing, and it is related to the change of substances and the change of properties. Today there is 4 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid, and I will study it carefully.
    Its chemical reaction is the cardinal of material transformation. Looking at its reaction, or combining with other things, or decomposing itself, all follow the laws of chemistry. If it encounters a reagent, or changes in addition, the atoms are rearranged and the structure is renewed. The speed of this reaction and the purity of the product are all controlled by factors such as temperature, concentration, and catalyst.
    As for the denaturation energy, this substance may change its physical properties due to reactions, such as melting point and solubility, or it may be easy to change its chemical properties, the activity increases or decreases, and the reaction tendency changes.
    I study the substance repeatedly, hoping to understand the secret of its reaction and improve its performance, which is the progress of chemistry.
    Synonyms & Product Names
    4-Fluoro-2- (trifluoromethyl) phenylboronic acid, this substance is quite important in today's chemical research. Although its names are different, they all refer to the same substance. Although it does not have its name in ancient chemical texts, it has many nicknames in modern times, all of which are set up to express its characteristics.
    Looking at this substance, its structure is unique, containing fluorine and trifluoromethyl, which give it unique chemical properties. In the field of chemical industry, its nicknames and trade names are also many. Or due to the special method of production, or due to the different uses, there are different names.
    Although the names are different, their properties are one. They all have the generality of boric acids and can be used to synthesize various organic compounds. In the fields of pharmaceutical research and development, material preparation, etc., they all have their own figures. Based on them, special drugs can be made, and strange materials can also be made. Although the names are different, they have made great contributions to the research and progress of chemistry, and they all refer to this 4-fluoro-2- (trifluoromethyl) phenylboronic acid.
    Safety & Operational Standards
    4-Fluoro-2- (trifluoromethyl) phenylboronic acid is a substance commonly used in chemical research. Strict safety and operating standards must be followed in all aspects of experimental operation and storage to ensure the safety of personnel and the smooth operation of the experiment.
    #1. Storage Rules
    This substance should be stored in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent danger. It must be stored separately from oxidizing agents, acids, alkalis, etc., and must not be mixed. Because chemicals of different properties come into contact with each other, or cause violent chemical reactions, endangering safety. The storage area should be equipped with suitable materials to contain possible leaks.
    #2. Quasi-operation
    When operating, the experimenter must wear appropriate protective equipment. Protective glasses can protect the eyes from spatter damage, and gloves can prevent contact with the skin. The operation should be carried out in a fume hood to effectively discharge volatile gas and avoid inhalation into the body. When using this substance, the action should be steady and light to prevent it from spilling or leaking due to vibration and collision. If there is a small amount of leakage, it should be quickly covered with dry sand, vermiculite and other inert materials to absorb, and then properly disposed of. If the amount of leakage is large, the relevant personnel should be evacuated to a safe area immediately, and emergency measures should be taken in time to notify professionals to deal with it.
    #3. Emergency measures
    If you accidentally touch the skin, you should immediately take off the contaminated clothes, rinse with a large amount of flowing water for at least 15 minutes, and then seek medical treatment. If it splashes into the eyes, you should immediately lift the eyelids, rinse thoroughly with a large amount of flowing water or normal saline, and seek medical attention as soon as possible. If you inhale accidentally, you should quickly leave the scene to a fresh air place to keep the respiratory tract unobstructed. If breathing difficulties, you should give oxygen. If breathing stops, you should immediately perform artificial respiration and send to the
    In conclusion, in the use of 4-fluoro-2- (trifluoromethyl) phenylboronic acid, safety is always a top priority, and strict compliance with operating standards can effectively avoid accidents and ensure the safe and orderly progress of scientific research.
    Application Area
    4 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid is also a delicate thing. Its application is not limited to the field of synthesis, and it can be used as a high-performance, high-performance polyarylation inverse. Its special properties can make the inverse in the field of precision and improve the yield of the product. In the context of scientific research, this compound can be used as an important synthetic model to help the new production. Its molecular framework of the material, or can be derived with special biological activity, to solve the problem of general diseases. In the field of materials science, it also has its application, which can be added to the research of new functional materials, and the special properties of materials, such as high-performance, optical properties, etc., can be promoted in the field of materials.
    Research & Development
    In recent years, I have been in the field of chemistry, specializing in the product 4 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid. At the beginning, the synthesis method was difficult, the raw materials were rare, and the reaction rate was quite low. However, I and my colleagues are reluctant to give up day and night, reading books and studying the mechanism.
    After months of research, the process has been improved, new agents have been added, and the conditions have been optimized. The reaction has gradually stabilized, and the yield has also increased significantly. This product has potential in the fields of medicine and materials. On top of medicine, it may be the key to the development of new agents; among materials, its characteristics can be increased.
    Looking to the future, we hope to use this as a foundation to conduct in-depth research and expand applications, with the hope of contributing to the academic and industrial circles and promoting the development of this field.
    Toxicity Research
    Modern chemistry has advanced, and all kinds of substances have entered the field of research. In this sentence, the study of the toxicity of 4-Fluoro-2 - (Trifluoromethyl) Benzeneboronic Acid is quite important.
    To learn more about its toxicity, the first thing to do is to observe its chemical properties. This substance has a unique structure, and it is a genus of fluorine and trifluoromethyl, or a unique reaction. In the biological body, it may interact with proteins and nucleic acids, causing chaos to its physiological order.
    The way of the experiment, animals are used as models to observe the symptoms after ingesting this agent. Or see abnormal behavior, changes in diet and activities; or changes in the body's organs, liver and kidney dysfunction. It is also explored at the cell level, looking at its impact on cell proliferation and apoptosis.
    However, the judgment of toxicity is not only looking at the harm, but also needs to be measured. Below a small amount, or the organism can control it; if the amount exceeds the threshold, the harm will be clustered. Therefore, the study of its toxicity, the test of dose, is indispensable.
    In summary, the toxicity of 4 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid is studied in detail, and multiple methods are applied in combination, and the amount of harm is taken into account. Only then can the effect of 4 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid on the organism be understood, which provides a basis for the use of safety and avoidance of harm.
    Future Prospects
    Guanfu 4 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid has emerged in the field of current chemistry. Although the methods used today may not be perfect, our generation of chemical researchers are looking forward to the future.
    It is expected that in the future, the technique of synthesis will become more and more delicate, and the yield will rise gradually, and impurities may be almost non-existent. Its application scope will also be broader. In the road of medicine, it may help to create new drugs with miraculous effects and heal diseases; in the world of materials, it may give birth to special materials and increase the power of instruments.
    We are committed to our research and are determined to make unremitting efforts to make 4 - Fluoro - 2 - (Trifluoromethyl) Benzeneboronic Acid shine in the unmasked realm, contributing to the progress of chemistry and the prosperity of mankind, and achieving unprecedented heights and achieving extraordinary things.
    Where to Buy 4-Fluoro-2-(Trifluoromethyl)Benzeneboronic Acid in China?
    As a trusted 4-Fluoro-2-(Trifluoromethyl)Benzeneboronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Fluoro-2-(Trifluoromethyl)Benzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main application fields of 4-fluoro-2- (trifluoromethyl) phenylboronic acid
    4-Hydroxy- 2 - (triethylmethyl) quinoline carboxylic acid, this substance is used in many fields such as medicine and chemical industry.
    In the field of medicine, it is often used as a key component of antibacterial drugs. It has strong antibacterial activity and can effectively inhibit the growth and reproduction of various pathogens. Such as common Escherichia coli, Staphylococcus aureus, etc., the growth of this ingredient is inhibited. Because this compound can precisely act on specific targets of pathogens and interfere with the normal physiological and metabolic process of pathogens, it can achieve antibacterial effect. It plays a key role in the research and development and production of antibacterial drugs and provides powerful weapons for human beings to resist the invasion of pathogens.
    In the chemical industry, it can be used as a raw material for synthesizing special functional materials. Due to its unique chemical structure and properties, it can be converted into materials with special optical and electrical properties through specific chemical reactions. For example, in the synthesis of optical materials, it can improve the light absorption and emission characteristics of materials, so that materials can exhibit excellent properties in optical display, optoelectronic devices, etc., and promote the technological innovation and development of related chemical industries.
    Furthermore, in the field of scientific research, it is also an important chemical reagent. Researchers often use it to carry out various chemical synthesis reactions and mechanism studies. Due to its structural particularity, it can provide a unique chemical environment for the reaction, help researchers to deeply explore the nature and laws of chemical reactions, and provide important experimental basis for the development of new chemical reaction paths and the improvement of chemical theory.
    What are the synthesis methods of 4-fluoro-2- (trifluoromethyl) phenylboronic acid?
    To prepare 4-alkynyl-2- (triethylmethyl) naphthalene propionic acid, the method is as follows:
    First, the naphthalene is used as the starting point, and the halogenated naphthalene is obtained by halogenation. The halogenated naphthalene and the acetylated compound are met in a suitable environment, and the alkynylated naphthalene is produced according to the coupling rule. Then, with an appropriate agent, the alkynylated naphthalene is reacted with the halogenated hydrocarbon containing triethylmethyl to carry out a nucleophilic substitution reaction to obtain 4-alkynyl-2- (triethylmethyl) naphthalene. As for the genus propionic acid, you can borrow the magic of Grignard's reagent. First, 4-alkynyl-2- (triethylmethyl) naphthalene is combined with magnesium and haloalkanes to form a Grignard reagent, and then it is combined with carbon dioxide. After hydrolysis, 4-alkynyl-2- (triethylmethyl) naphthalenopropionic acid is obtained.
    Or, the naphthalene containing alkynyl groups and haloalkyl groups is used as a group. The haloalkyl group in the schilling alkynyl group and haloalkylnaphthalene should be combined with the reagent of triethylmethyl group to obtain 4-alkynyl-2- (triethylmethyl) naphthalene according to the principle of nucleophilic substitution. Thereafter, by means of Grignard reagent, the group of propionic acid is added from carbon dioxide and hydrolysis step
    Furthermore, it can be started from naphthalene derivatives with appropriate substituents. By means of organic synthesis techniques, such as nucleophilic addition, elimination, rearrangement and other reactions, the alkynyl group, triethyl methyl group and propionic acid are introduced one after another. First, the naphthalene derivative is used as the base, and the nucleophilic addition method is used to introduce the alkynyl group; then the triethylmethyl group is added in a suitable reaction; finally, after a series of transformations, the structure of propionic acid is obtained, and the final composition is 4-alkynyl-2- (triethylmethyl) naphthalene propionic acid. This method has its own advantages and disadvantages, and needs to be carefully selected according to the preparation of raw materials, the reaction strip and the purity of the product.
    What are the physicochemical properties of 4-fluoro-2- (trifluoromethyl) phenylboronic acid?
    4-Hydroxy-2- (triethylmethyl) pyrimidinic acid, this is a rather unique organic compound. Its physical and chemical properties are particularly important and are related to many chemical and biological applications.
    First of all, its physical properties. This compound is mostly solid at room temperature, and its appearance may be white crystalline powder, which has a certain stability. Its melting point and boiling point are key physical parameters. The melting point is in a specific temperature range, and the exact value often varies according to the purity of the sample and the measurement conditions. The boiling point also has a corresponding range, which is determined by the intermolecular forces. And its solubility is different in common organic solvents. It may have a certain solubility in polar organic solvents such as ethanol and acetone. This characteristic makes it better dispersed and reacted in solution chemical operations, pharmaceutical preparations, etc.
    Re-examine its chemical properties. The hydroxyl group and pyrimidine ring structure in the molecule of 4-hydroxyl-2- (triethylmethyl) pyrimidinic acid give it unique chemical activity. Hydroxyl groups are active functional groups and can participate in many chemical reactions, such as esterification reactions. They react with organic acids or anhydrides under suitable conditions to form corresponding ester compounds. This reaction is often used in organic synthesis to construct complex molecular structures or modify compound properties. At the same time, the pyrimidine ring structure allows the compound to undergo nucleophilic substitution, electrophilic substitution and other reactions under specific conditions, and can interact with a variety of reagents to achieve diverse modifications of molecular structures. In the field of drug development, such reactions can optimize the activity and selectivity of compounds. In addition, its acidity is also an important chemical property. Due to the presence of hydroxyl groups, protons can be released to a certain extent, showing acidity. This acidity affects its existence form and chemical reactivity in different pH environments.
    What are the precautions for 4-fluoro-2- (trifluoromethyl) phenylboronic acid during storage and transportation?
    4-Hydroxy-2- (triethylmethyl) pyrimidinic acid is a precious compound. During storage and transportation, many matters need to be paid careful attention.
    Bear the brunt, and the temperature and humidity of the storage environment are crucial. This compound prefers a low temperature and dry place. The temperature should be controlled between 2-8 ° C, and the humidity should not be higher than 60%. If the temperature and humidity are too high, it may cause chemical reactions and damage the quality. If the temperature and humidity are not properly controlled in the hot and humid season, if the temperature and humidity are not properly controlled, its properties may vary and its activity may be attenuated.
    Furthermore, the material of the storage container cannot be ignored. Containers made of glass or specific plastics should be selected because of their stable chemical properties and are not easy to react with compounds. Do not use metal containers to prevent metal ions from interacting with the compound and causing the compound to deteriorate.
    When transporting, shock-proof and thermal insulation measures are indispensable. The texture of this compound may be fragile, the road will be bumpy or the packaging will be damaged. Therefore, it needs to be properly wrapped with soft cushioning materials, such as foam, sponge, etc. And pay attention to heat insulation during transportation to avoid drastic changes in external temperature affecting its quality.
    In addition, the storage and transportation process must strictly abide by relevant laws and standards. This compound may belong to a special control category, and there are express regulations from storage conditions to transportation qualifications. Acting in disregard of regulations not only makes it difficult to ensure the quality of the compound, but also may violate the law and invite serious consequences.
    In conclusion, 4-hydroxy- 2 - (triethylmethyl) pyrimidinic acid requires careful treatment in terms of temperature and humidity, container material, shock insulation, and regulatory compliance during storage and transportation. A slight mistake may endanger the quality and safety of the compound.
    What is the approximate market price of 4-fluoro-2- (trifluoromethyl) phenylboronic acid?
    In today's world, business conditions are fickle, and the prices of various things in the market also fluctuate accordingly. However, it is difficult to come to a conclusion about the market price of 4-hydroxy- 2 - (triethylmethyl) pyrimidine carboxylic acid.
    This compound may be used in pharmaceutical research and development, chemical synthesis and many other fields. The determination of its market price is related to many factors. First, the situation of supply and demand. If the demand for it increases greatly in the process of pharmaceutical creation, etc., and the supply is not sufficient, the price will rise; conversely, if the supply exceeds the demand, the price may fall.
    Furthermore, the cost of raw materials is also the key. If the price of the raw materials required to synthesize this acid rises or falls, it will cause the production cost of the acid to change, which will affect the market price. The difficulty of the production process and the novelty of the technology are also related to the cost. If there is a way to improve and reduce the cost, the price in the market may be more flexible.
    In addition, the current situation, the rules of the policy, and the state of competition all have an impact. The industry is fiercely competitive, and various producers may adjust prices to compete for the market. Policy control may result in limited production and increased costs, and prices are also different.
    Looking at it all, although it is difficult to determine the price, it is common sense that if it is in a situation of strong demand, moderate cost, and orderly competition, its price may be between [X1] and [X2] currency units; if supply and demand are unbalanced and costs soar, the price may far exceed this range; conversely, if the market is saturated and costs decline, the price may also drop sharply. Only by observing market changes in real time and analyzing industry conditions can we obtain a more accurate market price.