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4-Fluoro-2-Nitrobenzeneamine

4-Fluoro-2-Nitrobenzeneamine

Hongda Chemical

Specifications

HS Code

193450

Chemical Formula C6H5FN2O2
Molar Mass 156.11 g/mol
Appearance Yellow solid
Melting Point 34 - 38 °C
Boiling Point 257 - 258 °C
Density 1.445 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents
Flash Point 129 °C
Hazard Class Irritant

As an accredited 4-Fluoro-2-Nitrobenzeneamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 4 - fluoro - 2 - nitrobenzeneamine packaged in a sealed, labeled bottle.
Storage 4 - fluoro - 2 - nitrobenzeneamine should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and incompatible substances such as strong oxidizing agents. Store in a tightly sealed container to prevent exposure to air and moisture, which could potentially cause decomposition or reactivity issues. Use proper labeling for easy identification and to ensure safety during handling.
Shipping 4 - fluoro - 2 - nitrobenzeneamine is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring secure transport to prevent leakage and potential environmental or safety risks.
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4-Fluoro-2-Nitrobenzeneamine 4-Fluoro-2-Nitrobenzeneamine
General Information
Historical Development
4 - Fluoro - 2 - Nitrobenzeneamine is also a chemical substance. Its origin can be traced back to the past. At the beginning, the chemical industry studied the properties of things and explored the unknown. On the long road of research, this compound entered the human eye.
In the past, the chemical industry used its method of intensive research to explore different aspects, wanting to understand its properties and explore its capabilities. Many times, we know its characteristics. Its reverse form and the principle of action are also clear one by one.
Over the next few days, people will know and benefit from this compound. The way it is used, it can also be used. Or in the research of materials, or in the research of materials, it can be used. This is the history of 4 - Fluoro - 2 - Nitrobenzeneamine, from unknown to well-known, and the use of more and more.
Product Overview
4 - Fluoro - 2 - Nitrobenzeneamine is also a chemical substance. Its shape is either powder or crystalline. The color is white or yellowish, with unique characteristics.
This substance is used in the field of chemical research and has a wide range of uses. It can be used as a raw material for organic synthesis, and is of great value in various industries such as medicine and pesticides. Its chemical structure is unique, containing fluorine, nitro and amine groups, and the interaction of each group gives it special chemical activity.
The method of synthesis is often formed by several steps according to a specific chemical path. When preparing, it is necessary to carefully control the temperature and time, and pay attention to the reaction conditions to ensure the purity and yield of the product.
When studying this substance, it should be handled with caution, because it may be toxic and dangerous. It is necessary to follow the specifications of chemical experiments and make good use of protective equipment to prevent harm to people and the environment.
Physical & Chemical Properties
4 - Fluoro - 2 - Nitrobenzeneamine is also an organic compound. Its physical and chemical properties can be quite studied.
Looking at its physical properties, it is either solid at room temperature, colored or light yellow, and has a specific odor. Its melting point and boiling point are the keys to characterize its physical properties. The melting point is the temperature at which a substance changes from a solid state to a liquid state; the boiling point is the degree at which it converts from a liquid state to a gaseous state. Both of these have fixed values under specific circumstances and can be measured experimentally.
As for the chemical properties, the presence of fluorine, nitro and amino groups in its molecules gives it unique reactivity. Nitro has strong electron-absorbing properties, which can reduce the density of the electron cloud of the benzene ring, making the electrophilic substitution reaction more difficult. The amino group is the power supply group, which also affects the reactivity. The characteristics of fluorine atoms also participate in many reaction processes. For example, in the nucleophilic substitution reaction, fluorine atoms can exhibit unique reaction laws due to the change of the electron cloud distribution of the benzene ring. Such properties are the key to in-depth understanding of 4-Fluoro-2-Nitrobenzeneamine, and are of great significance in the field of organic synthesis and other fields.
Technical Specifications & Labeling
4-Fluoro-2-nitrobenzeneamine is also a chemical product. Its technical specifications and identification (product parameters) are related to its quality and application.
The production of this product must follow strict procedures. The raw materials are selected carefully and the ratio is accurate. Reaction conditions such as temperature and pressure are all key. High temperatures cause the reaction to be too fast and impurities are prone to occur; low temperatures cause the reaction to be slow and time-consuming. The pressure also needs to be moderate to promote a smooth reaction.
On the label, the name should be stated, that is, "4-Fluoro-2-Nitrobenzeneamine", and the exact composition and purity should be marked. In the product parameters, the physical and chemical properties and storage conditions should not be ignored. If it should be stored in a cool and dry place, avoid mixing with oxidants, acids, etc. to prevent danger. In this way, the quality of this chemical can be guaranteed and the needs of all parties can be met.
Preparation Method
To prepare 4 - Fluoro - 2 - Nitrobenzeneamine, the method is as follows:
In terms of raw materials, fluorobenzene, nitric acid, sulfuric acid, etc. need to be prepared. Fluorobenzene is used as the starting substrate, which is the foundation of the reaction.
Synthetic process, first take an appropriate amount of fluorobenzene and place it in a special reactor. Sulfuric acid and nitric acid are mixed into a mixed acid in a specific ratio, slowly dripped into the kettle, and the temperature is controlled in a moderate range to prevent side reactions from breeding. This step is a nitrification reaction, so that fluorobenzene is introduced into the nitro group to generate 2 - nitrofluorobenzene.
In the following steps, take out 2-nitrofluorobenzene, set up another reaction vessel, add an appropriate reducing agent, such as iron powder and hydrochloric acid system, react under suitable conditions, and the nitro group is then reduced to an amino group to obtain 4-Fluoro-2-Nitrobenzeneamine.
In order to ensure the purity of the product, a refining mechanism is set up. The crude product can be dissolved in a suitable solvent by recrystallization, filtered out impurities, and then cooled and crystallized to obtain a pure product. The whole process is carefully controlled at each step to obtain high-quality 4-Fluoro-2-Nitrobenzeneamine.
Chemical Reactions & Modifications
To taste the wonders of chemical industry, it is essential to change substances, react and modify them. Now, the chemical reaction of 4-Fluoro-2-Nitrobenzeneamine is worth in-depth study.
In the past research, it was common for it to participate in many reactions. However, at the beginning, the effect of the reaction was not perfect, or the conditions were not suitable, or the reagent was not compatible.
Later researchers thought hard, changed the reaction environment, adjusted the temperature, controlled the pressure, and selected suitable solvents and catalysts. Looking at its modification, adding groups and changing the structure to form new substances.
After repeated tests, a good method was obtained. The reaction rate is increased, and the yield is also increased. And the properties of the product are better than before, and it is more suitable for all kinds of uses. It can be seen that although the chemical reaction and modification are difficult, they are diligent and thoughtful, and they will be able to break through the difficulties and get exquisite results, which will add bricks and tiles to the prosperity of the chemical industry.
Synonyms & Product Names
4 - Fluoro - 2 - Nitrobenzeneamine is an important chemical substance. Its synonyms are numerous and each has its own origin. In the past, when chemical experts studied this substance, they called it according to its characteristics and structure. Or because of its unique morphology of fluorine, nitro, benzene ring, and amine group, named after the shape; or according to its preparation method and use, and assigned different names.
As for the trade name, when it is in circulation in the market, merchants also give different names in order to recognize its characteristics and facilitate identification. Or highlight its high purity, or show its wide application. However, regardless of synonyms or trade names, they all refer to this 4 - Fluoro - 2 - Nitrobenzeneamine. Chemists use different names to exchange research experiences, and merchants promote products under the name of commodities. Many terms, although different words refer to the same, refer to this chemical product, which plays an important role in the field of chemistry.
Safety & Operational Standards
4 - Fluoro - 2 - Nitrobenzeneamine Safety and Operation Specifications
Husband 4 - Fluoro - 2 - Nitrobenzeneamine is also a chemical substance. Its nature is special, so it is safe to operate and should not be careless.
#1. Safety precautions
This substance is dangerous to a certain extent. It may be irritating, and it can be caused by skin contact, or even pain. If it enters the eyes, it is very harmful, so you must quickly wash it with a lot of water and ask for treatment. And its smell, or pungent, inhaling it, fear of breathing. Therefore, this object must be kept in a good place, and appropriate anti-dumping equipment, such as masks, gloves, and eyes, must be worn to prevent accidents.
#2. Operating this object
To handle this object, you must first make it clear, understand its properties, uses, and pay attention. For the use of this object, take the fine measuring tool according to the required amount, not less. Mixing, slow in, and keep mixing to prevent it from reversing. If there is a reaction, pay close attention to its process and follow the established method. After the reaction is completed, the remaining things should not be disposed of as intended, but must be properly handled according to the corresponding conditions, so as not to pollute the environment.
Therefore, 4 - Fluoro - 2 - Nitrobenzeneamine has its uses in chemical research or manufacturing, but safe operation is the first thing. Those who do things must be careful and follow the rules to ensure safety and avoid disasters.
Application Area
4 - Fluoro - 2 - Nitrobenzeneamine is an important chemical substance with a wide range of application fields. In the field of pharmaceutical synthesis, this compound is often a key intermediate. Doctors want to make special drugs to treat various diseases, 4 - Fluoro - 2 - Nitrobenzeneamine can participate in subtle reactions and help to form powerful drugs.
Furthermore, in the field of materials science, it also has important functions. To make materials with special properties, such as those with unique electrical and optical properties, this material can play a role in optimizing the properties of the material to meet various needs.
In the process of scientific research and exploration, chemists have launched many innovative experiments based on 4-Fluoro-2-Nitrobenzeneamine, hoping to discover new reaction pathways, generate new compounds, and promote the continuous advancement of the field of chemistry, expanding the boundaries of human cognition.
Research & Development
I have studied a lot of chemical things. Recently, I studied 4 - Fluoro - 2 - Nitrobenzeneamine.
At the beginning, I explored the method of its synthesis, and I tried all kinds of twists and turns. The choice of raw materials and the method of reaction need to be carefully considered. Or due to the difference in temperature, or due to the amount of reagents, the results are often not as good as expected. However, I was not discouraged, and I tried again and again, and finally found a feasible method.
Then study its properties, physical characteristics, and chemical properties, all of which are investigated in detail. Understand the changes in different environments, and know the rules of its reaction with other substances.
As for the field of application, the prospects are promising. In the production of medicine, it may be used as a key agent; in the research of materials, it also has potential uses. I will make unremitting efforts to study it in depth, hoping to expand its use, contribute to the progress of chemistry, and make it shine in various fields, promoting the research and development of this substance to a higher level.
Toxicity Research
Since modern times, chemical refinement has advanced, and all kinds of new things have emerged. I focus on the toxicity study of 4-Fluoro-2-Nitrobenzeneamine.
At the beginning, observe its physical properties, observe its state, smell its gas, and record it in detail. Then try it with all kinds of creatures, there are insects and pikas. Observe its state after taking this thing, or restlessness, or depression, or even death.
Study its way into the body, either orally, or through the skin, or through respiration. Explore its changes in the body, and analyze its relationship with various organs and biochemical reactions.
After months of study, I know that this product is not lightly toxic. In the environment, it can sewage the soil and harm life; in the human body, it can damage the internal organs and mess with qi and blood. Therefore, it is necessary to be careful to prevent it from flowing, protect the well-being of all beings, and keep the world peaceful.
Future Prospects
I try to study in the field of chemistry, focusing on 4 - Fluoro - 2 - Nitrobenzeneamine. Looking at the current state, although there is a certain amount of research, there is still a lot of hope for the future.
This material is unique, and it may shine extraordinary light in many fields. In the field of medicine, it can be used for the research of new agents, opening up different paths to save patients from pain; in the field of materials, it can be used as a novel material, and it can be endowed with special powers.
My generation should hold a strong heart and explore its secrets deeply. With time, we will be able to uncover more of its esoteric principles, make 4 - Fluoro - 2 - Nitrobenzeneamine shine in the future, and use it for the world.
Where to Buy 4-Fluoro-2-Nitrobenzeneamine in China?
As a trusted 4-Fluoro-2-Nitrobenzeneamine manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 4-Fluoro-2-Nitrobenzeneamine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 4-Fluoro-2-Nitrobenzeneamine?
4-Fluoro-2-nitroaniline is one of organic compounds. Its chemical properties are unique and valuable for investigation.
In terms of structure, the molecule contains fluorine atoms, nitro groups and amino groups. Fluorine atoms have strong electronegativity, which will affect the distribution of molecular electron clouds, resulting in changes in the density of ortho and para-site electron clouds. In electrophilic substitution reactions, this property has a significant impact.
Nitro is a strong electron-absorbing group, which greatly reduces the electron cloud density of the benzene ring and weakens the activity of the electrophilic substitution reaction of the benzene ring. However, it can enhance the acidity of the adjacent and para-site hydrogen atoms on the benzene ring. Due to its electron-absorbing induction effect and conjugation effect, it can disperse the charges of adjacent and para-site carbon negative ions and enhance stability.
The amino group is an electron supply group, which can increase the electron cloud density of the benzene ring and improve the activity of the electrophilic substitution reaction of the benzene ring. In many reactions, amino groups are prone to acylation, alkylation and other reactions. For example, amides can be obtained by reacting with acid chlorides; under suitable conditions, they can react with halogenated hydrocarbons to form alkylation products.
4-fluoro-2-nitroaniline can also participate in the coupling reaction. Under specific catalysts and conditions, it can react with other compounds containing unsaturated bonds to form carbon-carbon bonds or carbon-hetero bonds, which is of great significance in the field of organic synthesis and is often used to prepare complex organic molecules and pharmaceutical intermediates.
In addition, the compound exhibits certain color and optical properties due to its chromophore content. In the field of materials science, optical materials may be developed based on this. Under the irradiation of specific wavelengths of light, the molecular structure or electron cloud distribution changes, resulting in photophysical or photochemical changes.
Its chemical properties are rich and diverse, and it has wide application and research value in many fields such as organic synthesis and materials science, providing many possibilities for the development of related fields.
What are the main uses of 4-Fluoro-2-Nitrobenzeneamine?
4-Fluoro-2-nitroaniline, this is an organic chemical. It has a wide range of uses and is often used as a key intermediate in the synthesis of dyes. Due to its molecular structure containing special groups, it can borrow many chemical reactions to derive dyes of various colors, which add color to fabrics, leather and other materials.
In the field of medicinal chemistry, it also plays an important role. After clever chemical modification and synthesis, compounds with specific biological activities can be created for the development of drugs for the treatment of various diseases. For example, it may be able to participate in the construction of drug molecular structures with antibacterial, anti-inflammatory and other effects, injecting new power into pharmaceutical research and development.
Furthermore, it also has a role in the field of pesticides. With its unique chemical properties, pesticides with insecticidal and bactericidal properties can be prepared, which can help agricultural prevention and control of pests and diseases, and ensure the robust growth and harvest of crops.
In addition, in the field of materials science, it can participate in the synthesis of materials with special properties. It can improve the stability, conductivity and other characteristics of materials, open up new paths for the research and development of new materials, and show potential application value in electronics, optics and other fields.
In short, although 4-fluoro-2-nitroaniline is an organic small molecule, it plays an important role in dyes, medicine, pesticides, materials and other fields, and has contributed to the development of related industries.
What are 4-Fluoro-2-Nitrobenzeneamine synthesis methods?
The synthesis method of 4-fluoro-2-nitroaniline has been explored throughout the ages. In the past, the commonly used method was to start with fluorobenzene, which was first nitrified, so that the nitro group entered the benzene ring, and then aminated, and the amino group was added to the benzene ring, so as to obtain the target product.
When nitrifying, mixed acid is often used as an agent, sulfuric acid and nitric acid are mixed to make fluorobenzene respond to it. This step requires careful control of temperature to prevent side reactions. If the temperature is high, dinitroides will be produced more and the yield will decrease.
The method of amination, or the technique of aminolysis. Use the nitrate of fluorobenzene and liquid ammonia or ammonia water under appropriate pressure and temperature. Pressure and temperature are both critical. High pressure and suitable temperature can promote the reaction speed and yield. There are also those who use metal catalysis for ammonolysis, such as palladium and nickel as catalysts, which can reduce the harshness of the reaction conditions.
There are also nitrobenzene as the starting one. First fluoride, then reduce nitro to amino group. The method of fluorine substitution can choose nucleophilic substitution or electrophilic substitution. When nucleophilic substitution, fluorinated reagents, such as potassium fluoride, are often selected, and they should be applied in appropriate solvents. Electrophilic substitution requires special reagents and conditions. To reduce nitro groups, hydrogen can be used to reduce them with the help of metal catalysts; chemical reducing agents, such as iron and hydrochloric acid, can also be used.
The way of synthesis, although the method is different, it is necessary to carefully control the conditions, select the appropriate reagents and steps, and obtain satisfactory yield and purity. Every step is about success or failure, and it is necessary to observe and proceed with caution.
What 4-Fluoro-2-Nitrobenzeneamine need to pay attention to when storing and transporting
4 - Fluoro - 2 - Nitrobenzeneamine, Chinese name 4 - fluoro - 2 - nitroaniline, this substance is a chemical substance. When storing and transporting, many matters need to be paid attention to.
Its properties are certain to be dangerous. The storage place must be dry, cool and well ventilated. Do not be near fire or heat sources to prevent the risk of fire and explosion. It must be stored separately from oxidizing agents, acids, alkalis, etc., because it is mixed with them, it is easy to cause chemical reactions and cause danger. The storage place should be prepared with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment, so that in the event of an emergency, it can be dealt with quickly.
When transporting, also need to be cautious. Packaging must be tight to ensure that there is no risk of leakage during transportation. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment. Driving routes should be avoided in sensitive areas such as densely populated areas and residential areas. During transportation, ensure that the container does not leak, collapse, fall or damage. Escort personnel must be familiar with the nature of the transported substances and emergency treatment methods. During transportation, they need to pay close attention to the condition of the goods. If there is any abnormality, deal with it quickly.
In short, the storage and transportation of 4 - Fluoro - 2 - Nitrobenzeneamine is related to safety. All links must be strictly adhered to, operated with caution, and must not be slack in the slightest. In this way, the safety of personnel, the environment and property can be guaranteed.
4-Fluoro-2-Nitrobenzeneamine impact on the environment and people
4-Fluoro-2-nitroaniline, this is an organic compound. Its impact on the environment and the human body cannot be ignored.
In terms of the environment, if it is accidentally released into nature, it will cause many problems. This compound has certain chemical activity and flows into the water body, which may affect the water quality. Aquatic organisms depend on pure water for survival and reproduction, but the existence of 4-fluoro-2-nitroaniline may change the chemical properties of the water body, causing the deterioration of the living environment of aquatic organisms. Fish and other organisms may be damaged due to their physiological functions, such as affecting their important physiological processes such as respiration and reproduction. If it enters the soil, it may change the chemical composition of the soil and affect the activities of soil microorganisms. Soil microorganisms are essential for maintaining soil fertility and decomposing organic matter. If they are affected, they may affect plant growth. Plants cannot obtain sufficient nutrients from the soil, and their growth and development will be hindered, which will affect the balance of the entire ecosystem.
As for the impact on the human body, it should not be underestimated. If people inhale air containing 4-fluoro-2-nitroaniline, or ingest it through skin contact or accidental ingestion, it is harmful. It may irritate the respiratory tract, causing people to cough, asthma, long-term exposure, or aggravate respiratory diseases. Through skin contact, or cause skin allergies, inflammation and other symptoms, skin redness, itching, rash. If eaten by mistake, it will damage the internal organs of the human body. This compound may affect the human digestive system, causing nausea, vomiting, abdominal pain and other symptoms. And because of its toxicity, or cause damage to the human liver, kidneys and other important organs, affect the normal function of organs, and in the long run, seriously threaten human health.
In summary, 4-fluoro-2-nitroaniline has potential harm to the environment and human body. During its production, use and disposal, proper measures must be taken to prevent its adverse effects on the environment and human body.