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What is the chemical structure of 4-Fluoro-α [2-Methyl-1-Oxopropyl] -γ-Oxo-N, β-Diphenylbenzene Butane Amide?
4 - Fluoro - α - [ 2 - Methyl - 1 - Oxo propyl ] - γ - oxo - N, β - Diphenylbenzene Butane Amide is an organic compound. To understand its chemical structure, you can follow the steps below.
In the naming of this compound, "4 - Fluoro" shows that there is a fluorine atom at position 4 on the benzene ring, and the fluorine atom is connected to the benzene ring carbon atom by a single bond. " Alpha - [2 - Methyl - 1 - Oxopropyl] "indicates that there is a 2 - methyl - 1 - oxopropyl group attached to the alpha-site carbon attached to a functional group. The propyl structure is: a carbonyl group (C = O) is attached to the first carbon, and the second carbon has a methyl substitution." γ-oxo "means that there is a carbonyl group on the gamma-site carbon, which is connected to the main chain." N, β-Diphenyl "means that the nitrogen atom (N) is connected to the beta-site carbon, respectively. And "Butane Amide" indicates that the main chain of the compound is a butylamide structure, which is composed of four carbon chains and amide groups (-CONH -).
In summary, its chemical structure can be outlined as follows: based on the main chain of butylamide, the carbon at a certain position of the main chain is connected with a benzene ring, and the benzene ring has a fluorine atom at position 4; the main chain α-position carbon is connected with 2-methyl-1-oxopropyl, and the γ-position carbon has a carbonyl group; the nitrogen atom and the β-position carbon are respectively connected to a benzene ring. In this way, the outline of its chemical structure can be roughly drawn.
What are the physical properties of 4-Fluoro-α [2-Methyl-1-Oxopropyl] -γ-Oxo-N, β-Diphenylbenzene Butane Amide
4-Fluorine - α - [ 2-methyl-1-oxopropyl ] - γ - oxo-N, β-diphenylphenylbutylamide, this is an organic compound. Its physical properties are unique, let me explain in detail.
Looking at its appearance, under room temperature and pressure, it may be in the form of a white to light yellow solid powder, just like the fine snow that falls at the beginning of winter, delicate and uniform, and like the yellowish ancient paper precipitated by years, simple and mysterious. This compound has a certain crystallinity. Under specific conditions, the crystalline form is regular, just like a carefully carved miniature crystal artwork, reflecting the beauty of science.
When it comes to the melting point, it is within a certain temperature range. The specific value is an important physical characteristic of the compound, which is like a precise key to open the door to the study of its physical properties. When the temperature gradually rises near the melting point, the compound slowly melts from the solid state to the liquid state, just like ice and snow meet the warm sun, quietly changing the state of matter.
In terms of solubility, in common organic solvents, it shows specific solubility characteristics. In some organic solvents such as ethanol and acetone, it can show a certain solubility, just like a fish entering water and gradually dispersing and fusing; in water, the solubility is quite limited, just like the incompatibility of oil and water, which is distinct. This difference in solubility is closely related to the molecular structure of the compound, and the characteristics of various groups in the molecule jointly determine its behavior in different solvent environments.
In addition, the density of the compound is also one of the key elements of its physical properties. The density value reflects the degree of close arrangement of its molecules, just like the structure of a building, which determines its space occupation and accumulation mode, which is of great significance for its practical application and research.
In summary, the physical properties of 4-fluoro - α - [ 2-methyl-1-oxopropyl ] - γ - oxo-N, β-diphenylbenzamide, from appearance, melting point, solubility to density, are important clues to explore its chemical nature and potential applications, and open many possible doors for chemical research.
What is the main use of 4-Fluoro-α [2-Methyl-1-Oxopropyl] -γ-Oxo-N, β-Diphenylbenzene Butane Amide
4-Fluoro - α - [ 2-methyl-1-oxopropyl ] - γ - oxo-N, β-diphenylphenylbutylamide, which is an organic compound. It has a wide range of uses in the field of medicine and is often used as an intermediate of active pharmaceutical ingredients. Due to its unique chemical structure, or specific biological activities and pharmacological properties, it can participate in many drug synthesis steps and help develop new therapeutic drugs, such as drugs for targeted treatment of specific diseases.
In the field of materials science, or due to its structural properties, it can be used as a raw material for the synthesis of functional materials. Through chemical reactions, materials with unique properties, such as those with special optical, electrical or mechanical properties, are constructed to meet the needs of different fields such as electronics and optics.
In organic synthetic chemistry, it is a key intermediate. Chemists can use various organic reactions to modify and derive their structures to synthesize organic compounds with more complex structures and unique functions, expanding the variety and application range of organic compounds, which is of great significance to promoting the development of organic synthetic chemistry.
What is the preparation method of 4-Fluoro-α [2-Methyl-1-Oxopropyl] -γ-Oxo-N, β-Diphenylbenzene Butane Amide
To prepare 4 - Fluoro - α - [ 2 - Methyl - 1 - Oxo propyl ] - γ - Oxo - N, β - Diphenylbenzene Butane Amide, you can follow the following ancient method.
First take an appropriate amount of fluorobenzaldehyde, place it in a clean kettle, dissolve it in an organic solvent, and make it a homogeneous phase. In this solution, slowly add the pretreated 2 - methylpropionyl chloride, and add an appropriate amount of acid binding agent to maintain the acid-base balance of the reaction system. Heat to a suitable temperature, about 50 to 60 degrees Celsius, stir it to fully react. The purpose of this step is to introduce the alpha - [2 - Methyl - 1 - Oxopropyl] group.
After the first step of the reaction is completed, cool down to room temperature, pour the reaction mixture into an appropriate amount of ice water to extract the organic phase. After drying the organic phase with anhydrous sodium sulfate, filter and remove the desiccant. Distillate under reduced pressure to obtain an intermediate product.
Take another kettle, add an appropriate amount of phenylacetonitrile, and treat it with a strong base to generate the corresponding negative ions. Then add the obtained intermediate product to this kettle, heat up to 80 to 90 degrees Celsius, and continue to stir the reaction. The key to this step of reaction is to construct the γ-Oxo structure.
After the reaction is completed, the system is cooled and neutralized to neutral with dilute acid. Extract again in an organic solvent, dry, filter, and distill to obtain another intermediate.
Finally, the intermediate product is mixed with aniline in a suitable solvent, an appropriate amount of catalyst is added, and heated to 120 to 130 degrees Celsius for amidation. After the reaction is completed, pure 4 - Fluoro - α - [ 2 - Methyl - 1 - Oxo propyl ] - γ - Oxo - N, β - Diphenylbenzene Butane Amide can be obtained by refining means such as recrystallization. The whole process requires attention to the control of reaction temperature, reagent dosage and reaction time in order to obtain satisfactory yield and purity.
4-Fluoro-α [2-Methyl-1-Oxopropyl] -γ-Oxo-N, β-Diphenylbenzene Butane Amide What are the safety precautions
4 - Fluoro - α - [ 2 - Methyl - 1 - Oxo propyl ] - γ - oxo - N, β - Diphenylbenzene Butane Amide is an organic compound. This substance has many safety precautions and needs to be treated with caution.
bear the brunt, this substance may be toxic. If inadvertently exposed, whether through skin penetration, inhalation of volatile gas, or accidental ingestion, it may cause damage to human health. After skin contact, it may cause redness, swelling, itching, and tingling. At this time, be sure to rinse the contact area with a lot of water immediately, wash the contaminated material, and then seek medical consultation if necessary according to the severity of symptoms. If inhaling its volatiles, it may cause respiratory discomfort, such as coughing, asthma, breathing difficulties, etc. Once encountering this situation, you should immediately move to a place with fresh air to keep breathing smoothly. If the symptoms do not slow down, rush to the hospital for first aid. If unfortunately ingested by mistake, do not induce vomiting, you should seek medical attention as soon as possible and follow the doctor's advice.
In addition, its chemical properties are lively. When storing, it should be kept away from fire and heat sources, because it may be flammable risk. In case of open flame or hot topic, it may cause combustion or even explosion. At the same time, avoid mixing with strong oxidants, strong acids, strong alkalis and other substances to prevent violent chemical reactions from occurring and causing danger. The storage environment should be dry, cool and well ventilated to maintain its chemical stability.
The operation process also needs to be strictly followed. It is recommended to carry out relevant operations in a fume hood, which can effectively reduce the concentration of volatile substances in the air and reduce the risk of inhalation. At the same time, the operator must wear appropriate protective equipment, such as protective gloves, which can be selected from chemically resistant materials, to isolate the skin from contact with the substance; protective glasses, which can protect the eyes from splash damage; gas masks, which can filter harmful ingredients in the inhaled air. After the operation, the used appliances should be properly cleaned to prevent subsequent dangers caused by residual substances.
In short, the treatment of 4 - Fluoro - α - [ 2 - Methyl - 1 - Oxo propyl ] - γ - oxo - N, β - Diphenylbenzene Butane Amide, from storage to operation, every link should not be taken lightly, strictly abide by safety regulations, in order to ensure personnel safety and environmental safety.