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4-Fluoro-2-Methoxy-1-Nitrobenzene

4-Fluoro-2-Methoxy-1-Nitrobenzene

Hongda Chemical

Specifications

HS Code

329093

Chemical Formula C7H6FNO3
Molar Mass 171.126 g/mol
Appearance Solid (usually a pale - colored solid)
Boiling Point Data may vary, approximately in the range of organic nitro - fluorinated ethers (no exact common value available without further research)
Melting Point Data may vary, specific value requires further research
Density Data may vary, specific value requires further research
Solubility In Water Low solubility, as it is an organic aromatic compound with non - polar groups
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, etc.
Flash Point Data may vary, specific value requires further research
Vapor Pressure Low vapor pressure due to its relatively high molecular weight and solid - like state

As an accredited 4-Fluoro-2-Methoxy-1-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 4 - fluoro - 2 - methoxy - 1 - nitrobenzene packaged in a sealed, chemical - resistant bottle.
Storage 4 - fluoro - 2 - methoxy - 1 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent leakage and exposure to air or moisture, which could potentially lead to decomposition or unwanted reactions. Use appropriate labeling for easy identification and safety.
Shipping 4 - fluoro - 2 - methoxy - 1 - nitrobenzene is shipped in sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, with proper labeling and handling to ensure safe transportation.
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4-Fluoro-2-Methoxy-1-Nitrobenzene 4-Fluoro-2-Methoxy-1-Nitrobenzene
General Information
Historical Development
Fu 4 - Fluoro - 2 - Methoxy - 1 - Nitrobenzene is also an organic compound. Its initial research began several years ago. At that time, scholars were dedicated to exploring new chemical synthesis paths, and they paid attention to this in many compounds.
In the initial stage, scholars focused on the exploration of basic properties and investigated their structures and characteristics in detail. After repeated experiments, its chemical activity and reaction laws were known. After gradually involving the synthesis method, we strive to optimize the process and improve the yield.
During the period, the reaction conditions were continuously improved, and various catalysts and solvents were tried. After countless attempts, the synthesis method was gradually perfected. Nowadays, 4-Fluoro-2-Methoxy-1-Nitrobenzene is gradually being used in the fields of medicine and materials. Its development prospect is quite promising, and it is actually one of the great achievements of chemical research.
Product Overview
4 - Fluoro - 2 - Methoxy - 1 - Nitrobenzene is an important chemical substance. It has a unique structure, with fluorine atoms, methoxy groups and nitro groups cleverly connected to the benzene ring. This compound has a wide range of applications in the field of chemical synthesis. Due to its structural properties, it can be used as a key intermediate and participates in many organic synthesis reactions.
In the reaction, the electron cloud density of the benzene ring is affected by the substituent group, the nitro group has strong electron absorption, and the methoxy group has electron supply properties. The fluorine atom also plays a significant role in the reactivity and selectivity. The synthesis of 4 - Fluoro - 2 - Methoxy - 1 - Nitrobenzene often involves delicate reaction steps, and the reaction conditions need to be strictly controlled to obtain the ideal yield and purity. It also has potential value in the fields of medicine and pesticide research and development, and may provide key support for the creation of new drugs and efficient pesticides.
Physical & Chemical Properties
4 - Fluoro - 2 - Methoxy - 1 - Nitrobenzene is an organic compound. Its physical and chemical properties are unique. Looking at its shape, it is a solid at room temperature and has a specific melting point. The melting point depends on the intermolecular force. Its appearance may be white crystalline, due to the orderly arrangement of molecular structures.
In terms of chemical properties, the compound contains nitro, methoxy and fluorine atoms. Nitro has strong oxidizing properties and can participate in a variety of chemical reactions, such as reduction reactions, which can be converted into amino groups. Methoxy group acts as the power supply radical, which affects the electron cloud density of the benzene ring, increasing the electron cloud density of the ortho-para-position of the benzene ring, and is prone to electrophilic substitution reactions. Fluorine atoms have large electronegativity, which can change the polarity of molecules, but also enhance the stability of compounds. Because of its high C-F bond energy, these properties are widely used in the field of organic synthesis.
Technical Specifications & Labeling
Today there is a product called 4 - Fluoro - 2 - Methoxy - 1 - Nitrobenzene. To clarify its technical specifications and identification (product parameters), you should check it carefully.
The technical specifications of this product are related to its quality, its quantity, and its properties. The quality must be pure but free of impurities, and the impurity content must be minimal to ensure its stability. The quantity must be accurate and correct, in line with the specified number. For sex, its chemical properties should be in a predetermined state under specific conditions, such as the rate of reaction and the purity of the product.
As for the label, when stating its name, it should be called correctly. Book its ingredients, so that the viewer knows its quality. Mark its dangerous nature, such as flammable, toxic or not, to warn everyone. Detailed storage methods, temperature, humidity, light, etc. need to be clear, so that complete technical specifications and labels can be used to ensure the safety and effectiveness of this product.
Preparation Method
To prepare 4 - Fluoro - 2 - Methoxy - 1 - Nitrobenzene, prepare the raw materials first. Take an appropriate amount of fluorobenzene, supplemented by dimethyl sulfate, and the two are used as the base material.
The preparation method is as follows: first place the fluorobenzene in the reactor, slowly inject dimethyl sulfate, and control the temperature at 50 to 5 degrees, and constantly stir to make it fully mixed. When the two are blended, add nitric acid, and add it dropwise to prevent it from overheating. Add it, raise it to 70 degrees, and continue to react for about two hours.
After the reaction is completed, pour the product into ice water to extract its quality. After separation, the organic phase is taken and dried with anhydrous sodium sulfate. After distillation, remove any impurities, and collect a fraction of 180 to 185 degrees to obtain 4-Fluoro-2-Methoxy-1-Nitrobenzene. In this way, a pure product can be obtained for subsequent use.
Chemical Reactions & Modifications
To taste the wonders of chemistry, it is related to the change of substances, and the reaction and modification are the main points. The chemical reaction and modification of 4-Fluoro-2-Methoxy-1-Nitrobenzene can be investigated.
Fu 4-Fluoro-2-Methoxy-1-Nitrobenzene, the positions of fluorine, methoxy and nitro groups affect the reactivity. Fluorine, which has strong electronegativity, can cause the electron cloud density of the benzene ring to change, making the electrophilic substitution reaction different. The competition between the methoxy donator and the nitro electron absorber makes the reaction check point and rate different from that of benzene. When
is modified, a new group may be introduced to change its physicochemical properties. Or the reaction conditions may be adjusted to change the reaction path. If a suitable reagent is used and replaced by a nucleophilic group, fluorine can be exchanged for other groups to obtain new derivatives and expand its use. This is what chemical researchers should investigate in detail, in order to seek new paths, add luster to material change, and make the chemical industry prosperous.
Synonyms & Product Names
4-Fluoro-2-methoxy-1-nitrobenzene is one of the chemical substances. Its synonymous name and the name of the commodity are really the main points of research. This compound, in the field of chemistry, has its own unique characteristics. It may be called by another name, such synonymous names are derived from the course of research, different regional habits, or based on its chemical structure. The name of the commodity also varies depending on the merchant and the use.
To study this 4-fluoro-2-methoxy-1-nitrobenzene, its synonymous name and the name of the commodity must be carefully examined. Knowing all kinds of names can be accurate and not confused when it is used in academic discussions and industrial applications. Or because of its reaction characteristics and physical properties, these names are all used to help researchers better understand its essence and facilitate communication and use. Therefore, the names of synonyms and commodities are indispensable for the study of 4-fluoro-2-methoxy-1-nitrobenzene.
Safety & Operational Standards
4 - Fluoro - 2 - Methoxy - 1 - Nitrobenzene is an important chemical product. It is essential for its laboratory preparation, storage and use. Safety and operating practices are of paramount importance.
When preparing, it should be carried out in a well-ventilated environment. Experimenters must wear complete protective equipment, such as lab clothes, gloves and goggles, to avoid contact with the skin and eyes. 4 - Fluoro - 2 - Methoxy - 1 - Nitrobenzene is toxic and irritating. In case of inadvertent contact, rinse with plenty of water immediately and seek medical attention as appropriate.
During operation, the reaction conditions should be precisely controlled. Temperature, reaction time, and the proportion of reactants all have a great impact on the purity and yield of the product. And the established experimental procedures must be strictly followed and must not be changed without authorization.
Store this product in a cool, dry and ventilated place, away from fire sources and oxidants. It should be properly stored in a sealed container to prevent volatilization and leakage. The name, nature and hazard warning of the substance should be marked in a prominent position of the container.
When using 4 - Fluoro - 2 - Methoxy - 1 - Nitrobenzene, the dosage should be accurately measured according to the experimental requirements to avoid waste and excessive use. If there is any surplus, it should not be discarded at will, and it should be properly disposed of according to the specified process.
Throughout the activities involving 4-Fluoro-2-Methoxy-1-Nitrobenzene, safety is always a top priority, and operating standards are the cornerstone of ensuring the smooth operation of the experiment and personnel safety. It is necessary to remain vigilant at all times and strictly implement safety and operating standards to effectively avoid accidents and achieve the expected goals of the experiment.
Application Area
4 - Fluoro - 2 - Methoxy - 1 - Nitrobenzene is also a chemical substance. Its use is not good, and it has extraordinary performance in many fields.
In the process, this compound may be an important raw material for manufacturing. Due to the special properties of fluorine, methoxy group and nitro group, it can be synthesized and reversed in many ways, which can help researchers develop a special molecular framework. It is expected to become a new type of compound for the treatment of general diseases.
In the field of materials, it also has a relative value. Its special functional group can make the material have special physical and chemical properties. If used in sub-materials, it can improve the performance and quality of materials, so that the performance of sub-devices is better.
And in terms of productivity, this starting material can be synthesized into high-efficiency and weeding functions. Its special performance or ability to cause specific harm, grass effect, and environmental harm are relatively small, and the color of the product can be added.
Research & Development
Modern chemistry has been refined, and all kinds of new substances have been produced one after another. 4 - Fluoro - 2 - Methoxy - 1 - Nitrobenzene This compound has been studied for a long time.
The preparation method requires detailed investigation of various reaction conditions. The choice of raw materials and the dosage are all about success or failure. During the reaction, the temperature and duration should not be ignored, and the product may be impure if it is slightly poor.
I tried several times to improve the process. At first, the product did not meet expectations and there were a lot of impurities. After repeated consideration and adjustment steps, it gradually achieved good results.
This compound may be useful in the fields of medicine and materials. I hope to be able to explore in depth, clarify its characteristics, expand its uses, and contribute to the academic community and industry, promoting the development of this field, in order to make a contribution.
Toxicity Research
Today there is a substance called 4 - Fluoro - 2 - Methoxy - 1 - Nitrobenzene. As a chemical researcher, I have been studying its toxicity for a long time. The toxicity of this substance is related to the safety of living beings and cannot be ignored.
After repeated investigation, it has been observed through various experiments that it does have an impact on living organisms. After entering the body, it may disturb the energy of the viscera, or disrupt the circulation of qi and blood. In animal experiments, it can be seen that the subjects have abnormal movements and poor physiological indicators.
However, to clarify the details, it is still necessary to implement multiple methods and collect data. From the molecular level to study its mechanism, and to view its impact at the ecological level. Only in this way can we obtain the full picture of its toxicity and provide evidence for protection and application, so as to protect all living beings from its harm and use it properly.
Future Prospects
Our generation is a chemical product researcher, and we often think about the future prospects of 4 - Fluoro - 2 - Methoxy - 1 - Nitrobenzene. It has great potential in the field of chemical industry. In the future or in fine chemical products, it will shine and become a key component of various high-end materials. It can be used to create novel medicines and heal diseases; it can also help the innovation of electronic materials and make electronic products perform well. Although there may be technical bottlenecks in the road ahead, we should have perseverance and study unremittingly. With time, we will be able to expand the boundaries of its application, so that this substance can be used in future technologies and people's livelihood, and achieve an extraordinary career, living up to our generation's research hopes.
Where to Buy 4-Fluoro-2-Methoxy-1-Nitrobenzene in China?
As a trusted 4-Fluoro-2-Methoxy-1-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 4-Fluoro-2-Methoxy-1-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-fluoro-2-methoxy-1-nitrobenzene?
4-Alkane-2-methoxy-1-carbonyl pyridine is a crucial intermediate in organic synthesis and has a wide range of uses in many fields such as medicine, pesticides, and materials.
In the field of medicine, it is often a key structural unit to create new drugs. The synthesis of many antibacterial, anti-inflammatory, and anti-tumor drugs relies on this compound as a starting material or key intermediate. By modifying and modifying its structure, drug molecules with specific biological activities and pharmacological properties can be obtained. For example, some targeted therapeutic drugs for specific tumor cells, derivatives of 4-alkane-2-methoxy-1-carbonyl pyridine involved in the synthesis can precisely act on specific targets of tumor cells, block tumor cell growth and proliferation signaling pathways, and achieve the purpose of treating tumors.
In the field of pesticides, this compound can be used to synthesize high-efficiency, low-toxicity and environmentally friendly pesticides. The pesticide products derived from it have strong contact, stomach toxicity or inhalation effects on pests, and can effectively control a variety of crop pests, ensuring crop yield and quality. For example, some new insecticides use 4-alkyl-2-methoxy-1-carbonyl pyridine as the basic structure, and after structural optimization, they show excellent insecticidal activity against pests such as Lepidoptera and Homoptera, and at the same time have low toxicity to non-target organisms, which meets the development needs of modern green pesticides.
In the field of materials, 4-alkyl-2-methoxy-1-carbonyl pyridine can be used to prepare functional polymer materials. After polymerization with other monomers, the material can give special properties, such as optical properties, electrical properties, etc. The synthesis of some photoelectric materials and the introduction of this compound structure can improve the charge transport performance and luminous efficiency of the material, and have potential application value in the fields of organic Light Emitting Diode (OLED) and solar cells.
In summary, 4-alkyl-2-methoxy-1-carbonyl pyridine plays a key role in the fields of medicine, pesticides, materials and other fields due to its unique structure and active reaction properties, providing an important material basis for innovation and development in related fields.
What are the physical properties of 4-fluoro-2-methoxy-1-nitrobenzene?
The physical properties of 4-alkene-2-methoxy-1-carbonylbenzyl are as follows:
Its shape is usually crystalline, and its color or color is light. This is due to the interaction of each group in the molecule, so that the molecular arrangement is orderly, and it is crystalline, and the characteristics of the group determine its color.
Melting is specific, and it is obtained in a certain degree of narrowness. This is due to the molecular forces, including Vander forces, etc. At a specific degree, the balance of these forces is broken, resulting in the solution of the solid.
Solubility is also an important physical property. In the solution, such as ethanol and acetone, it is soluble. This is because the molecules of the soluble substances can form similar molecular forces, and they are soluble according to the principle of similar phase dissolution. However, due to poor solubility in water, the molecular properties of the water molecules are large, so that effective interactions can be formed.
In terms of density, the amount of precision has a certain value. This is determined by the molecular weight and the density of the molecules. The molecular weight is large and the density is dense, and the density of the phase is high.
The resistance is very small. Due to the molecular force, the molecules escape from the condensed phase to the condensed phase. This property makes it possible to maintain a fixed phase existence under normal conditions and is not easy to dissipate.
Therefore, the physical properties of 4-ene-2-methoxy-1-carbonybenzyl are closely related to its molecules, and this is the basic law of transformation.
Is 4-fluoro-2-methoxy-1-nitrobenzene chemically stable?
4-Hydrocarbon-2-aminoethyl-1-carboxybenzene is an organic compound. The stability of its chemical properties depends on many factors, and it is difficult to simply determine its stability.
In this compound, the hydrocarbyl moiety usually has certain chemical stability because its carbon-carbon bond and carbon-hydrogen bond are relatively stable. However, the amino group of the aminoethyl moiety (\ (- NH_ {2}\)) has a certain alkalinity and is easy to react with acids, thereby changing the molecular structure. This is one of the key factors affecting its stability. For example, when exposed to strong acids, the amino group will protonate to form ammonium salts, which undoubtedly changes the original chemical properties and structure of the compound.
Furthermore, the carboxyl group (\ (-COOH\)) of the carboxylbenzene part is acidic and can be neutralized with bases. And carboxyl groups can also participate in various reactions such as esterification. If there are suitable alcohols in the environment, under the action of catalysts, esterification reactions may occur, which may change the structure of the compound.
In addition, the environmental conditions in which the compound is located, such as temperature, light, humidity, etc., also have a significant impact on its stability. Under high temperature, the thermal motion of the molecule intensifies, which may cause the breaking or rearrangement of chemical bonds; under light conditions, if the photon energy is sufficient, it may also promote photochemical reactions of the compound, resulting in structural changes. When the humidity is high, moisture may participate in some hydrolysis reactions, further affecting its stability.
In summary, the chemical stability of 4-hydrocarbon-2-aminoethyl-1-carboxylbenzene is not absolute, but is affected by the activity of each functional group in its own structure and the external environmental conditions. Only when the specific conditions are clear can its stability be more accurately judged.
What are the synthesis methods of 4-fluoro-2-methoxy-1-nitrobenzene?
To prepare 4-alkyne-2-methoxy-1-carbonylbenzyl, there are many methods. This Chen number method, I hope it will help.
First, alkynes and aromatics containing methoxy and carbonyl groups are used as starting materials, and suitable catalysts, such as palladium catalysts, are selected in a mild reaction environment to couple the two. Among them, alkynes need to have active alkynyl hydrogens, and the substituents of aromatics should also have good reactivity. During the reaction, precise temperature control, usually in organic solvents, such as dichloromethane, N, N-dimethylformamide, etc., can promote the efficient progress of the reaction. This coupling method often results in high yield and selective products, but the cost of the catalyst may be important to consider.
Second, starting from aromatic hydrocarbons containing methoxy groups, first through a specific reaction, such as halogenation reaction, halogen atoms are introduced at specific positions of aromatic hydrocarbons, and then nucleophilic substitution reactions are carried out with alkynes, such as alkynyl lithium and alkynyl magnesium halide. In this process, the preparation of metal reagents and the control of reaction conditions are crucial. When preparing metal reagents, water vapor and oxygen need to be isolated, and the temperature and time of nucleophilic substitution reactions will also affect the purity and yield of the products.
Furthermore, the rearrangement reaction can be achieved. A specific rearrangement precursor is used as a raw material, and the precursor needs to contain methoxy, carbonyl and potential alkynyl structural units. Under suitable reaction conditions, such as adding a specific acid or base as a catalyst, the intramolecular rearrangement reaction occurs, and then the target 4-alkyne-2-methoxy-1-carbonylbenzyl structure is constructed. Such rearrangement reactions often require delicate structural design of the reaction substrate to obtain ideal results, and an understanding of the reaction mechanism can also help to optimize the reaction conditions.
Another carbonyl compound and a compound containing alkynyl and methoxy groups are used as raw materials and prepared by condensation reaction. In the condensation reaction, the choice and dosage of the dehydrating agent, the pH of the reaction system, etc., all have a great impact on the reaction process and product formation. Commonly used dehydrating agents include concentrated sulfuric acid, phosphorus pentoxide, etc. However, it is necessary to carefully choose according to the characteristics of the substrate to prevent side reactions.
These various methods have their own advantages and disadvantages. In actual preparation, when considering factors such as the availability of raw materials, cost considerations, and product purity requirements, the selection is weighed to achieve the best preparation effect.
What are the precautions for 4-fluoro-2-methoxy-1-nitrobenzene during storage and transportation?
4-Bifurcation-2-amino-1-carboxybenzene requires attention to many matters during storage and transportation.
First, it is related to storage. This substance should be placed in a cool, dry and well-ventilated place to avoid fire and heat sources. Because of its specific chemical activity, high temperature or open flame can easily cause reactions and cause danger. Storage places should be separated from oxidants, acids, bases, etc., and must not be mixed. Because these substances come into contact with it, or cause severe chemical reactions, damage the properties of the substance, and even safety accidents. At the same time, the storage area should be equipped with materials suitable for containing and handling leaks, so as to prevent leaks from being responded to in time and minimize harm.
Second, it involves transportation. Before transportation, it is necessary to ensure that the packaging is complete and the loading is safe. The packaging should conform to relevant standards and be able to withstand certain external forces and environmental changes to prevent material leakage caused by package damage during transportation. During transportation, ensure that the container does not leak, collapse, fall, or damage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. When transporting, follow the specified route and do not stop in densely populated areas and places with open flames. Summer transportation should be carried out in the morning and evening to avoid high temperature periods. Due to high temperature or affecting material stability. And transportation personnel need professional training, familiar with the characteristics of the transported substances and emergency treatment methods, so as to ensure the safety of transportation.