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4-Fluoro-2-Isothiocyanato-1-Methylbenzene

4-Fluoro-2-Isothiocyanato-1-Methylbenzene

Hongda Chemical

    Specifications

    HS Code

    805038

    Chemical Formula C8H6FNS
    Molecular Weight 167.203 g/mol
    Appearance Colorless to light yellow liquid
    Boiling Point 225 - 227 °C
    Density 1.176 g/mL at 25 °C
    Solubility Soluble in organic solvents like dichloromethane, chloroform
    Flash Point 96 °C
    Refractive Index 1.576 (20 °C)

    As an accredited 4-Fluoro-2-Isothiocyanato-1-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 4 - fluoro - 2 - isothiocyanato - 1 - methylbenzene packaged in a sealed glass bottle.
    Storage 4 - fluoro - 2 - isothiocyanato - 1 - methylbenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it is likely flammable. Keep it in a tightly sealed container to prevent leakage and exposure to air, which could lead to degradation. Store it separately from incompatible substances like oxidizing agents and bases to avoid potential reactions.
    Shipping 4 - fluoro - 2 - isothiocyanato - 1 - methylbenzene is a chemical. Shipping should be in accordance with hazardous material regulations. Use properly labeled, sealed containers to prevent leakage during transportation to ensure safety.
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    4-Fluoro-2-Isothiocyanato-1-Methylbenzene 4-Fluoro-2-Isothiocyanato-1-Methylbenzene
    General Information
    Historical Development
    4-Fluoro-2-isothiocyanate-1-methylbenzene, the development of its materials can be described. At the beginning, the academic community did not study the way of organic synthesis in depth, and such compounds were little known. Later, with the deeper investigation of the organic reaction mechanism by various scholars, the synthesis method has improved.
    In the past, the road to synthesis was full of thorns, the raw materials were rare, the reaction conditions were harsh, and the yield was also low. However, many scholars are reluctant to study, and the changes over the years have improved the synthesis path and optimized the reaction conditions.
    In recent years, science and technology have been updated, and the analytical methods have become more refined, and the understanding of its structure and properties has become clearer. This compound has emerged in various fields such as medicine and materials, and its application is gradually widening. Its development process is the result of unremitting exploration by scholars, and it will surely show more brilliance in various fields in the future.
    Product Overview
    4 - Fluoro - 2 - Isothiocyanato - 1 - Methylbenzene is an important organic compound. Its unique chemical structure, containing fluorine atoms, isothiocyanate and methyl groups, endows this compound with specific physical and chemical properties.
    This compound has a wide range of uses in the field of organic synthesis. Because it contains isothiocyanate, it can react with many nucleophiles to form new chemical bonds, which can be used to prepare various sulfur-containing and nitrogen-containing heterocyclic compounds, providing an important synthetic building block for organic synthesis chemists.
    and its fluorine-containing atoms change the lipophilicity and stability of compounds. In the field of medicinal chemistry, this structure may be introduced to optimize the pharmacokinetic properties of drug molecules. In materials science, or due to its unique structure, it shows special optical and electrical properties and has potential application value.
    Physical & Chemical Properties
    4 - Fluoro - 2 - Isothiocyanato - 1 - Methylbenzene is an organic compound. Its physical and chemical properties are unique. Looking at it, it may be a liquid at room temperature and has a special odor. In terms of physical properties, it has a certain boiling point and melting point. Due to the specific functional groups in the molecular structure, its volatility is different.
    Chemically, it contains isothiocyanate groups with fluorine atoms and methyl groups, and its activity is significant. Isothiocyanate groups can react with many nucleophiles, such as reacting with amines to form thiourea derivatives and alcohols to form carbamates. Fluorine atoms change the electron cloud density of the benzene ring, which affects the reaction activity and selectivity. Methyl groups affect the steric hindrance and molecular polarity.
    In summary, 4 - Fluoro - 2 - Isothiocyanato - 1 - Methylbenzene has important application potential in organic synthesis and other fields due to its unique physical and chemical properties.
    Technical Specifications & Labeling
    Today there is a product called 4 - Fluoro - 2 - Isothiocyanato - 1 - Methylbenzene. Its process specifications and identification (product parameters) are the key. The process specifications of this substance need to be precisely controlled in all aspects. Since the selection of raw materials, it must be pure and flawless, and the impurities must not exceed the slightest. The method of synthesis should also follow specific procedures. The parameters such as temperature and pressure must meet the standards. There is a slight difference, or the quality may change.
    As for the logo (product parameters), from the appearance and color, it should be in a specific state, without variegation. The standard of purity must reach a very high level, and the impurities contained should be minimal. And the physical and chemical indicators, such as melting point, boiling point, etc., are fixed and must be strictly consistent. In this way, high-quality 4 - Fluoro - 2 - Isothiocyanato - 1 - Methylbenzene can be obtained to meet the needs of all parties.
    Preparation Method
    This product is made of 4 - Fluoro - 2 - Isothiocyanato - 1 - Methylbenzene. Its raw materials are crucial to the production process, reaction steps, and catalytic mechanism. First, take an appropriate amount of fluorotoluene as the initial raw material, mix sulfur phosgene in a specific ratio in a special reactor, add a little high-efficiency catalyst, and control the temperature in a suitable range, about 60 to 80 degrees Celsius, and continue to stir to make the two fully react. After several times, until the reaction is complete, the impurities are separated by distillation and purification, and the desired product is retained. Subsequent precision detection methods are used to verify the purity of the product, and the purification steps are repeated if it does not meet the standard criteria. In this way, the process and strict control of each link can produce high-quality 4-Fluoro-2-Isothiocyanato-1-Methylbenzene stably.
    Chemical Reactions & Modifications
    The wonders of chemical industry are related to the change of substances. The reaction and modification of 4 - Fluoro - 2 - Isothiocyanato - 1 - Methylbenzene are particularly worth studying.
    The reaction, the clutching of chemical bonds, and the rearrangement of atoms all obey the laws of chemistry. When this substance encounters a reagent, or nucleophilic addition, or electron transfer, it undergoes a wonderful change, generating new products, and the structure and function are changed accordingly.
    As for modification, it is designed to optimize its properties. Or increase its stability, so that it can be retained for a long time in different environments; or change its activity, so that it is easier to participate in specific reactions. Modification method, or adding groups, or changing configurations, fine operation to achieve the desired properties.
    The way of chemistry, exploring endless, in the reaction and modification of 4 - Fluoro - 2 - Isothiocyanato - 1 - Methylbenzene, unremitting research, in order to gain more mysteries, to benefit the chemical industry and benefit the world.
    Synonyms & Product Names
    4 - Fluoro - 2 - Isothiocyanato - 1 - Methylbenzene is a chemical substance. In the process of my chemical research, its nickname and trade name are quite important.
    The nickname of this substance, or it is related to its chemical properties and structure. Looking at its structure, fluorine atoms, isothiocyanate and methyl are based on specific positions in the benzene ring, or have different names because of this.
    As for trade names, when it comes to commercial circulation and application fields. In the chemical market, different manufacturers recognize their product characteristics or take unique trade names.
    However, whether it is a nickname or a trade name, it is to help us better understand this substance, accurately identify and communicate between research, production and application. Our chemical researchers need to know its many names in detail in order to navigate the realm of chemistry and promote research and development.
    Safety & Operational Standards
    4 - Fluoro - 2 - Isothiocyanato - 1 - Methylbenzene Safety and Operation Code
    Fu 4 - Fluoro - 2 - Isothiocyanato - 1 - Methylbenzene is an important chemical substance. When it is used in experiments and production, safety and operation standards are of paramount importance.
    First word safety. This substance has certain toxicity and irritation. Therefore, when taking it, it is necessary to wear protective equipment, such as gas masks, protective gloves and goggles, to prevent it from contacting the skin, inhaling the respiratory tract, and causing damage to the body. And it should be stored in a cool, dry and well-ventilated place, away from fire and heat sources, to prevent accidents.
    Times and operating specifications. In the experimental operation room, it is necessary to keep it clean and orderly, and the instruments and equipment should be regularly calibrated to ensure accuracy. When preparing or using this substance, the operation steps must strictly follow the established procedures. If dissolving or mixing operations are carried out slowly and constantly stirring to prevent local overheating or overreaction. After the operation is completed, the utensils used should be cleaned in time to prevent the residue of the substance from corroding the equipment or causing subsequent reactions.
    Furthermore, if you accidentally come into contact with this substance, you should immediately rinse the contact area with a large amount of water. If inhaling, quickly move to a fresh air place and seek medical treatment if necessary. In the event of a leak, unrelated personnel should be evacuated promptly, the leak area should be isolated, and the leakage area should be carefully collected or absorbed with suitable materials to avoid it spreading into the environment and causing pollution.
    In short, during the use of 4-Fluoro-2-Isothiocyanato-1-Methylbenzene, safety and operating standards are the key to ensuring the safety of personnel, the smooth operation of the experiment and the environment. Do not be negligent.
    Application Area
    4 - Fluoro - 2 - Isothiocyanato - 1 - Methylbenzene is also a chemical substance. Its application is not limited in the field. In the field of research, it can be used to solve the problem in the middle and help the person find a new way to solve the disease. Or it can be synthesized into special effects, to solve specific diseases, such as some diseases, to solve the suffering of patients.
    And in the field of materials, it can be modified. Make the material have special properties, such as increasing its quality, changing its surface properties, etc., so that the material is more suitable for different needs, used in equipment, equipment, etc., to promote the progress of science and technology. Furthermore, in the field of chemical analysis, it can be used as a special method to help the chemist analyze the composition of the material, understand the characteristics of the material, and promote the in-depth research of the chemical.
    Research & Development
    In recent years, I have been in the field of chemical industry, focusing on the research of 4 - Fluoro - 2 - Isothiocyanato - 1 - Methylbenzene. Its unique nature, in the way of chemical synthesis, has great potential.
    At the beginning, it was very laborious to analyze its structure and explore its physicochemical properties. After months of research, I knew its reaction mechanism, and then found a way to synthesize it. The initial trial of several strategies, or the yield did not meet expectations, or the impurities were difficult to remove. However, I did not give up, and failed to try again and again.
    Finally got a method to optimize the reaction conditions, temperature control, speed regulation, and agent selection are all exquisite. The yield gradually increases, and the quality is also good. And this product has made a name for itself in pharmaceutical intermediates, material synthesis, etc. Colleagues all praise it, and I am also very pleased. In the future, we should be more diligent, explore its new uses, and promote its wide spread, hoping to contribute to the rise of chemical industry.
    Toxicity Research
    Fu 4 - Fluoro - 2 - Isothiocyanato - 1 - Methylbenzene This substance is quite important in toxicity research. Its strong nature, or harmful to life. Looking at all experiments, touching it or eating it can cause changes in organisms. It can disrupt the order of cells and disturb the normal metabolism.
    And if the qi of this substance enters the lungs, it may cause diseases of the airway and damage the ability to breathe. The skin is close to it, and it may also cause inflammation. Although it may be useful in industry, its toxicity should not be ignored. It is necessary to study in detail to clarify the depth of its harm and the slow speed of its development, so that a good strategy can be used to avoid disasters before they arise, to protect the safety of the living, and to protect the tranquility of the environment. Research and review, do not slack off, and take the life and rest of all things.
    Future Prospects
    I now have a thing called 4 - Fluoro - 2 - Isothiocyanato - 1 - Methylbenzene. This is what I got from my research in chemistry. Observe its quality, observe its properties, and think about its future development.
    I expect this thing to have extraordinary uses in the field of medicine. With its unique structure, it may be able to create new agents, cure various diseases, and pave the way. In materials science, it is also expected to emerge, adding to the research and development of novel materials.
    Although my current knowledge is limited, I firmly believe that with time, with the wisdom of everyone and the power of poor research, I will be able to fully stimulate the hidden power of this substance. The future development will be like Kunpeng spreading its wings and skyrocketing, making outstanding contributions to human well-being.
    Where to Buy 4-Fluoro-2-Isothiocyanato-1-Methylbenzene in China?
    As a trusted 4-Fluoro-2-Isothiocyanato-1-Methylbenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 4-Fluoro-2-Isothiocyanato-1-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 4-Fluoro-2-Isothiocyanato-1-Methylbenzene?
    4-Fluoro-2-isothiocyanate-1-methylbenzene, this substance has a wide range of uses and has its presence in many fields.
    In the field of organic synthesis, it is often used as a key intermediate. Due to the unique activity of isothiocyanate and fluorine atoms in its structure, it can react with a variety of compounds to construct novel organic molecular structures. For example, when it encounters various amine compounds, it can follow a specific reaction mechanism to generate thiourea derivatives. These derivatives have the potential to be used as potential pharmaceutical active ingredients in the field of medicinal chemistry.
    In the field of materials science, it also has important uses. By reacting with a specific polymer monomer, its unique chemical structure can be introduced into the polymer material, thereby imparting different characteristics to the material. Such as improving the thermal stability and mechanical properties of the material, or endowing the material with special optical and electrical properties, it opens up new paths for the research and development of new functional materials.
    Furthermore, in agricultural chemistry, some compounds derived from 4-fluoro-2-isothiocyanate-1-methylbenzene have been found to have certain inhibitory and killing effects on certain crop pests and pathogens. Therefore, it may be used as a starting material for the development of new pesticides. After rational structural modification and activity screening, more efficient, low-toxic and environmentally friendly pesticide products can be created, which will help the sustainable development of agriculture.
    In conclusion, 4-fluoro-2-isothiocyanate-1-methylbenzene has shown high application value and development potential in many fields such as organic synthesis, materials science and agricultural chemistry due to its unique chemical structure and active reaction properties.
    What are the physical properties of 4-Fluoro-2-Isothiocyanato-1-Methylbenzene?
    4-Fluoro-2-isothiocyanate-1-methylbenzene, the physical properties of this substance are really the key to chemical research. At room temperature, it is mostly liquid. Looking at its color, it is usually colorless to light yellow and transparent, just like clear water, clear without losing its charm.
    Its smell is unique, and it smells like a spicy and irritating smell, just like a spicy spice, which is impressive. As for the density, it is slightly heavier than water, such as a stone sinking in water, and under the action of gravity, it naturally sinks to the bottom of the water.
    The boiling point of 4-fluoro-2-isothiocyanate-1-methyl benzene is within a certain temperature range. When the outside temperature rises to a specific value, it is like a sublimated mist, which gradually changes from liquid to gaseous state and begins to boil. The melting point is relatively low, and it can still maintain the liquid state in a milder low temperature environment.
    In addition, the substance has good solubility in many organic solvents, such as ethanol, ether, etc., just like salt melting in water, it can blend with organic solvents to form a uniform mixed system. However, the solubility in water is very small, and the two are like incompatible enemies, making it difficult to blend.
    The vapor pressure of this substance also has a specific value under certain temperature conditions. The magnitude of the vapor pressure is related to its volatilization performance. The higher the vapor pressure, the more significant the tendency to volatilize, and the diffusion rate in the air will be accelerated accordingly.
    The above physical properties are of crucial significance for in-depth understanding of the chemical behavior of 4-fluoro-2-isothiocyanate-1-methyl benzene, the chemical reactions it participates in, and its applications in industrial production, scientific research, and many other fields. Only by accurately grasping its physical properties can we better manipulate and utilize this substance, enabling it to contribute to the development and progress of humanity.
    Is 4-Fluoro-2-Isothiocyanato-1-Methylbenzene chemically stable?
    4 - Fluoro - 2 - Isothiocyanato - 1 - Methylbenzene, that is, 4 - fluoro - 2 - isothiocyanate - 1 - methylbenzene, is particularly complex. Looking at its structure, fluorine atoms, isothiocyanate groups and methyl are based on the benzene ring. Fluorine atoms are electronegative, which makes the distribution of molecular electron clouds different, affecting their chemical activity and polarity. Isothiocyanate groups are very active and are often the carry point of chemical reactions. They can interact with many nucleophiles, such as alcohols and amines, and can react with various compounds. The addition of methyl groups to the benzene ring also affects the spatial structure and electron cloud of the molecule, and can change its physical properties, such as boiling point, melting point, etc.
    When it comes to stability, its structure is still stable under the general environment of normal temperature and pressure. In case of high temperature, strong oxidant or specific catalyst, the stability is easily destroyed. In case of high temperature, the molecular vibration intensifies, the chemical bond energy increases, and it is easy to cause the bond to break, triggering decomposition reactions. Strong oxidants can seize its electrons, promoting changes in the structure of isothiocyanate groups and benzene rings.
    As for storage, it must be placed in a cool, dry and well-ventilated place, away from fire, heat and oxidants. Due to the special chemical properties of this substance, it is necessary to strictly follow safety procedures when storing and using it to prevent accidental reactions and safety accidents. In short, the chemical properties of 4-fluoro-2-isothiocyanate-1-methyl benzene are rich and complex, and the stability varies depending on environmental conditions. It needs to be treated with caution in chemical and scientific research applications.
    What is 4-Fluoro-2-Isothiocyanato-1-Methylbenzene production method?
    The preparation method of 4-fluoro-2-isothiocyanate-1-methylbenzene, although not detailed in ancient books, can now be deduced by modern chemical methods.
    To prepare this substance, the path of organic synthesis is often followed. 1-methyl-2-nitro-4-fluorobenzene can be used as the starting material. In this raw material, the nitro group can be converted into an amino group by means of reduction, using a suitable reducing agent, such as a combination of iron and hydrochloric acid, or hydrogen under the action of a catalyst (such as palladium carbon), to obtain 1-methyl-2-amino-4-fluorobenzene.
    After obtaining this amino compound, it can be reacted with sulphuric gas (or equivalent sulphurylation reagent). Sulphuric gas has high reactivity with amino groups and can convert amino groups into isothiocyanate groups, resulting in 4-fluoro-2-isothiocyanate-1-methylbenzene. Although sulfur phosgene is highly toxic, it should be handled with caution, in a well-ventilated environment, and strictly follow safety procedures.
    Another way is to introduce 1-methyl-4-fluorobenzene into the halogen atom first, such as halogenation with bromine or chlorine under appropriate conditions, to obtain the halogenated 1-methyl-4-fluorobenzene derivative. Then the halogen atom is nucleophilically substituted and introduced into a group containing thiocyanate, which is converted into an isothiocyanate group through subsequent reactions, and the target product can also be obtained. However, this path step is slightly complicated, and each step of the reaction requires precise control of the reaction conditions, such as temperature, reaction time, and the proportion of reactants, to ensure the smooth progress of the reaction and improve the purity and yield of the product.
    What 4-Fluoro-2-Isothiocyanato-1-Methylbenzene need to pay attention to when storing and transporting
    4-Fluoro-2-isothiocyanate-1-methylbenzene is a chemical substance. During storage and transportation, many matters must be paid attention to.
    First words storage. This material is very active and easy to react with other things, so it must be placed in a cool, dry and well-ventilated place. Avoid open flames and hot topics to prevent unexpected explosions. Because of its toxicity and corrosiveness, it should be stored in isolation from oxidants, acids, alkalis and food chemicals, and must not be mixed to avoid interaction and danger. And the storage place should be prepared with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment so as not to be in danger.
    As for transportation. Before transportation, it is necessary to ensure that the packaging is complete and the loading is safe. The packaging should be in accordance with relevant standards and have good sealing to prevent leakage. During transportation, the speed of the vehicle should be slow and the driving should be stable to avoid bumps, shocks and damage to the packaging. Transportation vehicles should also be equipped with corresponding fire protection and emergency treatment equipment. Personnel transporting this substance must undergo professional training and be familiar with its dangerous characteristics and emergency disposal methods. During transportation, it is not allowed to stop in densely populated areas or major traffic roads for a long time. In case of leakage and other emergencies, effective measures should be taken immediately to evacuate the crowd and handle it properly.
    Therefore, when storing and transporting 4-fluoro-2-isothiocyanate-1-methylbenzene, all precautions should be strictly observed to ensure safety.