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4-Fluoro-2-Bromo Nitrobenzene

4-Fluoro-2-Bromo Nitrobenzene

Hongda Chemical

Specifications

HS Code

555779

Chemical Formula C6H3BrFNO2
Molecular Weight 220.00
Appearance Solid (Typical description for this type of compound)
Solubility In Water Low (Aromatic nitro - halide compounds are generally sparingly soluble in water)
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform (Based on similar aromatic compounds' solubility behavior)
Vapor Pressure Low (Due to its relatively high molecular weight and non - volatile nature typical of aromatic nitro - halide compounds)
Stability Stable under normal conditions but may react with strong oxidizing or reducing agents

As an accredited 4-Fluoro-2-Bromo Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 4 - fluoro - 2 - bromonitrobenzene packaged in a sealed glass bottle.
Storage 4 - fluoro - 2 - bromonitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and ignition sources due to its potential flammability. Store it in a tightly closed container to prevent vapor leakage. Separate it from oxidizing agents, reducing agents, and bases to avoid chemical reactions. Label the storage container clearly for easy identification.
Shipping 4 - fluoro - 2 - bromo nitrobenzene is shipped in sealed, corrosion - resistant containers. Shipment follows strict hazardous chemical regulations, ensuring proper handling, storage, and transportation to prevent spills and risks during transit.
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4-Fluoro-2-Bromo Nitrobenzene 4-Fluoro-2-Bromo Nitrobenzene
General Information
Historical Development
In the realm of transformation, the origin of this compound, 4 - Fluoro - 2 - Bromo Nitrobenzene, is also rich and interesting. In the beginning, the sages explored in the subtle chemical world, and occasionally obtained clues of this quality. At that time, the means were still simple, and the analysis and observation only knew a little about its characteristics.
Years go by, and the art is gradually refined. The craftsmen are in the alchemy room, adjusting the potions, controlling the heat, and wanting to refine this quality and be good. Although they have gone through mistakes, they have not changed their determination. In the future, the equipment will become more refined, the theory will become clearer, and the technique of synthesis will become better every day.
4 - Fluoro - 2 - Bromo Nitrobenzene is gradually becoming more and more important in all kinds of chemical industries. Or it is a medicinal introduction to help fairy grass become pills; or it is a strange material to make ingenious things. Its development process is like a star gradually blazing, illuminating a corner of the chemical industry, and it is more and more shining as the years pass.
Product Overview
Today there is a substance called 4 - Fluoro - 2 - Bromo Nitrobenzene. This substance has unique characteristics in the field of chemistry. Its shape is either crystalline, the color is light, or it is colorless and transparent, and it looks like ice.
In terms of its properties, it has a specific melting and boiling point, and at a specific temperature, it may melt or boil. The chemical activity is quite considerable, and it is often a key raw material in the process of organic synthesis. It can react with many reagents to form other compounds, providing diverse possibilities for the research and production of organic chemistry.
The method of its preparation requires chemists to use exquisite skills and precise control to obtain it. And this substance is widely used in industry and scientific research. It has important value in pharmaceutical research and development, materials science and other fields, and it is an existence that cannot be ignored in the chemical world.
Physical & Chemical Properties
4-Fluoro-2-bromo-nitrobenzene is an organic compound. Its physical and chemical properties are related to the characteristics and uses of this substance. Looking at its physical properties, at room temperature, it is often solid, colored or light yellow, with a specific melting point and boiling point. This is the basis for identification and separation.
In terms of its chemical properties, due to the presence of fluorine, bromine, nitro and other functional groups, its activity is unique. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring, making the electrophilic substitution reaction difficult, but easy to lead to nucleophilic substitution. Fluorine and bromine atoms also affect the reactivity. The radius of fluorine atoms is small, and when connected to the benzene ring, it enhances the molecular stability; bromine atoms can be replaced by other groups through nucleophilic substitution.
This compound has a wide range of uses in the field of organic synthesis. It can be a key intermediate for the synthesis of complex organic molecules and assist in the preparation of drugs and pesticides with specific biological activities. It is a substance that cannot be ignored in chemical research and industrial production.
Technical Specifications & Labeling
There is now a way to make 4 - Fluoro - 2 - Bromo Nitrobenzene. Its technical regulations and identification (commodity parameters) are the key.
First technical regulations, in order to make this product, it is necessary to combine fluoride, bromide and nitrobenzene in a specific ratio at a suitable temperature. The temperature control must be accurate, and the slightest difference will be a thousand miles, which will affect the purity of the product. And the reaction time should also be appropriate. If it is too short, the synthesis will not be complete, and if it is too long, it will change.
As for the logo, the color of 4 - Fluoro - 2 - Bromo Nitrobenzene is light yellow, like an oil, with a special smell. When its purity is above 99%, the impurity content is extremely small. The melting point has a fixed number, which is an important mark, which can be used to verify its authenticity. According to this technical specification and logo, you can get high-quality 4 - Fluoro - 2 - Bromo Nitrobenzene.
Preparation Method
4-Fluoro-2-bromonitrobenzene is also an organic compound. The method of its preparation is related to the raw materials, production process, reaction steps and catalytic mechanism.
To prepare this substance, the selection of raw materials is the key. Starting with fluorobenzene and the like, bromine atoms are introduced through the bromination step. The brominating reagent used, or liquid bromine and catalyzed by iron filings, can cause the ortho-position of fluorobenzene, and the bromine atom is precisely introduced to obtain 2-bromofluorobenzene.
Then, the reaction of nitration of 2-bromofluorobenzene is carried out. Mixed acid (mixture of nitric acid and sulfuric acid) is used as the nitrifying reagent, which is prepared according to a specific ratio. During the reaction, the temperature is controlled at a suitable range, so that the nitro is precisely in place to obtain 4-fluoro-2-bromonitrobenzene.
In this process, the catalytic mechanism cannot be ignored. Iron filings in the bromination reaction can promote the polarization of bromine molecules and accelerate the reaction. In the nitrification reaction, the presence of sulfuric acid can help nitric acid to form nitroyl positive ions, which are active species of nitrification and accelerate the introduction of nitro groups. In this way, according to the selection of raw materials, step management, and catalytic assistance, the preparation of 4-fluoro-2-bromonitrobenzene can be obtained.
Chemical Reactions & Modifications
Today there is a thing called 4 - Fluoro - 2 - Bromo Nitrobenzene. In the field of chemistry, its reaction and modification are worth exploring.
Looking at its reaction, when it encounters various reagents, it often changes wonderfully. In case of nucleophiles, halogen atoms may be replaced and form a different structure. This is all due to the electron cloud distribution of the atoms on the benzene ring, which leads to the selection of reagents.
On its modification, chemists are exhausted. Or add a group to the benzene ring to change its electronic effect to adjust its physical and chemical properties. Adding an alkyl group can change its solubility; adding a nitrogen-containing heterocycle can change its reactivity.
Chemists use their wisdom and skills to control the reaction conditions, temperature, pressure, and catalyst. With precise control, they can obtain ideal products, so that 4-Fluoro-2-Bromo Nitrobenzene can perform extraordinary functions in materials, medicine, and other fields, and contribute to human well-being.
Synonyms & Product Names
4 - Fluoro - 2 - Bromo Nitrobenzene, this thing is also a treasure of chemistry. Its aliases are many and are well known in the academic world. In various classics, or the name is fluorobromonitrobenzene, which is a simple name to show its key components; there are also those called 2 - bromo - 4 - fluoronitrobenzene, which are precisely named according to their atomic positions, in order to show their structure.
As for its trade name, the industry also has a specific name. Or it is made by a trade name and given a unique name, but it is inseparable from its chemical essence. This substance has a wide range of uses in the field of chemical research, and can be an important raw material for the synthesis of other types of compounds. It plays a key role in organic synthesis, assisting the academic community in exploring the unknown, and promoting the refinement of chemical technology.
Safety & Operational Standards
4-Fluoro-2-bromonitrobenzene is an important substance in chemical research. During its experimental operation and use, safety is essential and should not be ignored.
First of all, it is related to storage. This substance should be placed in a cool, dry and well-ventilated place, away from fires and heat sources. Because of its certain chemical activity, improper storage is prone to danger. Do not mix with oxidizing agents, reducing agents, etc., to prevent chemical reactions and accidents.
Furthermore, when operating, the experimenter must wear suitable protective equipment. It is necessary to wear protective glasses to prevent liquid from splashing into the eyes and damaging the eyesight; wear protective gloves to avoid contact with the skin, because it may be irritating and corrosive to the skin. When there is a good ventilation equipment in the operation room, the volatile gas should be discharged in time to prevent it from accumulating in the air and causing poisoning and other hazards.
When taking this substance, the action should be gentle and precise. According to the amount required by the experiment, take it with appropriate equipment. Do not take it too much, which will cause waste and increase danger. If it is accidentally spilled, take emergency measures immediately. If it is spilled in small quantities, it can be absorbed by inert materials such as sand and vermiculite; if it is spilled in large quantities, it is necessary to evacuate personnel, seal the scene, and deal with it by professionals.
The reaction process also needs to be carefully monitored. Pay attention to the change of reaction temperature and pressure, and adjust the conditions according to the reaction characteristics. If the reaction is abnormal, take prompt measures to stop the reaction to ensure the safety of the experiment.
After the experiment is completed, the remaining 4-fluoro-2-bromo nitrobenzene and related waste should not be discarded at will. When in accordance with the chemical waste treatment specifications, collect them separately and dispose of them properly to protect the environment and avoid future problems.
In short, the whole process of using 4-fluoro-2-bromo nitrobenzene should strictly abide by safety and operating standards to ensure the smooth experiment, personnel safety and the environment.
Application Area
4-Fluoro-2-bromo nitrobenzene is a treasure of chemistry. Its application field is quite wide. In the field of pharmaceutical creation, it can be used as a key intermediate to help the development of new agents and cure various diseases. Such as the preparation of specific antibacterial drugs to resist the invasion of germs and protect the health of the human body.
In the field of materials science, it also has its uses. It can participate in the synthesis of special materials to improve the properties of materials, such as enhancing their stability, heat resistance, etc., making materials suitable for harsh environments and contributing to industrial development.
In the process of scientific research and exploration, it is a chemist's right-hand assistant. Help them explore the reaction mechanism, expand the boundaries of chemical cognition, lead the discipline of chemistry to a new frontier, and promote the continuous progress of the field of chemistry for the benefit of human society.
Research & Development
In recent years, I have been in the field of chemistry, specializing in the study of 4 - Fluoro - 2 - Bromo Nitrobenzene. It has unique properties and exquisite structure, and has great potential for organic synthesis.
At the beginning, I explored the preparation method of it, and it has been subject to many twists and turns. The choice of raw materials, the degree of proportions, and the control of conditions all need to be considered again and again. After several tests, a suitable method was obtained, and the yield was gradually satisfactory.
Then, the properties of the reaction were studied. Observing its action with various reagents, it has a unique performance in nucleophilic substitution and reduction reactions. Therefore, think of its application in new drug research and development, material creation, etc.
At present, although we have achieved something, the road ahead is still far away. To dig deeper into its capabilities and expand its applications, we have all contributed to the academic community. Unremitting research, hoping to lead its new changes and contribute to the progress of chemistry.
Toxicity Research
It is essential to study the toxicity of 4 - Fluoro - 2 - Bromo Nitrobenzene. This substance has halogen atoms and nitro groups, which are structural or latent risks.
Experiments show that it can react with substances in living organisms under specific circumstances. For the cells of the tested organisms, it seems to change their normal physiological functions. It also has the effect of interfering with the metabolic pathways of cells, or causing abnormal cell growth.
And it enters the ecosystem, or enriches through the food chain. After ingestion by low-level organisms, although the amount is small, it is passed through the layers, and may accumulate in high-level organisms to a considerable concentration, threatening the ecological balance.
In conclusion, the toxicity study of 4 - Fluoro - 2 - Bromo Nitrobenzene should not be underestimated, and it needs to be investigated in detail to clarify its harm and ensure ecological and human safety.
Future Prospects
Today, 4 - Fluoro - 2 - Bromo Nitrobenzene has not yet been developed in the field of my chemical research. Although the synthesis method and properties of it are known now, there is still a long way to go in the future.
Our generation can make research efforts on its derivatives, hoping to create all kinds of new chemical materials, or have specific properties, and emerge in the pharmaceutical, electronic and other industries. In the analysis of the reaction mechanism, we should also dig deep to achieve precise regulation, improve the yield and reduce by-products.
And look forward to the future, or we can use new technologies and new methods to expand its application. In the realm of nanomedicine, study its practical ability to make this material bloom and shine in the frontier field. In the future, 4 - Fluoro - 2 - Bromo Nitrobenzene will surely open new chapters and achieve great results for our researchers.
Where to Buy 4-Fluoro-2-Bromo Nitrobenzene in China?
As a trusted 4-Fluoro-2-Bromo Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 4-Fluoro-2-Bromo Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-fluoro-2-bromonitrobenzene?
"Tiangong Kaiwu" contains, Jiangsu and Zhejiang silkworm species, which have come for a long time, and are mainly produced in Huzhou. Silkworm species are crucial to silkworm breeding, and are related to the quality and quantity of silkworm cocoons. Its main uses are as follows:
First, it is related to the reproduction of silkworms. High-quality silkworm species have good genetics, which can ensure the stability of silkworm populations during the growth process. Such as silkworm body size and development cycle, which can be relatively consistent, which is convenient for silkworm farming management and production arrangements. And good genetic characteristics can make silkworms have strong vitality and high resistance to diseases, reduce the probability of silkworm disease outbreaks during breeding, and improve the overall survival rate of silkworm populations.
Second, affect the quality of cocoon silk. The cocoon silk produced by different silkworm species has obvious differences in quality. Huzhou silkworm species can produce cocoons with excellent silk quality. Its silk is long and thin, with good toughness and white color. With this kind of silkworm cocoon reeling silk, the finished product has fine texture and good gloss. It is favored in the market and can obtain higher economic value. Like the silk used in ancient royal families, cocoons produced by high-quality silkworm seeds are mostly used as raw materials.
Third, it determines the breeding efficiency. Excellent silkworm seeds grow rapidly, eat mulberry efficiently, and can reach the mature silk spinning stage in a relatively short time. This not only saves breeding time and costs, but also increases the number of sericulture batches in one year, improves the utilization rate of land and equipment, and brings more benefits to sericulturists. Therefore, silkworm farmers pay attention to the selection of silkworm seeds to obtain the best breeding benefits.
In short, Jiangsu and Zhejiang silkworm species, especially Huzhou silkworm species, play a key role in silkworm production, from reproduction, cocoon quality to breeding benefits, all-round impact on the entire sericulture industry.
What are the physical properties of 4-fluoro-2-bromonitrobenzene?
The physical properties of the 4-Jiang-2-River mussel shell are as follows:
Its texture is hard and has a certain toughness. The shell appearance is mostly oval or fan-shaped, with unique lines. These lines are like traces left by the years, or clear or obscure, or regular or complicated, which are the result of the environment and time of the mussel during the growth process.
The surface of the shell usually has a layer of luster, like a layer of gauze-like halo, which varies depending on the type of mussel, the growth environment and the preservation condition. Some shells are shiny and radiant, emitting a soft light like a pearl; others are relatively dull.
In terms of weight, it varies depending on the size and thickness of the shell. Generally, small mussel shells are lighter and feel lighter in hand; large mussel shells are relatively heavy, and their weight can be clearly felt in the hand.
Shells are rich and diverse in color, commonly gray-white, just like the mist in the early morning of winter, elegant and pure; there are also tan, like the color of the earth, calm and heavy; some shells also have colorful colors, such as rainbows falling on them, which are dazzling, mostly due to the influence of minerals and other factors in the environment.
Shells have high hardness and can withstand a certain degree of external impact, but their edges are relatively thin and brittle, and are prone to damage and fracture if they are hit by sharp objects or bent by large external forces. The internal surface of the clam is relatively smooth, and it feels delicate when touched. This is because during the long-term growth process of the clam, the secretions continue to polish the interior.
What are the chemical properties of 4-fluoro-2-bromonitrobenzene?
The river is the one with the largest flow of water; the river is the one with the connection of waterways. The river passes through, and all things are born. Today's talk 4-river-2 riverbed foundation gravel, this is the thing hidden under the river. Its chemical properties are related to the ecology of rivers and rivers, and it is also a matter of water conservancy, which cannot be ignored.
The riverbed foundation gravel is mostly stony, and the stable chemical properties are mostly silicates. Such substances, resistant to water erosion, have passed through the years at the bottom of the river, and are not hydrodynamic. Looking at its function with water, although water is soft, it initialized for a long time, and there are subtle changes. Water contains various ions, such as calcium, magnesium, iron, etc., which interact with the surface of the base gravel, or have ion exchange. If the base gravel contains metal minerals, or under the action of oxygen and carbon dioxide in the water, there is a slow oxidation and carbonation change.
The place where the base gravel is located, if it is near a mine, may be contaminated with heavy metals. Heavy metals, such as lead, mercury, and cadmium, have different chemical activities. Lead is more likely to react with acids. If the acidity in water is slightly stronger, lead ions or dissolution. Mercury is volatile in the air, but it is in the riverbed base gravel, or combined with sulfur and other elements to form stable compounds. When cadmium encounters strong acid, it can also dissolve ions, and its ions can migrate in water, affecting aquatic organisms.
Furthermore, in the land passed by the river, if the soil is different in acidity and alkalinity, it also affects the chemical properties of the base gravel. If it is a river in an acidic soil area, the concentration of hydrogen ions in the water is high, and it reacts with the base gravel to accelerate the dissolution of soluble substances in the base gravel. On the contrary, in the alkaline soil area, there are many hydroxide ions in the water, or they combine with some metal ions in the base gravel and precipitate on the surface of the base gravel or the bottom of the water.
In summary, the chemical properties of the 4-River-2 riverbed gravel are influenced by many factors such as water composition, surrounding geology, soil acidity and alkalinity. Although the change is slight, it has a profound impact on river ecology and water conservancy projects.
What are the synthesis methods of 4-fluoro-2-bromonitrobenzene?
The synthesis method of 4-ene-2-propargylamino is involved in "Tiangong Kaiwu", which is obtained by many experts in the field of chemical industry.
First, it can be started from the substrate containing alkenyl and alkynyl groups, and the method of nucleophilic substitution. Select suitable halogenated alkenes and propargylamines, use appropriate bases as acid binding agents, and control the appropriate temperature and time in organic solvents. If potassium carbonate is used as a base and acetonitrile is used as a solvent, heat and stir, the halogen atom of halogenated alkenes is replaced by the amino nucleophilic of propargylamines. This process needs to pay attention to the precise regulation of the proportion of substrates and reaction conditions to avoid the growth of side reactions and affect the purity and yield of the product.
Second, the coupling reaction catalyzed by transition metals. Select alkenyl borate or alkenyl halide with propargyl halide or the like, and use transition metals such as palladium and copper as catalysts, assisted by ligands, and react in the presence of bases. For example, palladium catalysts, bipyridine ligands, and cesium carbonate are used as bases in toluene solvents to form carbon-nitrogen bonds catalyzed by metals to achieve the construction of 4-alkenyl-2-propargylamino groups. This approach is crucial for the screening of catalysts and ligands, which has a significant impact on reaction activity and selectivity.
Third, through a multi-step reaction strategy. The alkenyl-containing structure is constructed first, and then the propargyl amino group is introduced. For example, the alkenyl intermediate is formed by allylation reaction first, and then the propargyl amino group is introduced by nucleophilic addition or substitution. Although this strategy has many steps, the reaction of each step can be fine-tuned according to needs to improve the quality and yield of the product.
There are various methods for synthesizing 4-ene-2-propargyl amino groups. The practical application needs to be based on the availability of substrates, the feasibility of reaction conditions, the requirements of product purity and yield, and the best synthesis path should be selected.
What should be paid attention to when storing and transporting 4-fluoro-2-bromonitrobenzene?
4 - Jiang - 2 - When storing and transporting mussel pearl shellfish, pay attention to the following numbers:
First, when storing, choose a cool and well-ventilated place. These two can make the ambient temperature suitable and prevent it from spoiling due to high temperature. If it is in a hot place, the shellfish are prone to qualitative changes and damage their quality. Good ventilation can keep the air smooth, disperse moisture, and prevent the shellfish from being immersed in a humid atmosphere, so as to prolong their storage period.
Second, it is also crucial for the control of humidity. If the humidity is too high, the shellfish are easy to breed mold and cause it to deteriorate; if the humidity is too low, it is afraid of dehydration and affect the quality. Therefore, when maintaining a moderate humidity, it can be covered with a damp cloth or placed in a medium method of shallow water to keep it moisturized but not too wet.
Third, the packaging must be firm during transportation. Use soft cushions, such as hay, soft cloth, etc., to cushion vibration and prevent shellfish from being damaged in bumps. And the loading should not be too dense, leaving some space, so that the shellfish can breathe smoothly and facilitate air circulation.
Fourth, the transportation time should be reduced as much as possible. Shellfish need specific conditions to survive. If it takes too long, the living environment will gradually deteriorate, and it is easy to cause death. Therefore, it is necessary to plan a reasonable route and choose a fast transportation method to reach the destination quickly.
Fifth, temperature regulation runs through the whole process of storage and transportation. Sudden temperature changes have a great impact on shellfish. It is advisable to cool down in summer, such as using ice packs; it is advisable to keep warm in winter, and can be wrapped in quilts and other materials to keep the ambient temperature relatively stable to ensure the quality and activity of 4-Jiang-2-River mussel pearl shells.