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4-Fluoro-1-Methoxy-2-Methylbenzene

4-Fluoro-1-Methoxy-2-Methylbenzene

Hongda Chemical

Specifications

HS Code

674962

Chemical Formula C8H9FO
Molar Mass 140.155 g/mol
Appearance Liquid (likely)
Solubility In Water Low (due to non - polar nature of aromatic ring)
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether

As an accredited 4-Fluoro-1-Methoxy-2-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 mL of 4 - fluoro - 1 - methoxy - 2 - methylbenzene in a sealed, labeled glass bottle.
Storage 4 - fluoro - 1 - methoxy - 2 - methylbenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames to prevent ignition as it is likely flammable. Keep it in a tightly - sealed container to avoid vapor leakage. Store separately from oxidizing agents and reactive chemicals to prevent potential reactions. Label the storage clearly for easy identification and safety.
Shipping 4 - fluoro - 1 - methoxy - 2 - methylbenzene is shipped in well - sealed, corrosion - resistant containers. Compliance with chemical transportation regulations is ensured. Shipment is carefully monitored for proper handling to prevent spills and maintain product integrity.
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4-Fluoro-1-Methoxy-2-Methylbenzene 4-Fluoro-1-Methoxy-2-Methylbenzene
General Information
Historical Development
4 - Fluoro - 1 - Methoxy - 2 - Methylbenzene is also an organic compound. Tracing back to its origin, chemists in the past dedicated themselves to the field of organic synthesis. In the early years, Zhu Xian dedicated himself to the exploration of aromatic compounds, and hoped to make special products with new techniques.
At that time, organic chemistry was first developed, but the synthesis method was not complete. However, the public was not afraid of difficulties and tried new methods again and again. After years of work, the structure and reaction of benzene ring derivatives gradually became clear.
After that, with the evolution of science, the art of analysis was improved, and the method of synthesis was improved. Due to the demand for compounds containing fluorine, methoxy and methyl groups, many wise people have carefully studied and finally obtained this 4-Fluoro-1-Methoxy-2-Methylbenzene. Since its advent, it has emerged in various fields such as medicine and materials. With the deepening of research, its application prospects have become increasingly broad, adding a splendor to the development of chemistry.
Product Overview
Today, there is a substance named 4 - Fluoro - 1 - Methoxy - 2 - Methylbenzene. In its shape, it is a colorless liquid with a special odor. This substance has a wide range of uses in the chemical industry.
Looking at its structure, the benzene ring is a group, and the fluorine atom, methoxy group and methyl group each occupy a specific position. The introduction of fluorine atoms gives it unique chemical properties. Methoxy groups and methyl groups also affect their reactivity and physical properties.
The method of preparation, through a specific organic reaction, the selection of suitable raw materials, and the control of precise reaction conditions, such as temperature, pressure, and catalyst, can obtain this substance.
At the application level, in the process of pharmaceutical synthesis, it can be a key intermediary to help create special drugs. In the field of materials science, it may be able to participate in the synthesis of new functional materials, contributing to the development of related industries. Its unique nature makes it show extraordinary value in the chemical industry.
Physical & Chemical Properties
4 - Fluoro - 1 - Methoxy - 2 - Methylbenzene is an organic compound. Its physical and chemical properties are quite important to scholars. Looking at its physical properties, at room temperature, it is a colorless liquid with a slightly aromatic taste and volatility. Its boiling point is moderate, about a certain degree, which makes it unique when separating and purifying.
When it comes to chemical properties, because its structure contains fluorine, methoxy and methyl groups, it has special reactivity. The introduction of fluorine atoms changes the electron cloud density of the benzene ring, resulting in different check points and rates of electrophilic substitution reactions. Methoxy group can enhance the electron cloud density of the benzene ring, making the reaction easier to occur. Methyl also affects the spatial structure and reactivity of the molecule. The interaction of various groups results in the unique physical and chemical properties of 4-Fluoro-1-Methoxy-2-Methylbenzene, which has broad application prospects in organic synthesis and other fields.
Technical Specifications & Labeling
4 - Fluoro - 1 - Methoxy - 2 - Methylbenzene is also an organic compound. Its process specifications and identification (commodity parameters) are crucial. In terms of its process specifications, the synthesis method needs to be accurate, and the purity of the raw material, the temperature and duration of the reaction are all fixed. The raw materials must be well selected, the reaction temperature shall prevail, and the duration shall also be appropriate, so as to ensure the quality of the product.
As for the identification (commodity parameters), from the perspective of physicochemical properties, the genus of color, taste, and state of melting and boiling must be specified. The color should be pure and free of impurities, the taste should be no odor, and the state should be stable. The melting and boiling point must be certain as the basis for identification. And the standard of its purity must be of high quality, and the content of impurities must be tiny. In this way, the essential meaning of 4-Fluoro-1-Methoxy-2-Methylbenzene process specifications and labels (commodity parameters) can be used as a criterion for production and application.
Preparation Method
To prepare 4 - Fluoro - 1 - Methoxy - 2 - Methylbenzene, the raw materials and production process, reaction steps and catalytic mechanism are the key.
First take appropriate raw materials, such as fluorine, methoxy and methyl-related compounds, and place them in the reactor according to a certain ratio. At the beginning of the reaction, it is necessary to precisely control the temperature and pressure to create a suitable reaction environment. A specific catalyst is used to intervene to catalyze the reaction process and accelerate the breaking and recombination of chemical bonds.
The reaction steps are orderly, first initiating the reaction of key groups, so that they interact to form a preliminary intermediate. Then, through subsequent reaction steps, the intermediate is finely adjusted and gradually directed to the target product. During this period, the reaction process is strictly monitored and the conditions are adjusted in a timely manner to ensure that the reaction proceeds according to the expected path.
The production process pays attention to detail control, from raw material pretreatment to product separation and purification, all require fine operation. During separation, appropriate separation methods are used to remove impurities and improve product purity. Finally, through a series of process treatments, high purity 4-Fluoro-1-Methoxy-2-Methylbenzene can be obtained.
Chemical Reactions & Modifications
4 - Fluoro - 1 - Methoxy - 2 - Methylbenzene is also an organic compound. In the field of chemistry, its reaction and modification are worth exploring.
Looking at its chemical properties, it can change its structure through various reactions, and then obtain products with specific properties. If it encounters an electrophilic reagent, it can lead to an electrophilic substitution reaction. The position of fluorine, methoxy or methyl can become a check point for the reaction, so that the structure of the molecule can be changed, and it has a different chemical activity.
The way of modification, or the introduction of new functional groups, or the change of its spatial configuration. This is of great significance for the creation of new substances and the optimization of performance. If a proper reaction is carried out, the addition of nitrogen-containing and oxygen-containing functional groups can make it have better solubility and biological activity.
Chemists study the reaction and modification of this compound, hoping to expand its use in materials, medicine and other industries, develop its talents, and be used by the world.
Synonyms & Product Names
4 - Fluoro - 1 - Methoxy - 2 - Methylbenzene is also a chemical product. Its trade name is the same, and there is no way to investigate it.
In the field of chemical research, this product may have a name, which is used by the person, or according to its nature, quality, or synthesis method and use, which are different. Its trade name is also due to the merchant.
Examination of ancient books, the existence of the same product, is convenient for those who communicate and write. The trade name is involved in business, hoping that in the name of special, its characteristics will be recognized, and it will attract business and users' attention.
If you want to study this thing, you must test its same product name, so that you can communicate with all parties. It is beneficial to chemical research, manufacturing, business circulation, etc., and will not be confused by the difference in name.
Safety & Operational Standards
4 - Fluoro - 1 - Methoxy - 2 - Methylbenzene Safety and Operation Specifications
Fu 4 - Fluoro - 1 - Methoxy - 2 - Methylbenzene, also organic compounds. It is used in chemical, pharmaceutical and other fields, and has a wide range of uses. If you want to use it, you must understand its safety and operation specifications, so as to ensure that everything goes smoothly and is safe.
#1. Storage Regulations
This compound should be stored in a cool, dry and well ventilated place. Keep away from fire and heat sources to prevent accidents. And it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Because mixed storage is prone to chemical reactions, dangerous breeding. The storage area should be equipped with suitable materials to contain leaks in case of emergency.
#2. Operation essentials
When operating, it is necessary to strictly abide by the operating procedures. Operators should be specially trained and familiar with various operation points before they can go to work. On the operation site, good ventilation should be maintained to dissipate harmful gases. And operators should wear self-priming filter gas masks (half masks), chemical safety glasses, anti-poison penetration overalls, and rubber oil-resistant gloves to protect themselves.
When taking it, handle it with care to avoid damage to the container. In case of accidental leakage, a small amount of leakage can be mixed with sand, dry lime or soda ash and collected in a dry, clean and covered container. If there is a large amount of leakage, an embankment should be built or a pit should be dug to contain it, covered with foam to reduce steam disasters. And quickly evacuate personnel from the leaked contaminated area to a safe area, quarantine, and strictly restrict access.
#3. Emergency measures
If anyone comes into contact with this compound and comes into contact with the skin, they should immediately take off the contaminated clothes, rinse with a large amount of flowing water for at least 15 minutes, and then seek medical attention. If you come into contact with the eyes, lift the eyelids, and rinse with flowing water or normal saline, you also need to seek medical attention. If inhaling, quickly leave the scene to a fresh place in the air to keep the respiratory tract unobstructed. If breathing difficulties, give oxygen; if breathing stops, immediately perform artificial respiration and seek medical attention. Those who ingest, drink enough warm water, induce vomiting, and seek medical attention.
In short, in the use of 4 - Fluoro - 1 - Methoxy - 2 - Methylbenzene, safety must be the priority, and operating standards must be observed in order to avoid disasters and make the best use of them.
Application Area
4 - Fluoro - 1 - Methoxy - 2 - Methylbenzene is an organic compound. Its application field is quite broad. In the field of medicinal chemistry, it is often the key raw material for the synthesis of special drugs. Because of its unique molecular structure, it can participate in a variety of reactions, helping to build complex drug molecular structures to treat various diseases.
In the field of materials science, it also has its uses. It can be used as a starting material for the preparation of special performance materials. After clever chemical transformation, it endows the materials with novel physical and chemical properties, such as optimizing the optical and electrical properties of the materials.
In the fine chemical industry, this compound can be used to produce high-end flavors, additives and other products. With its chemical properties, it can add unique functions and quality to the product and enhance the market competitiveness of the product. In short, 4 - Fluoro - 1 - Methoxy - 2 - Methylbenzene is of great value in many application fields and is indispensable for chemical research and industrial production.
Research & Development
In modern times, chemistry has flourished, and the art of research has become increasingly refined. I focus on 4-Fluoro-1-Methoxy-2-Methylbenzene to explore its mysteries.
At the beginning, I observed its properties and analyzed its structure in detail to clarify its chemical properties. In the context of the reaction, observe its changes, try different methods, and hope to get the best system. Or adjust the temperature, or change the agent, try again and again, and work tirelessly.
During the period, I also encountered various problems. The rate of reaction did not meet expectations, and the purity of the product was also insufficient. However, I was not discouraged, carefully reviewed the process, and traced back to the source. Refer to ancient books, ask colleagues for advice, and finally get the solution.
After a long time of study, I have gradually achieved success. The system of this product has become more and more refined, and the quality has steadily improved. I believe that with time, I will be able to contribute to the field of chemistry and make contributions to the development of the academic community.
Toxicity Research
The toxicity of 4 - Fluoro - 1 - Methoxy - 2 - Methylbenzene is of great significance. To investigate it in detail, a rigorous method is required. Observe its chemical composition, analyze its molecular properties, and explore its changes in different environments. After many experiments, observe its impact on various organisms. Or touch the skin, or enter the body, its reactions are recorded in detail. See it or cause skin discomfort, or disturb the function of the body. Although this substance has a wide range of uses, the problem of toxicity should not be ignored. It is necessary to study it carefully and understand the mechanism of its poison, so that we can get a proper method to avoid its harm and use it to protect the well-being of everyone and protect the tranquility of the environment. It must not be poisoned in future generations for temporary gain.
Future Prospects
Today there is a thing named 4 - Fluoro - 1 - Methoxy - 2 - Methylbenzene. Looking at its characteristics, it is quite novel. In the field of our research, its future situation is particularly foreseeable.
This thing has unique properties, and may be able to emerge in the genus of chemical processes and pharmaceutical research. With time, after intensive research and deep discussion, we will be able to explore its subtlety.
We will use advanced methods and solid ideas to study its characteristics and effectiveness in depth. When it is suddenly understood, it will definitely be able to benefit the world. Or add new life to medicine, or open up a vast path for chemical industry. This is the future situation we all look forward to, and it is also the swan of unremitting efforts.
Where to Buy 4-Fluoro-1-Methoxy-2-Methylbenzene in China?
As a trusted 4-Fluoro-1-Methoxy-2-Methylbenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 4-Fluoro-1-Methoxy-2-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the chemistry of 4-Fluoro-1-Methoxy-2-Methylbenzene?
4-Fluoro-1-methoxy-2-methylbenzene is one of the organic compounds. It has unique chemical properties and has attracted much attention in the field of organic synthesis.
Among this compound, fluorine atoms, methoxy groups and methyl groups all have far-reaching effects on its properties. Fluorine atoms have strong electronegativity, which can cause changes in the distribution of molecular electron clouds and enhance molecular polarity. This property may make the compound exhibit special activity in specific reactions such as nucleophilic substitution reactions. It can enhance the interaction between molecules and other polar molecules, affecting the solubility and reactivity of the compound.
Methoxy group is the power supply group, which can increase the density of the electron cloud of the benzene ring through the conjugation effect. In this way, the benzene ring is more susceptible to attack by electrophilic reagents. In the electrophilic substitution reaction, the reactivity of this compound may be increased due to the presence of methoxy groups, and the substitution position or the methoxy group localization effect is affected, and it is more inclined to react at a specific position.
methyl also has an effect on the properties of the compound. Although its electron supply capacity is weaker than that of methoxy, it can change the molecular spatial structure and electron cloud distribution, affecting the physical properties of the compound, such as boiling point, melting point, etc. The introduction of methyl can increase the molecular spatial resistance, which affects the reaction selectivity. In some reactions, due to methyl spatial obstruction, the reaction reagent is limited to a specific position close to the benzene ring, thus affecting the reaction path and product distribution.
The chemical properties of 4-fluoro-1-methoxy-2-methylbenzene are the result of the synergistic action of various substituents. In organic synthesis, chemists can design appropriate reaction pathways to achieve effective conversion and utilization of the compound to obtain organic molecules with specific functions and structures.
What are the common uses of 4-Fluoro-1-Methoxy-2-Methylbenzene?
4-Fluoro-1-methoxy-2-methylbenzene, this is an organic compound with a wide range of common uses.
In the field of organic synthesis, it is often used as a key intermediate. For example, when creating certain drug molecules with specific structures, it can be used as a starting material and converted into complex compounds with specific pharmacological activities through a series of delicate chemical reactions. Because of the fluorine atoms, methoxy groups and methyl groups contained in the molecule, it is endowed with unique chemical properties and can participate in various types of reactions, such as nucleophilic substitution reactions, electrophilic substitution reactions, etc., to construct different chemical bonds and achieve the synthesis of target compounds.
In the field of materials science, there is also a place for it. For example, when preparing some functional materials, such as organic optoelectronic materials, its special structure can be used to prepare materials with specific optoelectronic properties through appropriate chemical modification and polymerization reactions, which can be used in organic Light Emitting Diodes (OLEDs), organic solar cells and other devices to help improve the performance of these devices.
At the same time, in the fragrance industry, it may emit a specific odor due to its unique molecular structure, which may be used to prepare special fragrances. Due to its relatively stable chemical properties and certain volatility, it can provide long-lasting and unique aroma components in the fragrance system, adding characteristics to the fragrance formula.
When studying new catalysts or catalytic reaction mechanisms, 4-fluoro-1-methoxy-2-methylbenzene may also become a research object. By observing its reaction under various catalytic conditions, it is possible to deeply explore the activity of catalysts, reaction pathways and reaction kinetics and other key information, contributing to the development of catalysis science.
What is the preparation method of 4-Fluoro-1-Methoxy-2-Methylbenzene?
The preparation method of 4-fluoro-1-methoxy-2-methylbenzene can follow the following steps.
First, use suitable starting materials, such as 2-methyl-4-fluorophenol as the starting material. This compound can react with methylation reagents to introduce methoxy groups. Commonly used methylation reagents, such as dimethyl sulfate or iodomethane. If dimethyl sulfate is used as an example, in an alkaline environment, the nucleophilic substitution reaction can occur between the two. The choice of base is quite important, and generally a weak base such as potassium carbonate can be selected. In a suitable organic solvent, such as acetone or N, N-dimethylformamide (DMF), the reaction is carried out by heating and stirring. The reaction temperature needs to be carefully controlled, generally 50-80 ° C. In this temperature range, dimethyl sulfate and 2-methyl-4-fluorophenol can react efficiently and selectively to form the target product 4-fluoro-1-methoxy-2-methylbenzene.
Another route can be started from the corresponding halogenated aromatics. For example, 2-fluoro-4-methylbromobenzene is used as a raw material. The halogenated aromatic hydrocarbon is first reacted with sodium methoxide in a suitable solvent. The methoxy negative ion in the sodium methoxide acts as a nucleophilic reagent to attack the carbon atom connected to the bromine on the aromatic ring of the halogenated aromatic hydrocarbon, and a nucleophilic substitution reaction occurs. Bromine ions leave to form 4-fluoro-1-methoxy-2-methylbenzene. This reaction also needs to control the reaction conditions, such as reaction temperature, solvent type and proportion of reactants. The solvent can be selected as an aprotic solvent such as toluene, and the temperature is about 80-100 ° C. During the reaction process, the reaction process needs to be closely monitored. By means of thin-layer chromatography (TLC), the raw material point is basically eliminated, indicating that the reaction is basically completed. Subsequent separation and purification steps, such as vacuum distillation, column chromatography, etc., to obtain high-purity 4-fluoro-1-methoxy-2-methylbenzene.
4-Fluoro-1-Methoxy-2-Methylbenzene need to pay attention to when storing
4-Fluoro-1-methoxy-2-methylbenzene, when storing, you need to pay attention to many things. This substance has a certain chemical activity. When exposed to light or heat, it is afraid of chemical reactions and quality changes. Therefore, it should be stored in a cool and dark place to ensure its chemical stability.
Furthermore, it is quite sensitive to air or humidity. In humid air, or due to the action of moisture, it decomposes or deteriorates. Therefore, the storage place should be dry, and auxiliary means such as desiccants can be used to maintain a dry environment to prevent it from getting damp.
In addition, 4-fluoro-1-methoxy-2-methylbenzene may be toxic and volatile. If stored improperly, the escape of steam may cause health hazards, and volatilization will also damage its content and quality. Therefore, the storage container must be well sealed to prevent leakage and volatilization.
Also note that this substance may react with other chemicals. When storing, avoid coexisting with oxidants, strong acids, strong bases and other substances to prevent violent reactions and endanger safety.
In addition, the storage place should be clearly marked with the name, characteristics, hazards and other information of the substance, so that personnel can know that in the event of an emergency, they can respond quickly to ensure safe storage.
4-Fluoro-1-Methoxy-2-Methylbenzene impact on the environment
4-Fluoro-1-methoxy-2-methylbenzene is one of the organic compounds. Its impact on the environment is quite complex, and it should be carefully observed.
First, the physical characteristics of its environmental symptoms. This material has a specific boiling point, melting point and vapor pressure. The boiling point is established, at room temperature, or in a liquid state, and its vapor pressure causes some volatilization into the atmosphere. If released in large quantities into the atmosphere, or participate in photochemical reactions. Under light, or interact with other components in the atmosphere, such as nitrogen oxides, hydrocarbons, etc., to generate secondary pollutants such as ozone. If the ozone concentration is high, near the ground, it will harm human health and harm plant growth.
Furthermore, its chemical properties are related to the state of the environment. This compound contains fluorine, methoxy and methyl groups. Fluorine atoms are highly electronegative, which gives the molecule unique chemical activity. In the natural environment, it may be difficult to degrade. Once it enters the soil or water body, it may remain for a long time. After entering the soil, it may affect the community structure and function of soil microorganisms. Microorganisms play a key role in soil material cycle and nutrient transformation. If their community is disturbed, soil fertility and ecological balance will be affected.
As for water bodies, if 4-fluoro-1-methoxy-2-methylbenzene enters or dissolves in them. If aquatic organisms are exposed, toxic effects may occur. Because it is fat-soluble, or enriched in aquatic organisms, it is transmitted and amplified through the food chain. After ingestion by small aquatic organisms, although they are only slightly damaged by themselves or only slightly, when large fish or other advanced organisms prey on them, toxins accumulate in the body, and the amount increases gradually, or growth and reproduction are hindered, or even population numbers are reduced.
In addition, its production and use process is also a major cause of environmental impact. During production, if the process is not good, or a large amount of this material escapes, it will pollute the atmosphere, soil and water bodies. If the use process is not followed, it will also be scattered into the environment. Therefore, throughout its life cycle, it should be handled with caution to reduce harm to the environment and maintain ecological balance.